SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3uyk'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_A_115A2_2
(HMG-COA REDUCTASE)		 3uyk NDP-RHAMNOSYLTRANSFE
RASE
(Saccharopolyspor
a
spinosa) 		4 / 8 HIS A 140
LEU A  20
ALA A  23
LEU A  24
 None
 0.65A 1hwiB-3uykA:
undetectable		 1hwiB-3uykA:
24.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_C_115C4_2
(HMG-COA REDUCTASE)		 3uyk NDP-RHAMNOSYLTRANSFE
RASE
(Saccharopolyspor
a
spinosa) 		4 / 8 HIS A 140
LEU A  20
ALA A  23
LEU A  24
 None
 0.63A 1hwiD-3uykA:
undetectable		 1hwiD-3uykA:
24.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_D_115D3_1
(HMG-COA REDUCTASE)		 3uyk NDP-RHAMNOSYLTRANSFE
RASE
(Saccharopolyspor
a
spinosa) 		4 / 8 HIS A 140
LEU A  20
ALA A  23
LEU A  24
 None
 0.63A 1hwiC-3uykA:
undetectable		 1hwiC-3uykA:
24.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MZ9_A_VDYA1002_4
(CARTILAGE OLIGOMERIC
MATRIX PROTEIN)		 3uyk NDP-RHAMNOSYLTRANSFE
RASE
(Saccharopolyspor
a
spinosa) 		4 / 5 LEU A 304
CYH A 221
ALA A 255
CYH A 223
 None
 1.15A 1mz9D-3uykA:
undetectable		 1mz9D-3uykA:
8.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SQF_A_SAMA430_0
(SUN PROTEIN)		 3uyk NDP-RHAMNOSYLTRANSFE
RASE
(Saccharopolyspor
a
spinosa) 		5 / 12 GLY A 293
GLY A 294
ILE A 331
GLY A 328
PRO A 307
 None
 1.04A 1sqfA-3uykA:
2.9		 1sqfA-3uykA:
23.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A1H_A_GBNA502_1
(BRANCHED CHAIN
AMINOTRANSFERASE)		 3uyk NDP-RHAMNOSYLTRANSFE
RASE
(Saccharopolyspor
a
spinosa) 		4 / 8 ARG A 226
GLY A  45
THR A  42
ALA A  41
 None
 0.77A 2a1hA-3uykA:
undetectable
2a1hB-3uykA:
undetectable		 2a1hA-3uykA:
23.42
2a1hB-3uykA:
23.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ACL_A_REAA502_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 3uyk NDP-RHAMNOSYLTRANSFE
RASE
(Saccharopolyspor
a
spinosa) 		5 / 12 ALA A 329
ALA A 362
LEU A 324
ALA A 327
LEU A 283
 None
 0.99A 2aclA-3uykA:
undetectable
2aclE-3uykA:
undetectable		 2aclA-3uykA:
20.82
2aclE-3uykA:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ACL_G_REAG501_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 3uyk NDP-RHAMNOSYLTRANSFE
RASE
(Saccharopolyspor
a
spinosa) 		5 / 12 ALA A 329
ALA A 362
ILE A 369
LEU A 324
ALA A 327
 None
 0.94A 2aclG-3uykA:
undetectable		 2aclG-3uykA:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2I2Z_A_SALA1100_1
(SERUM ALBUMIN)		 3uyk NDP-RHAMNOSYLTRANSFE
RASE
(Saccharopolyspor
a
spinosa) 		4 / 5 LEU A 267
LEU A 237
ILE A 222
ALA A 242
 None
 0.74A 2i2zA-3uykA:
undetectable		 2i2zA-3uykA:
20.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J2P_B_SC2B1290_1
(FICOLIN-2)		 3uyk NDP-RHAMNOSYLTRANSFE
RASE
(Saccharopolyspor
a
spinosa) 		4 / 8 LEU A 171
LEU A 124
ASP A 153
ARG A 127
 None
 1.02A 2j2pA-3uykA:
undetectable
2j2pB-3uykA:
undetectable		 2j2pA-3uykA:
17.84
2j2pB-3uykA:
17.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y04_B_68HB601_1
(BETA-1 ADRENERGIC
RECEPTOR)		 3uyk NDP-RHAMNOSYLTRANSFE
RASE
(Saccharopolyspor
a
spinosa) 		5 / 12 THR A  90
VAL A  94
PHE A 151
SER A  98
TYR A  10
 None
 1.46A 2y04B-3uykA:
undetectable		 2y04B-3uykA:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ASD_A_BAXA1500_2
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		 3uyk NDP-RHAMNOSYLTRANSFE
RASE
(Saccharopolyspor
a
spinosa) 		4 / 6 ILE A 349
VAL A 289
ILE A 222
CYH A 221
 None
 0.86A 4asdA-3uykA:
undetectable		 4asdA-3uykA:
22.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RN6_A_15UA301_1
(THROMBIN HEAVY CHAIN)		 3uyk NDP-RHAMNOSYLTRANSFE
RASE
(Saccharopolyspor
a
spinosa) 		5 / 10 HIS A 166
LEU A 168
LEU A 106
ALA A 109
GLY A 130
 None
 1.30A 4rn6A-3uykA:
undetectable		 4rn6A-3uykA:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MM4_B_TA1B501_1
(TUBULIN BETA CHAIN)		 3uyk NDP-RHAMNOSYLTRANSFE
RASE
(Saccharopolyspor
a
spinosa) 		5 / 10 VAL A 250
LEU A 279
ALA A 244
PRO A 268
LEU A 267
 None
 1.08A 5mm4B-3uykA:
4.4		 5mm4B-3uykA:
12.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OV9_B_CVIB603_0
(ACETYLCHOLINESTERASE)		 3uyk NDP-RHAMNOSYLTRANSFE
RASE
(Saccharopolyspor
a
spinosa) 		4 / 7 GLN A 186
ASP A 179
HIS A 140
TYR A  10
 None
 1.00A 5ov9B-3uykA:
undetectable		 5ov9B-3uykA:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B5V_A_ECLA1001_1
(TRANSIENT RECEPTOR
POTENTIAL CATION
CHANNEL SUBFAMILY V
MEMBER 5)		 3uyk NDP-RHAMNOSYLTRANSFE
RASE
(Saccharopolyspor
a
spinosa) 		4 / 7 ILE A 306
LEU A 283
ILE A 349
ALA A 255
 None
 0.75A 6b5vA-3uykA:
undetectable
6b5vC-3uykA:
undetectable		 6b5vA-3uykA:
12.77
6b5vC-3uykA:
12.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B5V_C_ECLC1001_1
(TRANSIENT RECEPTOR
POTENTIAL CATION
CHANNEL SUBFAMILY V
MEMBER 5)		 3uyk NDP-RHAMNOSYLTRANSFE
RASE
(Saccharopolyspor
a
spinosa) 		4 / 7 ILE A 306
LEU A 283
ILE A 349
ALA A 255
 None
 0.75A 6b5vC-3uykA:
undetectable
6b5vD-3uykA:
undetectable		 6b5vC-3uykA:
12.77
6b5vD-3uykA:
12.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B5V_D_ECLD1001_1
(TRANSIENT RECEPTOR
POTENTIAL CATION
CHANNEL SUBFAMILY V
MEMBER 5)		 3uyk NDP-RHAMNOSYLTRANSFE
RASE
(Saccharopolyspor
a
spinosa) 		4 / 7 ALA A 255
ILE A 306
LEU A 283
ILE A 349
 None
 0.74A 6b5vB-3uykA:
undetectable
6b5vD-3uykA:
undetectable		 6b5vB-3uykA:
12.77
6b5vD-3uykA:
12.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DK1_B_GM4B301_0
(SIGMA NON-OPIOID
INTRACELLULAR
RECEPTOR 1)		 3uyk NDP-RHAMNOSYLTRANSFE
RASE
(Saccharopolyspor
a
spinosa) 		5 / 11 ALA A  91
LEU A 139
ASP A 145
ALA A 155
LEU A 159
 None
 1.22A 6dk1B-3uykA:
undetectable		 6dk1B-3uykA:
22.28