SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3v8d'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EA1_A_TPFA470_1
(CYTOCHROME P450
51-LIKE RV0764C)		 3v8d CHOLESTEROL
7-ALPHA-MONOOXYGENAS
E
(Homo
sapiens) 		4 / 8 TYR A 464
PHE A 465
MET A 461
PHE A 457
 None
 1.10A 1ea1A-3v8dA:
29.7		 1ea1A-3v8dA:
24.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ERR_B_RALB600_2
(ESTROGEN RECEPTOR)		 3v8d CHOLESTEROL
7-ALPHA-MONOOXYGENAS
E
(Homo
sapiens) 		4 / 6 LEU A 389
MET A 435
LEU A 430
HIS A 395
 None
None
UNX  A 610 ( 4.0A)
None
 1.15A 1errB-3v8dA:
undetectable		 1errB-3v8dA:
20.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1J96_B_TESB904_1
(3ALPHA-HYDROXYSTEROI
D DEHYDROGENASE TYPE
3)		 3v8d CHOLESTEROL
7-ALPHA-MONOOXYGENAS
E
(Homo
sapiens) 		4 / 7 TYR A 499
ILE A 152
GLU A 169
LEU A 298
 None
 0.98A 1j96B-3v8dA:
undetectable		 1j96B-3v8dA:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KT3_A_RTLA184_0
(PLASMA
RETINOL-BINDING
PROTEIN)		 3v8d CHOLESTEROL
7-ALPHA-MONOOXYGENAS
E
(Homo
sapiens) 		4 / 7 LEU A 469
MET A 171
LEU A 298
GLN A 300
 None
 0.89A 1kt3A-3v8dA:
undetectable		 1kt3A-3v8dA:
16.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XOQ_B_ROFB501_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		 3v8d CHOLESTEROL
7-ALPHA-MONOOXYGENAS
E
(Homo
sapiens) 		3 / 3 MET A 435
ASN A  81
GLN A  60
 None
SO4  A 603 (-3.7A)
None
 0.92A 1xoqB-3v8dA:
undetectable		 1xoqB-3v8dA:
20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YVP_B_ACTB2002_0
(60-KDA SS-A/RO
RIBONUCLEOPROTEIN)		 3v8d CHOLESTEROL
7-ALPHA-MONOOXYGENAS
E
(Homo
sapiens) 		4 / 6 SER A 358
ALA A 359
SER A 360
ASN A 289
 None
None
0GV  A 602 ( 3.1A)
HEM  A 601 (-4.1A)
 0.85A 1yvpB-3v8dA:
undetectable		 1yvpB-3v8dA:
22.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A8T_B_ADNB252_1
(U8 SNORNA-BINDING
PROTEIN X29)		 3v8d CHOLESTEROL
7-ALPHA-MONOOXYGENAS
E
(Homo
sapiens) 		4 / 8 GLY A 487
ILE A 488
SER A 358
GLN A 392
 0GV  A 602 ( 4.1A)
HEM  A 601 (-4.8A)
None
None
 1.05A 2a8tB-3v8dA:
undetectable		 2a8tB-3v8dA:
17.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CIZ_A_ACTA1321_0
(CHLOROPEROXIDASE)		 3v8d CHOLESTEROL
7-ALPHA-MONOOXYGENAS
E
(Homo
sapiens) 		4 / 5 LEU A 361
PHE A 100
VAL A  76
ALA A 388
 None
 1.15A 2cizA-3v8dA:
undetectable		 2cizA-3v8dA:
23.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2I91_A_ACTA601_0
(60 KDA SS-A/RO
RIBONUCLEOPROTEIN)		 3v8d CHOLESTEROL
7-ALPHA-MONOOXYGENAS
E
(Homo
sapiens) 		4 / 7 SER A 358
ALA A 359
SER A 360
ASN A 289
 None
None
0GV  A 602 ( 3.1A)
HEM  A 601 (-4.1A)
 0.98A 2i91A-3v8dA:
undetectable		 2i91A-3v8dA:
22.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2I91_B_ACTB602_0
(60 KDA SS-A/RO
RIBONUCLEOPROTEIN)		 3v8d CHOLESTEROL
7-ALPHA-MONOOXYGENAS
E
(Homo
sapiens) 		4 / 7 SER A 358
ALA A 359
SER A 360
ASN A 289
 None
None
0GV  A 602 ( 3.1A)
HEM  A 601 (-4.1A)
 0.98A 2i91B-3v8dA:
undetectable		 2i91B-3v8dA:
22.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J5M_A_ACTA1321_0
(CHLOROPEROXIDASE)		 3v8d CHOLESTEROL
7-ALPHA-MONOOXYGENAS
E
(Homo
sapiens) 		4 / 6 LEU A 361
PHE A 100
ILE A 386
ALA A 388
 None
 1.09A 2j5mA-3v8dA:
undetectable		 2j5mA-3v8dA:
23.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OD9_A_NCAA3721_0
(NAD-DEPENDENT
DEACETYLASE HST2)		 3v8d CHOLESTEROL
7-ALPHA-MONOOXYGENAS
E
(Homo
sapiens) 		3 / 3 PHE A 109
PHE A 212
PHE A 209
 None
 0.79A 2od9A-3v8dA:
undetectable		 2od9A-3v8dA:
20.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PYM_A_1UNA1001_3
(PROTEASE RETROPEPSIN)		 3v8d CHOLESTEROL
7-ALPHA-MONOOXYGENAS
E
(Homo
sapiens) 		3 / 3 ASP A 118
ASN A 120
THR A 278
 None
None
0GV  A 602 ( 4.3A)
 0.68A 2pymB-3v8dA:
undetectable		 2pymB-3v8dA:
11.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q63_A_1UNA1001_4
(PROTEASE RETROPEPSIN)		 3v8d CHOLESTEROL
7-ALPHA-MONOOXYGENAS
E
(Homo
sapiens) 		3 / 3 ASP A 118
ASN A 120
THR A 278
 None
None
0GV  A 602 ( 4.3A)
 0.67A 2q63B-3v8dA:
undetectable		 2q63B-3v8dA:
11.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QQG_A_NCAA3721_0
(NAD-DEPENDENT
DEACETYLASE HST2)		 3v8d CHOLESTEROL
7-ALPHA-MONOOXYGENAS
E
(Homo
sapiens) 		3 / 3 PHE A 109
PHE A 212
PHE A 209
 None
 0.79A 2qqgA-3v8dA:
undetectable		 2qqgA-3v8dA:
20.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AQI_A_CHDA2_0
(FERROCHELATASE)		 3v8d CHOLESTEROL
7-ALPHA-MONOOXYGENAS
E
(Homo
sapiens) 		4 / 6 ARG A 235
PRO A  40
GLY A 222
MET A  72
 None
 1.50A 3aqiA-3v8dA:
undetectable		 3aqiA-3v8dA:
22.66
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3B6H_A_MXDA551_1
(PROSTACYCLIN
SYNTHASE)		 3v8d CHOLESTEROL
7-ALPHA-MONOOXYGENAS
E
(Homo
sapiens) 		4 / 6 ALA A 218
LEU A 219
ALA A 231
THR A 230
 None
 0.82A 3b6hA-3v8dA:
44.0		 3b6hA-3v8dA:
36.33
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3B6H_B_MXDB551_1
(PROSTACYCLIN
SYNTHASE)		 3v8d CHOLESTEROL
7-ALPHA-MONOOXYGENAS
E
(Homo
sapiens) 		4 / 6 ALA A 218
LEU A 219
ALA A 231
THR A 230
 None
 0.75A 3b6hB-3v8dA:
45.3		 3b6hB-3v8dA:
36.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LN1_D_CELD682_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		 3v8d CHOLESTEROL
7-ALPHA-MONOOXYGENAS
E
(Homo
sapiens) 		4 / 5 LEU A 238
ARG A 250
ILE A 257
PHE A 188
 None
 1.21A 3ln1D-3v8dA:
0.0		 3ln1D-3v8dA:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LN1_D_CELD682_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		 3v8d CHOLESTEROL
7-ALPHA-MONOOXYGENAS
E
(Homo
sapiens) 		4 / 5 LEU A 280
ARG A 250
ILE A 187
PHE A 188
 None
 1.32A 3ln1D-3v8dA:
0.0		 3ln1D-3v8dA:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ME6_C_CGEC501_1
(CYTOCHROME P450 2B4)		 3v8d CHOLESTEROL
7-ALPHA-MONOOXYGENAS
E
(Homo
sapiens) 		5 / 9 ILE A 187
PHE A 449
ALA A 450
THR A 290
VAL A 282
 None
None
HEM  A 601 (-3.5A)
HEM  A 601 (-4.2A)
None
 1.19A 3me6C-3v8dA:
26.5		 3me6C-3v8dA:
26.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WIP_A_ACHA301_0
(ACETYLCHOLINE-BINDIN
G PROTEIN)		 3v8d CHOLESTEROL
7-ALPHA-MONOOXYGENAS
E
(Homo
sapiens) 		4 / 7 TYR A 401
THR A 422
TYR A 412
TYR A 433
 None
 1.36A 3wipA-3v8dA:
undetectable
3wipB-3v8dA:
undetectable		 3wipA-3v8dA:
17.98
3wipB-3v8dA:
17.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WIP_B_ACHB301_0
(ACETYLCHOLINE-BINDIN
G PROTEIN)		 3v8d CHOLESTEROL
7-ALPHA-MONOOXYGENAS
E
(Homo
sapiens) 		4 / 8 TYR A 401
THR A 422
TYR A 412
TYR A 433
 None
 1.40A 3wipB-3v8dA:
undetectable
3wipC-3v8dA:
undetectable		 3wipB-3v8dA:
17.98
3wipC-3v8dA:
17.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WIP_C_ACHC301_0
(ACETYLCHOLINE-BINDIN
G PROTEIN)		 3v8d CHOLESTEROL
7-ALPHA-MONOOXYGENAS
E
(Homo
sapiens) 		4 / 8 TYR A 401
THR A 422
TYR A 412
TYR A 433
 None
 1.38A 3wipC-3v8dA:
undetectable
3wipD-3v8dA:
undetectable		 3wipC-3v8dA:
17.98
3wipD-3v8dA:
17.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WIP_D_ACHD301_0
(ACETYLCHOLINE-BINDIN
G PROTEIN)		 3v8d CHOLESTEROL
7-ALPHA-MONOOXYGENAS
E
(Homo
sapiens) 		4 / 8 TYR A 401
THR A 422
TYR A 412
TYR A 433
 None
 1.39A 3wipD-3v8dA:
undetectable
3wipE-3v8dA:
undetectable		 3wipD-3v8dA:
17.98
3wipE-3v8dA:
17.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WIP_E_ACHE301_0
(ACETYLCHOLINE-BINDIN
G PROTEIN)		 3v8d CHOLESTEROL
7-ALPHA-MONOOXYGENAS
E
(Homo
sapiens) 		4 / 8 TYR A 401
THR A 422
TYR A 412
TYR A 433
 None
 1.45A 3wipA-3v8dA:
undetectable
3wipE-3v8dA:
undetectable		 3wipA-3v8dA:
17.98
3wipE-3v8dA:
17.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WNV_D_QI9D602_0
(CYTOCHROME P450 2D6)		 3v8d CHOLESTEROL
7-ALPHA-MONOOXYGENAS
E
(Homo
sapiens) 		4 / 7 PHE A 449
LEU A 133
SER A 140
PHE A 188
 None
HEM  A 601 (-4.4A)
None
None
 1.05A 4wnvD-3v8dA:
27.4		 4wnvD-3v8dA:
25.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A7M_A_ACTA1923_0
(BETA-XYLOSIDASE)		 3v8d CHOLESTEROL
7-ALPHA-MONOOXYGENAS
E
(Homo
sapiens) 		3 / 3 ASP A 385
ARG A 382
TYR A  75
 None
 1.02A 5a7mA-3v8dA:
undetectable		 5a7mA-3v8dA:
21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A7M_B_ACTB1924_0
(BETA-XYLOSIDASE)		 3v8d CHOLESTEROL
7-ALPHA-MONOOXYGENAS
E
(Homo
sapiens) 		3 / 3 ASP A 385
ARG A 382
TYR A  75
 None
 1.05A 5a7mB-3v8dA:
undetectable		 5a7mB-3v8dA:
21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EB3_A_UEGA202_1
(YFIR)		 3v8d CHOLESTEROL
7-ALPHA-MONOOXYGENAS
E
(Homo
sapiens) 		4 / 4 LEU A  71
ILE A  39
PRO A  52
LEU A  56
 None
 0.88A 5eb3A-3v8dA:
undetectable		 5eb3A-3v8dA:
16.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IEN_A_VDYA201_1
(CDL2.2)		 3v8d CHOLESTEROL
7-ALPHA-MONOOXYGENAS
E
(Homo
sapiens) 		5 / 12 LEU A 138
PHE A 449
LEU A 149
MET A 153
ILE A 333
 None
 1.39A 5ienA-3v8dA:
undetectable		 5ienA-3v8dA:
14.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JGL_B_SAMB301_1
(UBIE/COQ5 FAMILY
METHYLTRANSFERASE,
PUTATIVE)		 3v8d CHOLESTEROL
7-ALPHA-MONOOXYGENAS
E
(Homo
sapiens) 		3 / 3 ASP A 115
ASN A 124
PHE A 100
 None
 0.86A 5jglB-3v8dA:
undetectable		 5jglB-3v8dA:
20.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AWT_D_BEZD202_0
(PR 10 PROTEIN)		 3v8d CHOLESTEROL
7-ALPHA-MONOOXYGENAS
E
(Homo
sapiens) 		3 / 3 PHE A  95
ASP A  96
LYS A 367
 None
 0.87A 6awtD-3v8dA:
undetectable		 6awtD-3v8dA:
15.69