SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3v10'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HSG_B_MK1B902_1
(HIV-1 PROTEASE)		 3v10 RHUSIOPATHIAE
SURFACE PROTEIN B
(Erysipelothrix
rhusiopathiae) 		5 / 10 ALA A 261
VAL A 246
ILE A 269
GLY A 267
ILE A 257
 None
 0.94A 1hsgA-3v10A:
undetectable		 1hsgA-3v10A:
14.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QZR_B_CDXB901_1
(DNA TOPOISOMERASE II)		 3v10 RHUSIOPATHIAE
SURFACE PROTEIN B
(Erysipelothrix
rhusiopathiae) 		4 / 7 THR A 179
ASN A 152
TYR A 150
LEU A  92
 None
 0.90A 1qzrA-3v10A:
undetectable		 1qzrA-3v10A:
23.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QZR_B_CDXB901_2
(DNA TOPOISOMERASE II)		 3v10 RHUSIOPATHIAE
SURFACE PROTEIN B
(Erysipelothrix
rhusiopathiae) 		4 / 7 THR A 179
ASN A 152
TYR A 150
LEU A  92
 None
 0.79A 1qzrB-3v10A:
undetectable		 1qzrB-3v10A:
23.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YKI_A_NFZA1219_1
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 3v10 RHUSIOPATHIAE
SURFACE PROTEIN B
(Erysipelothrix
rhusiopathiae) 		4 / 8 ASN A 251
GLU A 249
GLY A 252
THR A 289
 None
 1.08A 1ykiA-3v10A:
undetectable
1ykiB-3v10A:
undetectable		 1ykiA-3v10A:
21.02
1ykiB-3v10A:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YKI_C_NFZC3219_1
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 3v10 RHUSIOPATHIAE
SURFACE PROTEIN B
(Erysipelothrix
rhusiopathiae) 		4 / 8 ASN A 251
GLU A 249
GLY A 252
THR A 289
 None
 1.07A 1ykiC-3v10A:
undetectable
1ykiD-3v10A:
undetectable		 1ykiC-3v10A:
21.02
1ykiD-3v10A:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VDY_B_HCYB1384_1
(CORTICOSTEROID-BINDI
NG GLOBULIN)		 3v10 RHUSIOPATHIAE
SURFACE PROTEIN B
(Erysipelothrix
rhusiopathiae) 		5 / 12 SER A 181
THR A 166
PHE A  59
ILE A  57
SER A 148
 None
 1.34A 2vdyB-3v10A:
undetectable		 2vdyB-3v10A:
22.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EKX_B_1UNB201_2
(PROTEASE)		 3v10 RHUSIOPATHIAE
SURFACE PROTEIN B
(Erysipelothrix
rhusiopathiae) 		5 / 11 ALA A 261
VAL A 246
ILE A 269
GLY A 267
ILE A 257
 None
 0.97A 3ekxB-3v10A:
undetectable		 3ekxB-3v10A:
14.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RF4_A_FUNA201_1
(MACROPHAGE MIGRATION
INHIBITORY FACTOR)		 3v10 RHUSIOPATHIAE
SURFACE PROTEIN B
(Erysipelothrix
rhusiopathiae) 		5 / 11 ILE A 269
VAL A 292
PHE A 290
VAL A 246
ILE A 216
 None
 1.08A 3rf4A-3v10A:
undetectable
3rf4C-3v10A:
undetectable		 3rf4A-3v10A:
17.69
3rf4C-3v10A:
17.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RF4_B_FUNB202_1
(MACROPHAGE MIGRATION
INHIBITORY FACTOR)		 3v10 RHUSIOPATHIAE
SURFACE PROTEIN B
(Erysipelothrix
rhusiopathiae) 		5 / 11 ILE A 216
ILE A 269
VAL A 292
PHE A 290
VAL A 246
 None
 1.04A 3rf4A-3v10A:
undetectable
3rf4B-3v10A:
undetectable		 3rf4A-3v10A:
17.69
3rf4B-3v10A:
17.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RF4_C_FUNC203_1
(MACROPHAGE MIGRATION
INHIBITORY FACTOR)		 3v10 RHUSIOPATHIAE
SURFACE PROTEIN B
(Erysipelothrix
rhusiopathiae) 		5 / 11 ILE A 216
ILE A 269
VAL A 292
PHE A 290
VAL A 246
 None
 1.04A 3rf4B-3v10A:
undetectable
3rf4C-3v10A:
undetectable		 3rf4B-3v10A:
17.69
3rf4C-3v10A:
17.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A7T_A_5FWA1002_1
(SUPEROXIDE DISMUTASE
[CU-ZN])		 3v10 RHUSIOPATHIAE
SURFACE PROTEIN B
(Erysipelothrix
rhusiopathiae) 		3 / 3 ASN A 215
TRP A 197
ASP A 247
 None
 0.74A 4a7tA-3v10A:
undetectable
4a7tF-3v10A:
undetectable		 4a7tA-3v10A:
20.50
4a7tF-3v10A:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QGI_A_ROCA101_2
(PROTEASE)		 3v10 RHUSIOPATHIAE
SURFACE PROTEIN B
(Erysipelothrix
rhusiopathiae) 		5 / 11 ALA A 261
VAL A 246
ILE A 269
GLY A 267
ILE A 257
 None
 0.85A 4qgiB-3v10A:
undetectable		 4qgiB-3v10A:
14.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QZU_D_ACTD201_0
(RETINOL-BINDING
PROTEIN 2)		 3v10 RHUSIOPATHIAE
SURFACE PROTEIN B
(Erysipelothrix
rhusiopathiae) 		3 / 3 ASP A 247
HIS A 256
LYS A 255
 None
 0.91A 4qzuD-3v10A:
undetectable		 4qzuD-3v10A:
18.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UCI_A_ADNA2414_1
(RNA-DIRECTED RNA
POLYMERASE L)		 3v10 RHUSIOPATHIAE
SURFACE PROTEIN B
(Erysipelothrix
rhusiopathiae) 		4 / 6 GLU A 129
PHE A 130
PHE A  80
HIS A 127
 None
 1.48A 4uciA-3v10A:
undetectable		 4uciA-3v10A:
21.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X3M_B_ADNB301_1
(RNA 2'-O RIBOSE
METHYLTRANSFERASE)		 3v10 RHUSIOPATHIAE
SURFACE PROTEIN B
(Erysipelothrix
rhusiopathiae) 		5 / 9 LEU A 168
GLY A 169
ILE A 178
SER A  86
LEU A  92
 None
 1.10A 4x3mB-3v10A:
undetectable		 4x3mB-3v10A:
23.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BQG_A_ERMA1201_1
(5-HYDROXYTRYPTAMINE
RECEPTOR 2C,SOLUBLE
CYTOCHROME B562)		 3v10 RHUSIOPATHIAE
SURFACE PROTEIN B
(Erysipelothrix
rhusiopathiae) 		5 / 12 VAL A  72
GLY A 344
ALA A 106
PHE A 130
GLU A  36
 None
 0.97A 6bqgA-3v10A:
undetectable		 6bqgA-3v10A:
14.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BTX_A_EDTA503_0
(SOLUTE CARRIER
FAMILY 39
(IRON-REGULATED
TRANSPORTER))		 3v10 RHUSIOPATHIAE
SURFACE PROTEIN B
(Erysipelothrix
rhusiopathiae) 		4 / 7 SER A  91
SER A 124
HIS A 125
GLY A 123
 None
 1.15A 6btxA-3v10A:
undetectable		 6btxA-3v10A:
19.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HU9_N_PCFN606_0
(CYTOCHROME B)		 3v10 RHUSIOPATHIAE
SURFACE PROTEIN B
(Erysipelothrix
rhusiopathiae) 		5 / 12 PHE A 290
TYR A 294
THR A 296
VAL A 278
VAL A 227
 None
 1.32A 6hu9N-3v10A:
undetectable		 6hu9N-3v10A:
22.36