SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3v7i'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID
Hit
Macromolecule
Res.
Matches
Interface HETATM RMSD Dali
Z-score
Seq.
Identity (%)
View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_E_FUAE706_2
(CHLORAMPHENICOL
ACETYLTRANSFERASE)
3v7i PUTATIVE POLYKETIDE
SYNTHASE

(Streptomyces
coelicolor)
4 / 4 ALA A 375
VAL A 176
ALA A 376
HIS A 261
None
1.20A 1q23F-3v7iA:
undetectable
1q23F-3v7iA:
18.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_J_FUAJ711_2
(CHLORAMPHENICOL
ACETYLTRANSFERASE)
3v7i PUTATIVE POLYKETIDE
SYNTHASE

(Streptomyces
coelicolor)
4 / 4 ALA A 375
VAL A 176
ALA A 376
HIS A 261
None
1.21A 1q23K-3v7iA:
undetectable
1q23K-3v7iA:
18.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZLQ_A_ACTA1502_0
(NICKEL-BINDING
PERIPLASMIC PROTEIN)
3v7i PUTATIVE POLYKETIDE
SYNTHASE

(Streptomyces
coelicolor)
4 / 5 PRO A 377
GLY A 348
ASN A 346
GLY A 314
None
1.15A 1zlqA-3v7iA:
undetectable
1zlqA-3v7iA:
23.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXE_A_1FLA2002_1
(SERUM ALBUMIN)
3v7i PUTATIVE POLYKETIDE
SYNTHASE

(Streptomyces
coelicolor)
5 / 10 ALA A 370
LEU A 310
ALA A 359
LEU A 389
VAL A 243
None
0.87A 2bxeA-3v7iA:
undetectable
2bxeA-3v7iA:
23.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXG_B_IBPB2002_1
(SERUM ALBUMIN)
3v7i PUTATIVE POLYKETIDE
SYNTHASE

(Streptomyces
coelicolor)
5 / 10 ALA A 370
LEU A 310
ALA A 359
LEU A 389
VAL A 243
None
0.95A 2bxgB-3v7iA:
undetectable
2bxgB-3v7iA:
23.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OAX_F_SNLF6001_2
(MINERALOCORTICOID
RECEPTOR)
3v7i PUTATIVE POLYKETIDE
SYNTHASE

(Streptomyces
coelicolor)
4 / 5 LEU A 335
LEU A 309
LEU A 372
MET A 322
None
1.13A 2oaxF-3v7iA:
undetectable
2oaxF-3v7iA:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VMY_B_FFOB505_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)
3v7i PUTATIVE POLYKETIDE
SYNTHASE

(Streptomyces
coelicolor)
5 / 12 LEU A 246
GLY A 386
LEU A   5
ALA A 370
GLY A 178
None
0.92A 2vmyA-3v7iA:
undetectable
2vmyA-3v7iA:
25.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W3A_A_TOPA1190_1
(DIHYDROFOLATE
REDUCTASE)
3v7i PUTATIVE POLYKETIDE
SYNTHASE

(Streptomyces
coelicolor)
5 / 11 ILE A 201
ALA A 229
PHE A 353
VAL A 199
THR A 228
None
1.25A 2w3aA-3v7iA:
undetectable
2w3aA-3v7iA:
19.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FC6_C_REAC501_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)
3v7i PUTATIVE POLYKETIDE
SYNTHASE

(Streptomyces
coelicolor)
5 / 12 VAL A 113
ALA A 120
ALA A 121
LEU A 198
ALA A   9
None
0.94A 3fc6C-3v7iA:
undetectable
3fc6C-3v7iA:
20.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JX1_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)
3v7i PUTATIVE POLYKETIDE
SYNTHASE

(Streptomyces
coelicolor)
4 / 8 PHE A 353
GLU A 203
SER A 202
VAL A 200
None
1.15A 3jx1A-3v7iA:
undetectable
3jx1B-3v7iA:
undetectable
3jx1A-3v7iA:
20.14
3jx1B-3v7iA:
20.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MB5_A_SAMA301_0
(SAM-DEPENDENT
METHYLTRANSFERASE)
3v7i PUTATIVE POLYKETIDE
SYNTHASE

(Streptomyces
coelicolor)
5 / 12 ILE A  11
VAL A  10
GLY A  13
ALA A 229
ILE A  48
None
0.99A 3mb5A-3v7iA:
undetectable
3mb5A-3v7iA:
20.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N0H_A_TOPA187_1
(DIHYDROFOLATE
REDUCTASE)
3v7i PUTATIVE POLYKETIDE
SYNTHASE

(Streptomyces
coelicolor)
5 / 11 ILE A 201
ALA A 120
PHE A 353
LEU A 182
VAL A 199
None
1.12A 3n0hA-3v7iA:
undetectable
3n0hA-3v7iA:
19.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N61_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE)
3v7i PUTATIVE POLYKETIDE
SYNTHASE

(Streptomyces
coelicolor)
4 / 7 PHE A 353
GLU A 203
SER A 202
VAL A 200
None
1.14A 3n61A-3v7iA:
undetectable
3n61B-3v7iA:
undetectable
3n61A-3v7iA:
20.14
3n61B-3v7iA:
20.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NLR_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)
3v7i PUTATIVE POLYKETIDE
SYNTHASE

(Streptomyces
coelicolor)
4 / 8 PHE A 353
GLU A 203
SER A 202
VAL A 200
None
1.18A 3nlrA-3v7iA:
undetectable
3nlrB-3v7iA:
0.5
3nlrA-3v7iA:
20.14
3nlrB-3v7iA:
20.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NLY_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)
3v7i PUTATIVE POLYKETIDE
SYNTHASE

(Streptomyces
coelicolor)
4 / 8 PHE A 353
GLU A 203
SER A 202
VAL A 200
None
1.17A 3nlyA-3v7iA:
undetectable
3nlyB-3v7iA:
0.6
3nlyA-3v7iA:
20.82
3nlyB-3v7iA:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R4X_A_PZAA597_0
(LACTOPEROXIDASE)
3v7i PUTATIVE POLYKETIDE
SYNTHASE

(Streptomyces
coelicolor)
4 / 5 GLN A 210
ASP A 213
HIS A 271
ARG A 266
None
0.85A 3r4xA-3v7iA:
undetectable
3r4xA-3v7iA:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R55_A_PZAA597_0
(LACTOPEROXIDASE)
3v7i PUTATIVE POLYKETIDE
SYNTHASE

(Streptomyces
coelicolor)
4 / 5 GLN A 210
ASP A 213
HIS A 271
ARG A 266
None
0.88A 3r55A-3v7iA:
undetectable
3r55A-3v7iA:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RQL_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)
3v7i PUTATIVE POLYKETIDE
SYNTHASE

(Streptomyces
coelicolor)
4 / 8 PHE A 353
GLU A 203
SER A 202
VAL A 200
None
1.16A 3rqlA-3v7iA:
undetectable
3rqlB-3v7iA:
undetectable
3rqlA-3v7iA:
20.82
3rqlB-3v7iA:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S3V_A_TOPA187_1
(DIHYDROFOLATE
REDUCTASE)
3v7i PUTATIVE POLYKETIDE
SYNTHASE

(Streptomyces
coelicolor)
5 / 12 ILE A 201
ALA A 120
PHE A 353
LEU A 182
VAL A 199
None
1.11A 3s3vA-3v7iA:
undetectable
3s3vA-3v7iA:
19.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TIC_D_ZMRD1002_2
(NEURAMINIDASE)
3v7i PUTATIVE POLYKETIDE
SYNTHASE

(Streptomyces
coelicolor)
4 / 5 LEU A 205
ARG A  51
TRP A  53
ILE A  22
None
1.31A 3ticD-3v7iA:
undetectable
3ticD-3v7iA:
22.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WIP_G_ACHG301_0
(ACETYLCHOLINE-BINDIN
G PROTEIN)
3v7i PUTATIVE POLYKETIDE
SYNTHASE

(Streptomyces
coelicolor)
4 / 8 TRP A 250
ARG A 296
LEU A 293
MET A 289
None
1.10A 3wipG-3v7iA:
undetectable
3wipH-3v7iA:
undetectable
3wipG-3v7iA:
19.25
3wipH-3v7iA:
19.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WIP_J_ACHJ301_0
(ACETYLCHOLINE-BINDIN
G PROTEIN)
3v7i PUTATIVE POLYKETIDE
SYNTHASE

(Streptomyces
coelicolor)
4 / 8 ARG A 296
LEU A 293
MET A 289
TRP A 250
None
1.30A 3wipF-3v7iA:
undetectable
3wipJ-3v7iA:
undetectable
3wipF-3v7iA:
19.25
3wipJ-3v7iA:
19.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A6E_A_SAMA1349_0
(HYDROXYINDOLE
O-METHYLTRANSFERASE)
3v7i PUTATIVE POLYKETIDE
SYNTHASE

(Streptomyces
coelicolor)
5 / 12 LEU A 389
TRP A 388
GLY A 367
ALA A 370
ASP A 247
None
1.12A 4a6eA-3v7iA:
undetectable
4a6eA-3v7iA:
22.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AWU_A_4CHA502_0
(OXIDOREDUCTASE,
FMN-BINDING)
3v7i PUTATIVE POLYKETIDE
SYNTHASE

(Streptomyces
coelicolor)
4 / 7 HIS A 312
ASN A 346
TYR A 342
LEU A 224
None
1.37A 4awuA-3v7iA:
undetectable
4awuA-3v7iA:
25.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CAP_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)
3v7i PUTATIVE POLYKETIDE
SYNTHASE

(Streptomyces
coelicolor)
4 / 8 PHE A 353
GLU A 203
SER A 202
VAL A 200
None
1.19A 4capA-3v7iA:
undetectable
4capB-3v7iA:
undetectable
4capA-3v7iA:
20.82
4capB-3v7iA:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D32_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)
3v7i PUTATIVE POLYKETIDE
SYNTHASE

(Streptomyces
coelicolor)
4 / 8 PHE A 353
GLU A 203
SER A 202
VAL A 200
None
1.17A 4d32A-3v7iA:
undetectable
4d32B-3v7iA:
undetectable
4d32A-3v7iA:
20.82
4d32B-3v7iA:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KFJ_B_FOLB202_0
(DIHYDROFOLATE
REDUCTASE)
3v7i PUTATIVE POLYKETIDE
SYNTHASE

(Streptomyces
coelicolor)
6 / 12 ILE A 201
ALA A 229
PHE A 353
LEU A   5
VAL A 199
THR A 228
None
1.32A 4kfjB-3v7iA:
undetectable
4kfjB-3v7iA:
19.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MWR_A_ZMRA513_2
(NEURAMINIDASE)
3v7i PUTATIVE POLYKETIDE
SYNTHASE

(Streptomyces
coelicolor)
4 / 5 LEU A 205
ARG A  51
TRP A  53
ILE A  22
None
1.34A 4mwrA-3v7iA:
undetectable
4mwrA-3v7iA:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MWX_A_ZMRA513_2
(NEURAMINIDASE)
3v7i PUTATIVE POLYKETIDE
SYNTHASE

(Streptomyces
coelicolor)
3 / 3 ARG A  51
TRP A  53
ILE A  22
None
0.95A 4mwxA-3v7iA:
undetectable
4mwxA-3v7iA:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MWZ_B_SAMB301_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE,
PUTATIVE)
3v7i PUTATIVE POLYKETIDE
SYNTHASE

(Streptomyces
coelicolor)
5 / 12 VAL A 113
GLY A 348
ARG A 180
SER A 141
LEU A 151
None
1.05A 4mwzB-3v7iA:
undetectable
4mwzB-3v7iA:
18.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QYQ_A_3CJA607_1
(LACTOPEROXIDASE)
3v7i PUTATIVE POLYKETIDE
SYNTHASE

(Streptomyces
coelicolor)
3 / 3 GLN A 210
HIS A 271
ARG A 266
None
0.72A 4qyqA-3v7iA:
undetectable
4qyqA-3v7iA:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QYQ_B_3CJB607_1
(LACTOPEROXIDASE)
3v7i PUTATIVE POLYKETIDE
SYNTHASE

(Streptomyces
coelicolor)
3 / 3 GLN A 210
HIS A 271
ARG A 266
None
0.62A 4qyqB-3v7iA:
undetectable
4qyqB-3v7iA:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TWD_A_377A402_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)
3v7i PUTATIVE POLYKETIDE
SYNTHASE

(Streptomyces
coelicolor)
5 / 9 ALA A 174
SER A 143
ALA A 177
SER A 141
ALA A 350
None
1.34A 4twdA-3v7iA:
undetectable
4twdB-3v7iA:
undetectable
4twdC-3v7iA:
undetectable
4twdD-3v7iA:
undetectable
4twdE-3v7iA:
undetectable
4twdA-3v7iA:
21.22
4twdB-3v7iA:
21.22
4twdC-3v7iA:
21.22
4twdD-3v7iA:
21.22
4twdE-3v7iA:
21.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V3Y_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)
3v7i PUTATIVE POLYKETIDE
SYNTHASE

(Streptomyces
coelicolor)
4 / 8 PHE A 353
GLU A 203
SER A 202
VAL A 200
None
1.15A 4v3yA-3v7iA:
undetectable
4v3yB-3v7iA:
undetectable
4v3yA-3v7iA:
20.82
4v3yB-3v7iA:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JQ7_B_T0RB705_1
(ENVELOPE
GLYCOPROTEIN
1,ENVELOPE
GLYCOPROTEIN
1,ENVELOPE
GLYCOPROTEIN 1
ENVELOPE
GLYCOPROTEIN 2)
3v7i PUTATIVE POLYKETIDE
SYNTHASE

(Streptomyces
coelicolor)
4 / 7 VAL A 200
ALA A 231
LEU A 155
LEU A 159
None
0.67A 5jq7A-3v7iA:
undetectable
5jq7A-3v7iA:
21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L17_A_ZMRA512_2
(NEURAMINIDASE)
3v7i PUTATIVE POLYKETIDE
SYNTHASE

(Streptomyces
coelicolor)
4 / 4 LEU A 205
ARG A  51
TRP A  53
ILE A  22
None
1.34A 5l17A-3v7iA:
undetectable
5l17A-3v7iA:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0O_A_SAMA501_1
(PEPTIDE
N-METHYLTRANSFERASE)
3v7i PUTATIVE POLYKETIDE
SYNTHASE

(Streptomyces
coelicolor)
3 / 3 ALA A 375
GLN A 283
THR A 285
None
0.72A 5n0oA-3v7iA:
undetectable
5n0oA-3v7iA:
21.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UO7_A_H4BA802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)
3v7i PUTATIVE POLYKETIDE
SYNTHASE

(Streptomyces
coelicolor)
4 / 8 SER A 202
VAL A 200
PHE A 353
GLU A 203
None
1.14A 5uo7A-3v7iA:
undetectable
5uo7B-3v7iA:
0.4
5uo7A-3v7iA:
20.34
5uo7B-3v7iA:
20.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UUN_A_ACTA307_0
(GLUTATHIONE
S-TRANSFERASE-LIKE
PROTEIN)
3v7i PUTATIVE POLYKETIDE
SYNTHASE

(Streptomyces
coelicolor)
4 / 4 LEU A   5
LEU A 246
SER A 181
ALA A 186
None
1.09A 5uunA-3v7iA:
undetectable
5uunA-3v7iA:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DWD_A_GLYA715_0
(DEOXYNUCLEOSIDE
TRIPHOSPHATE
TRIPHOSPHOHYDROLASE
SAMHD1)
3v7i PUTATIVE POLYKETIDE
SYNTHASE

(Streptomyces
coelicolor)
4 / 6 GLY A  52
ASP A 227
SER A 206
ARG A  51
None
1.22A 6dwdA-3v7iA:
undetectable
6dwdC-3v7iA:
undetectable
6dwdA-3v7iA:
20.68
6dwdC-3v7iA:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6JOG_A_ASCA201_0
(PHOSPHOPANTETHEINE
ADENYLYLTRANSFERASE)
3v7i PUTATIVE POLYKETIDE
SYNTHASE

(Streptomyces
coelicolor)
4 / 6 GLY A 315
THR A 316
ARG A 347
SER A 344
None
1.10A 6jogA-3v7iA:
undetectable
6jogA-3v7iA:
16.43