SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3v5n'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OUZ_A_C3DA999_0
(ESTROGEN RECEPTOR)		 3v5n OXIDOREDUCTASE
(Sinorhizobium
meliloti) 		5 / 12 THR A 301
LEU A 309
LEU A 298
LEU A 310
ILE A 160
 None
 1.08A 2ouzA-3v5nA:
undetectable		 2ouzA-3v5nA:
20.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R9T_A_BEZA264_0
(ECHA1_1)		 3v5n OXIDOREDUCTASE
(Sinorhizobium
meliloti) 		4 / 8 ALA A  36
LEU A  17
ALA A 346
ALA A 347
 None
 0.64A 3r9tA-3v5nA:
undetectable		 3r9tA-3v5nA:
24.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LXZ_C_SHHC406_1
(HISTONE DEACETYLASE
2)		 3v5n OXIDOREDUCTASE
(Sinorhizobium
meliloti) 		5 / 12 PRO A 119
GLY A 211
ASP A 243
PHE A 377
GLY A 205
 None
 1.20A 4lxzC-3v5nA:
undetectable		 4lxzC-3v5nA:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_R_BEZR801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 2
BEZ-LEU-LEU)		 3v5n OXIDOREDUCTASE
(Sinorhizobium
meliloti) 		4 / 7 SER A 318
ALA A 317
PRO A 151
LEU A 298
 None
 1.11A 5dzkD-3v5nA:
undetectable
5dzkR-3v5nA:
undetectable		 5dzkD-3v5nA:
19.61
5dzkR-3v5nA:
0.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKT_A_TLFA601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 3v5n OXIDOREDUCTASE
(Sinorhizobium
meliloti) 		3 / 3 LEU A  84
TYR A  71
SER A  68
 None
 0.74A 5iktA-3v5nA:
undetectable		 5iktA-3v5nA:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VCG_A_08YA602_1
(CYTOCHROME P450 3A4)		 3v5n OXIDOREDUCTASE
(Sinorhizobium
meliloti) 		5 / 12 PHE A 141
ILE A  28
THR A 121
PHE A 339
ALA A  35
 None
 1.16A 5vcgA-3v5nA:
undetectable		 5vcgA-3v5nA:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CZM_A_HISA402_0
(ATP
PHOSPHORIBOSYLTRANSF
ERASE CATALYTIC
SUBUNIT)		 3v5n OXIDOREDUCTASE
(Sinorhizobium
meliloti) 		5 / 10 GLY A  23
LEU A  49
VAL A  94
ALA A  92
LEU A  44
 None
 1.07A 6czmA-3v5nA:
undetectable
6czmC-3v5nA:
undetectable		 6czmA-3v5nA:
22.97
6czmC-3v5nA:
22.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NQA_K_SAMK500_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-79
SPECIFIC)		 3v5n OXIDOREDUCTASE
(Sinorhizobium
meliloti) 		5 / 10 GLY A 338
GLY A 334
GLN A 292
GLU A 337
ASN A 146
 None
 1.23A 6nqaK-3v5nA:
undetectable		 6nqaK-3v5nA:
21.77