SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3v78'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T9W_A_NFNA6002_1
(ACRIFLAVINE
RESISTANCE PROTEIN B)		 3v78 PROBABLE
TRANSCRIPTIONAL
REGULATORY PROTEIN
(PROBABLY
DEOR-FAMILY)
(Mycobacterium
tuberculosis) 		4 / 7 GLN A  17
ALA A  64
ARG A  15
ASN A  56
 None
 1.25A 1t9wA-3v78A:
undetectable		 1t9wA-3v78A:
11.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EJG_B_ADNB1502_1
(235AA LONG
HYPOTHETICAL
BIOTIN--[ACETYL-COA-
CARBOXYLASE] LIGASE)		 3v78 PROBABLE
TRANSCRIPTIONAL
REGULATORY PROTEIN
(PROBABLY
DEOR-FAMILY)
(Mycobacterium
tuberculosis) 		4 / 7 ARG A  16
GLU A  21
ASN A  71
ALA A  67
 None
 1.46A 2ejgB-3v78A:
undetectable		 2ejgB-3v78A:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RLF_B_RIMB299_1
(MATRIX PROTEIN 2)		 3v78 PROBABLE
TRANSCRIPTIONAL
REGULATORY PROTEIN
(PROBABLY
DEOR-FAMILY)
(Mycobacterium
tuberculosis) 		4 / 6 LEU A 114
LEU A 111
ILE A  27
ARG A  29
 None
ET  A 301 ( 4.3A)
None
None
 0.93A 2rlfB-3v78A:
undetectable
2rlfC-3v78A:
undetectable		 2rlfB-3v78A:
11.06
2rlfC-3v78A:
11.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZXW_J_CHDJ60_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 1)		 3v78 PROBABLE
TRANSCRIPTIONAL
REGULATORY PROTEIN
(PROBABLY
DEOR-FAMILY)
(Mycobacterium
tuberculosis) 		4 / 6 LEU A  32
ARG A  25
THR A 110
LEU A 114
 None
 1.09A 2zxwA-3v78A:
undetectable
2zxwJ-3v78A:
undetectable		 2zxwA-3v78A:
18.24
2zxwJ-3v78A:
13.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XDR_A_ADNA402_1
(FAD:PROTEIN FMN
TRANSFERASE)		 3v78 PROBABLE
TRANSCRIPTIONAL
REGULATORY PROTEIN
(PROBABLY
DEOR-FAMILY)
(Mycobacterium
tuberculosis) 		5 / 12 LEU A  35
VAL A  26
ALA A  41
ILE A  19
THR A  52
 None
 1.03A 4xdrA-3v78A:
undetectable		 4xdrA-3v78A:
24.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z7F_C_FOLC201_0
(FOLATE ECF
TRANSPORTER)		 3v78 PROBABLE
TRANSCRIPTIONAL
REGULATORY PROTEIN
(PROBABLY
DEOR-FAMILY)
(Mycobacterium
tuberculosis) 		5 / 12 SER A  73
THR A 152
ASN A 112
THR A 159
LEU A 102
 ET  A 301 (-2.7A)
None
ET  A 301 (-4.2A)
ET  A 301 (-3.8A)
None
 1.45A 4z7fC-3v78A:
undetectable		 4z7fC-3v78A:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5C0O_F_SAMF301_0
(TRNA
(ADENINE(58)-N(1))-M
ETHYLTRANSFERASE
TRMI)		 3v78 PROBABLE
TRANSCRIPTIONAL
REGULATORY PROTEIN
(PROBABLY
DEOR-FAMILY)
(Mycobacterium
tuberculosis) 		5 / 12 GLY A  33
GLY A  34
LEU A  35
GLU A 123
LEU A  66
 None
 0.95A 5c0oF-3v78A:
undetectable		 5c0oF-3v78A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ND4_B_TA1B601_1
(TUBULIN BETA-2B
CHAIN)		 3v78 PROBABLE
TRANSCRIPTIONAL
REGULATORY PROTEIN
(PROBABLY
DEOR-FAMILY)
(Mycobacterium
tuberculosis) 		5 / 12 ASP A 172
GLU A 173
LEU A 181
ALA A 177
PHE A 154
 None
 1.25A 5nd4B-3v78A:
undetectable		 5nd4B-3v78A:
19.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XDX_J_CHDJ101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT VIIA-HEART)		 3v78 PROBABLE
TRANSCRIPTIONAL
REGULATORY PROTEIN
(PROBABLY
DEOR-FAMILY)
(Mycobacterium
tuberculosis) 		4 / 7 LEU A  32
ARG A  25
THR A 110
LEU A 114
 None
 0.97A 5xdxA-3v78A:
undetectable
5xdxJ-3v78A:
undetectable		 5xdxA-3v78A:
18.24
5xdxJ-3v78A:
13.94