SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3v6o'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DSD_C_DVAC2_0
(ACTINOMYCIN D)		 3v6o MONOCLONAL ANTIBODY
9F8 FAB FRAGMENT
HEAVY CHAIN
(Mus
musculus) 		4 / 4 THR C 122
PRO C 124
THR C 123
PRO C 153
 None
 1.35A 1dsdC-3v6oC:
undetectable		 1dsdC-3v6oC:
13.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DSD_C_DVAC2_0
(ACTINOMYCIN D)		 3v6o MONOCLONAL ANTIBODY
9F8 FAB FRAGMENT
HEAVY CHAIN
(Mus
musculus) 		4 / 4 THR C 123
PRO C 153
THR C 122
PRO C 124
 None
 1.29A 1dsdC-3v6oC:
undetectable		 1dsdC-3v6oC:
13.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DSD_C_DVAC8_0
(ACTINOMYCIN D)		 3v6o MONOCLONAL ANTIBODY
9F8 FAB FRAGMENT
HEAVY CHAIN
(Mus
musculus) 		4 / 4 THR C 122
PRO C 124
THR C 123
PRO C 153
 None
 1.35A 1dsdC-3v6oC:
undetectable		 1dsdC-3v6oC:
13.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DSD_C_DVAC8_0
(ACTINOMYCIN D)		 3v6o MONOCLONAL ANTIBODY
9F8 FAB FRAGMENT
HEAVY CHAIN
(Mus
musculus) 		4 / 4 THR C 123
PRO C 153
THR C 122
PRO C 124
 None
 1.29A 1dsdC-3v6oC:
undetectable		 1dsdC-3v6oC:
13.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DU8_B_BEZB1352_0
(D-AMINO-ACID OXIDASE)		 3v6o LEPTIN RECEPTOR
(Homo
sapiens) 		4 / 6 LEU A 462
TYR A 496
ILE A 432
GLY A 494
 None
EDO  A 708 ( 4.1A)
None
None
 0.93A 2du8B-3v6oA:
undetectable		 2du8B-3v6oA:
20.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QWX_A_ML1A233_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 3v6o LEPTIN RECEPTOR
MONOCLONAL ANTIBODY
9F8 FAB FRAGMENT
HEAVY CHAIN
(Homo
sapiens;
Mus
musculus) 		4 / 8 ILE C  26
PHE A 504
GLY C  35
ILE C  53
 None
ACT  C 301 (-3.8A)
None
None
 0.96A 2qwxA-3v6oC:
undetectable
2qwxB-3v6oC:
undetectable		 2qwxA-3v6oC:
23.97
2qwxB-3v6oC:
23.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F8H_A_RKEA401_1
(PROTON-GATED ION
CHANNEL)		 3v6o MONOCLONAL ANTIBODY
9F8 FAB FRAGMENT
HEAVY CHAIN
(Mus
musculus) 		4 / 8 TYR C  95
ASP C  90
PHE C  65
LEU C  50
 None
 0.91A 4f8hA-3v6oC:
undetectable
4f8hB-3v6oC:
undetectable		 4f8hA-3v6oC:
19.68
4f8hB-3v6oC:
19.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F8H_B_RKEB401_1
(PROTON-GATED ION
CHANNEL)		 3v6o MONOCLONAL ANTIBODY
9F8 FAB FRAGMENT
HEAVY CHAIN
(Mus
musculus) 		4 / 8 TYR C  95
ASP C  90
PHE C  65
LEU C  50
 None
 0.92A 4f8hB-3v6oC:
undetectable
4f8hC-3v6oC:
undetectable		 4f8hB-3v6oC:
19.68
4f8hC-3v6oC:
19.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F8H_C_RKEC401_1
(PROTON-GATED ION
CHANNEL)		 3v6o MONOCLONAL ANTIBODY
9F8 FAB FRAGMENT
HEAVY CHAIN
(Mus
musculus) 		4 / 8 TYR C  95
ASP C  90
PHE C  65
LEU C  50
 None
 0.90A 4f8hC-3v6oC:
undetectable
4f8hD-3v6oC:
undetectable		 4f8hC-3v6oC:
19.68
4f8hD-3v6oC:
19.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F8H_D_RKED401_1
(PROTON-GATED ION
CHANNEL)		 3v6o MONOCLONAL ANTIBODY
9F8 FAB FRAGMENT
HEAVY CHAIN
(Mus
musculus) 		4 / 8 TYR C  95
ASP C  90
PHE C  65
LEU C  50
 None
 0.91A 4f8hD-3v6oC:
undetectable
4f8hE-3v6oC:
undetectable		 4f8hD-3v6oC:
19.68
4f8hE-3v6oC:
19.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F8H_E_RKEE401_1
(PROTON-GATED ION
CHANNEL)		 3v6o MONOCLONAL ANTIBODY
9F8 FAB FRAGMENT
HEAVY CHAIN
(Mus
musculus) 		4 / 8 PHE C  65
LEU C  50
TYR C  95
ASP C  90
 None
 0.91A 4f8hA-3v6oC:
undetectable
4f8hE-3v6oC:
undetectable		 4f8hA-3v6oC:
19.68
4f8hE-3v6oC:
19.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MMD_B_29EB603_1
(TRANSPORTER)		 3v6o MONOCLONAL ANTIBODY
9F8 FAB FRAGMENT
HEAVY CHAIN
(Mus
musculus) 		5 / 12 ASP C  85
VAL C  14
ALA C  15
SER C  86
SER C  17
 None
 1.07A 4mmdB-3v6oC:
undetectable		 4mmdB-3v6oC:
16.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QOG_A_ML1A302_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 3v6o LEPTIN RECEPTOR
MONOCLONAL ANTIBODY
9F8 FAB FRAGMENT
HEAVY CHAIN
(Homo
sapiens;
Mus
musculus) 		4 / 8 ILE C  26
PHE A 504
GLY C  35
ILE C  53
 None
ACT  C 301 (-3.8A)
None
None
 0.93A 4qogA-3v6oC:
undetectable
4qogB-3v6oC:
undetectable		 4qogA-3v6oC:
23.97
4qogB-3v6oC:
23.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RP8_C_ASCC501_1
(ASCORBATE-SPECIFIC
PERMEASE IIC
COMPONENT ULAA)		 3v6o LEPTIN RECEPTOR
MONOCLONAL ANTIBODY
9F8 FAB FRAGMENT
HEAVY CHAIN
(Homo
sapiens;
Mus
musculus) 		3 / 3 SER A 507
TYR A 509
ASP C  34
 None
None
ACT  C 301 (-2.8A)
 0.75A 4rp8C-3v6oA:
undetectable		 4rp8C-3v6oA:
18.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5C0O_F_SAMF301_0
(TRNA
(ADENINE(58)-N(1))-M
ETHYLTRANSFERASE
TRMI)		 3v6o MONOCLONAL ANTIBODY
9F8 FAB FRAGMENT
HEAVY CHAIN
(Mus
musculus) 		6 / 12 THR C  59
GLY C  35
GLY C  55
GLY C  57
ALA C  98
HIS C 100
 None
 1.31A 5c0oF-3v6oC:
undetectable		 5c0oF-3v6oC:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UUN_B_ACTB308_0
(GLUTATHIONE
S-TRANSFERASE-LIKE
PROTEIN)		 3v6o LEPTIN RECEPTOR
(Homo
sapiens) 		3 / 3 LEU A 603
ILE A 547
TYR A 574
 None
 0.69A 5uunB-3v6oA:
undetectable		 5uunB-3v6oA:
18.77