SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3v11'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CQP_A_803A311_1
(ANTIGEN CD11A (P180))		 3v11 TRANSLATION
INITIATION FACTOR 2
SUBUNIT ALPHA
(Sulfolobus
solfataricus) 		5 / 10 VAL B 110
ILE B 106
GLU B 130
LEU B 129
VAL B 156
 None
 1.04A 1cqpA-3v11B:
undetectable
1cqpB-3v11B:
undetectable		 1cqpA-3v11B:
25.30
1cqpB-3v11B:
25.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PTH_A_SALA710_1
(PROSTAGLANDIN H2
SYNTHASE-1)		 3v11 TRANSLATION
INITIATION FACTOR 2
SUBUNIT ALPHA
(Sulfolobus
solfataricus) 		4 / 7 VAL B  80
LEU B  41
ALA B  17
LEU B  15
 None
 0.89A 1pthA-3v11B:
undetectable		 1pthA-3v11B:
18.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W68_C_VIVC301_0
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)		 3v11 TRANSLATION
INITIATION FACTOR 2
SUBUNIT ALPHA
(Sulfolobus
solfataricus) 		5 / 12 VAL B  29
ILE B  54
VAL B  57
LEU B  58
VAL B  19
 None
 1.18A 3w68C-3v11B:
undetectable		 3w68C-3v11B:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UAC_A_ACRA501_2
(CARBOHYDRATE ABC
TRANSPORTER
SUBSTRATE-BINDING
PROTEIN, CUT1 FAMILY
(TC 3.A.1.1.-))		 3v11 TRANSLATION
INITIATION FACTOR 2
SUBUNIT ALPHA
(Sulfolobus
solfataricus) 		4 / 7 PRO B 136
GLU B 130
GLU B  33
THR B  18
 None
 1.15A 4uacA-3v11B:
undetectable		 4uacA-3v11B:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XI3_A_29SA601_1
(ESTROGEN RECEPTOR)		 3v11 TRANSLATION
INITIATION FACTOR 2
SUBUNIT ALPHA
(Sulfolobus
solfataricus) 		5 / 12 THR B  18
ALA B  17
ASP B  32
LEU B  82
ARG B  90
 None
 1.25A 4xi3A-3v11B:
undetectable		 4xi3A-3v11B:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B2S_A_ACTA107_0
(CRISPR-ASSOCIATED
ENDONUCLEASE CAS9
GUIDE RNA)		 3v11 TRANSLATION
INITIATION FACTOR 2
SUBUNIT ALPHA
(Sulfolobus
solfataricus) 		3 / 3 VAL B 264
THR B 184
ARG B 226
 None
 0.65A 5b2sB-3v11B:
undetectable		 5b2sB-3v11B:
12.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B2T_A_ACTA108_0
(CRISPR-ASSOCIATED
ENDONUCLEASE CAS9
GUIDE RNA)		 3v11 TRANSLATION
INITIATION FACTOR 2
SUBUNIT ALPHA
(Sulfolobus
solfataricus) 		3 / 3 VAL B 264
THR B 184
ARG B 226
 None
 0.61A 5b2tB-3v11B:
undetectable		 5b2tB-3v11B:
12.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CZM_B_HISB402_0
(ATP
PHOSPHORIBOSYLTRANSF
ERASE CATALYTIC
SUBUNIT)		 3v11 TRANSLATION
INITIATION FACTOR 2
SUBUNIT ALPHA
(Sulfolobus
solfataricus) 		5 / 9 VAL B  68
VAL B  29
GLY B  36
LEU B  37
GLN B  38
 None
 1.28A 6czmA-3v11B:
2.1
6czmB-3v11B:
3.1		 6czmA-3v11B:
23.25
6czmB-3v11B:
23.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CZM_C_HISC402_0
(ATP
PHOSPHORIBOSYLTRANSF
ERASE CATALYTIC
SUBUNIT)		 3v11 TRANSLATION
INITIATION FACTOR 2
SUBUNIT ALPHA
(Sulfolobus
solfataricus) 		5 / 9 VAL B  68
VAL B  29
GLY B  36
LEU B  37
GLN B  38
 None
 1.30A 6czmB-3v11B:
2.6
6czmC-3v11B:
undetectable		 6czmB-3v11B:
23.25
6czmC-3v11B:
23.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DWN_C_AQ4C602_0
(CYTOCHROME P450 1A1)		 3v11 TRANSLATION
INITIATION FACTOR 2
SUBUNIT ALPHA
(Sulfolobus
solfataricus) 		5 / 12 ILE B 217
ASN B 244
GLY B 181
ILE B 200
LEU B 250
 None
 1.05A 6dwnC-3v11B:
undetectable		 6dwnC-3v11B:
12.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DWN_D_AQ4D602_0
(CYTOCHROME P450 1A1)		 3v11 TRANSLATION
INITIATION FACTOR 2
SUBUNIT ALPHA
(Sulfolobus
solfataricus) 		5 / 12 ILE B 217
ASN B 244
GLY B 181
ILE B 200
LEU B 250
 None
 1.09A 6dwnD-3v11B:
undetectable		 6dwnD-3v11B:
12.41