SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3uyj'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C4D_B_DVAB8_0
(GRAMICIDIN A)		 3uyj LYSINE-SPECIFIC
DEMETHYLASE 8
(Homo
sapiens) 		3 / 3 TRP A 310
VAL A 330
TRP A 414
 AKG  A 601 (-3.1A)
None
AKG  A 601 (-4.4A)
 1.28A 1c4dA-3uyjA:
undetectable
1c4dB-3uyjA:
undetectable		 1c4dA-3uyjA:
7.48
1c4dB-3uyjA:
7.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DB1_A_VDXA428_1
(VITAMIN D NUCLEAR
RECEPTOR)		 3uyj LYSINE-SPECIFIC
DEMETHYLASE 8
(Homo
sapiens) 		5 / 12 TYR A 272
LEU A 392
LEU A 329
SER A 410
SER A 318
 AKG  A 601 (-4.7A)
None
AKG  A 601 ( 4.4A)
AKG  A 601 ( 4.7A)
AKG  A 601 (-2.6A)
 1.18A 1db1A-3uyjA:
undetectable		 1db1A-3uyjA:
23.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UOF_A_PNNA1312_0
(DEACETOXYCEPHALOSPOR
IN C SYNTHETASE)		 3uyj LYSINE-SPECIFIC
DEMETHYLASE 8
(Homo
sapiens) 		5 / 11 HIS A 321
ASP A 323
HIS A 400
VAL A 402
SER A 410
 NI  A 501 ( 3.2A)
NI  A 501 ( 2.4A)
NI  A 501 ( 3.4A)
AKG  A 601 (-4.1A)
AKG  A 601 ( 4.7A)
 0.96A 1uofA-3uyjA:
7.0		 1uofA-3uyjA:
22.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UPF_A_URFA999_1
(URACIL
PHOSPHORIBOSYLTRANSF
ERASE)		 3uyj LYSINE-SPECIFIC
DEMETHYLASE 8
(Homo
sapiens) 		4 / 5 ALA A 230
TYR A 225
ILE A 226
ASP A 288
 None
 1.14A 1upfA-3uyjA:
undetectable		 1upfA-3uyjA:
20.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UPF_C_URFC999_1
(URACIL
PHOSPHORIBOSYLTRANSF
ERASE)		 3uyj LYSINE-SPECIFIC
DEMETHYLASE 8
(Homo
sapiens) 		4 / 5 ALA A 230
TYR A 225
ILE A 226
ASP A 288
 None
 1.16A 1upfC-3uyjA:
undetectable		 1upfC-3uyjA:
20.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XRH_A_NIOA200_1
(PROTEIN HP0721)		 3uyj LYSINE-SPECIFIC
DEMETHYLASE 8
(Homo
sapiens) 		4 / 7 GLY A 312
ILE A 259
MET A 253
LEU A 273
 None
 0.79A 2xrhA-3uyjA:
undetectable		 2xrhA-3uyjA:
15.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KCX_A_CQLA1_0
(HYPOXIA-INDUCIBLE
FACTOR 1-ALPHA
INHIBITOR)		 3uyj LYSINE-SPECIFIC
DEMETHYLASE 8
(Homo
sapiens) 		7 / 10 TYR A 272
HIS A 321
ASP A 323
LYS A 336
ILE A 394
HIS A 400
TRP A 414
 AKG  A 601 (-4.7A)
NI  A 501 ( 3.2A)
NI  A 501 ( 2.4A)
AKG  A 601 (-2.6A)
None
NI  A 501 ( 3.4A)
AKG  A 601 (-4.4A)
 0.80A 3kcxA-3uyjA:
24.7		 3kcxA-3uyjA:
27.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IKJ_A_SUZA201_1
(TRANSTHYRETIN)		 3uyj LYSINE-SPECIFIC
DEMETHYLASE 8
(Homo
sapiens) 		4 / 7 LEU A 392
LEU A 329
SER A 410
SER A 408
 None
AKG  A 601 ( 4.4A)
AKG  A 601 ( 4.7A)
None
 0.95A 4ikjA-3uyjA:
undetectable
4ikjB-3uyjA:
undetectable		 4ikjA-3uyjA:
18.55
4ikjB-3uyjA:
18.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VLM_A_CVIA301_1
(REGULATORY PROTEIN
TETR)		 3uyj LYSINE-SPECIFIC
DEMETHYLASE 8
(Homo
sapiens) 		4 / 8 GLY A 173
ARG A 335
GLN A 331
ASP A 406
 None
 0.82A 5vlmA-3uyjA:
undetectable		 5vlmA-3uyjA:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VLM_B_CVIB301_1
(REGULATORY PROTEIN
TETR)		 3uyj LYSINE-SPECIFIC
DEMETHYLASE 8
(Homo
sapiens) 		4 / 8 GLY A 173
ARG A 335
GLN A 331
ASP A 406
 None
 0.89A 5vlmB-3uyjA:
undetectable		 5vlmB-3uyjA:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YCP_A_BRLA501_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 3uyj LYSINE-SPECIFIC
DEMETHYLASE 8
(Homo
sapiens) 		3 / 3 GLY A 271
VAL A 235
MET A 253
 None
 0.65A 5ycpA-3uyjA:
undetectable		 5ycpA-3uyjA:
17.07