SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3v70'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HSG_B_MK1B902_1
(HIV-1 PROTEASE)		 3v70 GTPASE IMAP FAMILY
MEMBER 1
(Homo
sapiens) 		5 / 10 LEU A 115
VAL A  81
GLY A 102
VAL A  33
ILE A  31
 None
 0.78A 1hsgA-3v70A:
undetectable		 1hsgA-3v70A:
15.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OHR_A_1UNA201_2
(ASPARTYLPROTEASE)		 3v70 GTPASE IMAP FAMILY
MEMBER 1
(Homo
sapiens) 		5 / 9 LEU A 115
VAL A  81
GLY A 102
VAL A  33
ILE A  31
 None
 0.74A 1ohrB-3v70A:
undetectable		 1ohrB-3v70A:
15.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T3R_A_017A1200_2
(PROTEASE RETROPEPSIN)		 3v70 GTPASE IMAP FAMILY
MEMBER 1
(Homo
sapiens) 		5 / 11 LEU A 115
VAL A  81
GLY A 102
VAL A  33
ILE A  31
 None
 0.83A 1t3rB-3v70A:
undetectable		 1t3rB-3v70A:
14.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2C12_D_SPMD1434_1
(NITROALKANE OXIDASE)		 3v70 GTPASE IMAP FAMILY
MEMBER 1
(Homo
sapiens) 		5 / 10 GLN A 120
VAL A 118
ALA A  38
SER A  41
ASP A  82
 GDP  A 401 (-4.1A)
None
GDP  A 401 (-4.0A)
MG  A 402 ( 2.2A)
MG  A 402 ( 4.0A)
 1.44A 2c12D-3v70A:
undetectable		 2c12D-3v70A:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IEN_B_017B402_1
(PROTEASE)		 3v70 GTPASE IMAP FAMILY
MEMBER 1
(Homo
sapiens) 		5 / 12 LEU A 115
VAL A  81
GLY A 102
VAL A  33
ILE A  31
 None
 0.78A 2ienA-3v70A:
undetectable		 2ienA-3v70A:
17.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2O4P_A_TPVA300_2
(PROTEASE)		 3v70 GTPASE IMAP FAMILY
MEMBER 1
(Homo
sapiens) 		5 / 9 LEU A 115
VAL A  81
GLY A 102
VAL A  33
ILE A  31
 None
 0.82A 2o4pB-3v70A:
undetectable		 2o4pB-3v70A:
15.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q64_B_1UNB1001_3
(PROTEASE RETROPEPSIN)		 3v70 GTPASE IMAP FAMILY
MEMBER 1
(Homo
sapiens) 		5 / 12 LEU A 115
VAL A  81
GLY A 102
VAL A  33
ILE A  31
 None
 0.84A 2q64B-3v70A:
undetectable		 2q64B-3v70A:
14.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BVB_B_017B401_1
(PROTEASE
(RETROPEPSIN))		 3v70 GTPASE IMAP FAMILY
MEMBER 1
(Homo
sapiens) 		5 / 12 LEU A 115
VAL A  81
GLY A 102
VAL A  33
ILE A  31
 None
 0.75A 3bvbA-3v70A:
undetectable		 3bvbA-3v70A:
17.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EM3_B_478B200_1
(PROTEASE)		 3v70 GTPASE IMAP FAMILY
MEMBER 1
(Homo
sapiens) 		5 / 10 LEU A 115
VAL A  81
GLY A 102
VAL A  33
ILE A  31
 None
 0.83A 3em3A-3v70A:
undetectable		 3em3A-3v70A:
19.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EM6_A_017A200_2
(PROTEASE)		 3v70 GTPASE IMAP FAMILY
MEMBER 1
(Homo
sapiens) 		5 / 12 LEU A 115
VAL A  81
GLY A 102
VAL A  33
ILE A  31
 None
 0.92A 3em6B-3v70A:
undetectable		 3em6B-3v70A:
19.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OXW_D_017D200_2
(HIV-1 PROTEASE)		 3v70 GTPASE IMAP FAMILY
MEMBER 1
(Homo
sapiens) 		5 / 10 LEU A 115
VAL A  81
GLY A 102
VAL A  33
ILE A  31
 None
 0.74A 3oxwD-3v70A:
undetectable		 3oxwD-3v70A:
16.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OY4_B_017B200_1
(HIV-1 PROTEASE)		 3v70 GTPASE IMAP FAMILY
MEMBER 1
(Homo
sapiens) 		5 / 11 LEU A 115
VAL A  81
GLY A 102
VAL A  33
ILE A  31
 None
 0.81A 3oy4A-3v70A:
undetectable		 3oy4A-3v70A:
16.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PWM_B_017B402_1
(PROTEASE)		 3v70 GTPASE IMAP FAMILY
MEMBER 1
(Homo
sapiens) 		5 / 12 LEU A 115
GLY A 111
VAL A  81
VAL A  33
ILE A  31
 None
 0.95A 3pwmA-3v70A:
undetectable		 3pwmA-3v70A:
16.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BQT_C_C5EC301_0
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 3v70 GTPASE IMAP FAMILY
MEMBER 1
(Homo
sapiens) 		4 / 8 VAL A 135
TYR A 105
CYH A 104
ILE A  86
 None
 1.26A 4bqtC-3v70A:
undetectable
4bqtD-3v70A:
undetectable		 4bqtC-3v70A:
20.08
4bqtD-3v70A:
20.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DQB_B_017B101_1
(ASPARTYL PROTEASE)		 3v70 GTPASE IMAP FAMILY
MEMBER 1
(Homo
sapiens) 		5 / 12 LEU A 115
VAL A  81
GLY A 102
VAL A  33
ILE A  31
 None
 0.90A 4dqbA-3v70A:
undetectable		 4dqbA-3v70A:
17.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DQE_B_017B101_1
(ASPARTYL PROTEASE)		 3v70 GTPASE IMAP FAMILY
MEMBER 1
(Homo
sapiens) 		5 / 11 LEU A 115
VAL A  81
GLY A 102
VAL A  33
ILE A  31
 None
 0.81A 4dqeA-3v70A:
undetectable		 4dqeA-3v70A:
17.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DQF_B_017B101_1
(ASPARTYL PROTEASE)		 3v70 GTPASE IMAP FAMILY
MEMBER 1
(Homo
sapiens) 		5 / 12 LEU A 115
VAL A  81
GLY A 102
VAL A  33
ILE A  31
 None
 0.84A 4dqfA-3v70A:
undetectable		 4dqfA-3v70A:
17.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DQH_B_017B101_1
(WILD-TYPE HIV-1
PROTEASE DIMER)		 3v70 GTPASE IMAP FAMILY
MEMBER 1
(Homo
sapiens) 		5 / 11 LEU A 115
VAL A  81
GLY A 102
VAL A  33
ILE A  31
 None
 0.88A 4dqhA-3v70A:
undetectable		 4dqhA-3v70A:
16.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O7G_A_ASCA303_0
(PROBABLE
TRANSMEMBRANE
ASCORBATE
FERRIREDUCTASE 2)		 3v70 GTPASE IMAP FAMILY
MEMBER 1
(Homo
sapiens) 		4 / 7 PHE A 151
ILE A 149
PHE A 124
ASN A 171
 None
 1.40A 4o7gA-3v70A:
undetectable
4o7gB-3v70A:
undetectable		 4o7gA-3v70A:
19.77
4o7gB-3v70A:
19.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QGI_A_ROCA101_2
(PROTEASE)		 3v70 GTPASE IMAP FAMILY
MEMBER 1
(Homo
sapiens) 		5 / 11 LEU A 115
VAL A  81
GLY A 102
VAL A  33
ILE A  31
 None
 0.81A 4qgiB-3v70A:
undetectable		 4qgiB-3v70A:
19.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_1_BEZ1801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 1
ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 2
BEZ-LEU-LEU)		 3v70 GTPASE IMAP FAMILY
MEMBER 1
(Homo
sapiens) 		3 / 3 LEU A  32
PHE A  87
ILE A  31
 None
 0.73A 5dzk1-3v70A:
undetectable
5dzkF-3v70A:
undetectable
5dzkM-3v70A:
undetectable		 5dzk1-3v70A:
1.98
5dzkF-3v70A:
19.37
5dzkM-3v70A:
23.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ERG_B_SAMB401_0
(TRNA
(ADENINE(58)-N(1))-M
ETHYLTRANSFERASE
CATALYTIC SUBUNIT
TRM61)		 3v70 GTPASE IMAP FAMILY
MEMBER 1
(Homo
sapiens) 		5 / 12 GLY A  69
SER A  70
VAL A 150
CYH A 186
LEU A 204
 None
 1.07A 5ergB-3v70A:
undetectable		 5ergB-3v70A:
20.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TUI_B_CTCB405_0
(TETRACYCLINE
DESTRUCTASE TET(50))		 3v70 GTPASE IMAP FAMILY
MEMBER 1
(Homo
sapiens) 		5 / 12 GLY A 206
VAL A 178
LEU A 211
GLY A 182
PHE A 188
 None
 1.05A 5tuiB-3v70A:
undetectable		 5tuiB-3v70A:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DGX_A_017A101_1
(PROTEASE)		 3v70 GTPASE IMAP FAMILY
MEMBER 1
(Homo
sapiens) 		5 / 12 LEU A 115
VAL A  81
GLY A 102
VAL A  33
ILE A  31
 None
 0.83A 6dgxB-3v70A:
undetectable		 6dgxB-3v70A:
16.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DIL_B_TPVB201_1
(HIV-1 PROTEASE)		 3v70 GTPASE IMAP FAMILY
MEMBER 1
(Homo
sapiens) 		5 / 12 LEU A 115
GLY A 111
VAL A  81
VAL A  33
ILE A  31
 None
 0.79A 6dilB-3v70A:
undetectable		 6dilB-3v70A:
16.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DIL_B_TPVB201_1
(HIV-1 PROTEASE)		 3v70 GTPASE IMAP FAMILY
MEMBER 1
(Homo
sapiens) 		5 / 12 LEU A 115
VAL A  81
GLY A 102
VAL A  33
ILE A  31
 None
 0.82A 6dilB-3v70A:
undetectable		 6dilB-3v70A:
16.45