SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3v6a'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KNY_A_KANA558_1
(KANAMYCIN
NUCLEOTIDYLTRANSFERA
SE)		 3v6a APOPTOSIS INHIBITOR
5
(Homo
sapiens) 		4 / 7 ASP A 185
GLU A 189
GLU A 190
GLU A 149
 None
 1.06A 1knyA-3v6aA:
undetectable
1knyB-3v6aA:
2.3		 1knyA-3v6aA:
19.39
1knyB-3v6aA:
19.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KNY_B_KANB559_1
(KANAMYCIN
NUCLEOTIDYLTRANSFERA
SE)		 3v6a APOPTOSIS INHIBITOR
5
(Homo
sapiens) 		4 / 8 ASP A 185
GLU A 189
GLU A 190
GLU A 149
 None
 1.16A 1knyA-3v6aA:
undetectable
1knyB-3v6aA:
2.3		 1knyA-3v6aA:
19.39
1knyB-3v6aA:
19.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OPX_A_DXCA1001_0
(ALDEHYDE
DEHYDROGENASE A)		 3v6a APOPTOSIS INHIBITOR
5
(Homo
sapiens) 		4 / 7 LEU A 159
PHE A 125
ILE A 175
PHE A 137
 None
 0.88A 2opxA-3v6aA:
undetectable		 2opxA-3v6aA:
22.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QX4_A_ML1A233_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 3v6a APOPTOSIS INHIBITOR
5
(Homo
sapiens) 		4 / 8 ILE A 140
PHE A 125
GLY A 135
GLY A 134
 None
 0.77A 2qx4A-3v6aA:
undetectable
2qx4B-3v6aA:
undetectable		 2qx4A-3v6aA:
19.58
2qx4B-3v6aA:
19.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KK6_B_CELB1701_1
(PROSTAGLANDIN G/H
SYNTHASE 1)		 3v6a APOPTOSIS INHIBITOR
5
(Homo
sapiens) 		5 / 12 VAL A 286
LEU A 287
LEU A 239
SER A 341
GLY A 271
 None
 1.22A 3kk6B-3v6aA:
undetectable		 3kk6B-3v6aA:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NDV_A_AICA375_1
(BETA-PEPTIDYL
AMINOPEPTIDASE)		 3v6a APOPTOSIS INHIBITOR
5
(Homo
sapiens) 		5 / 11 GLY A 209
LEU A 216
LEU A 248
LEU A 198
LEU A 204
 None
 1.37A 3ndvA-3v6aA:
undetectable
3ndvB-3v6aA:
undetectable		 3ndvA-3v6aA:
22.04
3ndvB-3v6aA:
22.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NDV_D_AICD374_1
(BETA-PEPTIDYL
AMINOPEPTIDASE)		 3v6a APOPTOSIS INHIBITOR
5
(Homo
sapiens) 		5 / 11 LEU A 198
LEU A 204
GLY A 209
LEU A 216
LEU A 248
 None
 1.38A 3ndvC-3v6aA:
undetectable
3ndvD-3v6aA:
undetectable		 3ndvC-3v6aA:
22.04
3ndvD-3v6aA:
22.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AZT_A_SAMA1472_1
(METHYLTRANSFERASE
WBDD)		 3v6a APOPTOSIS INHIBITOR
5
(Homo
sapiens) 		3 / 3 GLN A 142
ASP A 100
GLN A 104
 None
 0.86A 4aztA-3v6aA:
undetectable		 4aztA-3v6aA:
23.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4I89_B_1FLB201_1
(TRANSTHYRETIN)		 3v6a APOPTOSIS INHIBITOR
5
(Homo
sapiens) 		4 / 4 LYS A 411
ALA A 414
SER A 341
THR A 418
 None
 1.16A 4i89B-3v6aA:
undetectable		 4i89B-3v6aA:
14.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PEV_B_ADNB501_2
(MEMBRANE LIPOPROTEIN
FAMILY PROTEIN)		 3v6a APOPTOSIS INHIBITOR
5
(Homo
sapiens) 		3 / 3 PRO A 247
LEU A 248
GLN A 205
 None
 0.71A 4pevB-3v6aA:
undetectable		 4pevB-3v6aA:
22.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVW_K_BO2K301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 3v6a APOPTOSIS INHIBITOR
5
(Homo
sapiens) 		5 / 11 THR A 103
ALA A  90
GLY A 135
GLY A 134
ASP A 128
 None
 1.10A 4qvwK-3v6aA:
undetectable
4qvwL-3v6aA:
undetectable		 4qvwK-3v6aA:
18.79
4qvwL-3v6aA:
17.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVW_Y_BO2Y301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 3v6a APOPTOSIS INHIBITOR
5
(Homo
sapiens) 		5 / 11 THR A 103
ALA A  90
GLY A 135
GLY A 134
ASP A 128
 None
 1.10A 4qvwY-3v6aA:
undetectable
4qvwZ-3v6aA:
undetectable		 4qvwY-3v6aA:
18.79
4qvwZ-3v6aA:
17.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XE5_A_OBNA1104_2
(SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1)		 3v6a APOPTOSIS INHIBITOR
5
(Homo
sapiens) 		4 / 6 ILE A 197
VAL A 171
PHE A 137
ARG A 148
 None
 1.09A 4xe5A-3v6aA:
undetectable		 4xe5A-3v6aA:
18.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XE5_A_OBNA1104_2
(SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1)		 3v6a APOPTOSIS INHIBITOR
5
(Homo
sapiens) 		4 / 6 ILE A 197
VAL A 171
PHE A 137
THR A 132
 None
 1.13A 4xe5A-3v6aA:
undetectable		 4xe5A-3v6aA:
18.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XJ7_A_ADNA303_1
(5'/3'-NUCLEOTIDASE
SURE)		 3v6a APOPTOSIS INHIBITOR
5
(Homo
sapiens) 		5 / 10 ASN A 118
ALA A 129
ILE A 175
LEU A 159
LEU A 155
 None
 1.18A 4xj7A-3v6aA:
undetectable
4xj7B-3v6aA:
undetectable		 4xj7A-3v6aA:
20.25
4xj7B-3v6aA:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FSE_C_HQEC1583_1
(UREASE SUBUNIT ALPHA)		 3v6a APOPTOSIS INHIBITOR
5
(Homo
sapiens) 		4 / 5 ILE A  78
GLN A  47
ARG A  43
GLU A  85
 None
 1.48A 5fseC-3v6aA:
undetectable		 5fseC-3v6aA:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I1P_F_DVAF9_0
(D-VILLIN HEADPIECE
SUBDOMAIN
VILLIN-1)		 3v6a APOPTOSIS INHIBITOR
5
(Homo
sapiens) 		3 / 3 ALA A 112
ASN A 115
LEU A 116
 None
 0.39A 5i1pA-3v6aA:
undetectable		 5i1pA-3v6aA:
6.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I1P_G_DVAG9_0
(D-VILLIN HEADPIECE
SUBDOMAIN
VILLIN-1)		 3v6a APOPTOSIS INHIBITOR
5
(Homo
sapiens) 		3 / 3 ALA A 112
ASN A 115
LEU A 116
 None
 0.48A 5i1pD-3v6aA:
undetectable		 5i1pD-3v6aA:
6.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L4I_B_6J3B201_0
(TRANSTHYRETIN)		 3v6a APOPTOSIS INHIBITOR
5
(Homo
sapiens) 		4 / 6 LYS A 411
ALA A 414
SER A 341
THR A 418
 None
 1.16A 5l4iB-3v6aA:
undetectable		 5l4iB-3v6aA:
14.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M5K_B_ADNB502_2
(ADENOSYLHOMOCYSTEINA
SE)		 3v6a APOPTOSIS INHIBITOR
5
(Homo
sapiens) 		4 / 4 GLN A 205
THR A 206
LEU A 216
LEU A 213
 None
 1.26A 5m5kB-3v6aA:
undetectable		 5m5kB-3v6aA:
23.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_A_PCFA1801_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 3v6a APOPTOSIS INHIBITOR
5
(Homo
sapiens) 		4 / 6 ILE A 124
ILE A 140
LEU A 155
PHE A 154
 None
 1.02A 5vkqA-3v6aA:
0.9
5vkqB-3v6aA:
0.4		 5vkqA-3v6aA:
15.47
5vkqB-3v6aA:
15.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_B_PCFB1806_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 3v6a APOPTOSIS INHIBITOR
5
(Homo
sapiens) 		4 / 6 ILE A 124
ILE A 140
LEU A 155
PHE A 154
 None
 1.01A 5vkqB-3v6aA:
0.4
5vkqC-3v6aA:
0.4		 5vkqB-3v6aA:
15.47
5vkqC-3v6aA:
15.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_D_PCFD1807_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 3v6a APOPTOSIS INHIBITOR
5
(Homo
sapiens) 		4 / 6 ILE A 124
ILE A 140
LEU A 155
PHE A 154
 None
 1.00A 5vkqA-3v6aA:
0.9
5vkqD-3v6aA:
1.4		 5vkqA-3v6aA:
15.47
5vkqD-3v6aA:
15.47