SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3v7p'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4L_A_DCFA353_1
(ADENOSINE DEAMINASE)		 3v7p AMIDOHYDROLASE
FAMILY PROTEIN
(Nitratiruptor
sp.
SB155-2) 		6 / 12 HIS A  61
HIS A  63
HIS A 206
GLU A 209
HIS A 257
ASP A 306
 FE  A 429 (-3.2A)
FE  A 429 (-3.2A)
FE  A 429 (-3.3A)
UNL  A 436 ( 2.8A)
None
FE  A 429 (-3.1A)
 0.52A 1a4lA-3v7pA:
19.8		 1a4lA-3v7pA:
22.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4L_B_DCFB853_1
(ADENOSINE DEAMINASE)		 3v7p AMIDOHYDROLASE
FAMILY PROTEIN
(Nitratiruptor
sp.
SB155-2) 		5 / 12 HIS A  63
HIS A 206
GLU A 209
HIS A 257
ASP A 306
 FE  A 429 (-3.2A)
FE  A 429 (-3.3A)
UNL  A 436 ( 2.8A)
None
FE  A 429 (-3.1A)
 0.34A 1a4lB-3v7pA:
20.0		 1a4lB-3v7pA:
22.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4L_B_DCFB853_1
(ADENOSINE DEAMINASE)		 3v7p AMIDOHYDROLASE
FAMILY PROTEIN
(Nitratiruptor
sp.
SB155-2) 		5 / 12 LEU A  82
HIS A 206
GLU A 209
HIS A 257
ASP A 306
 None
FE  A 429 (-3.3A)
UNL  A 436 ( 2.8A)
None
FE  A 429 (-3.1A)
 0.84A 1a4lB-3v7pA:
20.0		 1a4lB-3v7pA:
22.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4L_C_DCFC1353_1
(ADENOSINE DEAMINASE)		 3v7p AMIDOHYDROLASE
FAMILY PROTEIN
(Nitratiruptor
sp.
SB155-2) 		6 / 12 HIS A  61
HIS A  63
HIS A 206
GLU A 209
HIS A 257
ASP A 306
 FE  A 429 (-3.2A)
FE  A 429 (-3.2A)
FE  A 429 (-3.3A)
UNL  A 436 ( 2.8A)
None
FE  A 429 (-3.1A)
 0.44A 1a4lC-3v7pA:
20.0		 1a4lC-3v7pA:
22.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4L_D_DCFD1853_1
(ADENOSINE DEAMINASE)		 3v7p AMIDOHYDROLASE
FAMILY PROTEIN
(Nitratiruptor
sp.
SB155-2) 		5 / 12 HIS A  63
HIS A 206
GLU A 209
HIS A 257
ASP A 306
 FE  A 429 (-3.2A)
FE  A 429 (-3.3A)
UNL  A 436 ( 2.8A)
None
FE  A 429 (-3.1A)
 0.33A 1a4lD-3v7pA:
19.9		 1a4lD-3v7pA:
22.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HBP_A_RTLA184_0
(RETINOL BINDING
PROTEIN)		 3v7p AMIDOHYDROLASE
FAMILY PROTEIN
(Nitratiruptor
sp.
SB155-2) 		5 / 11 LEU A 381
ALA A 346
ALA A 343
VAL A 385
LEU A  54
 None
 1.04A 1hbpA-3v7pA:
undetectable		 1hbpA-3v7pA:
19.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KB9_A_PCFA514_0
(CYTOCHROME B
CYTOCHROME C1, HEME
PROTEIN
UBIQUINOL-CYTOCHROME
C REDUCTASE COMPLEX
CORE PROTEIN I
UBIQUINOL-CYTOCHROME
C REDUCTASE
IRON-SULFUR SUBUNIT)		 3v7p AMIDOHYDROLASE
FAMILY PROTEIN
(Nitratiruptor
sp.
SB155-2) 		4 / 8 SER A 282
HIS A  61
ILE A 119
VAL A  85
 None
FE  A 429 (-3.2A)
None
None
 0.90A 1kb9A-3v7pA:
undetectable
1kb9C-3v7pA:
undetectable
1kb9D-3v7pA:
undetectable
1kb9E-3v7pA:
undetectable		 1kb9A-3v7pA:
23.78
1kb9C-3v7pA:
21.49
1kb9D-3v7pA:
19.36
1kb9E-3v7pA:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LHU_A_ESTA301_1
(SEX HORMONE-BINDING
GLOBULIN)		 3v7p AMIDOHYDROLASE
FAMILY PROTEIN
(Nitratiruptor
sp.
SB155-2) 		5 / 12 SER A 132
GLY A 117
ASN A 140
ILE A 116
LEU A 105
 None
 1.16A 1lhuA-3v7pA:
undetectable		 1lhuA-3v7pA:
17.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RBP_A_RTLA183_0
(PLASMA
RETINOL-BINDING
PROTEIN PRECURSOR)		 3v7p AMIDOHYDROLASE
FAMILY PROTEIN
(Nitratiruptor
sp.
SB155-2) 		5 / 12 LEU A 381
ALA A 346
ALA A 343
VAL A 385
LEU A  54
 None
 1.00A 1rbpA-3v7pA:
undetectable		 1rbpA-3v7pA:
19.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XZX_X_T3X500_1
(THYROID HORMONE
RECEPTOR BETA-1)		 3v7p AMIDOHYDROLASE
FAMILY PROTEIN
(Nitratiruptor
sp.
SB155-2) 		5 / 12 ILE A 341
ALA A 346
LEU A 293
ILE A 296
HIS A 278
 None
None
BCT  A 435 (-3.9A)
None
None
 1.22A 1xzxX-3v7pA:
undetectable		 1xzxX-3v7pA:
20.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J0D_A_ERYA1498_0
(CYTOCHROME P450 3A4)		 3v7p AMIDOHYDROLASE
FAMILY PROTEIN
(Nitratiruptor
sp.
SB155-2) 		5 / 12 ILE A   9
ILE A  30
ALA A  29
ALA A  43
GLU A  46
 None
 1.16A 2j0dA-3v7pA:
undetectable		 2j0dA-3v7pA:
22.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J9D_J_ACTJ1116_0
(HYPOTHETICAL
NITROGEN REGULATORY
PII-LIKE PROTEIN
MJ0059)		 3v7p AMIDOHYDROLASE
FAMILY PROTEIN
(Nitratiruptor
sp.
SB155-2) 		4 / 8 GLU A  46
ILE A   4
LYS A 394
GLU A 401
 None
 0.97A 2j9dJ-3v7pA:
undetectable
2j9dK-3v7pA:
undetectable
2j9dL-3v7pA:
undetectable		 2j9dJ-3v7pA:
15.11
2j9dK-3v7pA:
15.11
2j9dL-3v7pA:
15.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J9D_J_ACTJ1116_0
(HYPOTHETICAL
NITROGEN REGULATORY
PII-LIKE PROTEIN
MJ0059)		 3v7p AMIDOHYDROLASE
FAMILY PROTEIN
(Nitratiruptor
sp.
SB155-2) 		4 / 8 LYS A 394
GLU A 401
GLU A  46
ILE A   4
 None
 0.94A 2j9dJ-3v7pA:
undetectable
2j9dK-3v7pA:
undetectable
2j9dL-3v7pA:
undetectable		 2j9dJ-3v7pA:
15.11
2j9dK-3v7pA:
15.11
2j9dL-3v7pA:
15.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OZR_E_HAEE3003_1
(COLLAGENASE 3)		 3v7p AMIDOHYDROLASE
FAMILY PROTEIN
(Nitratiruptor
sp.
SB155-2) 		4 / 4 HIS A 206
GLU A 141
HIS A  63
HIS A  61
 FE  A 429 (-3.3A)
None
FE  A 429 (-3.2A)
FE  A 429 (-3.2A)
 1.35A 2ozrE-3v7pA:
undetectable		 2ozrE-3v7pA:
16.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PGF_A_ADNA501_1
(ADENOSINE DEAMINASE)		 3v7p AMIDOHYDROLASE
FAMILY PROTEIN
(Nitratiruptor
sp.
SB155-2) 		6 / 12 HIS A  63
HIS A 206
GLU A 209
HIS A 257
SER A 282
ASP A 306
 FE  A 429 (-3.2A)
FE  A 429 (-3.3A)
UNL  A 436 ( 2.8A)
None
None
FE  A 429 (-3.1A)
 0.31A 2pgfA-3v7pA:
20.4		 2pgfA-3v7pA:
24.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PGR_A_DCFA501_1
(ADENOSINE DEAMINASE)		 3v7p AMIDOHYDROLASE
FAMILY PROTEIN
(Nitratiruptor
sp.
SB155-2) 		6 / 12 HIS A  61
HIS A  63
HIS A 206
GLU A 209
HIS A 257
ASP A 306
 FE  A 429 (-3.2A)
FE  A 429 (-3.2A)
FE  A 429 (-3.3A)
UNL  A 436 ( 2.8A)
None
FE  A 429 (-3.1A)
 0.37A 2pgrA-3v7pA:
20.5		 2pgrA-3v7pA:
24.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QD5_A_CHDA701_0
(FERROCHELATASE)		 3v7p AMIDOHYDROLASE
FAMILY PROTEIN
(Nitratiruptor
sp.
SB155-2) 		4 / 8 LEU A  82
SER A 121
VAL A 184
GLY A 144
 None
UNL  A 437 ( 4.8A)
None
BEZ  A 430 ( 3.7A)
 1.05A 2qd5A-3v7pA:
undetectable		 2qd5A-3v7pA:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QD5_B_CHDB1103_0
(FERROCHELATASE)		 3v7p AMIDOHYDROLASE
FAMILY PROTEIN
(Nitratiruptor
sp.
SB155-2) 		4 / 8 LEU A  82
SER A 121
VAL A 184
GLY A 144
 None
UNL  A 437 ( 4.8A)
None
BEZ  A 430 ( 3.7A)
 1.10A 2qd5B-3v7pA:
undetectable		 2qd5B-3v7pA:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QO6_A_CHDA130_0
(LIVER-BASIC FATTY
ACID BINDING PROTEIN)		 3v7p AMIDOHYDROLASE
FAMILY PROTEIN
(Nitratiruptor
sp.
SB155-2) 		5 / 12 LEU A  10
ILE A 340
LEU A  54
THR A 389
HIS A 384
 None
 1.34A 2qo6A-3v7pA:
undetectable		 2qo6A-3v7pA:
15.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZWF_B_DAHB98_1
(TYROSINASE
MELC)		 3v7p AMIDOHYDROLASE
FAMILY PROTEIN
(Nitratiruptor
sp.
SB155-2) 		5 / 11 HIS A  63
ILE A 119
HIS A  61
HIS A 257
PRO A 181
 FE  A 429 (-3.2A)
None
FE  A 429 (-3.2A)
None
None
 1.45A 2zwfA-3v7pA:
undetectable
2zwfB-3v7pA:
undetectable		 2zwfA-3v7pA:
23.45
2zwfB-3v7pA:
15.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZWG_B_DAHB98_1
(TYROSINASE
MELC)		 3v7p AMIDOHYDROLASE
FAMILY PROTEIN
(Nitratiruptor
sp.
SB155-2) 		5 / 11 HIS A  63
ILE A 119
HIS A  61
HIS A 257
PRO A 181
 FE  A 429 (-3.2A)
None
FE  A 429 (-3.2A)
None
None
 1.43A 2zwgA-3v7pA:
undetectable
2zwgB-3v7pA:
undetectable		 2zwgA-3v7pA:
23.45
2zwgB-3v7pA:
15.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3J6P_B_TA1B502_1
(TUBULIN BETA CHAIN)		 3v7p AMIDOHYDROLASE
FAMILY PROTEIN
(Nitratiruptor
sp.
SB155-2) 		5 / 12 VAL A 256
SER A 204
THR A 113
GLY A 307
LEU A  62
 None
 1.23A 3j6pB-3v7pA:
2.8		 3j6pB-3v7pA:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NNE_G_ACTG601_0
(CHOLINE OXIDASE)		 3v7p AMIDOHYDROLASE
FAMILY PROTEIN
(Nitratiruptor
sp.
SB155-2) 		4 / 6 ALA A 177
ILE A 119
HIS A 206
VAL A 256
 None
None
FE  A 429 (-3.3A)
None
 1.18A 3nneG-3v7pA:
undetectable		 3nneG-3v7pA:
20.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QPK_A_CUA602_0
(LACCASE-1)		 3v7p AMIDOHYDROLASE
FAMILY PROTEIN
(Nitratiruptor
sp.
SB155-2) 		3 / 3 HIS A 206
HIS A  61
HIS A  63
 FE  A 429 (-3.3A)
FE  A 429 (-3.2A)
FE  A 429 (-3.2A)
 0.61A 3qpkA-3v7pA:
undetectable		 3qpkA-3v7pA:
20.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R24_A_SAMA302_0
(2'-O-METHYL
TRANSFERASE)		 3v7p AMIDOHYDROLASE
FAMILY PROTEIN
(Nitratiruptor
sp.
SB155-2) 		5 / 12 GLY A 289
SER A 282
GLY A  76
LEU A 291
ASP A 292
 None
None
None
None
BCT  A 435 (-4.6A)
 1.46A 3r24A-3v7pA:
undetectable		 3r24A-3v7pA:
undetectable
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3V7P_A_BEZA430_0
(AMIDOHYDROLASE
FAMILY PROTEIN)		 3v7p AMIDOHYDROLASE
FAMILY PROTEIN
(Nitratiruptor
sp.
SB155-2) 		6 / 7 ILE A 143
GLY A 144
SER A 145
SER A 183
PHE A 224
PHE A 228
 BEZ  A 430 (-4.5A)
BEZ  A 430 ( 3.7A)
BEZ  A 430 (-2.7A)
BEZ  A 430 (-4.8A)
None
BEZ  A 430 ( 4.6A)
 1.40A 3v7pA-3v7pA:
75.4		 3v7pA-3v7pA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3V7P_A_BEZA430_0
(AMIDOHYDROLASE
FAMILY PROTEIN)		 3v7p AMIDOHYDROLASE
FAMILY PROTEIN
(Nitratiruptor
sp.
SB155-2) 		7 / 7 ILE A 143
GLY A 144
SER A 145
SER A 183
PHE A 227
PHE A 228
LEU A 232
 BEZ  A 430 (-4.5A)
BEZ  A 430 ( 3.7A)
BEZ  A 430 (-2.7A)
BEZ  A 430 (-4.8A)
BEZ  A 430 ( 4.8A)
BEZ  A 430 ( 4.6A)
BEZ  A 430 (-4.5A)
 0.02A 3v7pA-3v7pA:
75.4		 3v7pA-3v7pA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AQL_A_TXCA1452_1
(GUANINE DEAMINASE)		 3v7p AMIDOHYDROLASE
FAMILY PROTEIN
(Nitratiruptor
sp.
SB155-2) 		6 / 12 HIS A 206
GLU A 209
GLU A 213
HIS A 257
SER A 282
ASP A 306
 FE  A 429 (-3.3A)
UNL  A 436 ( 2.8A)
None
None
None
FE  A 429 (-3.1A)
 0.76A 4aqlA-3v7pA:
40.4		 4aqlA-3v7pA:
24.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AQL_A_TXCA1452_1
(GUANINE DEAMINASE)		 3v7p AMIDOHYDROLASE
FAMILY PROTEIN
(Nitratiruptor
sp.
SB155-2) 		5 / 12 LEU A  82
GLU A 209
GLU A 213
HIS A 257
SER A 282
 None
UNL  A 436 ( 2.8A)
None
None
None
 0.83A 4aqlA-3v7pA:
40.4		 4aqlA-3v7pA:
24.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AQL_A_TXCA1452_2
(GUANINE DEAMINASE)		 3v7p AMIDOHYDROLASE
FAMILY PROTEIN
(Nitratiruptor
sp.
SB155-2) 		4 / 5 HIS A 206
LEU A 308
TRP A  81
LEU A  64
 FE  A 429 (-3.3A)
None
None
None
 1.33A 4aqlA-3v7pA:
40.4		 4aqlA-3v7pA:
24.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EF3_A_CUA1002_0
(BLUE COPPER OXIDASE
CUEO)		 3v7p AMIDOHYDROLASE
FAMILY PROTEIN
(Nitratiruptor
sp.
SB155-2) 		4 / 4 HIS A  61
HIS A  63
HIS A 257
HIS A 206
 FE  A 429 (-3.2A)
FE  A 429 (-3.2A)
None
FE  A 429 (-3.3A)
 1.17A 4ef3A-3v7pA:
undetectable		 4ef3A-3v7pA:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JVL_A_ESTA702_1
(ESTROGEN
SULFOTRANSFERASE)		 3v7p AMIDOHYDROLASE
FAMILY PROTEIN
(Nitratiruptor
sp.
SB155-2) 		4 / 9 TYR A 182
HIS A 206
PHE A  78
ILE A  86
 None
FE  A 429 (-3.3A)
None
None
 1.28A 4jvlA-3v7pA:
undetectable		 4jvlA-3v7pA:
19.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LJ0_A_ACTA505_0
(NAB2)		 3v7p AMIDOHYDROLASE
FAMILY PROTEIN
(Nitratiruptor
sp.
SB155-2) 		3 / 3 LEU A 245
LYS A 242
THR A 241
 None
 0.50A 4lj0A-3v7pA:
undetectable		 4lj0A-3v7pA:
7.37
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4M51_A_BEZA501_0
(AMIDOHYDROLASE
FAMILY PROTEIN)		 3v7p AMIDOHYDROLASE
FAMILY PROTEIN
(Nitratiruptor
sp.
SB155-2) 		6 / 6 ILE A  86
ARG A  89
ILE A 143
SER A 183
PHE A 227
LEU A 232
 None
None
BEZ  A 430 (-4.5A)
BEZ  A 430 (-4.8A)
BEZ  A 430 ( 4.8A)
BEZ  A 430 (-4.5A)
 0.36A 4m51A-3v7pA:
71.1		 4m51A-3v7pA:
99.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4N49_A_SAMA601_0
(CAP-SPECIFIC MRNA
(NUCLEOSIDE-2'-O-)-M
ETHYLTRANSFERASE 1)		 3v7p AMIDOHYDROLASE
FAMILY PROTEIN
(Nitratiruptor
sp.
SB155-2) 		5 / 12 GLY A  56
PRO A  55
GLY A 356
THR A 114
ILE A 108
 None
 1.01A 4n49A-3v7pA:
undetectable		 4n49A-3v7pA:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OBW_D_SAMD601_1
(2-METHOXY-6-POLYPREN
YL-1,4-BENZOQUINOL
METHYLASE,
MITOCHONDRIAL)		 3v7p AMIDOHYDROLASE
FAMILY PROTEIN
(Nitratiruptor
sp.
SB155-2) 		3 / 3 ASN A 262
ASP A 218
ASP A 240
 None
 0.85A 4obwD-3v7pA:
undetectable		 4obwD-3v7pA:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R88_A_1LDA501_0
(CYTOSINE DEAMINASE)		 3v7p AMIDOHYDROLASE
FAMILY PROTEIN
(Nitratiruptor
sp.
SB155-2) 		5 / 12 HIS A  63
HIS A 206
HIS A 257
LEU A 286
ASP A 306
 FE  A 429 (-3.2A)
FE  A 429 (-3.3A)
None
None
FE  A 429 (-3.1A)
 0.34A 4r88A-3v7pA:
33.3		 4r88A-3v7pA:
26.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R88_A_1LDA501_0
(CYTOSINE DEAMINASE)		 3v7p AMIDOHYDROLASE
FAMILY PROTEIN
(Nitratiruptor
sp.
SB155-2) 		5 / 12 HIS A  63
HIS A 206
HIS A 257
LEU A 286
SER A 309
 FE  A 429 (-3.2A)
FE  A 429 (-3.3A)
None
None
UNL  A 437 ( 3.1A)
 1.24A 4r88A-3v7pA:
33.3		 4r88A-3v7pA:
26.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R88_B_1LDB501_0
(CYTOSINE DEAMINASE)		 3v7p AMIDOHYDROLASE
FAMILY PROTEIN
(Nitratiruptor
sp.
SB155-2) 		5 / 12 HIS A  63
HIS A 206
GLU A 209
LEU A 286
ASP A 306
 FE  A 429 (-3.2A)
FE  A 429 (-3.3A)
UNL  A 436 ( 2.8A)
None
FE  A 429 (-3.1A)
 0.31A 4r88B-3v7pA:
33.9		 4r88B-3v7pA:
26.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R88_B_1LDB501_0
(CYTOSINE DEAMINASE)		 3v7p AMIDOHYDROLASE
FAMILY PROTEIN
(Nitratiruptor
sp.
SB155-2) 		5 / 12 HIS A  63
HIS A 206
GLU A 209
LEU A 286
SER A 309
 FE  A 429 (-3.2A)
FE  A 429 (-3.3A)
UNL  A 436 ( 2.8A)
None
UNL  A 437 ( 3.1A)
 1.15A 4r88B-3v7pA:
33.9		 4r88B-3v7pA:
26.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R88_C_1LDC501_0
(CYTOSINE DEAMINASE)		 3v7p AMIDOHYDROLASE
FAMILY PROTEIN
(Nitratiruptor
sp.
SB155-2) 		5 / 12 HIS A  63
HIS A 206
GLU A 209
LEU A 286
ASP A 306
 FE  A 429 (-3.2A)
FE  A 429 (-3.3A)
UNL  A 436 ( 2.8A)
None
FE  A 429 (-3.1A)
 0.31A 4r88C-3v7pA:
33.4		 4r88C-3v7pA:
26.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R88_C_1LDC501_0
(CYTOSINE DEAMINASE)		 3v7p AMIDOHYDROLASE
FAMILY PROTEIN
(Nitratiruptor
sp.
SB155-2) 		5 / 12 HIS A  63
HIS A 206
GLU A 209
LEU A 286
SER A 309
 FE  A 429 (-3.2A)
FE  A 429 (-3.3A)
UNL  A 436 ( 2.8A)
None
UNL  A 437 ( 3.1A)
 1.16A 4r88C-3v7pA:
33.4		 4r88C-3v7pA:
26.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R88_D_1LDD501_0
(CYTOSINE DEAMINASE)		 3v7p AMIDOHYDROLASE
FAMILY PROTEIN
(Nitratiruptor
sp.
SB155-2) 		5 / 12 HIS A  63
HIS A 206
GLU A 209
LEU A 286
ASP A 306
 FE  A 429 (-3.2A)
FE  A 429 (-3.3A)
UNL  A 436 ( 2.8A)
None
FE  A 429 (-3.1A)
 0.31A 4r88D-3v7pA:
33.3		 4r88D-3v7pA:
26.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R88_D_1LDD501_0
(CYTOSINE DEAMINASE)		 3v7p AMIDOHYDROLASE
FAMILY PROTEIN
(Nitratiruptor
sp.
SB155-2) 		5 / 12 HIS A  63
HIS A 206
GLU A 209
LEU A 286
SER A 309
 FE  A 429 (-3.2A)
FE  A 429 (-3.3A)
UNL  A 436 ( 2.8A)
None
UNL  A 437 ( 3.1A)
 1.13A 4r88D-3v7pA:
33.3		 4r88D-3v7pA:
26.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R88_E_1LDE501_0
(CYTOSINE DEAMINASE)		 3v7p AMIDOHYDROLASE
FAMILY PROTEIN
(Nitratiruptor
sp.
SB155-2) 		5 / 12 HIS A  63
HIS A 206
GLU A 209
LEU A 286
ASP A 306
 FE  A 429 (-3.2A)
FE  A 429 (-3.3A)
UNL  A 436 ( 2.8A)
None
FE  A 429 (-3.1A)
 0.32A 4r88E-3v7pA:
33.3		 4r88E-3v7pA:
26.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R88_E_1LDE501_0
(CYTOSINE DEAMINASE)		 3v7p AMIDOHYDROLASE
FAMILY PROTEIN
(Nitratiruptor
sp.
SB155-2) 		5 / 12 HIS A  63
HIS A 206
GLU A 209
LEU A 286
SER A 309
 FE  A 429 (-3.2A)
FE  A 429 (-3.3A)
UNL  A 436 ( 2.8A)
None
UNL  A 437 ( 3.1A)
 1.16A 4r88E-3v7pA:
33.3		 4r88E-3v7pA:
26.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R88_F_1LDF502_0
(CYTOSINE DEAMINASE)		 3v7p AMIDOHYDROLASE
FAMILY PROTEIN
(Nitratiruptor
sp.
SB155-2) 		5 / 12 HIS A  63
HIS A 206
GLU A 209
LEU A 286
ASP A 306
 FE  A 429 (-3.2A)
FE  A 429 (-3.3A)
UNL  A 436 ( 2.8A)
None
FE  A 429 (-3.1A)
 0.34A 4r88F-3v7pA:
33.4		 4r88F-3v7pA:
26.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R88_F_1LDF502_0
(CYTOSINE DEAMINASE)		 3v7p AMIDOHYDROLASE
FAMILY PROTEIN
(Nitratiruptor
sp.
SB155-2) 		5 / 12 HIS A  63
HIS A 206
GLU A 209
LEU A 286
SER A 309
 FE  A 429 (-3.2A)
FE  A 429 (-3.3A)
UNL  A 436 ( 2.8A)
None
UNL  A 437 ( 3.1A)
 1.17A 4r88F-3v7pA:
33.4		 4r88F-3v7pA:
26.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RTM_A_SAMA301_0
(DNA ADENINE
METHYLASE)		 3v7p AMIDOHYDROLASE
FAMILY PROTEIN
(Nitratiruptor
sp.
SB155-2) 		5 / 12 PHE A 353
GLY A 347
ALA A 346
ILE A 116
ASN A  59
 None
 1.04A 4rtmA-3v7pA:
undetectable		 4rtmA-3v7pA:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RTP_A_SAMA301_0
(DNA ADENINE
METHYLASE)		 3v7p AMIDOHYDROLASE
FAMILY PROTEIN
(Nitratiruptor
sp.
SB155-2) 		5 / 12 PHE A 353
GLY A 347
ALA A 346
ILE A 116
ASN A  59
 None
 1.02A 4rtpA-3v7pA:
undetectable		 4rtpA-3v7pA:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JSD_B_1GNB603_1
(PHIAB6 TAILSPIKE)		 3v7p AMIDOHYDROLASE
FAMILY PROTEIN
(Nitratiruptor
sp.
SB155-2) 		3 / 3 VAL A  85
GLU A 124
GLU A  65
 None
 0.94A 5jsdB-3v7pA:
undetectable
5jsdC-3v7pA:
undetectable		 5jsdB-3v7pA:
20.41
5jsdC-3v7pA:
20.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M5K_B_ADNB502_2
(ADENOSYLHOMOCYSTEINA
SE)		 3v7p AMIDOHYDROLASE
FAMILY PROTEIN
(Nitratiruptor
sp.
SB155-2) 		4 / 4 GLN A 367
THR A 113
LEU A 339
LEU A 320
 None
 1.23A 5m5kB-3v7pA:
undetectable		 5m5kB-3v7pA:
21.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M8N_A_MMSA514_1
(5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE)		 3v7p AMIDOHYDROLASE
FAMILY PROTEIN
(Nitratiruptor
sp.
SB155-2) 		5 / 10 HIS A 257
HIS A  61
HIS A  63
LEU A 314
SER A 282
 None
FE  A 429 (-3.2A)
FE  A 429 (-3.2A)
None
None
 1.39A 5m8nA-3v7pA:
undetectable		 5m8nA-3v7pA:
20.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MIG_A_CUA601_0
(LACCASE 2)		 3v7p AMIDOHYDROLASE
FAMILY PROTEIN
(Nitratiruptor
sp.
SB155-2) 		3 / 3 HIS A 206
HIS A  61
HIS A  63
 FE  A 429 (-3.3A)
FE  A 429 (-3.2A)
FE  A 429 (-3.2A)
 0.57A 5migA-3v7pA:
undetectable		 5migA-3v7pA:
22.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MVM_B_PFLB510_1
(PROTON-GATED ION
CHANNEL)		 3v7p AMIDOHYDROLASE
FAMILY PROTEIN
(Nitratiruptor
sp.
SB155-2) 		4 / 6 ILE A 397
ALA A 115
LEU A 134
ILE A 108
 None
 0.83A 5mvmB-3v7pA:
undetectable
5mvmC-3v7pA:
undetectable		 5mvmB-3v7pA:
10.77
5mvmC-3v7pA:
10.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OGC_B_TA1B601_1
(TUBULIN BETA CHAIN)		 3v7p AMIDOHYDROLASE
FAMILY PROTEIN
(Nitratiruptor
sp.
SB155-2) 		5 / 12 VAL A 256
SER A 204
THR A 113
GLY A 307
LEU A  62
 None
 1.11A 5ogcB-3v7pA:
2.6		 5ogcB-3v7pA:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIP_A_HFGA1003_1
(PROLYL-TRNA
SYNTHETASE, PUTATIVE)		 3v7p AMIDOHYDROLASE
FAMILY PROTEIN
(Nitratiruptor
sp.
SB155-2) 		3 / 3 GLU A 209
TRP A  81
HIS A 179
 UNL  A 436 ( 2.8A)
None
UNL  A 436 ( 3.9A)
 1.03A 5xipA-3v7pA:
undetectable		 5xipA-3v7pA:
21.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y2T_B_8LXB501_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 3v7p AMIDOHYDROLASE
FAMILY PROTEIN
(Nitratiruptor
sp.
SB155-2) 		4 / 8 PHE A 224
HIS A 179
PHE A 228
LEU A  82
 None
UNL  A 436 ( 3.9A)
BEZ  A 430 ( 4.6A)
None
 0.98A 5y2tB-3v7pA:
undetectable		 5y2tB-3v7pA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z0H_B_DAHB98_0
(MELC
TYROSINASE)		 3v7p AMIDOHYDROLASE
FAMILY PROTEIN
(Nitratiruptor
sp.
SB155-2) 		5 / 11 HIS A  63
ILE A 119
HIS A  61
HIS A 257
PRO A 181
 FE  A 429 (-3.2A)
None
FE  A 429 (-3.2A)
None
None
 1.43A 5z0hA-3v7pA:
undetectable
5z0hB-3v7pA:
undetectable		 5z0hA-3v7pA:
10.45
5z0hB-3v7pA:
9.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z0I_B_DAHB98_0
(MELC
TYROSINASE)		 3v7p AMIDOHYDROLASE
FAMILY PROTEIN
(Nitratiruptor
sp.
SB155-2) 		5 / 11 HIS A  63
ILE A 119
HIS A  61
HIS A 257
PRO A 181
 FE  A 429 (-3.2A)
None
FE  A 429 (-3.2A)
None
None
 1.50A 5z0iA-3v7pA:
undetectable
5z0iB-3v7pA:
undetectable		 5z0iA-3v7pA:
10.45
5z0iB-3v7pA:
9.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z0K_B_DAHB98_0
(MELC
TYROSINASE)		 3v7p AMIDOHYDROLASE
FAMILY PROTEIN
(Nitratiruptor
sp.
SB155-2) 		5 / 11 HIS A  63
ILE A 119
HIS A  61
HIS A 257
PRO A 181
 FE  A 429 (-3.2A)
None
FE  A 429 (-3.2A)
None
None
 1.48A 5z0kA-3v7pA:
undetectable
5z0kB-3v7pA:
undetectable		 5z0kA-3v7pA:
10.45
5z0kB-3v7pA:
9.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z0L_B_DAHB98_0
(MELC
TYROSINASE)		 3v7p AMIDOHYDROLASE
FAMILY PROTEIN
(Nitratiruptor
sp.
SB155-2) 		5 / 11 HIS A  63
ILE A 119
HIS A  61
HIS A 257
PRO A 181
 FE  A 429 (-3.2A)
None
FE  A 429 (-3.2A)
None
None
 1.42A 5z0lA-3v7pA:
undetectable
5z0lB-3v7pA:
undetectable		 5z0lA-3v7pA:
10.45
5z0lB-3v7pA:
9.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z0M_B_DAHB98_0
(MELC
TYROSINASE)		 3v7p AMIDOHYDROLASE
FAMILY PROTEIN
(Nitratiruptor
sp.
SB155-2) 		5 / 11 HIS A  63
ILE A 119
HIS A  61
HIS A 257
PRO A 181
 FE  A 429 (-3.2A)
None
FE  A 429 (-3.2A)
None
None
 1.30A 5z0mA-3v7pA:
undetectable
5z0mB-3v7pA:
undetectable		 5z0mA-3v7pA:
10.45
5z0mB-3v7pA:
9.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6N91_A_DCFA401_0
(ADENOSINE DEAMINASE)		 3v7p AMIDOHYDROLASE
FAMILY PROTEIN
(Nitratiruptor
sp.
SB155-2) 		5 / 12 HIS A  63
HIS A 206
GLU A 209
HIS A 257
ASP A 306
 FE  A 429 (-3.2A)
FE  A 429 (-3.3A)
UNL  A 436 ( 2.8A)
None
FE  A 429 (-3.1A)
 0.34A 6n91A-3v7pA:
20.2		 6n91A-3v7pA:
11.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6N91_B_DCFB401_0
(ADENOSINE DEAMINASE)		 3v7p AMIDOHYDROLASE
FAMILY PROTEIN
(Nitratiruptor
sp.
SB155-2) 		5 / 12 HIS A  63
HIS A 206
GLU A 209
HIS A 257
ASP A 306
 FE  A 429 (-3.2A)
FE  A 429 (-3.3A)
UNL  A 436 ( 2.8A)
None
FE  A 429 (-3.1A)
 0.36A 6n91B-3v7pA:
20.0		 6n91B-3v7pA:
11.58