SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3v8x'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CEA_A_ACAA90_1
(PLASMINOGEN)		 3v8x TRANSFERRIN-BINDING
PROTEIN 1
(Neisseria
meningitidis) 		4 / 8 ASP A 303
ASP A 342
TYR A 900
THR A 344
 None
 1.44A 1ceaA-3v8xA:
undetectable
1ceaB-3v8xA:
undetectable		 1ceaA-3v8xA:
6.53
1ceaB-3v8xA:
6.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HXB_A_ROCA100_2
(HIV-1 PROTEASE)		 3v8x TRANSFERRIN-BINDING
PROTEIN 1
(Neisseria
meningitidis) 		3 / 3 ARG A 132
THR A 295
VAL A 345
 None
 0.96A 1hxbA-3v8xA:
undetectable		 1hxbA-3v8xA:
7.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I7Q_A_BEZA1501_0
(ANTHRANILATE
SYNTHASE)		 3v8x TRANSFERRIN-BINDING
PROTEIN 1
(Neisseria
meningitidis) 		5 / 11 ILE A 101
GLY A 156
LEU A  61
GLY A  59
GLU A 679
 None
 1.38A 1i7qA-3v8xA:
undetectable		 1i7qA-3v8xA:
20.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NT2_A_SAMA301_0
(FIBRILLARIN-LIKE
PRE-RRNA PROCESSING
PROTEIN)		 3v8x TRANSFERRIN-BINDING
PROTEIN 1
(Neisseria
meningitidis) 		5 / 12 TYR A 708
GLY A 707
ALA A 728
ASP A 777
ILE A 778
 None
 1.15A 1nt2A-3v8xA:
undetectable		 1nt2A-3v8xA:
13.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RS6_A_MTLA870_0
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 3v8x TRANSFERRIN-BINDING
PROTEIN 1
(Neisseria
meningitidis) 		4 / 8 SER A 665
ASN A 567
GLN A 125
TRP A 659
 None
 1.33A 1rs6A-3v8xA:
undetectable		 1rs6A-3v8xA:
16.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VPO_H_TESH1010_1
(ANTI-TESTOSTERONE
(HEAVY CHAIN)
ANTI-TESTOSTERONE
(LIGHT CHAIN))		 3v8x TRANSFERRIN-BINDING
PROTEIN 1
(Neisseria
meningitidis) 		5 / 12 SER A 675
ALA A 166
GLY A 165
LEU A 167
PRO A 672
 None
 1.31A 1vpoH-3v8xA:
undetectable
1vpoL-3v8xA:
undetectable		 1vpoH-3v8xA:
14.27
1vpoL-3v8xA:
13.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q64_B_1UNB1001_2
(PROTEASE RETROPEPSIN)		 3v8x TRANSFERRIN-BINDING
PROTEIN 1
(Neisseria
meningitidis) 		3 / 3 ARG A 132
THR A 295
VAL A 345
 None
 0.96A 2q64A-3v8xA:
undetectable		 2q64A-3v8xA:
7.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QAK_A_1UNA1001_2
(PROTEASE RETROPEPSIN)		 3v8x TRANSFERRIN-BINDING
PROTEIN 1
(Neisseria
meningitidis) 		3 / 3 ARG A 132
THR A 295
VAL A 345
 None
 0.94A 2qakA-3v8xA:
undetectable		 2qakA-3v8xA:
7.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XDC_A_DVAA8_0
(GRAMICIDIN A)		 3v8x TRANSFERRIN-BINDING
PROTEIN 1
(Neisseria
meningitidis) 		3 / 3 VAL A 747
TRP A 744
TRP A 755
 None
 1.46A 2xdcA-3v8xA:
undetectable
2xdcB-3v8xA:
undetectable		 2xdcA-3v8xA:
2.21
2xdcB-3v8xA:
2.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XDC_A_DVAA8_0
(GRAMICIDIN A)		 3v8x TRANSFERRIN-BINDING
PROTEIN 1
(Neisseria
meningitidis) 		3 / 3 VAL A 747
TRP A 755
TRP A 744
 None
 1.30A 2xdcA-3v8xA:
undetectable
2xdcB-3v8xA:
undetectable		 2xdcA-3v8xA:
2.21
2xdcB-3v8xA:
2.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XDC_B_DVAB8_0
(GRAMICIDIN A)		 3v8x TRANSFERRIN-BINDING
PROTEIN 1
(Neisseria
meningitidis) 		3 / 3 TRP A 744
VAL A 747
TRP A 755
 None
 1.31A 2xdcA-3v8xA:
undetectable
2xdcB-3v8xA:
undetectable		 2xdcA-3v8xA:
2.21
2xdcB-3v8xA:
2.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XDC_B_DVAB8_0
(GRAMICIDIN A)		 3v8x TRANSFERRIN-BINDING
PROTEIN 1
(Neisseria
meningitidis) 		3 / 3 TRP A 755
VAL A 747
TRP A 744
 None
 1.43A 2xdcA-3v8xA:
undetectable
2xdcB-3v8xA:
undetectable		 2xdcA-3v8xA:
2.21
2xdcB-3v8xA:
2.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XDC_C_DVAC8_0
(GRAMICIDIN A)		 3v8x TRANSFERRIN-BINDING
PROTEIN 1
(Neisseria
meningitidis) 		3 / 3 VAL A 747
TRP A 744
TRP A 755
 None
 1.46A 2xdcC-3v8xA:
undetectable
2xdcD-3v8xA:
undetectable		 2xdcC-3v8xA:
2.21
2xdcD-3v8xA:
2.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XF3_A_J01A600_1
(ORF12)		 3v8x TRANSFERRIN-BINDING
PROTEIN 1
(Neisseria
meningitidis) 		5 / 11 SER A 159
THR A 623
SER A 625
GLY A 647
ARG A 701
 None
 1.38A 2xf3A-3v8xA:
1.7		 2xf3A-3v8xA:
18.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XF3_B_J01B600_1
(ORF12)		 3v8x TRANSFERRIN-BINDING
PROTEIN 1
(Neisseria
meningitidis) 		5 / 11 SER A 159
THR A 623
SER A 625
GLY A 647
ARG A 701
 None
 1.39A 2xf3B-3v8xA:
1.5		 2xf3B-3v8xA:
18.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XH9_A_J01A1437_1
(ORF12)		 3v8x TRANSFERRIN-BINDING
PROTEIN 1
(Neisseria
meningitidis) 		5 / 11 SER A 159
THR A 623
SER A 625
GLY A 647
ARG A 701
 None
 1.37A 2xh9A-3v8xA:
undetectable		 2xh9A-3v8xA:
18.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XH9_B_J01B1437_1
(ORF12)		 3v8x TRANSFERRIN-BINDING
PROTEIN 1
(Neisseria
meningitidis) 		5 / 10 SER A 159
THR A 623
SER A 625
GLY A 647
ARG A 701
 None
 1.41A 2xh9B-3v8xA:
1.5		 2xh9B-3v8xA:
18.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y5M_A_DVAA8_0
(VAL-GRAMICIDIN A)		 3v8x TRANSFERRIN-BINDING
PROTEIN 1
(Neisseria
meningitidis) 		3 / 3 VAL A 747
TRP A 744
TRP A 755
 None
 1.44A 2y5mA-3v8xA:
undetectable
2y5mB-3v8xA:
undetectable		 2y5mA-3v8xA:
2.21
2y5mB-3v8xA:
2.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y5M_A_DVAA8_0
(VAL-GRAMICIDIN A)		 3v8x TRANSFERRIN-BINDING
PROTEIN 1
(Neisseria
meningitidis) 		3 / 3 VAL A 747
TRP A 755
TRP A 744
 None
 1.30A 2y5mA-3v8xA:
undetectable
2y5mB-3v8xA:
undetectable		 2y5mA-3v8xA:
2.21
2y5mB-3v8xA:
2.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y6N_A_DVAA8_0
(VAL-GRAMICIDIN A)		 3v8x TRANSFERRIN-BINDING
PROTEIN 1
(Neisseria
meningitidis) 		3 / 3 VAL A 747
TRP A 744
TRP A 755
 None
 1.44A 2y6nA-3v8xA:
undetectable
2y6nB-3v8xA:
undetectable		 2y6nA-3v8xA:
2.21
2y6nB-3v8xA:
2.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y6N_A_DVAA8_0
(VAL-GRAMICIDIN A)		 3v8x TRANSFERRIN-BINDING
PROTEIN 1
(Neisseria
meningitidis) 		3 / 3 VAL A 747
TRP A 755
TRP A 744
 None
 1.30A 2y6nA-3v8xA:
undetectable
2y6nB-3v8xA:
undetectable		 2y6nA-3v8xA:
2.21
2y6nB-3v8xA:
2.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y6N_B_DVAB8_0
(VAL-GRAMICIDIN A)		 3v8x TRANSFERRIN-BINDING
PROTEIN 1
(Neisseria
meningitidis) 		3 / 3 TRP A 744
VAL A 747
TRP A 755
 None
 1.29A 2y6nA-3v8xA:
undetectable
2y6nB-3v8xA:
undetectable		 2y6nA-3v8xA:
2.21
2y6nB-3v8xA:
2.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y6N_B_DVAB8_0
(VAL-GRAMICIDIN A)		 3v8x TRANSFERRIN-BINDING
PROTEIN 1
(Neisseria
meningitidis) 		3 / 3 TRP A 755
VAL A 747
TRP A 744
 None
 1.44A 2y6nA-3v8xA:
undetectable
2y6nB-3v8xA:
undetectable		 2y6nA-3v8xA:
2.21
2y6nB-3v8xA:
2.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BWY_A_SAMA301_0
(COMT PROTEIN)		 3v8x TRANSFERRIN-BINDING
PROTEIN 1
(Neisseria
meningitidis) 		5 / 12 VAL A 792
GLY A  85
ILE A 786
SER A 100
ARG A 881
 None
 1.36A 3bwyA-3v8xA:
undetectable		 3bwyA-3v8xA:
12.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HAM_B_LLLB500_1
(AMINOGLYCOSIDE
PHOSPHOTRANSFERASE)		 3v8x TRANSFERRIN-BINDING
PROTEIN 1
(Neisseria
meningitidis) 		5 / 11 ASP A 418
ASN A 416
SER A 487
ASP A 424
ASP A 489
 None
 1.29A 3hamB-3v8xA:
0.0		 3hamB-3v8xA:
15.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K9F_H_LFXH0_1
(DNA TOPOISOMERASE 4
SUBUNIT A
DNA TOPOISOMERASE 4
SUBUNIT B)		 3v8x TRANSFERRIN-BINDING
PROTEIN 1
(Neisseria
meningitidis) 		4 / 6 SER A 464
GLY A 552
GLU A 263
GLU A 262
 None
 1.08A 3k9fA-3v8xA:
undetectable
3k9fB-3v8xA:
undetectable
3k9fD-3v8xA:
undetectable		 3k9fA-3v8xA:
20.07
3k9fB-3v8xA:
20.07
3k9fD-3v8xA:
15.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QOW_A_SAMA417_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE)		 3v8x TRANSFERRIN-BINDING
PROTEIN 1
(Neisseria
meningitidis) 		5 / 12 TYR A 473
GLY A 474
GLU A 475
ALA A 124
ASP A 571
 None
C8E  A1001 (-4.3A)
None
None
None
 1.24A 3qowA-3v8xA:
undetectable		 3qowA-3v8xA:
19.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ROD_A_NCAA302_0
(NICOTINAMIDE
N-METHYLTRANSFERASE)		 3v8x TRANSFERRIN-BINDING
PROTEIN 1
(Neisseria
meningitidis) 		4 / 8 TYR A 583
ALA A 172
SER A 170
SER A 110
 None
 1.11A 3rodA-3v8xA:
undetectable		 3rodA-3v8xA:
14.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RQW_C_ACHC323_0
(ELIC PENTAMERIC
LIGAND GATED ION
CHANNEL FROM ERWINIA
CHRYSANTHEMI)		 3v8x TRANSFERRIN-BINDING
PROTEIN 1
(Neisseria
meningitidis) 		4 / 8 ASN A 141
GLU A 332
LEU A 111
PHE A 173
 None
 1.09A 3rqwC-3v8xA:
undetectable
3rqwD-3v8xA:
undetectable		 3rqwC-3v8xA:
17.40
3rqwD-3v8xA:
17.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RQW_J_ACHJ323_0
(ELIC PENTAMERIC
LIGAND GATED ION
CHANNEL FROM ERWINIA
CHRYSANTHEMI)		 3v8x TRANSFERRIN-BINDING
PROTEIN 1
(Neisseria
meningitidis) 		4 / 8 GLU A 332
LEU A 111
PHE A 173
ASN A 141
 None
 1.09A 3rqwF-3v8xA:
undetectable
3rqwJ-3v8xA:
undetectable		 3rqwF-3v8xA:
17.40
3rqwJ-3v8xA:
17.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TAJ_A_NBOA700_1
(LACTOTRANSFERRIN)		 3v8x TRANSFERRIN-BINDING
PROTEIN 1
(Neisseria
meningitidis) 		4 / 7 GLY A 507
TYR A 473
GLY A 436
THR A 404
 C8E  A1001 (-4.4A)
None
C8E  A1001 ( 4.2A)
None
 0.80A 3tajA-3v8xA:
undetectable		 3tajA-3v8xA:
16.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AE1_B_NCAB1536_0
(DIPHTHERIA TOXIN)		 3v8x TRANSFERRIN-BINDING
PROTEIN 1
(Neisseria
meningitidis) 		4 / 5 HIS A 374
GLY A 377
TYR A 370
GLU A 263
 None
 1.38A 4ae1B-3v8xA:
undetectable		 4ae1B-3v8xA:
19.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E47_A_SAMA401_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD7)		 3v8x TRANSFERRIN-BINDING
PROTEIN 1
(Neisseria
meningitidis) 		5 / 11 ALA A 884
GLY A 885
GLY A  92
LYS A 892
TYR A 900
 None
 1.07A 4e47A-3v8xA:
undetectable		 4e47A-3v8xA:
15.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E47_B_SAMB800_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD7)		 3v8x TRANSFERRIN-BINDING
PROTEIN 1
(Neisseria
meningitidis) 		5 / 11 ALA A 884
GLY A 885
GLY A  92
LYS A 892
TYR A 900
 None
 1.06A 4e47B-3v8xA:
undetectable		 4e47B-3v8xA:
15.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E47_C_SAMC800_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD7)		 3v8x TRANSFERRIN-BINDING
PROTEIN 1
(Neisseria
meningitidis) 		5 / 11 ALA A 884
GLY A 885
GLY A  92
LYS A 892
TYR A 900
 None
 1.09A 4e47C-3v8xA:
undetectable		 4e47C-3v8xA:
15.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4I41_A_MIXA500_2
(SERINE/THREONINE-PRO
TEIN KINASE PIM-1)		 3v8x TRANSFERRIN-BINDING
PROTEIN 1
(Neisseria
meningitidis) 		4 / 4 LEU A 510
LEU A 437
GLN A 125
GLU A 655
 None
 1.25A 4i41A-3v8xA:
undetectable		 4i41A-3v8xA:
15.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JDS_A_SAMA401_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD7)		 3v8x TRANSFERRIN-BINDING
PROTEIN 1
(Neisseria
meningitidis) 		5 / 11 ALA A 884
GLY A 885
GLY A  92
LYS A 892
TYR A 900
 None
 1.06A 4jdsA-3v8xA:
undetectable		 4jdsA-3v8xA:
15.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JDS_B_SAMB401_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD7)		 3v8x TRANSFERRIN-BINDING
PROTEIN 1
(Neisseria
meningitidis) 		5 / 11 ALA A 884
GLY A 885
GLY A  92
LYS A 892
TYR A 900
 None
 1.05A 4jdsB-3v8xA:
undetectable		 4jdsB-3v8xA:
15.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JDS_C_SAMC401_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD7)		 3v8x TRANSFERRIN-BINDING
PROTEIN 1
(Neisseria
meningitidis) 		5 / 11 ALA A 884
GLY A 885
GLY A  92
LYS A 892
TYR A 900
 None
 1.05A 4jdsC-3v8xA:
undetectable		 4jdsC-3v8xA:
15.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JLG_A_SAMA401_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD7)		 3v8x TRANSFERRIN-BINDING
PROTEIN 1
(Neisseria
meningitidis) 		5 / 12 ALA A 884
GLY A 885
GLY A  92
LYS A 892
TYR A 900
 None
 1.05A 4jlgA-3v8xA:
undetectable		 4jlgA-3v8xA:
15.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KOU_A_C04A207_1
(UNCHARACTERIZED
PROTEIN)		 3v8x TRANSFERRIN-BINDING
PROTEIN 1
(Neisseria
meningitidis) 		3 / 3 GLY A 436
GLU A 401
THR A 402
 C8E  A1001 ( 4.2A)
None
None
 0.59A 4kouA-3v8xA:
undetectable		 4kouA-3v8xA:
10.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KR8_C_DM1C401_1
(OUTER MEMBRANE
PROTEIN F)		 3v8x TRANSFERRIN-BINDING
PROTEIN 1
(Neisseria
meningitidis) 		5 / 10 ARG A  81
TYR A 307
TYR A 867
THR A 204
ARG A 225
 None
 1.37A 4kr8C-3v8xA:
3.1		 4kr8C-3v8xA:
17.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LAJ_B_ACAB512_1
(HIV-1 YU2 GP120
ENVELOPE
GLYCOPROTEIN)		 3v8x TRANSFERRIN-BINDING
PROTEIN 1
(Neisseria
meningitidis) 		4 / 6 ARG A 553
GLY A 552
ASP A 460
PRO A 462
 None
 1.19A 4lajA-3v8xA:
undetectable
4lajB-3v8xA:
undetectable		 4lajA-3v8xA:
17.90
4lajB-3v8xA:
17.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MA8_C_Z80C301_1
(MAJOR PRION PROTEIN)		 3v8x TRANSFERRIN-BINDING
PROTEIN 1
(Neisseria
meningitidis) 		4 / 5 GLY A 211
ILE A 190
LYS A 914
GLN A 191
 None
 1.16A 4ma8C-3v8xA:
undetectable		 4ma8C-3v8xA:
7.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O1E_B_C2FB4000_0
(DIHYDROPTEROATE
SYNTHASE DHPS)		 3v8x TRANSFERRIN-BINDING
PROTEIN 1
(Neisseria
meningitidis) 		5 / 12 ILE A 143
ILE A 207
GLY A 224
SER A 309
ASN A  75
 None
 1.12A 4o1eB-3v8xA:
undetectable		 4o1eB-3v8xA:
14.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R38_B_RBFB201_1
(BLUE-LIGHT-ACTIVATED
HISTIDINE KINASE 2)		 3v8x TRANSFERRIN-BINDING
PROTEIN 1
(Neisseria
meningitidis) 		5 / 12 ASN A 677
ARG A 643
ASN A 737
ASN A 762
GLY A 103
 None
 1.10A 4r38B-3v8xA:
undetectable		 4r38B-3v8xA:
9.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UCI_B_ADNB2415_1
(RNA-DIRECTED RNA
POLYMERASE L)		 3v8x TRANSFERRIN-BINDING
PROTEIN 1
(Neisseria
meningitidis) 		4 / 7 GLU A 392
PHE A 463
TYR A 370
HIS A 374
 None
 1.49A 4uciB-3v8xA:
undetectable		 4uciB-3v8xA:
16.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X3U_B_SVRB102_1
(CHROMOBOX PROTEIN
HOMOLOG 7)		 3v8x TRANSFERRIN-BINDING
PROTEIN 1
(Neisseria
meningitidis) 		3 / 3 LYS A 467
ARG A 470
VAL A 471
 None
 0.76A 4x3uA-3v8xA:
undetectable
4x3uB-3v8xA:
undetectable		 4x3uA-3v8xA:
5.28
4x3uB-3v8xA:
5.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AYF_A_SAMA401_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD7)		 3v8x TRANSFERRIN-BINDING
PROTEIN 1
(Neisseria
meningitidis) 		5 / 11 ALA A 884
GLY A 885
GLY A  92
LYS A 892
TYR A 900
 None
 1.18A 5ayfA-3v8xA:
undetectable		 5ayfA-3v8xA:
15.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DX3_A_ESTA601_1
(ESTROGEN RECEPTOR)		 3v8x TRANSFERRIN-BINDING
PROTEIN 1
(Neisseria
meningitidis) 		5 / 10 ALA A 654
GLU A 655
ARG A 649
GLY A 474
LEU A 510
 None
None
None
C8E  A1001 (-4.3A)
None
 1.30A 5dx3A-3v8xA:
undetectable		 5dx3A-3v8xA:
12.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DXB_A_ESTA1000_1
(ESTROGEN RECEPTOR)		 3v8x TRANSFERRIN-BINDING
PROTEIN 1
(Neisseria
meningitidis) 		5 / 10 ALA A 654
GLU A 655
ARG A 649
GLY A 474
LEU A 510
 None
None
None
C8E  A1001 (-4.3A)
None
 1.27A 5dxbA-3v8xA:
undetectable		 5dxbA-3v8xA:
12.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DXG_B_ESTB601_1
(ESTROGEN RECEPTOR)		 3v8x TRANSFERRIN-BINDING
PROTEIN 1
(Neisseria
meningitidis) 		5 / 11 ALA A 654
GLU A 655
ARG A 649
GLY A 474
LEU A 510
 None
None
None
C8E  A1001 (-4.3A)
None
 1.25A 5dxgB-3v8xA:
undetectable		 5dxgB-3v8xA:
12.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JGL_B_SAMB301_0
(UBIE/COQ5 FAMILY
METHYLTRANSFERASE,
PUTATIVE)		 3v8x TRANSFERRIN-BINDING
PROTEIN 1
(Neisseria
meningitidis) 		5 / 12 ALA A 218
GLY A 211
LEU A 220
LEU A 331
ALA A 216
 None
 1.12A 5jglB-3v8xA:
undetectable		 5jglB-3v8xA:
16.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JSE_A_1GNA608_1
(PHIAB6 TAILSPIKE)		 3v8x TRANSFERRIN-BINDING
PROTEIN 1
(Neisseria
meningitidis) 		3 / 3 THR A 758
SER A 757
TYR A 756
 None
 0.88A 5jseA-3v8xA:
undetectable		 5jseA-3v8xA:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JSE_B_1GNB611_1
(PHIAB6 TAILSPIKE)		 3v8x TRANSFERRIN-BINDING
PROTEIN 1
(Neisseria
meningitidis) 		3 / 3 THR A 758
SER A 757
TYR A 756
 None
 0.88A 5jseB-3v8xA:
undetectable		 5jseB-3v8xA:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JSE_C_1GNC611_1
(PHIAB6 TAILSPIKE)		 3v8x TRANSFERRIN-BINDING
PROTEIN 1
(Neisseria
meningitidis) 		3 / 3 THR A 758
SER A 757
TYR A 756
 None
 0.88A 5jseC-3v8xA:
undetectable		 5jseC-3v8xA:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5O4Y_F_CCSF14_0
(PHE-MAA-ASN-PRO-HIS-
LEU-SER-TRP-SER-TRP-
9KK-9KK-ARG-CCS-GLY-
NH2)		 3v8x TRANSFERRIN-BINDING
PROTEIN 1
(Neisseria
meningitidis) 		4 / 6 PHE A 783
LEU A 821
SER A 780
GLY A 823
 None
 0.97A 5o4yF-3v8xA:
undetectable		 5o4yF-3v8xA:
1.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QGJ_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 3v8x TRANSFERRIN-BINDING
PROTEIN 1
(Neisseria
meningitidis) 		3 / 3 VAL A  88
VAL A  89
GLN A  91
 None
 0.59A 5qgjA-3v8xA:
undetectable		 5qgjA-3v8xA:
12.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QGM_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 3v8x TRANSFERRIN-BINDING
PROTEIN 1
(Neisseria
meningitidis) 		3 / 3 VAL A  88
VAL A  89
GLN A  91
 None
 0.59A 5qgmA-3v8xA:
undetectable		 5qgmA-3v8xA:
12.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QGN_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 3v8x TRANSFERRIN-BINDING
PROTEIN 1
(Neisseria
meningitidis) 		3 / 3 VAL A  88
VAL A  89
GLN A  91
 None
 0.60A 5qgnA-3v8xA:
undetectable		 5qgnA-3v8xA:
12.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QGY_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 3v8x TRANSFERRIN-BINDING
PROTEIN 1
(Neisseria
meningitidis) 		3 / 3 VAL A  88
VAL A  89
GLN A  91
 None
 0.62A 5qgyA-3v8xA:
undetectable		 5qgyA-3v8xA:
12.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QGZ_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 3v8x TRANSFERRIN-BINDING
PROTEIN 1
(Neisseria
meningitidis) 		3 / 3 VAL A  88
VAL A  89
GLN A  91
 None
 0.61A 5qgzA-3v8xA:
undetectable		 5qgzA-3v8xA:
12.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QH0_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 3v8x TRANSFERRIN-BINDING
PROTEIN 1
(Neisseria
meningitidis) 		3 / 3 VAL A  88
VAL A  89
GLN A  91
 None
 0.62A 5qh0A-3v8xA:
undetectable		 5qh0A-3v8xA:
12.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QH2_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 3v8x TRANSFERRIN-BINDING
PROTEIN 1
(Neisseria
meningitidis) 		3 / 3 VAL A  88
VAL A  89
GLN A  91
 None
 0.62A 5qh2A-3v8xA:
undetectable		 5qh2A-3v8xA:
12.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QH3_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 3v8x TRANSFERRIN-BINDING
PROTEIN 1
(Neisseria
meningitidis) 		3 / 3 VAL A  88
VAL A  89
GLN A  91
 None
 0.61A 5qh3A-3v8xA:
undetectable		 5qh3A-3v8xA:
12.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QH5_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 3v8x TRANSFERRIN-BINDING
PROTEIN 1
(Neisseria
meningitidis) 		3 / 3 VAL A  88
VAL A  89
GLN A  91
 None
 0.62A 5qh5A-3v8xA:
undetectable		 5qh5A-3v8xA:
12.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QH6_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 3v8x TRANSFERRIN-BINDING
PROTEIN 1
(Neisseria
meningitidis) 		3 / 3 VAL A  88
VAL A  89
GLN A  91
 None
 0.61A 5qh6A-3v8xA:
undetectable		 5qh6A-3v8xA:
12.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QH7_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 3v8x TRANSFERRIN-BINDING
PROTEIN 1
(Neisseria
meningitidis) 		3 / 3 VAL A  88
VAL A  89
GLN A  91
 None
 0.60A 5qh7A-3v8xA:
undetectable		 5qh7A-3v8xA:
12.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QHA_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 3v8x TRANSFERRIN-BINDING
PROTEIN 1
(Neisseria
meningitidis) 		3 / 3 VAL A  88
VAL A  89
GLN A  91
 None
 0.62A 5qhaA-3v8xA:
undetectable		 5qhaA-3v8xA:
12.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QHH_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 3v8x TRANSFERRIN-BINDING
PROTEIN 1
(Neisseria
meningitidis) 		3 / 3 VAL A  88
VAL A  89
GLN A  91
 None
 0.61A 5qhhA-3v8xA:
undetectable		 5qhhA-3v8xA:
12.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TL8_A_X2NA502_2
(PROTEIN CYP51)		 3v8x TRANSFERRIN-BINDING
PROTEIN 1
(Neisseria
meningitidis) 		4 / 6 TYR A 122
PRO A 651
LEU A 650
PHE A 653
 None
 1.08A 5tl8A-3v8xA:
undetectable		 5tl8A-3v8xA:
18.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5U6N_A_SALA505_1
(UDP-GLYCOSYLTRANSFER
ASE 74F2)		 3v8x TRANSFERRIN-BINDING
PROTEIN 1
(Neisseria
meningitidis) 		4 / 8 SER A 137
HIS A 403
PHE A 338
GLN A 336
 None
 1.36A 5u6nA-3v8xA:
undetectable		 5u6nA-3v8xA:
19.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5U6N_B_SALB504_1
(UDP-GLYCOSYLTRANSFER
ASE 74F2)		 3v8x TRANSFERRIN-BINDING
PROTEIN 1
(Neisseria
meningitidis) 		4 / 6 SER A 137
HIS A 403
PHE A 338
GLN A 336
 None
 1.34A 5u6nB-3v8xA:
undetectable		 5u6nB-3v8xA:
19.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BPL_B_PA1B605_1
(LIPID A EXPORT
ATP-BINDING/PERMEASE
PROTEIN MSBA)		 3v8x TRANSFERRIN-BINDING
PROTEIN 1
(Neisseria
meningitidis) 		3 / 3 ARG A 132
ARG A 899
ARG A  93
 None
 1.10A 6bplA-3v8xA:
undetectable
6bplB-3v8xA:
undetectable		 6bplA-3v8xA:
6.58
6bplB-3v8xA:
6.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DWN_C_AQ4C602_1
(CYTOCHROME P450 1A1)		 3v8x TRANSFERRIN-BINDING
PROTEIN 1
(Neisseria
meningitidis) 		3 / 3 SER A  69
SER A  65
ALA A 208
 None
 0.73A 6dwnC-3v8xA:
undetectable		 6dwnC-3v8xA:
6.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MHT_D_SAMD328_0
(CYTOSINE-SPECIFIC
METHYLTRANSFERASE
HHAI)		 3v8x TRANSFERRIN-BINDING
PROTEIN 1
(Neisseria
meningitidis) 		5 / 12 GLY A 165
LEU A 167
GLY A 169
ASP A 504
ASN A 107
 None
 0.85A 6mhtA-3v8xA:
undetectable		 6mhtA-3v8xA:
17.05