SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3v0w'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LBC_A_CYZA330_1
(GLUTAMINE RECEPTOR 2)		 3v0w WN1 222-5 FAB
(IGG2A) HEAVY CHAIN
WN1 222-5 FAB
(IGG2A) LIGHT CHAIN
(Mus
musculus) 		5 / 12 MET L 175
SER L 174
LEU H 177
SER H 178
SER H 180
 None
 1.44A 1lbcA-3v0wL:
undetectable
1lbcC-3v0wL:
undetectable		 1lbcA-3v0wL:
20.07
1lbcC-3v0wL:
20.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RMT_B_ADNB1502_1
(CLASS B ACID
PHOSPHATASE)		 3v0w WN1 222-5 FAB
(IGG2A) HEAVY CHAIN
(Mus
musculus) 		4 / 7 PHE H 146
LEU H 170
THR H 117
TYR H 145
 None
 1.24A 1rmtB-3v0wH:
undetectable		 1rmtB-3v0wH:
18.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QD2_A_CHDA2_0
(FERROCHELATASE)		 3v0w WN1 222-5 FAB
(IGG2A) HEAVY CHAIN
WN1 222-5 FAB
(IGG2A) LIGHT CHAIN
(Mus
musculus;
Mus
musculus) 		4 / 8 MET L 175
LEU L 136
SER H 178
VAL L 159
 None
 0.98A 2qd2A-3v0wL:
undetectable		 2qd2A-3v0wL:
20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZIF_A_SAMA298_0
(PUTATIVE
MODIFICATION
METHYLASE)		 3v0w WN1 222-5 FAB
(IGG2A) HEAVY CHAIN
(Mus
musculus) 		5 / 12 ALA H  23
GLY H 106
THR H  89
GLU H   6
LEU H   4
 None
 1.22A 2zifA-3v0wH:
undetectable		 2zifA-3v0wH:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZIF_A_SAMA298_0
(PUTATIVE
MODIFICATION
METHYLASE)		 3v0w WN1 222-5 FAB
(IGG2A) HEAVY CHAIN
(Mus
musculus) 		5 / 12 ALA H  23
GLY H 106
THR H  89
LEU H   4
VAL H  93
 None
 1.21A 2zifA-3v0wH:
undetectable		 2zifA-3v0wH:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ILT_H_TRUH800_1
(GLUTAMATE RECEPTOR 2)		 3v0w WN1 222-5 FAB
(IGG2A) LIGHT CHAIN
(Mus
musculus) 		3 / 3 ILE L  83
SER L  12
SER L  14
 None
 0.53A 3iltH-3v0wL:
undetectable		 3iltH-3v0wL:
20.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RAV_A_RAVA183_1
(FERRITIN LIGHT CHAIN)		 3v0w WN1 222-5 FAB
(IGG2A) HEAVY CHAIN
(Mus
musculus) 		4 / 6 LEU H  48
SER H  60
TYR H  59
ALA H  61
 None
 1.02A 3ravA-3v0wH:
undetectable		 3ravA-3v0wH:
22.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WIP_G_ACHG301_0
(ACETYLCHOLINE-BINDIN
G PROTEIN)		 3v0w WN1 222-5 FAB
(IGG2A) HEAVY CHAIN
WN1 222-5 FAB
(IGG2A) LIGHT CHAIN
(Mus
musculus;
Mus
musculus) 		4 / 8 TYR L  94
TRP H  47
THR H  35
LEU H  80
 GM0  H 306 (-4.5A)
None
None
None
 0.99A 3wipG-3v0wL:
undetectable
3wipH-3v0wL:
undetectable		 3wipG-3v0wL:
25.10
3wipH-3v0wL:
25.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WIP_J_ACHJ301_0
(ACETYLCHOLINE-BINDIN
G PROTEIN)		 3v0w WN1 222-5 FAB
(IGG2A) HEAVY CHAIN
WN1 222-5 FAB
(IGG2A) LIGHT CHAIN
(Mus
musculus;
Mus
musculus) 		4 / 8 LEU H  80
TYR L  94
TRP H  47
THR H  35
 None
GM0  H 306 (-4.5A)
None
None
 0.98A 3wipF-3v0wH:
undetectable
3wipJ-3v0wH:
undetectable		 3wipF-3v0wH:
20.49
3wipJ-3v0wH:
20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O2B_B_LOCB503_1
(TUBULIN ALPHA-1B
CHAIN
TUBULIN BETA-2B
CHAIN)		 3v0w WN1 222-5 FAB
(IGG2A) HEAVY CHAIN
(Mus
musculus) 		3 / 3 SER H 203
ALA H 198
VAL H 197
 None
 0.63A 4o2bA-3v0wH:
undetectable		 4o2bA-3v0wH:
19.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EYP_B_LOCB502_1
(TUBULIN ALPHA CHAIN
TUBULIN BETA CHAIN)		 3v0w WN1 222-5 FAB
(IGG2A) HEAVY CHAIN
(Mus
musculus) 		3 / 3 SER H 203
ALA H 198
VAL H 197
 None
 0.57A 5eypA-3v0wH:
undetectable		 5eypA-3v0wH:
19.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B58_A_ACTA606_0
(FUMARATE REDUCTASE
FLAVOPROTEIN SUBUNIT)		 3v0w WN1 222-5 FAB
(IGG2A) HEAVY CHAIN
(Mus
musculus) 		4 / 5 GLU H 148
PHE H 146
HIS H 199
THR H 110
 None
 1.14A 6b58A-3v0wH:
undetectable		 6b58A-3v0wH:
15.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BP4_A_SAMA505_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-9 SPECIFIC)		 3v0w WN1 222-5 FAB
(IGG2A) HEAVY CHAIN
WN1 222-5 FAB
(IGG2A) LIGHT CHAIN
(Mus
musculus;
Mus
musculus) 		5 / 12 GLY H  98
ARG H  94
TYR L  36
ARG L  96
LEU L  89
 GMH  H 307 (-4.1A)
SO4  H 314 (-3.2A)
None
None
None
 1.40A 6bp4A-3v0wH:
undetectable		 6bp4A-3v0wH:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DEB_B_MTXB302_1
(BIFUNCTIONAL PROTEIN
FOLD)		 3v0w WN1 222-5 FAB
(IGG2A) HEAVY CHAIN
WN1 222-5 FAB
(IGG2A) LIGHT CHAIN
(Mus
musculus) 		5 / 12 LEU H 124
PRO H 123
PHE L 135
THR H 165
VAL H 163
 None
 1.12A 6debB-3v0wH:
undetectable		 6debB-3v0wH:
17.59