SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3v48'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1AV2_C_DVAC6_0
(GRAMICIDIN A)		 3v48 PUTATIVE
AMINOACRYLATE
HYDROLASE RUTD
(Escherichia
coli) 		3 / 3 ALA A  91
VAL A  85
TRP A  29
 None
 0.86A 1av2C-3v48A:
undetectable
1av2D-3v48A:
undetectable		 1av2C-3v48A:
6.99
1av2D-3v48A:
6.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1BDW_A_DVAA6_0
(GRAMICIDIN A)		 3v48 PUTATIVE
AMINOACRYLATE
HYDROLASE RUTD
(Escherichia
coli) 		3 / 3 ALA A 139
VAL A 141
TRP A 140
 None
None
SCN  A 269 (-4.4A)
 0.77A 1bdwA-3v48A:
undetectable
1bdwB-3v48A:
undetectable		 1bdwA-3v48A:
6.99
1bdwB-3v48A:
6.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1BDW_A_DVAA6_0
(GRAMICIDIN A)		 3v48 PUTATIVE
AMINOACRYLATE
HYDROLASE RUTD
(Escherichia
coli) 		3 / 3 ALA A 143
VAL A 141
TRP A 140
 None
None
SCN  A 269 (-4.4A)
 0.89A 1bdwA-3v48A:
undetectable
1bdwB-3v48A:
undetectable		 1bdwA-3v48A:
6.99
1bdwB-3v48A:
6.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MAG_A_DVAA6_0
(GRAMICIDIN A)		 3v48 PUTATIVE
AMINOACRYLATE
HYDROLASE RUTD
(Escherichia
coli) 		3 / 3 ALA A  91
VAL A  85
TRP A  29
 None
 0.95A 1magA-3v48A:
undetectable		 1magA-3v48A:
6.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MAG_B_DVAB6_0
(GRAMICIDIN A)		 3v48 PUTATIVE
AMINOACRYLATE
HYDROLASE RUTD
(Escherichia
coli) 		3 / 3 ALA A  91
VAL A  85
TRP A  29
 None
 0.96A 1magB-3v48A:
undetectable		 1magB-3v48A:
6.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NRM_A_DVAA6_0
(GRAMICIDIN A)		 3v48 PUTATIVE
AMINOACRYLATE
HYDROLASE RUTD
(Escherichia
coli) 		3 / 3 ALA A  91
VAL A  85
TRP A  29
 None
 0.88A 1nrmA-3v48A:
undetectable		 1nrmA-3v48A:
6.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NRM_B_DVAB6_0
(GRAMICIDIN A)		 3v48 PUTATIVE
AMINOACRYLATE
HYDROLASE RUTD
(Escherichia
coli) 		3 / 3 ALA A  91
VAL A  85
TRP A  29
 None
 0.88A 1nrmB-3v48A:
undetectable		 1nrmB-3v48A:
6.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NT5_A_DVAA6_0
(GRAMICIDIN A)		 3v48 PUTATIVE
AMINOACRYLATE
HYDROLASE RUTD
(Escherichia
coli) 		3 / 3 ALA A  91
VAL A  85
TRP A  29
 None
 0.88A 1nt5A-3v48A:
undetectable		 1nt5A-3v48A:
6.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NT5_B_DVAB6_0
(GRAMICIDIN A)		 3v48 PUTATIVE
AMINOACRYLATE
HYDROLASE RUTD
(Escherichia
coli) 		3 / 3 ALA A  91
VAL A  85
TRP A  29
 None
 0.88A 1nt5B-3v48A:
undetectable		 1nt5B-3v48A:
6.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NT6_A_DVAA6_0
(GRAMICIDIN C)		 3v48 PUTATIVE
AMINOACRYLATE
HYDROLASE RUTD
(Escherichia
coli) 		3 / 3 ALA A  91
VAL A  85
TRP A  29
 None
 0.84A 1nt6A-3v48A:
undetectable		 1nt6A-3v48A:
8.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NT6_B_DVAB6_0
(GRAMICIDIN C)		 3v48 PUTATIVE
AMINOACRYLATE
HYDROLASE RUTD
(Escherichia
coli) 		3 / 3 ALA A  91
VAL A  85
TRP A  29
 None
 0.84A 1nt6B-3v48A:
undetectable		 1nt6B-3v48A:
8.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_H_FUAH709_1
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 3v48 PUTATIVE
AMINOACRYLATE
HYDROLASE RUTD
(Escherichia
coli) 		5 / 12 SER A   6
LEU A  18
VAL A  85
VAL A 107
ALA A  83
 None
 1.13A 1q23H-3v48A:
undetectable
1q23I-3v48A:
undetectable		 1q23H-3v48A:
19.08
1q23I-3v48A:
19.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XVA_B_ACTB294_0
(GLYCINE
N-METHYLTRANSFERASE)		 3v48 PUTATIVE
AMINOACRYLATE
HYDROLASE RUTD
(Escherichia
coli) 		4 / 6 ALA A  73
TYR A  82
ILE A  79
LEU A  70
 None
 1.02A 1xvaA-3v48A:
undetectable
1xvaB-3v48A:
undetectable		 1xvaA-3v48A:
22.29
1xvaB-3v48A:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z9H_D_IMND476_1
(MEMBRANE-ASSOCIATED
PROSTAGLANDIN E
SYNTHASE-2)		 3v48 PUTATIVE
AMINOACRYLATE
HYDROLASE RUTD
(Escherichia
coli) 		5 / 12 ILE A  19
VAL A  84
TYR A  82
VAL A  93
LEU A 108
 None
 1.19A 1z9hD-3v48A:
undetectable		 1z9hD-3v48A:
24.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HMA_A_SAMA375_0
(PROBABLE TRNA
(5-METHYLAMINOMETHYL
-2-THIOURIDYLATE)-ME
THYLTRANSFERASE)		 3v48 PUTATIVE
AMINOACRYLATE
HYDROLASE RUTD
(Escherichia
coli) 		5 / 11 GLY A  26
SER A  20
GLY A  24
GLN A 173
PHE A 172
 None
None
None
SCN  A 269 ( 4.8A)
None
 1.28A 2hmaA-3v48A:
undetectable		 2hmaA-3v48A:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3I5U_A_SAMA401_0
(O-METHYLTRANSFERASE)		 3v48 PUTATIVE
AMINOACRYLATE
HYDROLASE RUTD
(Escherichia
coli) 		5 / 12 PHE A 125
HIS A 237
LEU A 148
GLY A  23
ALA A  88
 None
SCN  A 270 (-3.8A)
GOL  A 267 (-4.7A)
GOL  A 267 ( 3.5A)
SCN  A 270 (-3.3A)
 1.04A 3i5uA-3v48A:
undetectable		 3i5uA-3v48A:
23.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NBQ_B_URFB400_1
(URIDINE
PHOSPHORYLASE 1)		 3v48 PUTATIVE
AMINOACRYLATE
HYDROLASE RUTD
(Escherichia
coli) 		4 / 8 GLY A  90
GLN A  47
LEU A  92
ILE A  63
 None
 0.81A 3nbqB-3v48A:
undetectable		 3nbqB-3v48A:
19.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NBQ_C_URFC400_1
(URIDINE
PHOSPHORYLASE 1)		 3v48 PUTATIVE
AMINOACRYLATE
HYDROLASE RUTD
(Escherichia
coli) 		4 / 8 GLY A  90
GLN A  47
LEU A  92
ILE A  63
 None
 0.82A 3nbqC-3v48A:
undetectable		 3nbqC-3v48A:
19.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZOS_A_0LIA1004_1
(EPITHELIAL DISCOIDIN
DOMAIN-CONTAINING
RECEPTOR 1)		 3v48 PUTATIVE
AMINOACRYLATE
HYDROLASE RUTD
(Escherichia
coli) 		5 / 11 ALA A  98
LEU A 108
GLY A  90
ILE A 203
PHE A 190
 None
 1.04A 3zosA-3v48A:
undetectable
3zosB-3v48A:
undetectable		 3zosA-3v48A:
24.50
3zosB-3v48A:
24.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GC9_A_SAMA401_0
(DIMETHYLADENOSINE
TRANSFERASE 1,
MITOCHONDRIAL)		 3v48 PUTATIVE
AMINOACRYLATE
HYDROLASE RUTD
(Escherichia
coli) 		5 / 12 LEU A  18
GLY A  94
GLY A  90
LEU A 108
VAL A 201
 None
 1.01A 4gc9A-3v48A:
undetectable		 4gc9A-3v48A:
20.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BP4_A_SAMA505_1
(HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-9 SPECIFIC)		 3v48 PUTATIVE
AMINOACRYLATE
HYDROLASE RUTD
(Escherichia
coli) 		3 / 3 ILE A 109
ASN A 112
CYH A 216
 None
 0.74A 6bp4A-3v48A:
undetectable		 6bp4A-3v48A:
20.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CK2_C_IPHC101_0
(INSULIN A CHAIN
INSULIN B CHAIN)		 3v48 PUTATIVE
AMINOACRYLATE
HYDROLASE RUTD
(Escherichia
coli) 		4 / 4 ILE A  19
LEU A   3
HIS A  71
ALA A  73
 None
 0.97A 6ck2C-3v48A:
undetectable
6ck2D-3v48A:
undetectable		 6ck2C-3v48A:
7.85
6ck2D-3v48A:
8.80