SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3v34'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F8L_A_SAMA400_0
(HYPOTHETICAL PROTEIN
LMO1582)		 3v34 RIBONUCLEASE ZC3H12A
(Homo
sapiens) 		5 / 12 ALA A 146
ASN A 271
LEU A 162
GLY A 142
PHE A 155
 None
 1.12A 2f8lA-3v34A:
undetectable		 2f8lA-3v34A:
19.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U88_A_CHDA611_0
(MENIN)		 3v34 RIBONUCLEASE ZC3H12A
(Homo
sapiens) 		3 / 3 SER A 268
PHE A 274
LYS A 273
 None
 0.92A 3u88A-3v34A:
undetectable		 3u88A-3v34A:
15.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HNZ_B_TA1B902_1
(TUBULIN BETA-2B
CHAIN)		 3v34 RIBONUCLEASE ZC3H12A
(Homo
sapiens) 		5 / 12 VAL A 139
ASP A 226
ALA A 233
SER A 236
PHE A 259
 None
MG  A   1 (-2.8A)
None
None
None
 1.27A 5hnzB-3v34A:
undetectable		 5hnzB-3v34A:
18.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0T_A_SAMA501_0
(PEPTIDE
N-METHYLTRANSFERASE)		 3v34 RIBONUCLEASE ZC3H12A
(Homo
sapiens) 		6 / 12 ILE A 175
VAL A 209
PHE A 178
VAL A 179
ILE A 239
VAL A 241
 None
 1.35A 5n0tA-3v34A:
undetectable		 5n0tA-3v34A:
19.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0W_B_SAMB501_0
(PEPTIDE
N-METHYLTRANSFERASE)		 3v34 RIBONUCLEASE ZC3H12A
(Homo
sapiens) 		6 / 12 ILE A 175
VAL A 209
PHE A 178
VAL A 179
ILE A 239
VAL A 241
 None
 1.33A 5n0wB-3v34A:
undetectable		 5n0wB-3v34A:
19.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N4I_A_SAMA501_0
(PEPTIDE
N-METHYLTRANSFERASE)		 3v34 RIBONUCLEASE ZC3H12A
(Homo
sapiens) 		6 / 12 ILE A 175
VAL A 209
PHE A 178
VAL A 179
ILE A 239
VAL A 241
 None
 1.33A 5n4iA-3v34A:
undetectable		 5n4iA-3v34A:
19.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6H7M_B_68HB405_0
(BETA-1 ADRENERGIC
RECEPTOR)		 3v34 RIBONUCLEASE ZC3H12A
(Homo
sapiens) 		5 / 12 VAL A 139
VAL A 240
SER A 236
PHE A 259
TYR A 246
 None
 1.39A 6h7mB-3v34A:
undetectable		 6h7mB-3v34A:
19.13