SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3v0a'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ERR_B_CCSB381_0
(ESTROGEN RECEPTOR)		 3v0a NTNH
(Clostridium
botulinum) 		3 / 3 GLU B 831
ALA B 826
SER B 823
 None
 0.56A 1errB-3v0aB:
undetectable		 1errB-3v0aB:
12.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LQT_A_ACTA1871_0
(FPRA)		 3v0a NTNH
(Clostridium
botulinum) 		4 / 7 PHE B  30
ALA B  42
PHE B 172
TRP B  40
 None
 1.08A 1lqtA-3v0aB:
undetectable		 1lqtA-3v0aB:
16.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LQU_A_ACTA1428_0
(FPRA)		 3v0a NTNH
(Clostridium
botulinum) 		4 / 7 PHE B  30
ALA B  42
PHE B 172
TRP B  40
 None
 1.07A 1lquA-3v0aB:
undetectable		 1lquA-3v0aB:
16.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MCN_P_DHIP1_0
(IMMUNOGLOBULIN
LAMBDA DIMER MCG
(LIGHT CHAIN)
PEPTIDE
N-ACETYL-D-HIS-L-PRO
-NH2)		 3v0a NTNH
(Clostridium
botulinum) 		3 / 3 PHE B 203
TYR B 368
PRO B 205
 None
 0.98A 1mcnA-3v0aB:
undetectable
1mcnB-3v0aB:
undetectable
1mcnP-3v0aB:
undetectable		 1mcnA-3v0aB:
10.25
1mcnB-3v0aB:
10.25
1mcnP-3v0aB:
3.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ME7_A_MOAA600_1
(INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE)		 3v0a NTNH
(Clostridium
botulinum) 		4 / 8 ASN B 397
ILE B 396
GLY B  62
GLY B 422
 None
None
None
SO4  B1195 (-3.3A)
 0.77A 1me7A-3v0aB:
undetectable		 1me7A-3v0aB:
18.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NOD_B_H4BB902_1
(NITRIC OXIDE
SYNTHASE)		 3v0a NTNH
(Clostridium
botulinum) 		3 / 3 ARG B  24
ILE B 201
TRP B 202
 None
 1.05A 1nodB-3v0aB:
undetectable		 1nodB-3v0aB:
14.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YAT_A_FK5A108_1
(FK506 BINDING
PROTEIN)		 3v0a NTNH
(Clostridium
botulinum) 		5 / 11 ILE B 573
TRP B 591
TYR B 569
LEU B 697
PHE B 535
 None
 1.29A 1yatA-3v0aB:
undetectable		 1yatA-3v0aB:
7.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z11_B_8MOB501_0
(CYTOCHROME P450,
FAMILY 2, SUBFAMILY
A, POLYPEPTIDE 6)		 3v0a NTNH
(Clostridium
botulinum) 		5 / 11 PHE B 748
ASN B 586
ILE B 579
LEU B 617
PHE B 605
 None
 1.07A 1z11B-3v0aB:
undetectable		 1z11B-3v0aB:
16.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BR4_E_SAME301_1
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 3v0a NTNH
(Clostridium
botulinum) 		3 / 3 SER B 258
ASP B 682
CYH B 685
 None
 1.08A 2br4E-3v0aB:
undetectable		 2br4E-3v0aB:
9.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IZQ_A_DVAA8_0
(GRAMICIDIN D)		 3v0a NTNH
(Clostridium
botulinum) 		3 / 3 VAL B 588
TRP B 591
VAL B 745
 None
 0.95A 2izqA-3v0aB:
undetectable
2izqB-3v0aB:
undetectable		 2izqA-3v0aB:
1.19
2izqB-3v0aB:
1.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J2P_F_SC2F1291_1
(FICOLIN-2)		 3v0a NTNH
(Clostridium
botulinum) 		5 / 6 SER B 903
LEU B1020
SER B 969
ASP B 971
GLU B1028
 None
 1.42A 2j2pE-3v0aB:
undetectable
2j2pF-3v0aB:
undetectable		 2j2pE-3v0aB:
10.15
2j2pF-3v0aB:
10.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J9C_C_ACTC1120_0
(HYPOTHETICAL
NITROGEN REGULATORY
PII-LIKE PROTEIN
MJ0059)		 3v0a NTNH
(Clostridium
botulinum) 		3 / 3 LYS B 663
TYR B 281
PRO B 280
 None
MES  B1202 ( 4.0A)
None
 1.28A 2j9cC-3v0aB:
undetectable		 2j9cC-3v0aB:
7.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NOD_B_H4BB902_1
(NITRIC OXIDE
SYNTHASE)		 3v0a NTNH
(Clostridium
botulinum) 		3 / 3 ARG B  24
ILE B 201
TRP B 202
 None
 1.08A 2nodB-3v0aB:
undetectable		 2nodB-3v0aB:
14.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q63_A_1UNA1001_2
(PROTEASE RETROPEPSIN)		 3v0a NTNH
(Clostridium
botulinum) 		3 / 3 ARG B 249
ASN B 397
THR B 488
 SO4  B1201 (-3.3A)
None
SO4  B1195 ( 4.0A)
 0.80A 2q63A-3v0aB:
undetectable		 2q63A-3v0aB:
7.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QL8_A_BEZA143_0
(PUTATIVE REDOX
PROTEIN)		 3v0a NTNH
(Clostridium
botulinum) 		4 / 7 ALA B 575
THR B 574
ALA B 741
TYR B 569
 None
 0.97A 2ql8A-3v0aB:
undetectable
2ql8B-3v0aB:
undetectable		 2ql8A-3v0aB:
8.03
2ql8B-3v0aB:
8.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W1B_A_DXCA2034_0
(ACRIFLAVIN
RESISTANCE PROTEIN B)		 3v0a NTNH
(Clostridium
botulinum) 		3 / 3 PHE B 358
SER B 258
LEU B 248
 None
 0.39A 2w1bA-3v0aB:
undetectable		 2w1bA-3v0aB:
20.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W3A_A_TOPA1190_1
(DIHYDROFOLATE
REDUCTASE)		 3v0a NTNH
(Clostridium
botulinum) 		5 / 11 ILE B 968
ALA B 987
PHE B 941
ILE B 994
VAL B 970
 None
 1.00A 2w3aA-3v0aB:
undetectable		 2w3aA-3v0aB:
9.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W9S_C_TOPC1160_1
(DIHYDROFOLATE
REDUCTASE TYPE 1
FROM TN4003)		 3v0a NTNH
(Clostridium
botulinum) 		5 / 10 ILE B 615
ALA B 753
LEU B 749
ILE B 618
ILE B 598
 None
 1.11A 2w9sC-3v0aB:
undetectable		 2w9sC-3v0aB:
8.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WEK_B_DIFB1374_1
(ZINC-BINDING ALCOHOL
DEHYDROGENASE
DOMAIN-CONTAINING
PROTEIN 2)		 3v0a NTNH
(Clostridium
botulinum) 		4 / 6 PRO B  37
ILE B   3
ASN B  17
LEU B   7
 None
 1.34A 2wekB-3v0aB:
undetectable		 2wekB-3v0aB:
14.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZZM_A_SAMA401_1
(UNCHARACTERIZED
PROTEIN MJ0883)		 3v0a NTNH
(Clostridium
botulinum) 		3 / 3 ARG B1043
ASP B1110
ASN B1148
 None
 0.89A 2zzmA-3v0aB:
undetectable		 2zzmA-3v0aB:
15.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AIC_A_ACRA5044_2
(GLUCOSYLTRANSFERASE-
SI)		 3v0a NTNH
(Clostridium
botulinum) 		3 / 3 LEU B 516
TRP B 591
TYR B 533
 None
 0.93A 3aicA-3v0aB:
undetectable		 3aicA-3v0aB:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AIC_B_ACRB5044_2
(GLUCOSYLTRANSFERASE-
SI)		 3v0a NTNH
(Clostridium
botulinum) 		3 / 3 LEU B 516
TRP B 591
TYR B 533
 None
 0.91A 3aicB-3v0aB:
undetectable		 3aicB-3v0aB:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AIC_E_ACRE5044_2
(GLUCOSYLTRANSFERASE-
SI)		 3v0a NTNH
(Clostridium
botulinum) 		3 / 3 LEU B 516
TRP B 591
TYR B 533
 None
 0.93A 3aicE-3v0aB:
undetectable		 3aicE-3v0aB:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AIC_F_ACRF5044_2
(GLUCOSYLTRANSFERASE-
SI)		 3v0a NTNH
(Clostridium
botulinum) 		3 / 3 LEU B 516
TRP B 591
TYR B 533
 None
 0.96A 3aicF-3v0aB:
undetectable		 3aicF-3v0aB:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AIC_G_ACRG5044_2
(GLUCOSYLTRANSFERASE-
SI)		 3v0a NTNH
(Clostridium
botulinum) 		3 / 3 LEU B 516
TRP B 591
TYR B 533
 None
 0.93A 3aicG-3v0aB:
undetectable		 3aicG-3v0aB:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AIC_H_ACRH5044_2
(GLUCOSYLTRANSFERASE-
SI)		 3v0a NTNH
(Clostridium
botulinum) 		3 / 3 LEU B 516
TRP B 591
TYR B 533
 None
 0.91A 3aicH-3v0aB:
undetectable		 3aicH-3v0aB:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CCF_B_BEZB261_0
(CYCLOPROPANE-FATTY-A
CYL-PHOSPHOLIPID
SYNTHASE)		 3v0a NTNH
(Clostridium
botulinum) 		4 / 8 ILE B 236
TRP B 332
PHE B 288
TYR B 231
 None
None
MES  B1202 ( 4.0A)
None
 1.29A 3ccfB-3v0aB:
undetectable		 3ccfB-3v0aB:
12.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3E7I_B_H4BB2902_1
(NITRIC OXIDE
SYNTHASE, INDUCIBLE)		 3v0a NTNH
(Clostridium
botulinum) 		3 / 3 ARG B  24
ILE B 201
TRP B 202
 None
 1.11A 3e7iB-3v0aB:
undetectable		 3e7iB-3v0aB:
15.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ILT_H_TRUH800_1
(GLUTAMATE RECEPTOR 2)		 3v0a NTNH
(Clostridium
botulinum) 		3 / 3 ILE B 932
SER B1007
SER B 918
 None
 0.63A 3iltH-3v0aB:
undetectable		 3iltH-3v0aB:
12.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JB2_A_SAMA1102_0
(STRUCTURAL PROTEIN
VP3)		 3v0a NTNH
(Clostridium
botulinum) 		5 / 12 ILE B  83
PRO B  43
ALA B  42
ALA B  36
VAL B  35
 None
 1.00A 3jb2A-3v0aB:
undetectable		 3jb2A-3v0aB:
21.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JB3_A_SAMA1102_0
(STRUCTURAL PROTEIN
VP3)		 3v0a NTNH
(Clostridium
botulinum) 		5 / 12 ILE B  83
PRO B  43
ALA B  42
ALA B  36
VAL B  35
 None
 1.09A 3jb3A-3v0aB:
undetectable		 3jb3A-3v0aB:
21.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JQA_A_DX4A270_0
(PTERIDINE REDUCTASE
1)		 3v0a LLAMA ANTIBODY F12
(Lama
glama) 		4 / 6 ARG C  71
SER C  35
TYR C  99
PRO C  53
 None
 1.14A 3jqaA-3v0aC:
undetectable		 3jqaA-3v0aC:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JQA_A_DX4A270_0
(PTERIDINE REDUCTASE
1)		 3v0a LLAMA ANTIBODY F12
(Lama
glama) 		4 / 6 ARG C  71
SER C  50
TYR C  99
PRO C  53
 None
 1.46A 3jqaA-3v0aC:
undetectable		 3jqaA-3v0aC:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JQA_B_DX4B270_0
(PTERIDINE REDUCTASE
1)		 3v0a LLAMA ANTIBODY F12
(Lama
glama) 		4 / 6 ARG C  71
SER C  35
TYR C  99
PRO C  53
 None
 1.18A 3jqaB-3v0aC:
undetectable		 3jqaB-3v0aC:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JQA_C_DX4C270_0
(PTERIDINE REDUCTASE
1)		 3v0a LLAMA ANTIBODY F12
(Lama
glama) 		4 / 6 ARG C  71
SER C  35
TYR C  99
PRO C  53
 None
 1.12A 3jqaC-3v0aC:
undetectable		 3jqaC-3v0aC:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3L8L_B_DVAB8_0
(GRAMICIDIN D)		 3v0a NTNH
(Clostridium
botulinum) 		3 / 3 VAL B 745
VAL B 588
TRP B 591
 None
 0.90A 3l8lA-3v0aB:
undetectable
3l8lB-3v0aB:
undetectable		 3l8lA-3v0aB:
1.19
3l8lB-3v0aB:
1.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N0H_A_TOPA187_1
(DIHYDROFOLATE
REDUCTASE)		 3v0a NTNH
(Clostridium
botulinum) 		5 / 11 ILE B 968
ALA B 987
PHE B 941
ILE B 994
VAL B 970
 None
 0.89A 3n0hA-3v0aB:
undetectable		 3n0hA-3v0aB:
10.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OCT_A_1N1A663_2
(TYROSINE-PROTEIN
KINASE BTK)		 3v0a NTNH
(Clostridium
botulinum) 		4 / 5 ILE B 684
MET B 817
ASN B 816
PHE B 681
 None
 1.35A 3octA-3v0aB:
undetectable		 3octA-3v0aB:
12.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S3V_A_TOPA187_1
(DIHYDROFOLATE
REDUCTASE)		 3v0a NTNH
(Clostridium
botulinum) 		5 / 12 ILE B 968
ALA B 987
PHE B 941
ILE B 994
VAL B 970
 None
 0.89A 3s3vA-3v0aB:
undetectable		 3s3vA-3v0aB:
10.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TEH_B_DAHB786_1
(PHENYLALANYL-TRNA
SYNTHETASE BETA
CHAIN)		 3v0a NTNH
(Clostridium
botulinum) 		4 / 7 LEU B 908
GLY B 872
GLU B1048
ALA B 877
 None
 0.98A 3tehB-3v0aB:
undetectable		 3tehB-3v0aB:
19.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UJ6_A_SAMA300_1
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE)		 3v0a NTNH
(Clostridium
botulinum) 		4 / 4 SER B 258
ASP B 272
ASP B 349
ALA B 354
 None
 1.42A 3uj6A-3v0aB:
undetectable		 3uj6A-3v0aB:
12.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VHU_A_SNLA1001_2
(MINERALOCORTICOID
RECEPTOR)		 3v0a NTNH
(Clostridium
botulinum) 		4 / 5 LEU B 838
LEU B 840
LEU B1005
SER B1004
 None
 1.01A 3vhuA-3v0aB:
undetectable		 3vhuA-3v0aB:
12.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AC9_C_DXCC1478_0
(MJ0495-LIKE PROTEIN)		 3v0a LLAMA ANTIBODY F12
(Lama
glama) 		4 / 7 ASP C 102
GLY C  98
THR C  97
PHE C  45
 SO4  C 144 ( 4.6A)
None
None
None
 0.78A 4ac9C-3v0aC:
undetectable		 4ac9C-3v0aC:
13.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AFG_A_QMRA1214_1
(CAPITELLA TELETA
ACHBP)		 3v0a NTNH
(Clostridium
botulinum) 		5 / 9 TYR B 660
TYR B 438
ILE B 634
ILE B 776
PHE B 661
 None
 1.43A 4afgA-3v0aB:
0.0
4afgB-3v0aB:
0.0		 4afgA-3v0aB:
12.30
4afgB-3v0aB:
12.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AFG_C_QMRC1214_1
(CAPITELLA TELETA
ACHBP)		 3v0a NTNH
(Clostridium
botulinum) 		4 / 8 TYR B 660
TYR B 438
ILE B 634
ILE B 776
 None
 0.98A 4afgD-3v0aB:
undetectable
4afgE-3v0aB:
undetectable		 4afgD-3v0aB:
12.30
4afgE-3v0aB:
12.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AFG_D_QMRD1214_1
(CAPITELLA TELETA
ACHBP)		 3v0a NTNH
(Clostridium
botulinum) 		5 / 9 TYR B 660
TYR B 438
ILE B 634
ILE B 776
PHE B 661
 None
 1.48A 4afgC-3v0aB:
0.0
4afgD-3v0aB:
0.0		 4afgC-3v0aB:
12.30
4afgD-3v0aB:
12.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AQ7_A_LEUA902_0
(LEUCINE--TRNA LIGASE)		 3v0a NTNH
(Clostridium
botulinum) 		4 / 7 MET B 346
ASP B 349
SER B 823
GLU B 213
 None
 1.19A 4aq7A-3v0aB:
undetectable		 4aq7A-3v0aB:
19.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AT0_A_ACTA1490_0
(3-KETOSTEROID-DELTA4
-5ALPHA-DEHYDROGENAS
E)		 3v0a NTNH
(Clostridium
botulinum) 		3 / 3 GLU B 342
TYR B 338
SER B 452
 None
 0.51A 4at0A-3v0aB:
undetectable		 4at0A-3v0aB:
16.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BLV_A_SAMA1281_1
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE J)		 3v0a NTNH
(Clostridium
botulinum) 		4 / 6 SER B 890
GLU B 837
ASP B 733
ASP B 892
 None
 1.27A 4blvA-3v0aB:
undetectable		 4blvA-3v0aB:
12.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FEV_B_KANB301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 3v0a NTNH
(Clostridium
botulinum) 		4 / 7 ASP B 479
ASP B 190
ASN B 193
GLU B 192
 None
 1.18A 4fevB-3v0aB:
undetectable		 4fevB-3v0aB:
11.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FEW_B_KANB301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 3v0a NTNH
(Clostridium
botulinum) 		4 / 7 ASP B 479
ASP B 190
ASN B 193
GLU B 192
 None
 1.21A 4fewB-3v0aB:
1.9		 4fewB-3v0aB:
11.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LV9_B_20JB601_1
(NICOTINAMIDE
PHOSPHORIBOSYLTRANSF
ERASE)		 3v0a NTNH
(Clostridium
botulinum) 		4 / 7 PHE B 358
ASP B 421
SER B 258
SER B 250
 None
 0.93A 4lv9A-3v0aB:
undetectable
4lv9B-3v0aB:
undetectable		 4lv9A-3v0aB:
16.50
4lv9B-3v0aB:
16.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M2X_A_TMQA202_2
(DIHYDROFOLATE
REDUCTASE)		 3v0a NTNH
(Clostridium
botulinum) 		3 / 3 TRP B 673
GLN B 259
THR B 674
 None
 0.96A 4m2xA-3v0aB:
undetectable		 4m2xA-3v0aB:
8.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M6K_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 3v0a NTNH
(Clostridium
botulinum) 		5 / 12 ILE B 981
ALA B 987
LEU B 977
PHE B 941
ILE B 904
 None
 1.09A 4m6kA-3v0aB:
undetectable		 4m6kA-3v0aB:
9.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PCL_B_SAMB301_0
(O-METHYLTRANSFERASE
FAMILY PROTEIN)		 3v0a NTNH
(Clostridium
botulinum) 		5 / 12 GLN B 385
LEU B 386
GLY B 380
ASN B 858
ASN B 375
 None
 1.13A 4pclB-3v0aB:
undetectable		 4pclB-3v0aB:
11.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QB9_E_PARE500_1
(ENHANCED
INTRACELLULAR
SURVIVAL PROTEIN)		 3v0a NTNH
(Clostridium
botulinum) 		5 / 12 PHE B 358
LEU B 248
THR B 674
SER B 678
ASP B 670
 None
 1.43A 4qb9E-3v0aB:
undetectable		 4qb9E-3v0aB:
13.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4W5N_A_IPHA902_0
(PROTEIN ARGONAUTE-2)		 3v0a NTNH
(Clostridium
botulinum) 		4 / 6 LEU B 101
ILE B 102
LEU B 230
TYR B 234
 None
 0.84A 4w5nA-3v0aB:
2.9		 4w5nA-3v0aB:
19.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4W9N_C_CCSC1548_0
(ENOYL-[ACYL-CARRIER-
PROTEIN] REDUCTASE)		 3v0a NTNH
(Clostridium
botulinum) 		3 / 3 ALA B  32
TRP B  40
VAL B  41
 None
 0.35A 4w9nC-3v0aB:
undetectable		 4w9nC-3v0aB:
11.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XUE_A_SAMA303_0
(CATECHOL
O-METHYLTRANSFERASE)		 3v0a NTNH
(Clostridium
botulinum) 		5 / 12 ASN B 586
ILE B 573
ILE B 740
ASN B 743
SER B 570
 None
 1.16A 4xueA-3v0aB:
undetectable		 4xueA-3v0aB:
10.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B8I_C_FK5C201_2
(CALCINEURIN SUBUNIT
B, VARIANT
PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE)		 3v0a NTNH
(Clostridium
botulinum) 		4 / 4 LEU B 516
MET B 540
VAL B 539
ASN B 568
 None
 1.37A 5b8iB-3v0aB:
0.2		 5b8iB-3v0aB:
9.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CSY_B_ACRB601_2
(4-ALPHA-GLUCANOTRANS
FERASE DPE1,
CHLOROPLASTIC/AMYLOP
LASTIC)		 3v0a NTNH
(Clostridium
botulinum) 		4 / 5 TYR B 372
PHE B  78
LEU B  86
PRO B 205
 None
 1.41A 5csyB-3v0aB:
undetectable		 5csyB-3v0aB:
17.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HW8_A_FK5A201_1
(FK506-BINDING
PROTEIN 1)		 3v0a NTNH
(Clostridium
botulinum) 		5 / 11 TYR B 431
ASP B 670
PHE B 430
ILE B 436
ILE B 262
 None
 0.98A 5hw8A-3v0aB:
undetectable
5hw8D-3v0aB:
undetectable		 5hw8A-3v0aB:
7.57
5hw8D-3v0aB:
7.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M54_B_TA1B502_1
(TUBULIN BETA-2B
CHAIN)		 3v0a NTNH
(Clostridium
botulinum) 		5 / 12 ASP B 746
ALA B 753
GLN B 815
ARG B 350
LEU B 820
 None
 1.48A 5m54B-3v0aB:
undetectable		 5m54B-3v0aB:
16.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MVM_B_PFLB510_1
(PROTON-GATED ION
CHANNEL)		 3v0a NTNH
(Clostridium
botulinum) 		4 / 6 ILE B  89
ALA B 219
LEU B 222
ILE B  82
 None
 0.85A 5mvmB-3v0aB:
4.6
5mvmC-3v0aB:
4.7		 5mvmB-3v0aB:
5.53
5mvmC-3v0aB:
5.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TZO_A_7V7A201_1
(ENDO-1,4-BETA-XYLANA
SE A)		 3v0a NTNH
(Clostridium
botulinum) 		4 / 8 TRP B 561
THR B 727
THR B 899
ARG B 563
 None
 1.38A 5tzoA-3v0aB:
undetectable		 5tzoA-3v0aB:
9.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_A_PCFA1803_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 3v0a NTNH
(Clostridium
botulinum) 		5 / 10 TYR B 871
ILE B1014
LEU B1006
ILE B 851
ASN B 849
 SO4  B1199 ( 4.5A)
None
None
None
None
 1.46A 5vkqA-3v0aB:
5.4
5vkqD-3v0aB:
5.4		 5vkqA-3v0aB:
20.75
5vkqD-3v0aB:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_B_PCFB1808_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 3v0a NTNH
(Clostridium
botulinum) 		5 / 10 ILE B 851
ASN B 849
TYR B 871
ILE B1014
LEU B1006
 None
None
SO4  B1199 ( 4.5A)
None
None
 1.39A 5vkqA-3v0aB:
5.4
5vkqB-3v0aB:
5.4		 5vkqA-3v0aB:
20.75
5vkqB-3v0aB:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_D_PCFD1801_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 3v0a NTNH
(Clostridium
botulinum) 		5 / 10 ILE B 851
ASN B 849
TYR B 871
ILE B1014
LEU B1006
 None
None
SO4  B1199 ( 4.5A)
None
None
 1.44A 5vkqC-3v0aB:
5.4
5vkqD-3v0aB:
5.4		 5vkqC-3v0aB:
20.75
5vkqD-3v0aB:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YW0_A_ACTA409_0
(UNCHARACTERIZED
PROTEIN KDOO)		 3v0a NTNH
(Clostridium
botulinum) 		3 / 3 ASP B 971
PHE B 571
ARG B 567
 None
 1.15A 5yw0A-3v0aB:
undetectable		 5yw0A-3v0aB:
13.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FGD_A_ACTA824_0
(GEPHYRIN)		 3v0a NTNH
(Clostridium
botulinum) 		4 / 4 LEU B  85
ASP B 217
PRO B 218
ARG B  88
 None
 1.42A 6fgdA-3v0aB:
2.2		 6fgdA-3v0aB:
16.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6R2E_H_FFOH403_0
(THYMIDYLATE SYNTHASE)		 3v0a LLAMA ANTIBODY F12
(Lama
glama) 		5 / 12 TYR C  93
LEU C  80
ASP C  59
GLY C  60
ALA C  57
 None
 1.23A 6r2eH-3v0aC:
undetectable		 6r2eH-3v0aC:
20.27