SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3v4v'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BR4_B_SAMB301_0
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 3v4v INTEGRIN BETA-7
(Homo
sapiens) 		5 / 12 GLY B 242
ASN B 235
ASP B 244
ALA B 245
ALA B 249
 None
CA  B2003 ( 3.1A)
None
None
None
 1.18A 2br4B-3v4vB:
undetectable		 2br4B-3v4vB:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F8L_A_SAMA400_1
(HYPOTHETICAL PROTEIN
LMO1582)		 3v4v INTEGRIN BETA-7
(Homo
sapiens) 		4 / 4 THR B 188
THR B 181
ASP B 179
ASP B 271
 None
None
CA  B2003 (-3.8A)
None
 1.41A 2f8lA-3v4vB:
undetectable		 2f8lA-3v4vB:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2O4L_A_TPVA403_1
(PROTEASE)		 3v4v INTEGRIN BETA-7
(Homo
sapiens) 		5 / 12 LEU B 424
ASP B 405
PRO B 382
VAL B 385
ILE B 387
 None
 1.24A 2o4lA-3v4vB:
undetectable		 2o4lA-3v4vB:
10.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VDM_B_AGGB1462_1
(INTEGRIN ALPHA-IIB
INTEGRIN BETA-3)		 3v4v INTEGRIN BETA-7
(Homo
sapiens) 		5 / 12 SER B 142
TYR B 143
SER B 144
ASN B 235
GLU B 240
 MG  B2001 ( 2.9A)
0DU  B4000 (-4.4A)
MG  B2001 ( 2.9A)
CA  B2003 ( 3.1A)
0DU  B4000 (-3.3A)
 0.58A 2vdmA-3v4vB:
undetectable
2vdmB-3v4vB:
33.3		 2vdmA-3v4vB:
23.29
2vdmB-3v4vB:
42.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X7H_B_PFNB1374_1
(ZINC-BINDING ALCOHOL
DEHYDROGENASE
DOMAIN-CONTAINING
PROTEIN 2)		 3v4v INTEGRIN BETA-7
(Homo
sapiens) 		4 / 4 TYR B 136
LEU B 135
LEU B 216
HIS B 212
 None
 1.46A 2x7hB-3v4vB:
undetectable		 2x7hB-3v4vB:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B7P_C_SPMC503_1
(SPERMIDINE SYNTHASE)		 3v4v INTEGRIN BETA-7
(Homo
sapiens) 		5 / 12 TYR B 308
HIS B 274
ASP B 237
ASP B 179
ILE B 284
 None
None
CA  B2003 ( 3.6A)
CA  B2003 (-3.8A)
None
 1.23A 3b7pC-3v4vB:
undetectable		 3b7pC-3v4vB:
19.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CO4_A_GCSA401_1
(CHITINASE)		 3v4v INTEGRIN BETA-7
(Homo
sapiens) 		3 / 3 GLU B 226
HIS B 212
HIS B 211
 None
 0.89A 3co4A-3v4vB:
undetectable		 3co4A-3v4vB:
18.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UFN_A_ROCA401_2
(HIV-1 PROTEASE)		 3v4v INTEGRIN BETA-7
(Homo
sapiens) 		4 / 7 VAL B 111
ILE B 448
VAL B 123
VAL B 422
 None
 0.73A 3ufnB-3v4vB:
undetectable		 3ufnB-3v4vB:
10.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A99_D_MIYD392_1
(TETX2 PROTEIN)		 3v4v INTEGRIN BETA-7
(Homo
sapiens) 		4 / 5 HIS B 211
SER B 176
GLN B 205
VAL B 178
 None
 1.42A 4a99D-3v4vB:
undetectable		 4a99D-3v4vB:
20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FGL_D_CLQD303_0
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 3v4v INTEGRIN BETA-7
(Homo
sapiens) 		4 / 7 GLY B 241
PHE B 267
ILE B 246
PHE B 327
 None
 0.70A 4fglC-3v4vB:
2.6		 4fglC-3v4vB:
18.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QOG_B_ML1B302_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 3v4v INTEGRIN BETA-7
(Homo
sapiens) 		4 / 6 GLY B 241
PHE B 267
ILE B 246
PHE B 327
 None
 0.74A 4qogA-3v4vB:
3.6
4qogB-3v4vB:
3.4		 4qogA-3v4vB:
18.82
4qogB-3v4vB:
18.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TIX_B_OQRB302_0
(SULFOTRANSFERASE)		 3v4v INTEGRIN BETA-7
(Homo
sapiens) 		5 / 10 PRO B 106
LEU B 447
VAL B  86
LEU B  87
GLU B 450
 None
 1.42A 5tixB-3v4vB:
undetectable		 5tixB-3v4vB:
17.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TZO_A_7V7A201_1
(ENDO-1,4-BETA-XYLANA
SE A)		 3v4v INTEGRIN BETA-7
(Homo
sapiens) 		4 / 8 THR B 419
ARG B 124
GLN B 122
TRP B 421
 None
 1.37A 5tzoA-3v4vB:
undetectable		 5tzoA-3v4vB:
16.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TZO_C_7V7C202_1
(ENDO-1,4-BETA-XYLANA
SE A)		 3v4v INTEGRIN BETA-7
(Homo
sapiens) 		4 / 8 THR B 419
ARG B 124
GLN B 122
TRP B 421
 None
 1.37A 5tzoC-3v4vB:
undetectable		 5tzoC-3v4vB:
16.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VC0_A_RITA602_2
(CYTOCHROME P450 3A4)		 3v4v INTEGRIN BETA-7
(Homo
sapiens) 		4 / 7 ILE B 326
LEU B 159
THR B 167
ARG B 259
 None
 0.99A 5vc0A-3v4vB:
undetectable		 5vc0A-3v4vB:
22.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VOO_A_C2FA3001_0
(5-METHYLTETRAHYDROFO
LATE HOMOCYSTEINE
S-METHYLTRANSFERASE)		 3v4v INTEGRIN BETA-7
(Homo
sapiens) 		5 / 12 GLU B 240
GLY B 241
LEU B 193
GLY B 234
SER B 142
 0DU  B4000 (-3.3A)
None
None
0DU  B4000 (-3.4A)
MG  B2001 ( 2.9A)
 1.06A 5vooA-3v4vB:
2.6		 5vooA-3v4vB:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VOO_B_C2FB702_0
(5-METHYLTETRAHYDROFO
LATE HOMOCYSTEINE
S-METHYLTRANSFERASE)		 3v4v INTEGRIN BETA-7
(Homo
sapiens) 		5 / 12 GLU B 240
GLY B 241
LEU B 193
GLY B 234
SER B 142
 0DU  B4000 (-3.3A)
None
None
0DU  B4000 (-3.4A)
MG  B2001 ( 2.9A)
 1.09A 5vooB-3v4vB:
2.6		 5vooB-3v4vB:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VOO_C_C2FC702_0
(5-METHYLTETRAHYDROFO
LATE HOMOCYSTEINE
S-METHYLTRANSFERASE)		 3v4v INTEGRIN BETA-7
(Homo
sapiens) 		5 / 12 GLU B 240
GLY B 241
LEU B 193
GLY B 234
SER B 142
 0DU  B4000 (-3.3A)
None
None
0DU  B4000 (-3.4A)
MG  B2001 ( 2.9A)
 1.06A 5vooC-3v4vB:
2.4		 5vooC-3v4vB:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VOO_D_C2FD3001_0
(5-METHYLTETRAHYDROFO
LATE HOMOCYSTEINE
S-METHYLTRANSFERASE)		 3v4v INTEGRIN BETA-7
(Homo
sapiens) 		5 / 12 GLU B 240
GLY B 241
LEU B 193
GLY B 234
SER B 142
 0DU  B4000 (-3.3A)
None
None
0DU  B4000 (-3.4A)
MG  B2001 ( 2.9A)
 1.09A 5vooD-3v4vB:
2.8		 5vooD-3v4vB:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VOO_E_C2FE3001_0
(5-METHYLTETRAHYDROFO
LATE HOMOCYSTEINE
S-METHYLTRANSFERASE)		 3v4v INTEGRIN BETA-7
(Homo
sapiens) 		5 / 12 GLU B 240
GLY B 241
ASP B 237
GLY B 234
SER B 142
 0DU  B4000 (-3.3A)
None
CA  B2003 ( 3.6A)
0DU  B4000 (-3.4A)
MG  B2001 ( 2.9A)
 1.17A 5vooE-3v4vB:
2.3		 5vooE-3v4vB:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VOO_E_C2FE3001_0
(5-METHYLTETRAHYDROFO
LATE HOMOCYSTEINE
S-METHYLTRANSFERASE)		 3v4v INTEGRIN BETA-7
(Homo
sapiens) 		5 / 12 GLU B 240
GLY B 241
LEU B 193
GLY B 234
SER B 142
 0DU  B4000 (-3.3A)
None
None
0DU  B4000 (-3.4A)
MG  B2001 ( 2.9A)
 1.18A 5vooE-3v4vB:
2.3		 5vooE-3v4vB:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VOO_F_C2FF3001_0
(5-METHYLTETRAHYDROFO
LATE HOMOCYSTEINE
S-METHYLTRANSFERASE)		 3v4v INTEGRIN BETA-7
(Homo
sapiens) 		5 / 12 GLU B 240
GLY B 241
LEU B 193
GLY B 234
SER B 142
 0DU  B4000 (-3.3A)
None
None
0DU  B4000 (-3.4A)
MG  B2001 ( 2.9A)
 1.15A 5vooF-3v4vB:
2.8		 5vooF-3v4vB:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VOP_A_C2FA3001_0
(5-METHYLTETRAHYDROFO
LATE HOMOCYSTEINE
S-METHYLTRANSFERASE)		 3v4v INTEGRIN BETA-7
(Homo
sapiens) 		5 / 12 GLU B 240
GLY B 241
LEU B 193
GLY B 234
SER B 142
 0DU  B4000 (-3.3A)
None
None
0DU  B4000 (-3.4A)
MG  B2001 ( 2.9A)
 1.07A 5vopA-3v4vB:
undetectable		 5vopA-3v4vB:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VOP_B_C2FB3001_0
(5-METHYLTETRAHYDROFO
LATE HOMOCYSTEINE
S-METHYLTRANSFERASE)		 3v4v INTEGRIN BETA-7
(Homo
sapiens) 		5 / 12 GLU B 240
GLY B 241
LEU B 193
GLY B 234
SER B 142
 0DU  B4000 (-3.3A)
None
None
0DU  B4000 (-3.4A)
MG  B2001 ( 2.9A)
 1.19A 5vopB-3v4vB:
2.8		 5vopB-3v4vB:
20.94