SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3v75'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CBR_A_REAA200_1
(CELLULAR RETINOIC
ACID BINDING PROTEIN
TYPE I)		 3v75 OROTIDINE
5'-PHOSPHATE
DECARBOXYLASE
(Streptomyces
avermitilis) 		5 / 12 LEU A 262
ALA A 266
ALA A 270
PRO A  19
VAL A  22
 None
 1.21A 1cbrA-3v75A:
undetectable		 1cbrA-3v75A:
19.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CBR_B_REAB200_1
(CELLULAR RETINOIC
ACID BINDING PROTEIN
TYPE I)		 3v75 OROTIDINE
5'-PHOSPHATE
DECARBOXYLASE
(Streptomyces
avermitilis) 		5 / 12 LEU A 262
ALA A 266
ALA A 270
PRO A  19
VAL A  22
 None
 1.21A 1cbrB-3v75A:
undetectable		 1cbrB-3v75A:
19.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HBP_A_RTLA184_0
(RETINOL BINDING
PROTEIN)		 3v75 OROTIDINE
5'-PHOSPHATE
DECARBOXYLASE
(Streptomyces
avermitilis) 		5 / 11 LEU A  20
ALA A  88
ALA A  86
VAL A  22
LEU A  54
 None
 1.24A 1hbpA-3v75A:
undetectable		 1hbpA-3v75A:
19.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A3B_B_CFFB2434_1
(CHITINASE)		 3v75 OROTIDINE
5'-PHOSPHATE
DECARBOXYLASE
(Streptomyces
avermitilis) 		4 / 6 GLU A   4
ASP A 123
PHE A 121
ARG A  87
 None
 1.33A 2a3bB-3v75A:
9.4		 2a3bB-3v75A:
20.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CWK_A_REAA300_1
(CELLULAR RETINOIC
ACID-BINDING PROTEIN
2)		 3v75 OROTIDINE
5'-PHOSPHATE
DECARBOXYLASE
(Streptomyces
avermitilis) 		5 / 12 LEU A 262
ALA A 266
ALA A 270
PRO A  19
VAL A  22
 None
 1.19A 3cwkA-3v75A:
undetectable		 3cwkA-3v75A:
16.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HBB_B_TMQB612_1
(DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 3v75 OROTIDINE
5'-PHOSPHATE
DECARBOXYLASE
(Streptomyces
avermitilis) 		5 / 9 VAL A 248
ASP A  25
THR A 203
SER A 157
ILE A 223
 None
 1.42A 3hbbB-3v75A:
undetectable		 3hbbB-3v75A:
20.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3I45_A_NIOA500_1
(TWIN-ARGININE
TRANSLOCATION
PATHWAY SIGNAL
PROTEIN)		 3v75 OROTIDINE
5'-PHOSPHATE
DECARBOXYLASE
(Streptomyces
avermitilis) 		4 / 8 SER A 146
LEU A 114
PHE A 196
LEU A 150
 None
 1.03A 3i45A-3v75A:
undetectable		 3i45A-3v75A:
23.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UR0_B_SVRB516_1
(RNA-DEPENDENT RNA
POLYMERASE)		 3v75 OROTIDINE
5'-PHOSPHATE
DECARBOXYLASE
(Streptomyces
avermitilis) 		4 / 7 PRO A 192
GLY A   7
ALA A   8
ALA A  13
 None
 0.80A 3ur0B-3v75A:
undetectable		 3ur0B-3v75A:
23.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZOS_A_0LIA1004_1
(EPITHELIAL DISCOIDIN
DOMAIN-CONTAINING
RECEPTOR 1)		 3v75 OROTIDINE
5'-PHOSPHATE
DECARBOXYLASE
(Streptomyces
avermitilis) 		5 / 11 VAL A 244
GLY A 235
ILE A 273
LEU A 212
GLY A 238
 None
 1.11A 3zosA-3v75A:
undetectable
3zosB-3v75A:
undetectable		 3zosA-3v75A:
24.49
3zosB-3v75A:
24.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EQ4_B_SALB601_1
(4-SUBSTITUTED
BENZOATES-GLUTAMATE
LIGASE GH3.12)		 3v75 OROTIDINE
5'-PHOSPHATE
DECARBOXYLASE
(Streptomyces
avermitilis) 		4 / 8 THR A  82
ILE A  24
VAL A  22
GLY A  55
 None
 0.72A 4eq4B-3v75A:
undetectable		 4eq4B-3v75A:
18.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5F9Z_A_HFGA702_0
(AMINOACYL-TRNA
SYNTHETASE)		 3v75 OROTIDINE
5'-PHOSPHATE
DECARBOXYLASE
(Streptomyces
avermitilis) 		5 / 12 LEU A 180
GLY A 197
VAL A 200
SER A 135
GLY A 100
 None
 1.28A 5f9zA-3v75A:
undetectable		 5f9zA-3v75A:
19.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NY7_A_NCAA303_0
(AMIDASE)		 3v75 OROTIDINE
5'-PHOSPHATE
DECARBOXYLASE
(Streptomyces
avermitilis) 		4 / 6 ARG A 274
GLY A  18
PRO A  19
GLU A 271
 None
 1.11A 5ny7A-3v75A:
1.8		 5ny7A-3v75A:
29.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TUI_B_CTCB405_0
(TETRACYCLINE
DESTRUCTASE TET(50))		 3v75 OROTIDINE
5'-PHOSPHATE
DECARBOXYLASE
(Streptomyces
avermitilis) 		5 / 12 VAL A  93
LEU A  20
PRO A  63
PHE A  46
VAL A  50
 None
 1.29A 5tuiB-3v75A:
undetectable		 5tuiB-3v75A:
26.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5W7B_B_PA1B204_1
(ACYLOXYACYL
HYDROLASE SMALL
SUBUNIT
ACYLOXYACYL
HYDROLASE LARGE
SUBUNIT)		 3v75 OROTIDINE
5'-PHOSPHATE
DECARBOXYLASE
(Streptomyces
avermitilis) 		3 / 3 GLY A 194
ASN A 187
ARG A 144
 None
 0.46A 5w7bD-3v75A:
undetectable		 5w7bD-3v75A:
12.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X80_A_SALA201_1
(UNCHARACTERIZED
HTH-TYPE
TRANSCRIPTIONAL
REGULATOR RV2887)		 3v75 OROTIDINE
5'-PHOSPHATE
DECARBOXYLASE
(Streptomyces
avermitilis) 		4 / 5 VAL A 175
PRO A 129
GLY A 132
TYR A 130
 None
 1.13A 5x80A-3v75A:
undetectable
5x80B-3v75A:
undetectable		 5x80A-3v75A:
25.83
5x80B-3v75A:
25.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X80_C_SALC201_1
(UNCHARACTERIZED
HTH-TYPE
TRANSCRIPTIONAL
REGULATOR RV2887)		 3v75 OROTIDINE
5'-PHOSPHATE
DECARBOXYLASE
(Streptomyces
avermitilis) 		5 / 7 VAL A 175
VAL A 152
PRO A 129
GLY A 132
TYR A 130
 None
 1.43A 5x80C-3v75A:
undetectable
5x80D-3v75A:
undetectable		 5x80C-3v75A:
25.83
5x80D-3v75A:
25.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X80_D_SALD201_1
(UNCHARACTERIZED
HTH-TYPE
TRANSCRIPTIONAL
REGULATOR RV2887)		 3v75 OROTIDINE
5'-PHOSPHATE
DECARBOXYLASE
(Streptomyces
avermitilis) 		4 / 5 PRO A 129
GLY A 132
TYR A 130
VAL A 175
 None
 1.09A 5x80C-3v75A:
undetectable
5x80D-3v75A:
undetectable		 5x80C-3v75A:
25.83
5x80D-3v75A:
25.83