SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3uzv'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C4D_A_DVAA8_0
(GRAMICIDIN A)		 3uzv ANTI-DENGUE MAB 4E11
(Mus
musculus) 		3 / 3 VAL B 161
TRP B 232
TRP B 101
 None
 1.38A 1c4dA-3uzvB:
undetectable
1c4dB-3uzvB:
undetectable		 1c4dA-3uzvB:
9.90
1c4dB-3uzvB:
9.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FBM_B_RTLB951_0
(PROTEIN (CARTILAGE
OLIGOMERIC MATRIX
PROTEIN))		 3uzv ANTI-DENGUE MAB 4E11
(Mus
musculus) 		4 / 4 THR B  88
LEU B  87
LEU B  21
GLN B   7
 None
 1.16A 1fbmA-3uzvB:
undetectable		 1fbmA-3uzvB:
11.06
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1I7Z_A_COCA301_1
(CHIMERA OF IG KAPPA
CHAIN: HUMAN
CONSTANT REGION AND
MOUSE VARIABLE
REGION)		 3uzv ANTI-DENGUE MAB 4E11
(Mus
musculus) 		4 / 8 HIS B 170
TYR B 172
TYR B 185
SER B 227
 None
 0.76A 1i7zA-3uzvB:
16.8		 1i7zA-3uzvB:
33.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JQD_A_HSMA600_1
(HISTAMINE
N-METHYLTRANSFERASE)		 3uzv ANTI-DENGUE MAB 4E11
ENVELOPE PROTEIN
(Dengue
virus;
Mus
musculus) 		4 / 7 GLU A 311
VAL B 230
TRP B 232
TRP B  48
 None
 1.17A 1jqdA-3uzvA:
undetectable		 1jqdA-3uzvA:
13.31
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1VPO_H_TESH1010_1
(ANTI-TESTOSTERONE
(HEAVY CHAIN)
ANTI-TESTOSTERONE
(LIGHT CHAIN))		 3uzv ANTI-DENGUE MAB 4E11
(Mus
musculus) 		5 / 12 TRP B  48
SER B  36
TYR B  34
GLY B 103
VAL B 230
 None
 1.28A 1vpoH-3uzvB:
19.8
1vpoL-3uzvB:
21.6		 1vpoH-3uzvB:
34.11
1vpoL-3uzvB:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IJX_H_HCZH800_1
(GLUTAMATE RECEPTOR 2)		 3uzv ANTI-DENGUE MAB 4E11
(Mus
musculus) 		4 / 5 LYS B  14
PRO B  15
SER B  89
SER B  86
 None
 1.45A 3ijxH-3uzvB:
undetectable		 3ijxH-3uzvB:
22.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUE_D_SUED1201_2
(NS3 PROTEASE, NS4A
PROTEIN)		 3uzv ANTI-DENGUE MAB 4E11
(Mus
musculus) 		3 / 3 TYR B  34
LEU B   4
LYS B   3
 None
 0.79A 3sueD-3uzvB:
1.4		 3sueD-3uzvB:
23.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QZT_A_RTLA201_0
(RETINOL-BINDING
PROTEIN 2)		 3uzv ANTI-DENGUE MAB 4E11
(Mus
musculus) 		5 / 12 ILE B 184
GLN B 138
TYR B 222
GLN B  40
LEU B  46
 None
 1.40A 4qztA-3uzvB:
undetectable		 4qztA-3uzvB:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BTA_H_MFXH101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
GGTCATGAATGACTATGCAC
GTAA)		 3uzv ENVELOPE PROTEIN
(Dengue
virus) 		4 / 6 ARG A 350
GLY A 349
THR A 319
GLU A 370
 None
 1.05A 5btaA-3uzvA:
undetectable
5btaB-3uzvA:
undetectable
5btaC-3uzvA:
undetectable		 5btaA-3uzvA:
12.63
5btaB-3uzvA:
16.14
5btaC-3uzvA:
12.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BTC_G_CPFG101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
TTACGTGCATAGTCATTCAT
GACC)		 3uzv ENVELOPE PROTEIN
(Dengue
virus) 		4 / 6 ARG A 350
GLY A 349
THR A 319
GLU A 370
 None
 1.10A 5btcA-3uzvA:
undetectable
5btcC-3uzvA:
undetectable
5btcD-3uzvA:
undetectable		 5btcA-3uzvA:
12.63
5btcC-3uzvA:
12.63
5btcD-3uzvA:
16.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BTF_G_GFNG101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
TTACGTGCATAGTCATTCAT
GACC)		 3uzv ENVELOPE PROTEIN
(Dengue
virus) 		4 / 7 ARG A 350
GLY A 349
THR A 319
GLU A 370
 None
 1.03A 5btfA-3uzvA:
undetectable
5btfC-3uzvA:
undetectable
5btfD-3uzvA:
undetectable		 5btfA-3uzvA:
12.63
5btfC-3uzvA:
12.63
5btfD-3uzvA:
16.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BTI_F_LFXF101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
TTACGTGCATAGTCATTCAT
GACC)		 3uzv ENVELOPE PROTEIN
(Dengue
virus) 		4 / 5 ARG A 350
GLY A 349
THR A 319
GLU A 370
 None
 1.16A 5btiC-3uzvA:
undetectable
5btiD-3uzvA:
undetectable		 5btiC-3uzvA:
12.63
5btiD-3uzvA:
16.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UXC_A_ZITA306_1
(PREDICTED
AMINOGLYCOSIDE
PHOSPHOTRANSFERASE)		 3uzv ANTI-DENGUE MAB 4E11
ENVELOPE PROTEIN
(Dengue
virus;
Mus
musculus) 		4 / 7 THR B  33
ARG A 323
ARG B  99
SER A 331
 EOH  B 254 (-3.2A)
None
None
None
 1.28A 5uxcA-3uzvB:
undetectable		 5uxcA-3uzvB:
23.10