SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3uzb'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1BX4_A_ADNA355_1
(PROTEIN (ADENOSINE
KINASE))		 3uzb BRANCHED-CHAIN-AMINO
-ACID
AMINOTRANSFERASE
(Deinococcus
radiodurans) 		5 / 12 THR A 309
GLY A 300
ILE A 236
ALA A 239
ILE A 226
 None
 0.88A 1bx4A-3uzbA:
undetectable		 1bx4A-3uzbA:
21.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LQT_A_ACTA1871_0
(FPRA)		 3uzb BRANCHED-CHAIN-AMINO
-ACID
AMINOTRANSFERASE
(Deinococcus
radiodurans) 		4 / 7 PHE A 244
ALA A 299
PHE A 323
PHE A 296
 None
 1.19A 1lqtA-3uzbA:
undetectable		 1lqtA-3uzbA:
22.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LQU_A_ACTA1428_0
(FPRA)		 3uzb BRANCHED-CHAIN-AMINO
-ACID
AMINOTRANSFERASE
(Deinococcus
radiodurans) 		4 / 7 PHE A 244
ALA A 299
PHE A 323
PHE A 296
 None
 1.19A 1lquA-3uzbA:
undetectable		 1lquA-3uzbA:
22.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q13_A_TESA501_1
(PROSTAGLANDIN-E2
9-REDUCTASE)		 3uzb BRANCHED-CHAIN-AMINO
-ACID
AMINOTRANSFERASE
(Deinococcus
radiodurans) 		4 / 6 TYR A 190
HIS A 233
GLU A 216
VAL A 225
 None
 1.06A 1q13A-3uzbA:
undetectable		 1q13A-3uzbA:
21.03
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2A1H_A_GBNA502_1
(BRANCHED CHAIN
AMINOTRANSFERASE)		 3uzb BRANCHED-CHAIN-AMINO
-ACID
AMINOTRANSFERASE
(Deinococcus
radiodurans) 		5 / 8 TYR A 143
ARG A 145
GLY A 303
THR A 304
ALA A 305
 COI  A1517 (-4.8A)
None
PLP  A 371 (-3.6A)
PLP  A 371 ( 3.7A)
COI  A1517 (-3.1A)
 0.43A 2a1hA-3uzbA:
38.8
2a1hB-3uzbA:
38.7		 2a1hA-3uzbA:
31.84
2a1hB-3uzbA:
31.84
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2COI_A_GBNA420_1
(BRANCHED CHAIN
AMINOTRANSFERASE 1,
CYTOSOLIC)		 3uzb BRANCHED-CHAIN-AMINO
-ACID
AMINOTRANSFERASE
(Deinococcus
radiodurans) 		6 / 10 TYR A 143
ARG A 145
TYR A 175
GLY A 303
THR A 304
ALA A 305
 COI  A1517 (-4.8A)
None
COI  A1517 ( 4.8A)
PLP  A 371 (-3.6A)
PLP  A 371 ( 3.7A)
COI  A1517 (-3.1A)
 0.69A 2coiA-3uzbA:
39.5
2coiB-3uzbA:
39.7		 2coiA-3uzbA:
32.66
2coiB-3uzbA:
32.66
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2COI_B_GBNB420_1
(BRANCHED CHAIN
AMINOTRANSFERASE 1,
CYTOSOLIC)		 3uzb BRANCHED-CHAIN-AMINO
-ACID
AMINOTRANSFERASE
(Deinococcus
radiodurans) 		6 / 10 TYR A 143
ARG A 145
TYR A 175
GLY A 303
THR A 304
ALA A 305
 COI  A1517 (-4.8A)
None
COI  A1517 ( 4.8A)
PLP  A 371 (-3.6A)
PLP  A 371 ( 3.7A)
COI  A1517 (-3.1A)
 0.68A 2coiA-3uzbA:
39.5
2coiB-3uzbA:
39.7		 2coiA-3uzbA:
32.66
2coiB-3uzbA:
32.66
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2COI_B_GBNB420_1
(BRANCHED CHAIN
AMINOTRANSFERASE 1,
CYTOSOLIC)		 3uzb BRANCHED-CHAIN-AMINO
-ACID
AMINOTRANSFERASE
(Deinococcus
radiodurans) 		5 / 10 TYR A 207
TYR A 175
GLY A 303
THR A 304
ALA A 305
 COI  A1517 (-4.7A)
COI  A1517 ( 4.8A)
PLP  A 371 (-3.6A)
PLP  A 371 ( 3.7A)
COI  A1517 (-3.1A)
 1.23A 2coiA-3uzbA:
39.5
2coiB-3uzbA:
39.7		 2coiA-3uzbA:
32.66
2coiB-3uzbA:
32.66
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2COJ_A_GBNA420_1
(BRANCHED CHAIN
AMINOTRANSFERASE 1,
CYTOSOLIC)		 3uzb BRANCHED-CHAIN-AMINO
-ACID
AMINOTRANSFERASE
(Deinococcus
radiodurans) 		7 / 11 PHE A  76
TYR A 143
ARG A 145
TYR A 175
GLY A 303
THR A 304
ALA A 305
 COI  A1517 (-4.9A)
COI  A1517 (-4.8A)
None
COI  A1517 ( 4.8A)
PLP  A 371 (-3.6A)
PLP  A 371 ( 3.7A)
COI  A1517 (-3.1A)
 0.49A 2cojA-3uzbA:
39.7
2cojB-3uzbA:
39.9		 2cojA-3uzbA:
32.66
2cojB-3uzbA:
32.66
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2COJ_B_GBNB420_1
(BRANCHED CHAIN
AMINOTRANSFERASE 1,
CYTOSOLIC)		 3uzb BRANCHED-CHAIN-AMINO
-ACID
AMINOTRANSFERASE
(Deinococcus
radiodurans) 		5 / 9 TYR A 143
ARG A 145
GLY A 303
THR A 304
ALA A 305
 COI  A1517 (-4.8A)
None
PLP  A 371 (-3.6A)
PLP  A 371 ( 3.7A)
COI  A1517 (-3.1A)
 0.40A 2cojA-3uzbA:
39.7
2cojB-3uzbA:
39.9		 2cojA-3uzbA:
32.66
2cojB-3uzbA:
32.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EJ3_A_GBNA2414_1
(BRANCHED-CHAIN AMINO
ACID
AMINOTRANSFERASE)		 3uzb BRANCHED-CHAIN-AMINO
-ACID
AMINOTRANSFERASE
(Deinococcus
radiodurans) 		6 / 8 TYR A 143
ARG A 145
GLY A 303
THR A 304
ALA A 305
ALA A 306
 COI  A1517 (-4.8A)
None
PLP  A 371 (-3.6A)
PLP  A 371 ( 3.7A)
COI  A1517 (-3.1A)
COI  A1517 (-4.1A)
 0.43A 2ej3A-3uzbA:
33.2		 2ej3A-3uzbA:
29.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EJ3_B_GBNB914_1
(BRANCHED-CHAIN AMINO
ACID
AMINOTRANSFERASE)		 3uzb BRANCHED-CHAIN-AMINO
-ACID
AMINOTRANSFERASE
(Deinococcus
radiodurans) 		8 / 10 PHE A  76
TYR A 143
ARG A 145
TYR A 207
GLY A 303
THR A 304
ALA A 305
ALA A 306
 COI  A1517 (-4.9A)
COI  A1517 (-4.8A)
None
COI  A1517 (-4.7A)
PLP  A 371 (-3.6A)
PLP  A 371 ( 3.7A)
COI  A1517 (-3.1A)
COI  A1517 (-4.1A)
 0.53A 2ej3B-3uzbA:
33.3		 2ej3B-3uzbA:
29.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZT7_A_GLYA1300_0
(GLYCYL-TRNA
SYNTHETASE)		 3uzb BRANCHED-CHAIN-AMINO
-ACID
AMINOTRANSFERASE
(Deinococcus
radiodurans) 		4 / 7 ARG A 100
TYR A 207
ARG A 192
GLU A 238
 PLP  A 371 (-3.0A)
COI  A1517 (-4.7A)
PLP  A 371 ( 3.7A)
PLP  A 371 (-3.7A)
 0.98A 2zt7A-3uzbA:
undetectable		 2zt7A-3uzbA:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BPX_A_SALA257_1
(TRANSCRIPTIONAL
REGULATOR)		 3uzb BRANCHED-CHAIN-AMINO
-ACID
AMINOTRANSFERASE
(Deinococcus
radiodurans) 		4 / 8 ALA A 223
THR A 309
ILE A 311
THR A 183
 None
 0.93A 3bpxA-3uzbA:
undetectable
3bpxB-3uzbA:
undetectable		 3bpxA-3uzbA:
18.36
3bpxB-3uzbA:
18.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CFL_A_5CHA693_1
(LACTOTRANSFERRIN)		 3uzb BRANCHED-CHAIN-AMINO
-ACID
AMINOTRANSFERASE
(Deinococcus
radiodurans) 		4 / 4 THR A 304
VAL A 341
GLY A 140
THR A 138
 PLP  A 371 ( 3.7A)
None
None
None
 1.04A 3cflA-3uzbA:
undetectable		 3cflA-3uzbA:
22.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LSL_G_PZIG801_0
(GLUTAMATE RECEPTOR 2)		 3uzb BRANCHED-CHAIN-AMINO
-ACID
AMINOTRANSFERASE
(Deinococcus
radiodurans) 		3 / 3 PRO A 182
SER A 325
ASN A 184
 None
 0.94A 3lslG-3uzbA:
0.8		 3lslG-3uzbA:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FVQ_A_ACTA904_0
(TYROSINE-PROTEIN
KINASE JAK2)		 3uzb BRANCHED-CHAIN-AMINO
-ACID
AMINOTRANSFERASE
(Deinococcus
radiodurans) 		3 / 3 PHE A 296
VAL A 255
GLU A 284
 None
 0.84A 4fvqA-3uzbA:
undetectable		 4fvqA-3uzbA:
22.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KSZ_A_CYSA620_0
(LACTOPEROXIDASE)		 3uzb BRANCHED-CHAIN-AMINO
-ACID
AMINOTRANSFERASE
(Deinococcus
radiodurans) 		3 / 3 ARG A 145
GLU A  77
PHE A 118
 None
 0.74A 4kszA-3uzbA:
undetectable		 4kszA-3uzbA:
20.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HFJ_C_SAMC301_0
(ADENINE SPECIFIC DNA
METHYLTRANSFERASE
(DPNA))		 3uzb BRANCHED-CHAIN-AMINO
-ACID
AMINOTRANSFERASE
(Deinococcus
radiodurans) 		5 / 12 ASP A  50
PRO A 111
THR A 159
GLY A 150
GLU A 162
 None
 1.29A 5hfjC-3uzbA:
undetectable		 5hfjC-3uzbA:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TUD_A_ERMA2001_2
(5-HYDROXYTRYPTAMINE
RECEPTOR 2B,SOLUBLE
CYTOCHROME B562
CHIMERA)		 3uzb BRANCHED-CHAIN-AMINO
-ACID
AMINOTRANSFERASE
(Deinococcus
radiodurans) 		4 / 7 THR A 267
LEU A 279
GLN A 252
GLU A 282
 PLP  A 371 (-3.5A)
None
None
None
 1.03A 5tudA-3uzbA:
undetectable		 5tudA-3uzbA:
22.69