SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3v1z'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DG3_A_RAPA501_1
(FK506-BINDING
PROTEIN 1A)		 3v1z ENDONUCLEASE
BSE634IR
(Geobacillus
stearothermophil
us) 		5 / 11 ASP A 173
PHE A  27
GLU A  80
VAL A  81
ILE A  85
 None
 1.23A 2dg3A-3v1zA:
undetectable		 2dg3A-3v1zA:
16.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DG4_A_RAPA501_1
(FK506-BINDING
PROTEIN 1A)		 3v1z ENDONUCLEASE
BSE634IR
(Geobacillus
stearothermophil
us) 		5 / 11 ASP A 173
PHE A  27
GLU A  80
VAL A  81
ILE A  85
 None
 1.18A 2dg4A-3v1zA:
undetectable		 2dg4A-3v1zA:
16.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2UVN_A_ECNA1409_1
(CYTOCHROME P450 130)		 3v1z ENDONUCLEASE
BSE634IR
(Geobacillus
stearothermophil
us) 		5 / 12 PRO A  26
THR A  74
THR A  77
GLY A  76
THR A 199
 None
 1.11A 2uvnA-3v1zA:
undetectable		 2uvnA-3v1zA:
19.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OZU_A_X89A411_1
(FLAVOHEMOPROTEIN)		 3v1z ENDONUCLEASE
BSE634IR
(Geobacillus
stearothermophil
us) 		5 / 12 ILE A 290
LEU A 287
LEU A 147
ALA A 175
LEU A 178
 None
 1.22A 3ozuA-3v1zA:
undetectable		 3ozuA-3v1zA:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DRJ_A_RAPA201_1
(PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP4)		 3v1z ENDONUCLEASE
BSE634IR
(Geobacillus
stearothermophil
us) 		5 / 11 ASP A 173
PHE A  27
GLU A  80
VAL A  81
ILE A  85
 None
 1.25A 4drjA-3v1zA:
undetectable		 4drjA-3v1zA:
20.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KTV_A_ADNA403_1
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)		 3v1z ENDONUCLEASE
BSE634IR
(Geobacillus
stearothermophil
us) 		5 / 12 ASP A 284
SER A  87
ASP A 282
ILE A  43
ILE A  83
 None
 1.38A 4ktvA-3v1zA:
undetectable
4ktvB-3v1zA:
undetectable		 4ktvA-3v1zA:
19.85
4ktvB-3v1zA:
19.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QT2_A_RAPA202_1
(FK506-BINDING
PROTEIN (FKBP)-TYPE
PEPTIDYL-PROPYL
ISOMERASE)		 3v1z ENDONUCLEASE
BSE634IR
(Geobacillus
stearothermophil
us) 		5 / 10 ASP A 173
PHE A  27
GLU A  80
VAL A  81
ILE A  85
 None
 1.26A 4qt2A-3v1zA:
undetectable		 4qt2A-3v1zA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QT3_A_RAPA202_1
(FK506-BINDING
PROTEIN (FKBP)-TYPE
PEPTIDYL-PROPYL
ISOMERASE)		 3v1z ENDONUCLEASE
BSE634IR
(Geobacillus
stearothermophil
us) 		5 / 10 ASP A 173
PHE A  27
GLU A  80
VAL A  81
ILE A  85
 None
 1.31A 4qt3A-3v1zA:
undetectable		 4qt3A-3v1zA:
17.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DXE_A_ESTA1000_1
(ESTROGEN RECEPTOR)		 3v1z ENDONUCLEASE
BSE634IR
(Geobacillus
stearothermophil
us) 		4 / 8 LEU A 140
LEU A 216
HIS A 222
LEU A 124
 None
 1.20A 5dxeA-3v1zA:
undetectable		 5dxeA-3v1zA:
22.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WWS_A_SAMA501_0
(PUTATIVE
METHYLTRANSFERASE
NSUN6)		 3v1z ENDONUCLEASE
BSE634IR
(Geobacillus
stearothermophil
us) 		5 / 12 PRO A 243
ASP A 146
GLY A 196
ASP A 248
LEU A 209
 None
 1.08A 5wwsA-3v1zA:
undetectable		 5wwsA-3v1zA:
22.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X7P_A_ACRA1421_1
(GLYCOSIDE HYDROLASE
FAMILY 31
ALPHA-GLUCOSIDASE)		 3v1z ENDONUCLEASE
BSE634IR
(Geobacillus
stearothermophil
us) 		4 / 5 TYR A 236
TYR A 237
GLY A 238
GLY A 196
 None
 1.22A 5x7pA-3v1zA:
undetectable		 5x7pA-3v1zA:
12.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CBZ_A_ESTA601_1
(ESTROGEN RECEPTOR)		 3v1z ENDONUCLEASE
BSE634IR
(Geobacillus
stearothermophil
us) 		4 / 8 LEU A 140
LEU A 216
HIS A 222
LEU A 124
 None
 1.20A 6cbzA-3v1zA:
undetectable		 6cbzA-3v1zA:
17.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EBP_A_DAHA123_0
(RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE,
BETA SUBUNIT)		 3v1z ENDONUCLEASE
BSE634IR
(Geobacillus
stearothermophil
us) 		5 / 9 LEU A  47
ASP A  48
SER A  42
GLY A  41
PHE A 280
 None
 1.20A 6ebpA-3v1zA:
undetectable		 6ebpA-3v1zA:
15.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EBP_B_DAHB123_0
(RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE,
BETA SUBUNIT)		 3v1z ENDONUCLEASE
BSE634IR
(Geobacillus
stearothermophil
us) 		5 / 10 LEU A  47
ASP A  48
SER A  42
GLY A  41
PHE A 280
 None
 1.21A 6ebpB-3v1zA:
undetectable		 6ebpB-3v1zA:
15.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EBP_C_DAHC123_0
(RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE,
BETA SUBUNIT)		 3v1z ENDONUCLEASE
BSE634IR
(Geobacillus
stearothermophil
us) 		5 / 10 LEU A  47
ASP A  48
SER A  42
GLY A  41
PHE A 280
 None
 1.23A 6ebpC-3v1zA:
undetectable		 6ebpC-3v1zA:
15.05