SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3v77'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2I2Z_A_SALA1100_1
(SERUM ALBUMIN)		 3v77 PUTATIVE
FUMARYLACETOACETATE
ISOMERASE/HYDROLASE
(Oleispira
antarctica) 		4 / 5 LEU A 216
ILE A  95
ILE A 146
ALA A 145
 None
 0.74A 2i2zA-3v77A:
undetectable		 2i2zA-3v77A:
17.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OXT_B_SAMB300_1
(NUCLEOSIDE-2'-O-METH
YLTRANSFERASE)		 3v77 PUTATIVE
FUMARYLACETOACETATE
ISOMERASE/HYDROLASE
(Oleispira
antarctica) 		4 / 5 SER A  91
GLY A  77
ASP A 100
ASP A 186
 None
None
ZN  A 301 ( 3.1A)
None
 1.14A 2oxtB-3v77A:
undetectable		 2oxtB-3v77A:
20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VMY_B_FFOB505_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 3v77 PUTATIVE
FUMARYLACETOACETATE
ISOMERASE/HYDROLASE
(Oleispira
antarctica) 		5 / 12 LEU A  99
GLY A  98
LEU A 205
VAL A 223
GLY A 197
 None
 1.00A 2vmyA-3v77A:
undetectable		 2vmyA-3v77A:
22.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YS6_A_GLYA431_0
(PHOSPHORIBOSYLGLYCIN
AMIDE SYNTHETASE)		 3v77 PUTATIVE
FUMARYLACETOACETATE
ISOMERASE/HYDROLASE
(Oleispira
antarctica) 		4 / 8 ASP A 100
LYS A 121
GLY A 191
GLU A  71
 ZN  A 301 ( 3.1A)
TAR  A 303 (-2.8A)
TAR  A 303 ( 3.8A)
ZN  A 301 ( 2.3A)
 0.91A 2ys6A-3v77A:
undetectable		 2ys6A-3v77A:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FO4_B_MOAB502_1
(INOSINE
5'-MONOPHOSPHATE
DEHYDROGENASE)		 3v77 PUTATIVE
FUMARYLACETOACETATE
ISOMERASE/HYDROLASE
(Oleispira
antarctica) 		4 / 8 SER A 206
GLY A  98
THR A 130
GLY A  54
 None
 0.82A 4fo4B-3v77A:
undetectable		 4fo4B-3v77A:
22.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HPU_A_IPHA101_0
(INSULIN, CHAIN A
INSULIN, CHAIN B)		 3v77 PUTATIVE
FUMARYLACETOACETATE
ISOMERASE/HYDROLASE
(Oleispira
antarctica) 		4 / 4 CYH A 127
LEU A 189
LEU A 129
ALA A  73
 None
 1.12A 5hpuA-3v77A:
undetectable
5hpuB-3v77A:
undetectable		 5hpuA-3v77A:
7.04
5hpuB-3v77A:
8.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FGD_A_ACTA807_0
(GEPHYRIN)		 3v77 PUTATIVE
FUMARYLACETOACETATE
ISOMERASE/HYDROLASE
(Oleispira
antarctica) 		4 / 4 PRO A  37
LEU A 166
VAL A  21
ARG A  23
 None
None
None
ACT  A 304 ( 3.9A)
 1.41A 6fgdA-3v77A:
undetectable		 6fgdA-3v77A:
21.88