SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3v57'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E7B_A_HLTA4002_1
(SERUM ALBUMIN)		 3v57 PHYCOERYTHRIN BETA
SUBUNIT
(Porphyridium
purpureum) 		4 / 4 ARG B  37
ALA B  40
ALA B 162
GLU B 164
 None
PEB  B 204 ( 4.0A)
None
None
 1.18A 1e7bA-3v57B:
undetectable		 1e7bA-3v57B:
13.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IWH_A_PEMA501_1
(HEMOGLOBIN ALPHA
CHAIN)		 3v57 PHYCOERYTHRIN ALPHA
SUBUNIT
(Porphyridium
purpureum) 		4 / 6 ALA A  50
LYS A  53
ASP A  57
ALA A  58
 PEB  A 202 (-3.5A)
None
None
None
 0.29A 1iwhA-3v57A:
9.1		 1iwhA-3v57A:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1K5Q_B_PACB559_0
(PENICILLIN G ACYLASE
ALPHA SUBUNIT
PENICILLIN G ACYLASE
BETA SUBUNIT)		 3v57 PHYCOERYTHRIN ALPHA
SUBUNIT
(Porphyridium
purpureum) 		4 / 7 ALA A 113
TYR A 117
SER A 164
ALA A 162
 None
 0.96A 1k5qA-3v57A:
undetectable
1k5qB-3v57A:
undetectable		 1k5qA-3v57A:
21.33
1k5qB-3v57A:
14.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BR4_E_SAME301_1
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 3v57 PHYCOERYTHRIN BETA
SUBUNIT
(Porphyridium
purpureum) 		3 / 3 SER B  46
ASP B  39
CYH B 158
 None
PEB  B 204 (-3.3A)
PEB  B 204 ( 1.7A)
 1.15A 2br4E-3v57B:
undetectable		 2br4E-3v57B:
24.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JAP_A_J01A1249_1
(CLAVALDEHYDE
DEHYDROGENASE)		 3v57 PHYCOERYTHRIN BETA
SUBUNIT
(Porphyridium
purpureum) 		5 / 12 SER B  43
ILE B  44
ALA B  40
VAL B 165
ALA B 162
 None
None
PEB  B 204 ( 4.0A)
None
None
 1.25A 2japA-3v57B:
undetectable		 2japA-3v57B:
24.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JAP_B_J01B1249_1
(CLAVALDEHYDE
DEHYDROGENASE)		 3v57 PHYCOERYTHRIN BETA
SUBUNIT
(Porphyridium
purpureum) 		5 / 12 SER B  43
ILE B  44
ALA B  40
VAL B 165
ALA B 162
 None
None
PEB  B 204 ( 4.0A)
None
None
 1.24A 2japB-3v57B:
undetectable		 2japB-3v57B:
24.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JAP_C_J01C1249_1
(CLAVALDEHYDE
DEHYDROGENASE)		 3v57 PHYCOERYTHRIN BETA
SUBUNIT
(Porphyridium
purpureum) 		5 / 12 SER B  43
ILE B  44
ALA B  40
VAL B 165
ALA B 162
 None
None
PEB  B 204 ( 4.0A)
None
None
 1.23A 2japC-3v57B:
undetectable		 2japC-3v57B:
24.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JAP_D_J01D1249_1
(CLAVALDEHYDE
DEHYDROGENASE)		 3v57 PHYCOERYTHRIN BETA
SUBUNIT
(Porphyridium
purpureum) 		5 / 12 SER B  43
ILE B  44
ALA B  40
VAL B 165
ALA B 162
 None
None
PEB  B 204 ( 4.0A)
None
None
 1.24A 2japD-3v57B:
undetectable		 2japD-3v57B:
24.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W8Y_A_486A1000_2
(PROGESTERONE
RECEPTOR)		 3v57 PHYCOERYTHRIN ALPHA
SUBUNIT
(Porphyridium
purpureum) 		4 / 7 LEU A 120
ASN A 121
GLU A  71
LEU A  66
 PEB  A 201 (-4.6A)
None
None
PEB  A 201 ( 3.8A)
 1.17A 2w8yA-3v57A:
undetectable		 2w8yA-3v57A:
18.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LXI_A_CAMA423_0
(CYTOCHROME P450)		 3v57 PHYCOERYTHRIN ALPHA
SUBUNIT
(Porphyridium
purpureum) 		5 / 10 THR A 134
LEU A 159
LEU A 156
VAL A  52
VAL A  51
 None
None
None
None
PEB  A 202 (-4.7A)
 1.26A 3lxiA-3v57A:
undetectable		 3lxiA-3v57A:
18.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LXI_B_CAMB423_0
(CYTOCHROME P450)		 3v57 PHYCOERYTHRIN ALPHA
SUBUNIT
(Porphyridium
purpureum) 		5 / 11 THR A 134
LEU A 159
LEU A 156
VAL A  52
VAL A  51
 None
None
None
None
PEB  A 202 (-4.7A)
 1.31A 3lxiB-3v57A:
undetectable		 3lxiB-3v57A:
18.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OZU_A_X89A411_1
(FLAVOHEMOPROTEIN)		 3v57 PHYCOERYTHRIN BETA
SUBUNIT
(Porphyridium
purpureum) 		5 / 12 ALA B  99
LEU B  98
VAL B  41
ALA B  48
LEU B  90
 None
 1.27A 3ozuA-3v57B:
5.7		 3ozuA-3v57B:
17.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C9P_A_CAMA423_0
(CYTOCHROME P450)		 3v57 PHYCOERYTHRIN ALPHA
SUBUNIT
(Porphyridium
purpureum) 		5 / 9 THR A 134
LEU A 159
LEU A 156
VAL A  52
VAL A  51
 None
None
None
None
PEB  A 202 (-4.7A)
 1.26A 4c9pA-3v57A:
undetectable		 4c9pA-3v57A:
18.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C9P_B_CAMB423_0
(CYTOCHROME P450)		 3v57 PHYCOERYTHRIN ALPHA
SUBUNIT
(Porphyridium
purpureum) 		5 / 10 THR A 134
LEU A 159
LEU A 156
VAL A  52
VAL A  51
 None
None
None
None
PEB  A 202 (-4.7A)
 1.25A 4c9pB-3v57A:
undetectable		 4c9pB-3v57A:
18.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D32_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3v57 PHYCOERYTHRIN ALPHA
SUBUNIT
(Porphyridium
purpureum) 		4 / 8 GLU A  25
SER A  26
ARG A  17
VAL A   8
 None
 1.39A 4d32A-3v57A:
undetectable
4d32B-3v57A:
undetectable		 4d32A-3v57A:
17.33
4d32B-3v57A:
17.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RFQ_A_SAMA401_1
(HISTIDINE PROTEIN
METHYLTRANSFERASE 1
HOMOLOG)		 3v57 PHYCOERYTHRIN ALPHA
SUBUNIT
(Porphyridium
purpureum) 		4 / 4 THR A   6
GLY A 103
ASP A 106
SER A   3
 None
 1.26A 4rfqA-3v57A:
undetectable		 4rfqA-3v57A:
24.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LSU_A_SAMA1304_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
NSD2)		 3v57 PHYCOERYTHRIN BETA
SUBUNIT
(Porphyridium
purpureum) 		5 / 12 GLY B 121
ASN B  63
CYH B  73
CYH B  82
LEU B  66
 MEN  B  72 ( 4.5A)
None
PEB  B 203 (-3.4A)
PEB  B 203 (-1.8A)
PEB  B 203 ( 4.6A)
 1.41A 5lsuA-3v57B:
undetectable		 5lsuA-3v57B:
20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UMW_B_RBFB201_1
(GLYOXALASE/BLEOMYCIN
RESISANCE
PROTEIN/DIOXYGENASE)		 3v57 PHYCOERYTHRIN ALPHA
SUBUNIT
PHYCOERYTHRIN BETA
SUBUNIT
(Porphyridium
purpureum) 		4 / 7 VAL A  52
ARG A  91
TYR B  18
LEU A 105
 None
 1.02A 5umwB-3v57A:
undetectable
5umwE-3v57A:
undetectable		 5umwB-3v57A:
19.51
5umwE-3v57A:
19.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X24_A_LSNA502_1
(CYTOCHROME P450 2C9)		 3v57 PHYCOERYTHRIN ALPHA
SUBUNIT
PHYCOERYTHRIN BETA
SUBUNIT
(Porphyridium
purpureum) 		5 / 12 ALA B  40
LEU B 161
VAL B 165
VAL B  93
THR A   6
 PEB  B 204 ( 4.0A)
None
None
None
None
 1.23A 5x24A-3v57B:
undetectable		 5x24A-3v57B:
14.65