SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3v5r'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID
Hit
Macromolecule
Res.
Matches
Interface HETATM RMSD Dali
Z-score
Seq.
Identity (%)
View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FK6_A_LNLA1201_1
(NON-SPECIFIC LIPID
TRANSFER PROTEIN)
3v5r PROTEIN GAL3
(Saccharomyces
cerevisiae)
5 / 12 LEU A  63
ARG A 395
ALA A 399
LEU A 400
ILE A 324
None
1.00A 1fk6A-3v5rA:
undetectable
1fk6A-3v5rA:
11.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1G50_B_ESTB1600_1
(ESTROGEN RECEPTOR)
3v5r PROTEIN GAL3
(Saccharomyces
cerevisiae)
5 / 12 LEU A 397
LEU A 421
ILE A  55
GLY A  52
LEU A  63
None
SO4  A 524 (-4.9A)
None
None
None
1.01A 1g50B-3v5rA:
undetectable
1g50B-3v5rA:
19.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1G50_C_ESTC2600_1
(ESTROGEN RECEPTOR)
3v5r PROTEIN GAL3
(Saccharomyces
cerevisiae)
5 / 11 LEU A 397
LEU A 421
ILE A  55
GLY A  52
LEU A  63
None
SO4  A 524 (-4.9A)
None
None
None
1.01A 1g50C-3v5rA:
undetectable
1g50C-3v5rA:
19.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1H7X_A_URFA1033_1
(DIHYDROPYRIMIDINE
DEHYDROGENASE)
3v5r PROTEIN GAL3
(Saccharomyces
cerevisiae)
4 / 6 ILE A 438
ASN A 441
SER A 436
THR A 466
None
1.16A 1h7xA-3v5rA:
undetectable
1h7xA-3v5rA:
20.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1H7X_B_URFB1033_1
(DIHYDROPYRIMIDINE
DEHYDROGENASE)
3v5r PROTEIN GAL3
(Saccharomyces
cerevisiae)
4 / 6 ILE A 438
ASN A 441
SER A 436
THR A 466
None
1.16A 1h7xB-3v5rA:
undetectable
1h7xB-3v5rA:
20.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1H7X_C_URFC1033_1
(DIHYDROPYRIMIDINE
DEHYDROGENASE)
3v5r PROTEIN GAL3
(Saccharomyces
cerevisiae)
4 / 6 ILE A 438
ASN A 441
SER A 436
THR A 466
None
1.15A 1h7xC-3v5rA:
undetectable
1h7xC-3v5rA:
20.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1H7X_D_URFD1033_1
(DIHYDROPYRIMIDINE
DEHYDROGENASE)
3v5r PROTEIN GAL3
(Saccharomyces
cerevisiae)
4 / 6 ILE A 438
ASN A 441
SER A 436
THR A 466
None
1.16A 1h7xD-3v5rA:
undetectable
1h7xD-3v5rA:
20.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ONI_H_BEZH515_0
(14.5 KDA
TRANSLATIONAL
INHIBITOR PROTEIN)
3v5r PROTEIN GAL3
(Saccharomyces
cerevisiae)
4 / 6 PHE A 237
ALA A 221
ILE A  67
PRO A 511
None
1.20A 1oniH-3v5rA:
undetectable
1oniI-3v5rA:
undetectable
1oniH-3v5rA:
14.37
1oniI-3v5rA:
14.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QZF_A_FOLA605_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)
3v5r PROTEIN GAL3
(Saccharomyces
cerevisiae)
5 / 12 ALA A 357
LEU A 382
THR A 274
ILE A 271
LEU A 370
None
1.14A 1qzfA-3v5rA:
undetectable
1qzfA-3v5rA:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA3_B_STRB2001_2
(MINERALOCORTICOID
RECEPTOR)
3v5r PROTEIN GAL3
(Saccharomyces
cerevisiae)
3 / 3 LEU A 397
LEU A 332
MET A 306
None
0.73A 1ya3B-3v5rA:
undetectable
1ya3B-3v5rA:
21.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A7Q_A_CFBA328_2
(DEOXYCYTIDINE KINASE)
3v5r PROTEIN GAL3
(Saccharomyces
cerevisiae)
4 / 4 ILE A 135
ASP A 184
LEU A 190
ARG A 139
None
None
None
SO4  A 523 (-3.8A)
1.23A 2a7qA-3v5rA:
undetectable
2a7qA-3v5rA:
19.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NV4_B_SAMB202_0
(UPF0066 PROTEIN
AF_0241)
3v5r PROTEIN GAL3
(Saccharomyces
cerevisiae)
5 / 12 ALA A 169
GLN A 210
ASP A 155
GLY A 161
SER A 154
None
None
None
SO4  A   4 (-3.2A)
None
1.22A 2nv4B-3v5rA:
undetectable
2nv4B-3v5rA:
15.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OIP_A_MTXA605_1
(CHAIN A, CRYSTAL
STRUCTURE OF DHFR)
3v5r PROTEIN GAL3
(Saccharomyces
cerevisiae)
5 / 12 ALA A 357
LEU A 382
THR A 274
ILE A 271
LEU A 370
None
1.08A 2oipA-3v5rA:
undetectable
2oipA-3v5rA:
21.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OIP_D_MTXD617_1
(CHAIN A, CRYSTAL
STRUCTURE OF DHFR)
3v5r PROTEIN GAL3
(Saccharomyces
cerevisiae)
5 / 12 ALA A 357
LEU A 382
THR A 274
ILE A 271
LEU A 370
None
1.07A 2oipD-3v5rA:
undetectable
2oipD-3v5rA:
21.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AIA_B_SAMB206_0
(UPF0217 PROTEIN
MJ1640)
3v5r PROTEIN GAL3
(Saccharomyces
cerevisiae)
4 / 5 SER A 425
GLY A 459
GLU A 392
CYH A 435
None
0.95A 3aiaA-3v5rA:
undetectable
3aiaB-3v5rA:
undetectable
3aiaA-3v5rA:
17.79
3aiaB-3v5rA:
17.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FL9_D_TOPD200_1
(DIHYDROFOLATE
REDUCTASE (DHFR))
3v5r PROTEIN GAL3
(Saccharomyces
cerevisiae)
5 / 9 ALA A 357
LEU A 382
ILE A 271
LEU A 370
PHE A 365
None
1.46A 3fl9D-3v5rA:
undetectable
3fl9D-3v5rA:
17.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HJ3_A_MTXA605_1
(CHAIN A, CRYSTAL
STRUCTURE OF DHFR)
3v5r PROTEIN GAL3
(Saccharomyces
cerevisiae)
5 / 12 ALA A 357
LEU A 382
THR A 274
ILE A 271
LEU A 370
None
1.15A 3hj3A-3v5rA:
undetectable
3hj3A-3v5rA:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HJ3_B_MTXB609_1
(CHAIN A, CRYSTAL
STRUCTURE OF DHFR)
3v5r PROTEIN GAL3
(Saccharomyces
cerevisiae)
5 / 12 ALA A 357
LEU A 382
THR A 274
ILE A 271
LEU A 370
None
1.08A 3hj3B-3v5rA:
undetectable
3hj3B-3v5rA:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HJ3_D_MTXD615_1
(CHAIN A, CRYSTAL
STRUCTURE OF DHFR)
3v5r PROTEIN GAL3
(Saccharomyces
cerevisiae)
5 / 12 ALA A 357
LEU A 382
THR A 274
ILE A 271
LEU A 370
None
1.05A 3hj3D-3v5rA:
undetectable
3hj3D-3v5rA:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KM6_B_EAAB222_1
(GLUTATHIONE
S-TRANSFERASE P)
3v5r PROTEIN GAL3
(Saccharomyces
cerevisiae)
5 / 9 TYR A  34
PHE A  30
VAL A  27
GLN A 520
ASN A  89
None
1.45A 3km6B-3v5rA:
undetectable
3km6B-3v5rA:
17.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LSL_A_PZIA801_0
(GLUTAMATE RECEPTOR 2)
3v5r PROTEIN GAL3
(Saccharomyces
cerevisiae)
4 / 8 PRO A  83
GLY A 147
PRO A 144
ASN A 178
None
0.97A 3lslA-3v5rA:
undetectable
3lslD-3v5rA:
undetectable
3lslA-3v5rA:
20.72
3lslD-3v5rA:
20.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LSL_D_PZID801_0
(GLUTAMATE RECEPTOR 2)
3v5r PROTEIN GAL3
(Saccharomyces
cerevisiae)
4 / 8 PRO A 144
ASN A 178
PRO A  83
GLY A 147
None
0.95A 3lslA-3v5rA:
undetectable
3lslD-3v5rA:
undetectable
3lslA-3v5rA:
20.72
3lslD-3v5rA:
20.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MBG_A_ACTA207_0
(FAD-LINKED
SULFHYDRYL OXIDASE
ALR)
3v5r PROTEIN GAL3
(Saccharomyces
cerevisiae)
4 / 7 LEU A  65
ARG A  47
THR A 212
ALA A  66
None
SO4  A   4 (-2.8A)
None
None
1.32A 3mbgA-3v5rA:
undetectable
3mbgB-3v5rA:
undetectable
3mbgA-3v5rA:
12.67
3mbgB-3v5rA:
12.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OWX_A_XRAA233_2
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])
3v5r PROTEIN GAL3
(Saccharomyces
cerevisiae)
4 / 5 VAL A  27
ILE A 150
PHE A 121
PHE A 166
None
1.13A 3owxB-3v5rA:
undetectable
3owxB-3v5rA:
18.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OWX_A_XRAA233_2
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])
3v5r PROTEIN GAL3
(Saccharomyces
cerevisiae)
4 / 5 VAL A 478
PHE A 415
PHE A 418
PHE A 414
None
1.10A 3owxB-3v5rA:
undetectable
3owxB-3v5rA:
18.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SFE_C_TMGC1_1
(SUCCINATE
DEHYDROGENASE
[UBIQUINONE]
IRON-SULFUR SUBUNIT,
MITOCHONDRIAL
SUCCINATE
DEHYDROGENASE
CYTOCHROME B560
SUBUNIT,
MITOCHONDRIAL)
3v5r PROTEIN GAL3
(Saccharomyces
cerevisiae)
4 / 8 PRO A 157
ILE A 156
ILE A  67
ARG A  47
None
None
None
SO4  A   4 (-2.8A)
1.06A 3sfeB-3v5rA:
undetectable
3sfeC-3v5rA:
undetectable
3sfeB-3v5rA:
20.81
3sfeC-3v5rA:
14.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SI7_A_ACTA4_0
(CYSTIC FIBROSIS
TRANSMEMBRANE
CONDUCTANCE
REGULATOR)
3v5r PROTEIN GAL3
(Saccharomyces
cerevisiae)
4 / 4 LEU A 469
GLY A 454
GLY A 419
THR A 416
None
0.83A 3si7A-3v5rA:
undetectable
3si7A-3v5rA:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3Z_A_9PLA501_1
(CYTOCHROME P450 2E1)
3v5r PROTEIN GAL3
(Saccharomyces
cerevisiae)
4 / 6 PHE A  99
PHE A 121
THR A 174
LEU A 101
None
0.97A 3t3zA-3v5rA:
undetectable
3t3zA-3v5rA:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3Z_B_9PLB501_1
(CYTOCHROME P450 2E1)
3v5r PROTEIN GAL3
(Saccharomyces
cerevisiae)
4 / 6 PHE A  99
PHE A 121
THR A 174
LEU A 101
None
0.99A 3t3zB-3v5rA:
undetectable
3t3zB-3v5rA:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3Z_C_9PLC501_1
(CYTOCHROME P450 2E1)
3v5r PROTEIN GAL3
(Saccharomyces
cerevisiae)
4 / 5 PHE A  99
PHE A 121
THR A 174
LEU A 101
None
0.99A 3t3zC-3v5rA:
0.9
3t3zC-3v5rA:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DTZ_B_LDPB501_1
(CYTOCHROME P450 BM3
VARIANT 8C8)
3v5r PROTEIN GAL3
(Saccharomyces
cerevisiae)
4 / 6 PHE A 237
ALA A 221
ALA A 399
LEU A  50
None
1.12A 4dtzB-3v5rA:
undetectable
4dtzB-3v5rA:
22.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FIM_A_CELA711_1
(LACTOTRANSFERRIN)
3v5r PROTEIN GAL3
(Saccharomyces
cerevisiae)
5 / 9 VAL A 224
PRO A 234
GLU A 218
GLY A 216
TYR A 215
None
1.33A 4fimA-3v5rA:
undetectable
4fimA-3v5rA:
22.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QKN_A_JMSA602_1
(ALPHA-KETOGLUTARATE-
DEPENDENT
DIOXYGENASE FTO)
3v5r PROTEIN GAL3
(Saccharomyces
cerevisiae)
4 / 8 LEU A 302
THR A 274
ARG A 299
LEU A 288
None
None
SO4  A  10 (-4.3A)
SO4  A  10 (-4.5A)
1.07A 4qknA-3v5rA:
undetectable
4qknA-3v5rA:
22.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UBE_A_2FAA401_1
(ADENOSINE KINASE)
3v5r PROTEIN GAL3
(Saccharomyces
cerevisiae)
5 / 12 SER A 452
GLY A 419
GLY A 454
ASN A 423
ALA A 447
None
1.05A 4ubeA-3v5rA:
undetectable
4ubeA-3v5rA:
22.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_R_BEZR801_1
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 2
BEZ-LEU-LEU)
3v5r PROTEIN GAL3
(Saccharomyces
cerevisiae)
4 / 8 SER A 428
ALA A 427
HIS A 388
LEU A 457
None
1.19A 5dzkd-3v5rA:
undetectable
5dzkr-3v5rA:
undetectable
5dzkd-3v5rA:
18.77
5dzkr-3v5rA:
0.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HW4_A_SAMA801_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE I)
3v5r PROTEIN GAL3
(Saccharomyces
cerevisiae)
5 / 12 ILE A 324
GLY A 325
THR A 326
LEU A 400
VAL A 396
None
1.14A 5hw4A-3v5rA:
undetectable
5hw4A-3v5rA:
18.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TJY_A_BEZA304_0
(4-HYDROXY-TETRAHYDRO
DIPICOLINATE
REDUCTASE)
3v5r PROTEIN GAL3
(Saccharomyces
cerevisiae)
3 / 3 MET A 306
GLU A 329
ARG A 330
None
None
SO4  A   1 (-3.9A)
1.09A 5tjyA-3v5rA:
undetectable
5tjyA-3v5rA:
19.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TJZ_A_BEZA302_0
(4-HYDROXY-TETRAHYDRO
DIPICOLINATE
REDUCTASE)
3v5r PROTEIN GAL3
(Saccharomyces
cerevisiae)
3 / 3 MET A 306
GLU A 329
ARG A 330
None
None
SO4  A   1 (-3.9A)
1.12A 5tjzA-3v5rA:
undetectable
5tjzA-3v5rA:
19.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YCN_A_8LXA501_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)
3v5r PROTEIN GAL3
(Saccharomyces
cerevisiae)
4 / 6 PHE A  60
CYH A  58
SER A 297
HIS A 291
None
1.41A 5ycnA-3v5rA:
undetectable
5ycnA-3v5rA:
20.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B0I_B_TA1B502_1
(TUBULIN BETA CHAIN)
3v5r PROTEIN GAL3
(Saccharomyces
cerevisiae)
5 / 12 VAL A  75
ASP A  39
LEU A 125
ARG A 139
GLY A 180
None
None
None
SO4  A 523 (-3.8A)
SO4  A   7 (-3.2A)
1.06A 6b0iB-3v5rA:
undetectable
6b0iB-3v5rA:
10.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B0L_B_TA1B502_1
(TUBULIN BETA CHAIN)
3v5r PROTEIN GAL3
(Saccharomyces
cerevisiae)
5 / 12 VAL A  75
ASP A  39
LEU A 125
ARG A 139
GLY A 180
None
None
None
SO4  A 523 (-3.8A)
SO4  A   7 (-3.2A)
1.06A 6b0lB-3v5rA:
undetectable
6b0lB-3v5rA:
10.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FOS_B_PQNB2002_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A2)
3v5r PROTEIN GAL3
(Saccharomyces
cerevisiae)
4 / 6 MET A 208
ALA A 221
LEU A  65
ALA A  66
None
1.19A 6fosB-3v5rA:
2.1
6fosB-3v5rA:
11.31