SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3v2y'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTI_A_CCSA47_0
(GLUTATHIONE
S-TRANSFERASE)		 3v2y SPHINGOSINE
1-PHOSPHATE RECEPTOR
1, LYSOZYME CHIMERA
(E.C.3.2.1.17)
(Homo
sapiens;
Escherichia
virus
T4) 		4 / 7 LEU A1033
LEU A1015
GLY A1028
LEU A1066
 None
 0.81A 1gtiA-3v2yA:
undetectable		 1gtiA-3v2yA:
15.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IOL_A_ESTA400_1
(ESTROGENIC 17-BETA
HYDROXYSTEROID
DEHYDROGENASE)		 3v2y SPHINGOSINE
1-PHOSPHATE RECEPTOR
1, LYSOZYME CHIMERA
(E.C.3.2.1.17)
(Escherichia
virus
T4;
Homo
sapiens) 		5 / 11 GLY A1028
LEU A1013
TYR A1018
PHE A1067
GLU A1005
 None
 1.44A 1iolA-3v2yA:
undetectable		 1iolA-3v2yA:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ACL_A_REAA502_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 3v2y SPHINGOSINE
1-PHOSPHATE RECEPTOR
1, LYSOZYME CHIMERA
(E.C.3.2.1.17)
(Escherichia
virus
T4;
Homo
sapiens) 		5 / 12 ALA A1129
PHE A1153
LEU A1133
ALA A1130
ILE A1078
 None
 0.97A 2aclA-3v2yA:
undetectable
2aclE-3v2yA:
undetectable		 2aclA-3v2yA:
17.80
2aclE-3v2yA:
17.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2E1Q_A_SALA2006_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)		 3v2y SPHINGOSINE
1-PHOSPHATE RECEPTOR
1, LYSOZYME CHIMERA
(E.C.3.2.1.17)
(Escherichia
virus
T4;
Homo
sapiens) 		4 / 6 PHE A1153
VAL A1087
LEU A1118
ALA A1129
 None
 1.02A 2e1qA-3v2yA:
undetectable		 2e1qA-3v2yA:
17.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2E1Q_C_SALC4006_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)		 3v2y SPHINGOSINE
1-PHOSPHATE RECEPTOR
1, LYSOZYME CHIMERA
(E.C.3.2.1.17)
(Escherichia
virus
T4;
Homo
sapiens) 		4 / 6 PHE A1153
VAL A1087
LEU A1118
ALA A1129
 None
 1.01A 2e1qC-3v2yA:
undetectable		 2e1qC-3v2yA:
17.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HJH_A_NCAA900_0
(NAD-DEPENDENT
HISTONE DEACETYLASE
SIR2)		 3v2y SPHINGOSINE
1-PHOSPHATE RECEPTOR
1, LYSOZYME CHIMERA
(E.C.3.2.1.17)
(Homo
sapiens;
Escherichia
virus
T4) 		4 / 5 ILE A 309
PRO A 308
PHE A 322
PHE A  65
 None
 1.15A 2hjhA-3v2yA:
undetectable		 2hjhA-3v2yA:
22.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XYT_G_TC9G1206_2
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 3v2y SPHINGOSINE
1-PHOSPHATE RECEPTOR
1, LYSOZYME CHIMERA
(E.C.3.2.1.17)
(Escherichia
virus
T4;
Homo
sapiens) 		4 / 8 THR A1034
TYR A1025
ILE A1017
SER A1036
 None
 1.13A 2xytH-3v2yA:
undetectable		 2xytH-3v2yA:
17.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AX7_A_SALA1336_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)		 3v2y SPHINGOSINE
1-PHOSPHATE RECEPTOR
1, LYSOZYME CHIMERA
(E.C.3.2.1.17)
(Escherichia
virus
T4;
Homo
sapiens) 		4 / 8 PHE A1153
VAL A1087
LEU A1118
ALA A1129
 None
 0.99A 3ax7A-3v2yA:
undetectable		 3ax7A-3v2yA:
16.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FAL_C_REAC501_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 3v2y SPHINGOSINE
1-PHOSPHATE RECEPTOR
1, LYSOZYME CHIMERA
(E.C.3.2.1.17)
(Escherichia
virus
T4;
Homo
sapiens) 		5 / 10 ALA A1129
PHE A1153
LEU A1133
ALA A1130
ILE A1078
 None
 1.04A 3falC-3v2yA:
undetectable		 3falC-3v2yA:
18.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FC6_A_REAA501_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 3v2y SPHINGOSINE
1-PHOSPHATE RECEPTOR
1, LYSOZYME CHIMERA
(E.C.3.2.1.17)
(Escherichia
virus
T4;
Homo
sapiens) 		5 / 11 ALA A1129
PHE A1153
LEU A1133
ALA A1130
ILE A1078
 None
 0.98A 3fc6A-3v2yA:
undetectable		 3fc6A-3v2yA:
18.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UNI_A_SALA1344_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)		 3v2y SPHINGOSINE
1-PHOSPHATE RECEPTOR
1, LYSOZYME CHIMERA
(E.C.3.2.1.17)
(Escherichia
virus
T4;
Homo
sapiens) 		4 / 7 PHE A1153
VAL A1087
LEU A1118
ALA A1129
 None
 1.01A 3uniA-3v2yA:
undetectable		 3uniA-3v2yA:
16.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZVM_B_DM2B303_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 3v2y SPHINGOSINE
1-PHOSPHATE RECEPTOR
1, LYSOZYME CHIMERA
(E.C.3.2.1.17)
(Escherichia
virus
T4;
Homo
sapiens) 		5 / 11 VAL A 209
GLY A 175
GLY A 176
MET A 180
ILE A 173
 None
 1.48A 4zvmA-3v2yA:
undetectable
4zvmB-3v2yA:
undetectable		 4zvmA-3v2yA:
17.27
4zvmB-3v2yA:
17.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A06_B_SORB1341_0
(ALDOSE-ALDOSE
OXIDOREDUCTASE)		 3v2y SPHINGOSINE
1-PHOSPHATE RECEPTOR
1, LYSOZYME CHIMERA
(E.C.3.2.1.17)
(Homo
sapiens;
Escherichia
virus
T4) 		4 / 7 ARG A1145
PHE A1004
ARG A1008
ILE A1029
 None
 1.29A 5a06B-3v2yA:
undetectable		 5a06B-3v2yA:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AN0_A_HISA520_0
(HISTIDINOL
DEHYDROGENASE)		 3v2y SPHINGOSINE
1-PHOSPHATE RECEPTOR
1, LYSOZYME CHIMERA
(E.C.3.2.1.17)
(Homo
sapiens;
Escherichia
virus
T4) 		4 / 6 GLU A1064
GLU A1062
ALA A1063
LYS A1060
 None
 1.22A 6an0A-3v2yA:
undetectable		 6an0A-3v2yA:
24.70