SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3v7n'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_H_FUAH709_1
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 3v7n THREONINE SYNTHASE
(Burkholderia
thailandensis) 		5 / 12 LEU A 341
VAL A 373
PHE A 304
VAL A 293
HIS A 279
 None
 1.21A 1q23H-3v7nA:
undetectable
1q23I-3v7nA:
undetectable		 1q23H-3v7nA:
18.48
1q23I-3v7nA:
18.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2C49_A_ADNA1301_1
(SUGAR KINASE MJ0406)		 3v7n THREONINE SYNTHASE
(Burkholderia
thailandensis) 		5 / 12 ALA A  26
ASP A  28
GLY A  29
GLY A  30
ALA A   9
 None
 0.90A 2c49A-3v7nA:
2.7		 2c49A-3v7nA:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J2P_E_SC2E1290_1
(FICOLIN-2)		 3v7n THREONINE SYNTHASE
(Burkholderia
thailandensis) 		5 / 9 VAL A 349
LEU A  31
SER A   5
LEU A  25
ASP A  28
 None
 1.49A 2j2pD-3v7nA:
0.0
2j2pE-3v7nA:
0.0		 2j2pD-3v7nA:
17.96
2j2pE-3v7nA:
17.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W3M_B_FOLB1188_0
(DIHYDROFOLATE
REDUCTASE)		 3v7n THREONINE SYNTHASE
(Burkholderia
thailandensis) 		5 / 12 ALA A 189
LEU A 459
GLU A 457
PHE A 453
TYR A 164
 None
 1.23A 2w3mB-3v7nA:
2.1		 2w3mB-3v7nA:
18.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ADS_A_IMNA2_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 3v7n THREONINE SYNTHASE
(Burkholderia
thailandensis) 		5 / 12 PHE A 304
LEU A  31
PHE A 337
LEU A 341
LEU A 352
 None
 1.43A 3adsA-3v7nA:
undetectable		 3adsA-3v7nA:
20.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AX9_B_SALB1340_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)		 3v7n THREONINE SYNTHASE
(Burkholderia
thailandensis) 		4 / 8 PHE A 125
THR A 158
ALA A 430
ALA A 124
 None
MLA  A 484 ( 3.4A)
None
None
 1.01A 3ax9B-3v7nA:
undetectable		 3ax9B-3v7nA:
16.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B9M_A_SALA1100_1
(SERUM ALBUMIN)		 3v7n THREONINE SYNTHASE
(Burkholderia
thailandensis) 		4 / 4 LEU A 456
ARG A  90
LEU A 123
ALA A 452
 None
 1.19A 3b9mA-3v7nA:
1.3		 3b9mA-3v7nA:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_C_SVRC505_2
(PHOSPHOLIPASE A2)		 3v7n THREONINE SYNTHASE
(Burkholderia
thailandensis) 		4 / 5 VAL A 246
VAL A 245
PHE A  58
ARG A 336
 None
None
EDO  A 485 ( 4.9A)
None
 1.37A 3bjwH-3v7nA:
undetectable		 3bjwH-3v7nA:
9.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FHX_B_PXLB313_1
(PYRIDOXAL KINASE)		 3v7n THREONINE SYNTHASE
(Burkholderia
thailandensis) 		4 / 8 VAL A 275
VAL A 338
PHE A 334
VAL A 293
 None
 1.15A 3fhxB-3v7nA:
undetectable		 3fhxB-3v7nA:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NS1_C_PM6C1_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)		 3v7n THREONINE SYNTHASE
(Burkholderia
thailandensis) 		4 / 6 PHE A 125
THR A 158
ALA A 430
ALA A 124
 None
MLA  A 484 ( 3.4A)
None
None
 0.97A 3ns1C-3v7nA:
undetectable		 3ns1C-3v7nA:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NS1_L_PM6L1_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)		 3v7n THREONINE SYNTHASE
(Burkholderia
thailandensis) 		4 / 8 PHE A 125
THR A 158
ALA A 430
ALA A 124
 None
MLA  A 484 ( 3.4A)
None
None
 0.98A 3ns1L-3v7nA:
undetectable		 3ns1L-3v7nA:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OKX_A_SAMA201_0
(YAEB-LIKE PROTEIN
RPA0152)		 3v7n THREONINE SYNTHASE
(Burkholderia
thailandensis) 		5 / 12 LEU A 104
LEU A 101
ARG A  91
GLY A 251
LEU A 114
 None
 1.21A 3okxA-3v7nA:
undetectable		 3okxA-3v7nA:
18.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OLS_A_ESTA600_1
(ESTROGEN RECEPTOR
BETA)		 3v7n THREONINE SYNTHASE
(Burkholderia
thailandensis) 		5 / 12 LEU A 123
ALA A 430
GLU A 428
ARG A  91
GLY A 436
 None
 1.03A 3olsA-3v7nA:
undetectable		 3olsA-3v7nA:
18.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OU7_B_SAMB300_1
(SAM-DEPENDENT
METHYLTRANSFERASE)		 3v7n THREONINE SYNTHASE
(Burkholderia
thailandensis) 		3 / 3 TYR A 164
ASP A 127
ASP A 157
 None
None
MLA  A 484 (-4.8A)
 1.00A 3ou7B-3v7nA:
undetectable		 3ou7B-3v7nA:
18.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JLT_A_8PRA505_1
(CYTOCHROME P450 2B4)		 3v7n THREONINE SYNTHASE
(Burkholderia
thailandensis) 		4 / 8 ALA A 277
VAL A 267
PRO A 268
VAL A 425
 None
 0.84A 4jltA-3v7nA:
undetectable		 4jltA-3v7nA:
23.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L4A_A_CAMA502_0
(CAMPHOR
5-MONOOXYGENASE)		 3v7n THREONINE SYNTHASE
(Burkholderia
thailandensis) 		4 / 8 THR A 391
THR A 266
VAL A 413
VAL A 112
 None
 1.01A 4l4aA-3v7nA:
undetectable		 4l4aA-3v7nA:
23.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L4E_A_CAMA503_0
(CAMPHOR
5-MONOOXYGENASE)		 3v7n THREONINE SYNTHASE
(Burkholderia
thailandensis) 		4 / 8 THR A 391
THR A 266
VAL A 413
VAL A 112
 None
 1.03A 4l4eA-3v7nA:
undetectable		 4l4eA-3v7nA:
23.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L4F_A_CAMA503_0
(CAMPHOR
5-MONOOXYGENASE)		 3v7n THREONINE SYNTHASE
(Burkholderia
thailandensis) 		4 / 8 THR A 391
THR A 266
VAL A 413
VAL A 112
 None
 1.02A 4l4fA-3v7nA:
undetectable		 4l4fA-3v7nA:
23.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PXM_A_ESTA2000_1
(ESTROGEN RECEPTOR)		 3v7n THREONINE SYNTHASE
(Burkholderia
thailandensis) 		5 / 12 LEU A 123
ALA A 430
GLU A 428
ARG A  91
GLY A 436
 None
 1.10A 4pxmA-3v7nA:
undetectable		 4pxmA-3v7nA:
18.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DXB_A_ESTA1000_1
(ESTROGEN RECEPTOR)		 3v7n THREONINE SYNTHASE
(Burkholderia
thailandensis) 		5 / 10 LEU A 123
ALA A 430
GLU A 428
ARG A  91
GLY A 436
 None
 1.01A 5dxbA-3v7nA:
undetectable		 5dxbA-3v7nA:
18.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GWX_A_SAMA301_0
(GLYCINE SARCOSINE
N-METHYLTRANSFERASE)		 3v7n THREONINE SYNTHASE
(Burkholderia
thailandensis) 		5 / 12 GLY A 159
SER A 160
ARG A 240
GLY A 168
LEU A 133
 None
None
BO3  A 487 (-2.8A)
None
None
 1.10A 5gwxA-3v7nA:
2.3		 5gwxA-3v7nA:
19.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HNW_B_TA1B902_1
(TUBULIN BETA-2B
CHAIN)		 3v7n THREONINE SYNTHASE
(Burkholderia
thailandensis) 		5 / 12 LEU A 104
LEU A 411
LEU A 114
ARG A 400
PRO A 432
 None
 1.18A 5hnwB-3v7nA:
2.5		 5hnwB-3v7nA:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JHD_J_EDTJ301_0
(TCRBETA CHAIN)		 3v7n THREONINE SYNTHASE
(Burkholderia
thailandensis) 		4 / 5 TYR A  32
GLU A  13
GLY A  10
SER A   5
 None
 1.08A 5jhdJ-3v7nA:
undetectable		 5jhdJ-3v7nA:
18.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5U4S_A_BEZA301_0
(PUTATIVE SHORT CHAIN
DEHYDROGENASE)		 3v7n THREONINE SYNTHASE
(Burkholderia
thailandensis) 		4 / 7 ASN A 259
ILE A 288
LEU A 286
LEU A  45
 None
 0.90A 5u4sA-3v7nA:
2.0		 5u4sA-3v7nA:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5U4S_B_BEZB301_0
(PUTATIVE SHORT CHAIN
DEHYDROGENASE)		 3v7n THREONINE SYNTHASE
(Burkholderia
thailandensis) 		4 / 8 ASN A 259
ILE A 288
LEU A 286
LEU A  45
 None
 0.89A 5u4sB-3v7nA:
2.1		 5u4sB-3v7nA:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y2T_B_8LXB501_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 3v7n THREONINE SYNTHASE
(Burkholderia
thailandensis) 		4 / 8 PHE A 304
HIS A 279
PHE A 305
LEU A 341
 None
 1.08A 5y2tB-3v7nA:
undetectable		 5y2tB-3v7nA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZW4_A_SAMA302_1
(PUTATIVE
O-METHYLTRANSFERASE
YRRM)		 3v7n THREONINE SYNTHASE
(Burkholderia
thailandensis) 		4 / 6 ARG A  78
ARG A  79
ASP A  55
ASP A  72
 None
 1.27A 5zw4A-3v7nA:
2.3		 5zw4A-3v7nA:
17.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FGD_A_ACTA810_0
(GEPHYRIN)		 3v7n THREONINE SYNTHASE
(Burkholderia
thailandensis) 		3 / 3 LEU A 104
LEU A 114
ARG A  91
 None
 0.66A 6fgdA-3v7nA:
undetectable		 6fgdA-3v7nA:
21.78