SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3v4y'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EKJ_A_ACTA3001_0
(BETA-CARBONIC
ANHYDRASE)		 3v4y SERINE/THREONINE-PRO
TEIN PHOSPHATASE
PP1-ALPHA CATALYTIC
SUBUNIT
(Homo
sapiens) 		4 / 8 ASP A 208
GLY A 174
GLY A 175
GLN A 249
 None
 0.72A 1ekjA-3v4yA:
undetectable
1ekjB-3v4yA:
undetectable		 1ekjA-3v4yA:
21.54
1ekjB-3v4yA:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EKJ_E_ACTE3005_0
(BETA-CARBONIC
ANHYDRASE)		 3v4y SERINE/THREONINE-PRO
TEIN PHOSPHATASE
PP1-ALPHA CATALYTIC
SUBUNIT
(Homo
sapiens) 		4 / 7 ASP A 208
GLY A 174
GLY A 175
GLN A 249
 None
 0.77A 1ekjE-3v4yA:
undetectable
1ekjF-3v4yA:
undetectable		 1ekjE-3v4yA:
21.54
1ekjF-3v4yA:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EKJ_F_ACTF3008_0
(BETA-CARBONIC
ANHYDRASE)		 3v4y SERINE/THREONINE-PRO
TEIN PHOSPHATASE
PP1-ALPHA CATALYTIC
SUBUNIT
(Homo
sapiens) 		4 / 8 GLN A 249
ASP A 208
GLY A 174
GLY A 175
 None
 0.75A 1ekjE-3v4yA:
undetectable
1ekjF-3v4yA:
undetectable		 1ekjE-3v4yA:
21.54
1ekjF-3v4yA:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EKJ_G_ACTG3002_0
(BETA-CARBONIC
ANHYDRASE)		 3v4y SERINE/THREONINE-PRO
TEIN PHOSPHATASE
PP1-ALPHA CATALYTIC
SUBUNIT
(Homo
sapiens) 		4 / 8 ASP A 208
GLY A 174
GLY A 175
GLN A 249
 None
 0.73A 1ekjG-3v4yA:
undetectable
1ekjH-3v4yA:
undetectable		 1ekjG-3v4yA:
21.54
1ekjH-3v4yA:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OE1_A_CUA502_0
(DISSIMILATORY
COPPER-CONTAINING
NITRITE REDUCTASE)		 3v4y SERINE/THREONINE-PRO
TEIN PHOSPHATASE
PP1-ALPHA CATALYTIC
SUBUNIT
(Homo
sapiens) 		3 / 3 ASP A  92
HIS A 125
HIS A  66
 MN  A 401 ( 2.8A)
MN  A 402 ( 4.8A)
MN  A 402 (-3.3A)
 0.66A 1oe1A-3v4yA:
undetectable		 1oe1A-3v4yA:
19.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OE3_A_CUA502_0
(DISSIMILATORY
COPPER-CONTAINING
NITRITE REDUCTASE)		 3v4y SERINE/THREONINE-PRO
TEIN PHOSPHATASE
PP1-ALPHA CATALYTIC
SUBUNIT
(Homo
sapiens) 		3 / 3 ASP A  92
HIS A 125
HIS A  66
 MN  A 401 ( 2.8A)
MN  A 402 ( 4.8A)
MN  A 402 (-3.3A)
 0.65A 1oe3A-3v4yA:
undetectable		 1oe3A-3v4yA:
19.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UUJ_B_ACTB1077_0
(PLATELET-ACTIVATING
FACTOR
ACETYLHYDROLASE IB
ALPHA SUBUNIT)		 3v4y SERINE/THREONINE-PRO
TEIN PHOSPHATASE
PP1-ALPHA CATALYTIC
SUBUNIT
(Homo
sapiens) 		3 / 3 ARG A 132
TYR A 137
LYS A 141
 None
 0.98A 1uujB-3v4yA:
undetectable		 1uujB-3v4yA:
13.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_B_CTXB1283_1
(CES1 PROTEIN)		 3v4y SERINE/THREONINE-PRO
TEIN PHOSPHATASE
PP1-ALPHA CATALYTIC
SUBUNIT
(Homo
sapiens) 		4 / 7 LEU A  90
GLY A  91
LEU A  88
PRO A 160
 None
 0.91A 1ya4B-3v4yA:
undetectable		 1ya4B-3v4yA:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2B25_A_SAMA601_0
(HYPOTHETICAL PROTEIN)		 3v4y SERINE/THREONINE-PRO
TEIN PHOSPHATASE
PP1-ALPHA CATALYTIC
SUBUNIT
(Homo
sapiens) 		5 / 12 GLY A  91
GLY A 123
GLY A 174
VAL A  94
ILE A  65
 None
 1.04A 2b25A-3v4yA:
undetectable		 2b25A-3v4yA:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2B9E_A_SAMA1201_0
(NOL1/NOP2/SUN DOMAIN
FAMILY, MEMBER 5
ISOFORM 2)		 3v4y SERINE/THREONINE-PRO
TEIN PHOSPHATASE
PP1-ALPHA CATALYTIC
SUBUNIT
(Homo
sapiens) 		5 / 12 PRO A  24
GLY A  25
LEU A  72
ASP A  71
PHE A  81
 None
 1.41A 2b9eA-3v4yA:
undetectable		 2b9eA-3v4yA:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2H79_A_T3A1_1
(THRA PROTEIN)		 3v4y SERINE/THREONINE-PRO
TEIN PHOSPHATASE
PP1-ALPHA CATALYTIC
SUBUNIT
(Homo
sapiens) 		5 / 12 ILE A 104
LEU A  38
SER A  42
LEU A  16
ILE A  13
 None
 1.03A 2h79A-3v4yA:
undetectable		 2h79A-3v4yA:
22.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2P2F_A_ACTA653_0
(ACETYL-COENZYME A
SYNTHETASE)		 3v4y SERINE/THREONINE-PRO
TEIN PHOSPHATASE
PP1-ALPHA CATALYTIC
SUBUNIT
(Homo
sapiens) 		4 / 5 VAL A 264
THR A 265
VAL A 251
GLY A 254
 None
 1.12A 2p2fA-3v4yA:
undetectable		 2p2fA-3v4yA:
16.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2P2F_B_ACTB653_0
(ACETYL-COENZYME A
SYNTHETASE)		 3v4y SERINE/THREONINE-PRO
TEIN PHOSPHATASE
PP1-ALPHA CATALYTIC
SUBUNIT
(Homo
sapiens) 		4 / 4 VAL A 264
THR A 265
VAL A 251
GLY A 254
 None
 1.11A 2p2fB-3v4yA:
undetectable		 2p2fB-3v4yA:
16.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X7H_A_PFNA1374_1
(ZINC-BINDING ALCOHOL
DEHYDROGENASE
DOMAIN-CONTAINING
PROTEIN 2)		 3v4y SERINE/THREONINE-PRO
TEIN PHOSPHATASE
PP1-ALPHA CATALYTIC
SUBUNIT
(Homo
sapiens) 		4 / 6 PRO A  82
SER A  85
LYS A  60
TYR A  87
 None
 1.16A 2x7hA-3v4yA:
undetectable		 2x7hA-3v4yA:
23.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XXG_A_CUA1338_0
(DISSIMILATORY
COPPER-CONTAINING
NITRITE REDUCTASE)		 3v4y SERINE/THREONINE-PRO
TEIN PHOSPHATASE
PP1-ALPHA CATALYTIC
SUBUNIT
(Homo
sapiens) 		3 / 3 ASP A  92
HIS A 125
HIS A  66
 MN  A 401 ( 2.8A)
MN  A 402 ( 4.8A)
MN  A 402 (-3.3A)
 0.68A 2xxgA-3v4yA:
undetectable		 2xxgA-3v4yA:
20.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XXG_C_CUC1339_0
(DISSIMILATORY
COPPER-CONTAINING
NITRITE REDUCTASE)		 3v4y SERINE/THREONINE-PRO
TEIN PHOSPHATASE
PP1-ALPHA CATALYTIC
SUBUNIT
(Homo
sapiens) 		3 / 3 ASP A  92
HIS A 125
HIS A  66
 MN  A 401 ( 2.8A)
MN  A 402 ( 4.8A)
MN  A 402 (-3.3A)
 0.69A 2xxgC-3v4yA:
undetectable		 2xxgC-3v4yA:
20.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AY0_B_ADNB402_1
(UNCHARACTERIZED
PROTEIN MJ0883)		 3v4y SERINE/THREONINE-PRO
TEIN PHOSPHATASE
PP1-ALPHA CATALYTIC
SUBUNIT
(Homo
sapiens) 		5 / 10 TYR A 137
GLY A 135
ASP A  95
ILE A 130
ASN A 131
 None
None
None
GOL  A 405 ( 4.8A)
None
 1.30A 3ay0B-3v4yA:
undetectable		 3ay0B-3v4yA:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NVK_J_SAMJ228_0
(FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE
NOP5/NOP56 RELATED
PROTEIN)		 3v4y SERINE/THREONINE-PRO
TEIN PHOSPHATASE
PP1-ALPHA CATALYTIC
SUBUNIT
(Homo
sapiens) 		5 / 12 TYR A 272
GLY A 254
ALA A 279
ASP A  64
VAL A 251
 None
None
None
MN  A 402 (-3.0A)
None
 0.91A 3nvkF-3v4yA:
undetectable
3nvkJ-3v4yA:
undetectable		 3nvkF-3v4yA:
22.51
3nvkJ-3v4yA:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OU7_A_SAMA300_0
(SAM-DEPENDENT
METHYLTRANSFERASE)		 3v4y SERINE/THREONINE-PRO
TEIN PHOSPHATASE
PP1-ALPHA CATALYTIC
SUBUNIT
(Homo
sapiens) 		5 / 12 LEU A  75
TYR A 255
ALA A 279
GLY A 254
SER A 268
 None
 1.17A 3ou7A-3v4yA:
undetectable		 3ou7A-3v4yA:
22.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OU7_B_SAMB300_0
(SAM-DEPENDENT
METHYLTRANSFERASE)		 3v4y SERINE/THREONINE-PRO
TEIN PHOSPHATASE
PP1-ALPHA CATALYTIC
SUBUNIT
(Homo
sapiens) 		5 / 12 LEU A  75
TYR A 255
ALA A 279
GLY A 254
SER A 268
 None
 1.13A 3ou7B-3v4yA:
undetectable		 3ou7B-3v4yA:
22.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OU7_D_SAMD300_0
(SAM-DEPENDENT
METHYLTRANSFERASE)		 3v4y SERINE/THREONINE-PRO
TEIN PHOSPHATASE
PP1-ALPHA CATALYTIC
SUBUNIT
(Homo
sapiens) 		5 / 12 LEU A  75
TYR A 255
ALA A 279
GLY A 254
SER A 268
 None
 1.16A 3ou7D-3v4yA:
undetectable		 3ou7D-3v4yA:
22.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PGL_A_RZXA257_1
(CARBOXY-TERMINAL
DOMAIN RNA
POLYMERASE II
POLYPEPTIDE A SMALL
PHOSPHATASE 1)		 3v4y NUCLEAR INHIBITOR OF
PROTEIN PHOSPHATASE
1
SERINE/THREONINE-PRO
TEIN PHOSPHATASE
PP1-ALPHA CATALYTIC
SUBUNIT
(Homo
sapiens) 		4 / 7 ASP B 207
PHE B 203
VAL A 264
TYR A 255
 None
 0.91A 3pglA-3v4yB:
undetectable		 3pglA-3v4yB:
14.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RV5_A_DXCA91_0
(TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES)		 3v4y SERINE/THREONINE-PRO
TEIN PHOSPHATASE
PP1-ALPHA CATALYTIC
SUBUNIT
(Homo
sapiens) 		3 / 3 PHE A  76
GLN A 294
PHE A 118
 None
 0.74A 3rv5A-3v4yA:
undetectable		 3rv5A-3v4yA:
14.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S54_B_017B201_1
(PROTEASE)		 3v4y SERINE/THREONINE-PRO
TEIN PHOSPHATASE
PP1-ALPHA CATALYTIC
SUBUNIT
(Homo
sapiens) 		5 / 12 LEU A   9
GLY A  37
ILE A 104
ILE A  13
ILE A  12
 None
 0.79A 3s54A-3v4yA:
undetectable		 3s54A-3v4yA:
18.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UQ6_B_ADNB401_1
(ADENOSINE KINASE,
PUTATIVE)		 3v4y SERINE/THREONINE-PRO
TEIN PHOSPHATASE
PP1-ALPHA CATALYTIC
SUBUNIT
(Homo
sapiens) 		5 / 12 ASP A  64
LEU A 263
ASN A 124
THR A 265
GLY A 123
 MN  A 402 (-3.0A)
None
MN  A 401 (-2.7A)
None
None
 1.10A 3uq6B-3v4yA:
undetectable		 3uq6B-3v4yA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V4T_E_ACTE502_0
(UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE)		 3v4y SERINE/THREONINE-PRO
TEIN PHOSPHATASE
PP1-ALPHA CATALYTIC
SUBUNIT
(Homo
sapiens) 		3 / 3 LYS A 111
ARG A 191
LEU A  53
 None
None
GOL  A 404 (-3.4A)
 1.43A 3v4tE-3v4yA:
undetectable		 3v4tE-3v4yA:
19.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VAQ_B_ADNB401_1
(PUTATIVE ADENOSINE
KINASE)		 3v4y SERINE/THREONINE-PRO
TEIN PHOSPHATASE
PP1-ALPHA CATALYTIC
SUBUNIT
(Homo
sapiens) 		5 / 12 ASP A  64
LEU A 263
ASN A 124
THR A 265
GLY A 123
 MN  A 402 (-3.0A)
None
MN  A 401 (-2.7A)
None
None
 1.11A 3vaqB-3v4yA:
undetectable		 3vaqB-3v4yA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VAS_A_ADNA401_1
(PUTATIVE ADENOSINE
KINASE)		 3v4y SERINE/THREONINE-PRO
TEIN PHOSPHATASE
PP1-ALPHA CATALYTIC
SUBUNIT
(Homo
sapiens) 		5 / 12 ASP A  64
LEU A 263
ASN A 124
THR A 265
GLY A 123
 MN  A 402 (-3.0A)
None
MN  A 401 (-2.7A)
None
None
 1.06A 3vasA-3v4yA:
undetectable		 3vasA-3v4yA:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DUB_A_LDPA501_1
(CYTOCHROME P450 BM3
VARIANT 9D7)		 3v4y SERINE/THREONINE-PRO
TEIN PHOSPHATASE
PP1-ALPHA CATALYTIC
SUBUNIT
(Homo
sapiens) 		4 / 6 PHE A 170
ALA A 162
GLY A 174
LEU A 204
 None
 1.06A 4dubA-3v4yA:
undetectable		 4dubA-3v4yA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FEU_F_KANF301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 3v4y SERINE/THREONINE-PRO
TEIN PHOSPHATASE
PP1-ALPHA CATALYTIC
SUBUNIT
(Homo
sapiens) 		4 / 8 ASP A  92
ASP A 194
ASN A 124
GLU A 126
 MN  A 401 ( 2.8A)
GOL  A 405 ( 4.5A)
MN  A 401 (-2.7A)
None
 1.19A 4feuF-3v4yA:
undetectable		 4feuF-3v4yA:
23.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FEV_D_KAND301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 3v4y SERINE/THREONINE-PRO
TEIN PHOSPHATASE
PP1-ALPHA CATALYTIC
SUBUNIT
(Homo
sapiens) 		4 / 7 ASP A  95
ASP A  92
ASN A 124
GLU A 126
 None
MN  A 401 ( 2.8A)
MN  A 401 (-2.7A)
None
 1.22A 4fevD-3v4yA:
undetectable		 4fevD-3v4yA:
23.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FEV_F_KANF301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 3v4y SERINE/THREONINE-PRO
TEIN PHOSPHATASE
PP1-ALPHA CATALYTIC
SUBUNIT
(Homo
sapiens) 		4 / 7 ASP A  92
ASP A 194
ASN A 124
GLU A 126
 MN  A 401 ( 2.8A)
GOL  A 405 ( 4.5A)
MN  A 401 (-2.7A)
None
 1.20A 4fevF-3v4yA:
undetectable		 4fevF-3v4yA:
23.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FEV_F_KANF301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 3v4y SERINE/THREONINE-PRO
TEIN PHOSPHATASE
PP1-ALPHA CATALYTIC
SUBUNIT
(Homo
sapiens) 		4 / 7 ASP A  95
ASP A  92
ASN A 124
GLU A 126
 None
MN  A 401 ( 2.8A)
MN  A 401 (-2.7A)
None
 1.21A 4fevF-3v4yA:
undetectable		 4fevF-3v4yA:
23.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FEW_D_KAND301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 3v4y SERINE/THREONINE-PRO
TEIN PHOSPHATASE
PP1-ALPHA CATALYTIC
SUBUNIT
(Homo
sapiens) 		4 / 8 ASP A  95
ASP A  92
ASN A 124
GLU A 126
 None
MN  A 401 ( 2.8A)
MN  A 401 (-2.7A)
None
 1.20A 4fewD-3v4yA:
undetectable		 4fewD-3v4yA:
23.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FEW_F_KANF301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 3v4y SERINE/THREONINE-PRO
TEIN PHOSPHATASE
PP1-ALPHA CATALYTIC
SUBUNIT
(Homo
sapiens) 		4 / 8 ASP A  92
ASP A 194
ASN A 124
GLU A 126
 MN  A 401 ( 2.8A)
GOL  A 405 ( 4.5A)
MN  A 401 (-2.7A)
None
 1.21A 4fewF-3v4yA:
undetectable		 4fewF-3v4yA:
23.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FEW_F_KANF301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 3v4y SERINE/THREONINE-PRO
TEIN PHOSPHATASE
PP1-ALPHA CATALYTIC
SUBUNIT
(Homo
sapiens) 		4 / 8 ASP A  95
ASP A  92
ASN A 124
GLU A 126
 None
MN  A 401 ( 2.8A)
MN  A 401 (-2.7A)
None
 1.19A 4fewF-3v4yA:
undetectable		 4fewF-3v4yA:
23.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FEX_B_KANB301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 3v4y SERINE/THREONINE-PRO
TEIN PHOSPHATASE
PP1-ALPHA CATALYTIC
SUBUNIT
(Homo
sapiens) 		4 / 7 ASP A  92
ASP A 194
ASN A 124
GLU A 126
 MN  A 401 ( 2.8A)
GOL  A 405 ( 4.5A)
MN  A 401 (-2.7A)
None
 1.22A 4fexB-3v4yA:
undetectable		 4fexB-3v4yA:
23.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GKH_G_KANG301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 3v4y SERINE/THREONINE-PRO
TEIN PHOSPHATASE
PP1-ALPHA CATALYTIC
SUBUNIT
(Homo
sapiens) 		4 / 7 ASP A  92
ASP A 194
ASN A 124
GLU A 126
 MN  A 401 ( 2.8A)
GOL  A 405 ( 4.5A)
MN  A 401 (-2.7A)
None
 1.20A 4gkhG-3v4yA:
undetectable		 4gkhG-3v4yA:
23.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GKH_G_KANG301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 3v4y SERINE/THREONINE-PRO
TEIN PHOSPHATASE
PP1-ALPHA CATALYTIC
SUBUNIT
(Homo
sapiens) 		4 / 7 ASP A  95
ASP A  92
ASN A 124
GLU A 126
 None
MN  A 401 ( 2.8A)
MN  A 401 (-2.7A)
None
 1.19A 4gkhG-3v4yA:
undetectable		 4gkhG-3v4yA:
23.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GKH_J_KANJ301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 3v4y SERINE/THREONINE-PRO
TEIN PHOSPHATASE
PP1-ALPHA CATALYTIC
SUBUNIT
(Homo
sapiens) 		4 / 6 ASP A  92
ASP A 194
ASN A 124
GLU A 126
 MN  A 401 ( 2.8A)
GOL  A 405 ( 4.5A)
MN  A 401 (-2.7A)
None
 1.26A 4gkhJ-3v4yA:
undetectable		 4gkhJ-3v4yA:
23.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GKI_A_KANA301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 3v4y SERINE/THREONINE-PRO
TEIN PHOSPHATASE
PP1-ALPHA CATALYTIC
SUBUNIT
(Homo
sapiens) 		4 / 8 ASP A  95
ASP A  92
ASN A 124
GLU A 126
 None
MN  A 401 ( 2.8A)
MN  A 401 (-2.7A)
None
 1.20A 4gkiA-3v4yA:
undetectable		 4gkiA-3v4yA:
23.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GKI_C_KANC301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 3v4y SERINE/THREONINE-PRO
TEIN PHOSPHATASE
PP1-ALPHA CATALYTIC
SUBUNIT
(Homo
sapiens) 		4 / 8 ASP A  92
ASP A 194
ASN A 124
GLU A 126
 MN  A 401 ( 2.8A)
GOL  A 405 ( 4.5A)
MN  A 401 (-2.7A)
None
 1.19A 4gkiC-3v4yA:
undetectable		 4gkiC-3v4yA:
23.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LMN_A_EUIA503_1
(DUAL SPECIFICITY
MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE 1)		 3v4y SERINE/THREONINE-PRO
TEIN PHOSPHATASE
PP1-ALPHA CATALYTIC
SUBUNIT
(Homo
sapiens) 		5 / 12 LEU A 200
ILE A 186
GLY A 175
SER A 177
LEU A 180
 None
 1.03A 4lmnA-3v4yA:
undetectable		 4lmnA-3v4yA:
20.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LNX_A_T3A502_1
(THYROID HORMONE
RECEPTOR ALPHA)		 3v4y SERINE/THREONINE-PRO
TEIN PHOSPHATASE
PP1-ALPHA CATALYTIC
SUBUNIT
(Homo
sapiens) 		5 / 12 ILE A 104
LEU A  38
SER A  42
LEU A  16
ILE A  13
 None
 1.04A 4lnxA-3v4yA:
undetectable		 4lnxA-3v4yA:
22.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PD4_C_AOQC4003_1
(CYTOCHROME B)		 3v4y NUCLEAR INHIBITOR OF
PROTEIN PHOSPHATASE
1
SERINE/THREONINE-PRO
TEIN PHOSPHATASE
PP1-ALPHA CATALYTIC
SUBUNIT
(Homo
sapiens) 		5 / 12 GLY A  67
ILE A  65
TYR A  70
LEU A  73
ILE B 210
 None
 1.04A 4pd4C-3v4yA:
undetectable		 4pd4C-3v4yA:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WNU_A_QDNA602_1
(CYTOCHROME P450 2D6)		 3v4y SERINE/THREONINE-PRO
TEIN PHOSPHATASE
PP1-ALPHA CATALYTIC
SUBUNIT
(Homo
sapiens) 		5 / 11 LEU A  90
LEU A 241
LEU A  88
ALA A 163
PHE A 235
 None
 1.12A 4wnuA-3v4yA:
undetectable		 4wnuA-3v4yA:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z53_F_TR6F101_1
(DNA TOPOISOMERASE 4
SUBUNIT B,DNA
TOPOISOMERASE 4
SUBUNIT A
E-SITE DNA)		 3v4y SERINE/THREONINE-PRO
TEIN PHOSPHATASE
PP1-ALPHA CATALYTIC
SUBUNIT
(Homo
sapiens) 		4 / 6 GLY A  63
GLY A  91
SER A 207
ARG A 246
 None
 1.03A 4z53A-3v4yA:
undetectable
4z53B-3v4yA:
undetectable		 4z53A-3v4yA:
18.99
4z53B-3v4yA:
18.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E5J_A_017A201_2
(PROTEASE)		 3v4y SERINE/THREONINE-PRO
TEIN PHOSPHATASE
PP1-ALPHA CATALYTIC
SUBUNIT
(Homo
sapiens) 		5 / 12 LEU A   9
GLY A  37
ILE A 104
ILE A  13
ILE A  12
 None
 0.83A 5e5jB-3v4yA:
undetectable		 5e5jB-3v4yA:
18.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JI0_A_9CRA501_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 3v4y SERINE/THREONINE-PRO
TEIN PHOSPHATASE
PP1-ALPHA CATALYTIC
SUBUNIT
(Homo
sapiens) 		5 / 11 ILE A 104
LEU A  30
LEU A 108
ALA A 109
CYH A 140
 None
 1.16A 5ji0A-3v4yA:
undetectable		 5ji0A-3v4yA:
23.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KC4_A_RBFA201_1
(RIBOFLAVIN
TRANSPORTER RIBU)		 3v4y SERINE/THREONINE-PRO
TEIN PHOSPHATASE
PP1-ALPHA CATALYTIC
SUBUNIT
(Homo
sapiens) 		5 / 12 GLU A 126
LEU A 121
ASP A  64
GLY A  63
PHE A 118
 None
None
MN  A 402 (-3.0A)
None
None
 1.33A 5kc4A-3v4yA:
undetectable		 5kc4A-3v4yA:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NCD_D_ACTD301_0
(PEPTIDOGLYCAN
N-ACETYLGLUCOSAMINE
DEACETYLASE)		 3v4y SERINE/THREONINE-PRO
TEIN PHOSPHATASE
PP1-ALPHA CATALYTIC
SUBUNIT
(Homo
sapiens) 		4 / 4 ASP A  92
HIS A 173
HIS A 248
HIS A 125
 MN  A 401 ( 2.8A)
MN  A 401 (-3.3A)
MN  A 401 (-3.3A)
MN  A 402 ( 4.8A)
 1.47A 5ncdD-3v4yA:
undetectable		 5ncdD-3v4yA:
22.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OS7_A_ACTA403_0
(CASEIN KINASE II
SUBUNIT ALPHA)		 3v4y SERINE/THREONINE-PRO
TEIN PHOSPHATASE
PP1-ALPHA CATALYTIC
SUBUNIT
(Homo
sapiens) 		4 / 4 ARG A  96
TYR A 134
HIS A 125
HIS A  66
 None
None
MN  A 402 ( 4.8A)
MN  A 402 (-3.3A)
 1.46A 5os7A-3v4yA:
0.0		 5os7A-3v4yA:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GMD_B_ACTB403_0
(CASEIN KINASE II
SUBUNIT ALPHA)		 3v4y SERINE/THREONINE-PRO
TEIN PHOSPHATASE
PP1-ALPHA CATALYTIC
SUBUNIT
(Homo
sapiens) 		4 / 4 ARG A  96
TYR A 134
HIS A 125
HIS A  66
 None
None
MN  A 402 ( 4.8A)
MN  A 402 (-3.3A)
 1.46A 6gmdB-3v4yA:
0.0		 6gmdB-3v4yA:
21.54