SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3v94'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UDU_B_CIAB2003_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		 3v94 CYCLIC NUCLEOTIDE
SPECIFIC
PHOSPHODIESTERASE
(Trypanosoma
cruzi) 		5 / 12 TYR A 367
ALA A 524
PHE A 542
GLN A 570
PHE A 573
 WYQ  A 701 (-4.5A)
None
WYQ  A 701 (-4.7A)
WYQ  A 701 (-3.3A)
WYQ  A 701 (-3.4A)
 0.59A 1uduB-3v94A:
33.5		 1uduB-3v94A:
28.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UHO_A_VDNA1000_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		 3v94 CYCLIC NUCLEOTIDE
SPECIFIC
PHOSPHODIESTERASE
(Trypanosoma
cruzi) 		5 / 10 TYR A 367
HIS A 368
PHE A 542
GLN A 570
PHE A 573
 WYQ  A 701 (-4.5A)
None
WYQ  A 701 (-4.7A)
WYQ  A 701 (-3.3A)
WYQ  A 701 (-3.4A)
 0.41A 1uhoA-3v94A:
34.4		 1uhoA-3v94A:
28.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XLX_A_CIOA101_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B)		 3v94 CYCLIC NUCLEOTIDE
SPECIFIC
PHOSPHODIESTERASE
(Trypanosoma
cruzi) 		6 / 12 TYR A 367
HIS A 368
HIS A 413
ILE A 538
GLN A 570
PHE A 573
 WYQ  A 701 (-4.5A)
None
None
WYQ  A 701 ( 4.1A)
WYQ  A 701 (-3.3A)
WYQ  A 701 (-3.4A)
 0.43A 1xlxA-3v94A:
40.1		 1xlxA-3v94A:
27.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XLX_A_CIOA101_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B)		 3v94 CYCLIC NUCLEOTIDE
SPECIFIC
PHOSPHODIESTERASE
(Trypanosoma
cruzi) 		6 / 12 TYR A 367
HIS A 413
MET A 482
ILE A 538
GLN A 570
PHE A 573
 WYQ  A 701 (-4.5A)
None
WYQ  A 701 (-4.5A)
WYQ  A 701 ( 4.1A)
WYQ  A 701 (-3.3A)
WYQ  A 701 (-3.4A)
 0.85A 1xlxA-3v94A:
40.1		 1xlxA-3v94A:
27.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XLX_B_CIOB102_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B)		 3v94 CYCLIC NUCLEOTIDE
SPECIFIC
PHOSPHODIESTERASE
(Trypanosoma
cruzi) 		8 / 12 TYR A 367
HIS A 368
HIS A 413
MET A 482
ILE A 538
PHE A 542
GLN A 570
PHE A 573
 WYQ  A 701 (-4.5A)
None
None
WYQ  A 701 (-4.5A)
WYQ  A 701 ( 4.1A)
WYQ  A 701 (-4.7A)
WYQ  A 701 (-3.3A)
WYQ  A 701 (-3.4A)
 0.77A 1xlxB-3v94A:
39.9		 1xlxB-3v94A:
27.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XMU_A_ROFA101_0
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B)		 3v94 CYCLIC NUCLEOTIDE
SPECIFIC
PHOSPHODIESTERASE
(Trypanosoma
cruzi) 		7 / 12 TYR A 367
HIS A 368
ASP A 521
TRP A 535
ILE A 538
PHE A 542
PHE A 573
 WYQ  A 701 (-4.5A)
None
ZN  A 702 (-1.9A)
None
WYQ  A 701 ( 4.1A)
WYQ  A 701 (-4.7A)
WYQ  A 701 (-3.4A)
 0.77A 1xmuA-3v94A:
39.9		 1xmuA-3v94A:
27.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XMU_A_ROFA101_0
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B)		 3v94 CYCLIC NUCLEOTIDE
SPECIFIC
PHOSPHODIESTERASE
(Trypanosoma
cruzi) 		5 / 12 TYR A 367
TRP A 535
PHE A 542
SER A 569
PHE A 573
 WYQ  A 701 (-4.5A)
None
WYQ  A 701 (-4.7A)
None
WYQ  A 701 (-3.4A)
 0.94A 1xmuA-3v94A:
39.9		 1xmuA-3v94A:
27.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XMU_B_ROFB102_0
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B)		 3v94 CYCLIC NUCLEOTIDE
SPECIFIC
PHOSPHODIESTERASE
(Trypanosoma
cruzi) 		6 / 12 TYR A 367
HIS A 368
ASP A 521
TRP A 535
ILE A 538
PHE A 542
 WYQ  A 701 (-4.5A)
None
ZN  A 702 (-1.9A)
None
WYQ  A 701 ( 4.1A)
WYQ  A 701 (-4.7A)
 0.61A 1xmuB-3v94A:
40.1		 1xmuB-3v94A:
27.11
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1XOM_A_CIOA603_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		 3v94 CYCLIC NUCLEOTIDE
SPECIFIC
PHOSPHODIESTERASE
(Trypanosoma
cruzi) 		8 / 12 TYR A 367
HIS A 368
MET A 482
ASP A 521
ILE A 538
PHE A 542
GLN A 570
PHE A 573
 WYQ  A 701 (-4.5A)
None
WYQ  A 701 (-4.5A)
ZN  A 702 (-1.9A)
WYQ  A 701 ( 4.1A)
WYQ  A 701 (-4.7A)
WYQ  A 701 (-3.3A)
WYQ  A 701 (-3.4A)
 0.81A 1xomA-3v94A:
40.2		 1xomA-3v94A:
30.62
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1XOM_B_CIOB601_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		 3v94 CYCLIC NUCLEOTIDE
SPECIFIC
PHOSPHODIESTERASE
(Trypanosoma
cruzi) 		7 / 12 TYR A 367
HIS A 368
MET A 482
ILE A 538
PHE A 542
GLN A 570
PHE A 573
 WYQ  A 701 (-4.5A)
None
WYQ  A 701 (-4.5A)
WYQ  A 701 ( 4.1A)
WYQ  A 701 (-4.7A)
WYQ  A 701 (-3.3A)
WYQ  A 701 (-3.4A)
 0.81A 1xomB-3v94A:
40.2		 1xomB-3v94A:
30.62
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1XOQ_A_ROFA502_0
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		 3v94 CYCLIC NUCLEOTIDE
SPECIFIC
PHOSPHODIESTERASE
(Trypanosoma
cruzi) 		5 / 12 TYR A 367
HIS A 368
ILE A 538
SER A 569
PHE A 573
 WYQ  A 701 (-4.5A)
None
WYQ  A 701 ( 4.1A)
None
WYQ  A 701 (-3.4A)
 0.77A 1xoqA-3v94A:
40.1		 1xoqA-3v94A:
30.62
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1XOQ_A_ROFA502_0
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		 3v94 CYCLIC NUCLEOTIDE
SPECIFIC
PHOSPHODIESTERASE
(Trypanosoma
cruzi) 		6 / 12 TYR A 367
HIS A 368
MET A 482
ASP A 521
ILE A 538
PHE A 573
 WYQ  A 701 (-4.5A)
None
WYQ  A 701 (-4.5A)
ZN  A 702 (-1.9A)
WYQ  A 701 ( 4.1A)
WYQ  A 701 (-3.4A)
 0.76A 1xoqA-3v94A:
40.1		 1xoqA-3v94A:
30.62
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1XOQ_B_ROFB501_0
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		 3v94 CYCLIC NUCLEOTIDE
SPECIFIC
PHOSPHODIESTERASE
(Trypanosoma
cruzi) 		6 / 12 TYR A 367
HIS A 368
ASP A 521
TRP A 535
ILE A 538
PHE A 573
 WYQ  A 701 (-4.5A)
None
ZN  A 702 (-1.9A)
None
WYQ  A 701 ( 4.1A)
WYQ  A 701 (-3.4A)
 0.71A 1xoqB-3v94A:
40.0		 1xoqB-3v94A:
30.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XOS_A_VIAA1_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B)		 3v94 CYCLIC NUCLEOTIDE
SPECIFIC
PHOSPHODIESTERASE
(Trypanosoma
cruzi) 		5 / 12 MET A 482
ASP A 521
PHE A 542
GLN A 570
PHE A 573
 WYQ  A 701 (-4.5A)
ZN  A 702 (-1.9A)
WYQ  A 701 (-4.7A)
WYQ  A 701 (-3.3A)
WYQ  A 701 (-3.4A)
 0.97A 1xosA-3v94A:
40.0		 1xosA-3v94A:
27.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XOS_A_VIAA1_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B)		 3v94 CYCLIC NUCLEOTIDE
SPECIFIC
PHOSPHODIESTERASE
(Trypanosoma
cruzi) 		6 / 12 TYR A 367
HIS A 368
ASP A 521
PHE A 542
GLN A 570
PHE A 573
 WYQ  A 701 (-4.5A)
None
ZN  A 702 (-1.9A)
WYQ  A 701 (-4.7A)
WYQ  A 701 (-3.3A)
WYQ  A 701 (-3.4A)
 0.74A 1xosA-3v94A:
40.0		 1xosA-3v94A:
27.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XOT_A_VDNA101_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B)		 3v94 CYCLIC NUCLEOTIDE
SPECIFIC
PHOSPHODIESTERASE
(Trypanosoma
cruzi) 		5 / 12 TYR A 367
HIS A 368
ILE A 538
GLN A 570
PHE A 573
 WYQ  A 701 (-4.5A)
None
WYQ  A 701 ( 4.1A)
WYQ  A 701 (-3.3A)
WYQ  A 701 (-3.4A)
 0.32A 1xotA-3v94A:
40.0		 1xotA-3v94A:
27.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XOT_A_VDNA101_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B)		 3v94 CYCLIC NUCLEOTIDE
SPECIFIC
PHOSPHODIESTERASE
(Trypanosoma
cruzi) 		5 / 12 TYR A 367
MET A 482
ILE A 538
GLN A 570
PHE A 573
 WYQ  A 701 (-4.5A)
WYQ  A 701 (-4.5A)
WYQ  A 701 ( 4.1A)
WYQ  A 701 (-3.3A)
WYQ  A 701 (-3.4A)
 0.76A 1xotA-3v94A:
40.0		 1xotA-3v94A:
27.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XOT_B_VDNB102_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B)		 3v94 CYCLIC NUCLEOTIDE
SPECIFIC
PHOSPHODIESTERASE
(Trypanosoma
cruzi) 		5 / 12 TYR A 367
HIS A 368
ILE A 538
GLN A 570
PHE A 573
 WYQ  A 701 (-4.5A)
None
WYQ  A 701 ( 4.1A)
WYQ  A 701 (-3.3A)
WYQ  A 701 (-3.4A)
 0.34A 1xotB-3v94A:
40.1		 1xotB-3v94A:
27.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XOT_B_VDNB102_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B)		 3v94 CYCLIC NUCLEOTIDE
SPECIFIC
PHOSPHODIESTERASE
(Trypanosoma
cruzi) 		5 / 12 TYR A 367
MET A 482
ILE A 538
GLN A 570
PHE A 573
 WYQ  A 701 (-4.5A)
WYQ  A 701 (-4.5A)
WYQ  A 701 ( 4.1A)
WYQ  A 701 (-3.3A)
WYQ  A 701 (-3.4A)
 0.84A 1xotB-3v94A:
40.1		 1xotB-3v94A:
27.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XOZ_A_CIAA501_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		 3v94 CYCLIC NUCLEOTIDE
SPECIFIC
PHOSPHODIESTERASE
(Trypanosoma
cruzi) 		5 / 12 TYR A 367
ALA A 524
PHE A 542
GLN A 570
PHE A 573
 WYQ  A 701 (-4.5A)
None
WYQ  A 701 (-4.7A)
WYQ  A 701 (-3.3A)
WYQ  A 701 (-3.4A)
 0.68A 1xozA-3v94A:
37.1		 1xozA-3v94A:
27.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2H42_A_VIAA901_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		 3v94 CYCLIC NUCLEOTIDE
SPECIFIC
PHOSPHODIESTERASE
(Trypanosoma
cruzi) 		6 / 11 TYR A 367
HIS A 368
ALA A 524
PHE A 542
GLN A 570
PHE A 573
 WYQ  A 701 (-4.5A)
None
None
WYQ  A 701 (-4.7A)
WYQ  A 701 (-3.3A)
WYQ  A 701 (-3.4A)
 0.78A 2h42A-3v94A:
34.4		 2h42A-3v94A:
27.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2H42_B_VIAB902_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		 3v94 CYCLIC NUCLEOTIDE
SPECIFIC
PHOSPHODIESTERASE
(Trypanosoma
cruzi) 		5 / 12 TYR A 367
HIS A 368
ALA A 524
GLN A 570
PHE A 573
 WYQ  A 701 (-4.5A)
None
None
WYQ  A 701 (-3.3A)
WYQ  A 701 (-3.4A)
 0.69A 2h42B-3v94A:
34.2		 2h42B-3v94A:
27.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QXS_A_RALA600_1
(ESTROGEN RECEPTOR)		 3v94 CYCLIC NUCLEOTIDE
SPECIFIC
PHOSPHODIESTERASE
(Trypanosoma
cruzi) 		5 / 12 LEU A 516
LEU A 517
ILE A 472
LEU A 394
PRO A 389
 None
 0.90A 2qxsA-3v94A:
undetectable		 2qxsA-3v94A:
22.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QXS_B_RALB600_1
(ESTROGEN RECEPTOR)		 3v94 CYCLIC NUCLEOTIDE
SPECIFIC
PHOSPHODIESTERASE
(Trypanosoma
cruzi) 		5 / 12 LEU A 516
LEU A 517
ILE A 472
LEU A 394
PRO A 389
 None
 0.97A 2qxsB-3v94A:
undetectable		 2qxsB-3v94A:
22.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V2G_A_BEZA1222_0
(PEROXIREDOXIN 6)		 3v94 CYCLIC NUCLEOTIDE
SPECIFIC
PHOSPHODIESTERASE
(Trypanosoma
cruzi) 		4 / 7 PRO A 427
VAL A 428
SER A 429
PRO A 284
 None
 0.82A 2v2gA-3v94A:
undetectable
2v2gB-3v94A:
undetectable		 2v2gA-3v94A:
20.17
2v2gB-3v94A:
20.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V2G_B_BEZB1220_0
(PEROXIREDOXIN 6)		 3v94 CYCLIC NUCLEOTIDE
SPECIFIC
PHOSPHODIESTERASE
(Trypanosoma
cruzi) 		4 / 7 PRO A 284
PRO A 427
VAL A 428
SER A 429
 None
 0.82A 2v2gA-3v94A:
undetectable
2v2gB-3v94A:
undetectable		 2v2gA-3v94A:
20.17
2v2gB-3v94A:
20.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V2G_C_BEZC1222_0
(PEROXIREDOXIN 6)		 3v94 CYCLIC NUCLEOTIDE
SPECIFIC
PHOSPHODIESTERASE
(Trypanosoma
cruzi) 		4 / 7 PRO A 427
VAL A 428
SER A 429
PRO A 284
 None
 0.83A 2v2gC-3v94A:
undetectable
2v2gD-3v94A:
undetectable		 2v2gC-3v94A:
20.17
2v2gD-3v94A:
20.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V2G_D_BEZD1221_0
(PEROXIREDOXIN 6)		 3v94 CYCLIC NUCLEOTIDE
SPECIFIC
PHOSPHODIESTERASE
(Trypanosoma
cruzi) 		4 / 7 PRO A 284
PRO A 427
VAL A 428
SER A 429
 None
 0.86A 2v2gC-3v94A:
undetectable
2v2gD-3v94A:
undetectable		 2v2gC-3v94A:
20.17
2v2gD-3v94A:
20.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V32_A_BEZA1222_0
(PEROXIREDOXIN 6)		 3v94 CYCLIC NUCLEOTIDE
SPECIFIC
PHOSPHODIESTERASE
(Trypanosoma
cruzi) 		4 / 8 PRO A 427
VAL A 428
SER A 429
PRO A 284
 None
 0.84A 2v32A-3v94A:
undetectable
2v32B-3v94A:
undetectable		 2v32A-3v94A:
20.17
2v32B-3v94A:
20.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V32_B_BEZB1220_0
(PEROXIREDOXIN 6)		 3v94 CYCLIC NUCLEOTIDE
SPECIFIC
PHOSPHODIESTERASE
(Trypanosoma
cruzi) 		4 / 8 PRO A 284
PRO A 427
VAL A 428
SER A 429
 None
 0.82A 2v32A-3v94A:
undetectable
2v32B-3v94A:
undetectable		 2v32A-3v94A:
20.17
2v32B-3v94A:
20.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V32_C_BEZC1222_0
(PEROXIREDOXIN 6)		 3v94 CYCLIC NUCLEOTIDE
SPECIFIC
PHOSPHODIESTERASE
(Trypanosoma
cruzi) 		4 / 8 PRO A 427
VAL A 428
SER A 429
PRO A 284
 None
 0.82A 2v32C-3v94A:
undetectable
2v32D-3v94A:
undetectable		 2v32C-3v94A:
20.17
2v32D-3v94A:
20.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V32_D_BEZD1221_0
(PEROXIREDOXIN 6)		 3v94 CYCLIC NUCLEOTIDE
SPECIFIC
PHOSPHODIESTERASE
(Trypanosoma
cruzi) 		4 / 8 PRO A 284
PRO A 427
VAL A 428
SER A 429
 None
 0.80A 2v32C-3v94A:
undetectable
2v32D-3v94A:
undetectable		 2v32C-3v94A:
20.17
2v32D-3v94A:
20.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V41_C_BEZC1218_0
(PEROXIREDOXIN 6.)		 3v94 CYCLIC NUCLEOTIDE
SPECIFIC
PHOSPHODIESTERASE
(Trypanosoma
cruzi) 		4 / 8 PRO A 427
VAL A 428
SER A 429
PRO A 284
 None
 0.80A 2v41C-3v94A:
undetectable
2v41D-3v94A:
undetectable		 2v41C-3v94A:
20.17
2v41D-3v94A:
20.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V41_D_BEZD1222_0
(PEROXIREDOXIN 6.)		 3v94 CYCLIC NUCLEOTIDE
SPECIFIC
PHOSPHODIESTERASE
(Trypanosoma
cruzi) 		4 / 8 PRO A 284
PRO A 427
VAL A 428
SER A 429
 None
 0.86A 2v41C-3v94A:
undetectable
2v41D-3v94A:
undetectable		 2v41C-3v94A:
20.17
2v41D-3v94A:
20.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V41_E_BEZE1222_0
(PEROXIREDOXIN 6.)		 3v94 CYCLIC NUCLEOTIDE
SPECIFIC
PHOSPHODIESTERASE
(Trypanosoma
cruzi) 		4 / 7 PRO A 427
VAL A 428
SER A 429
PRO A 284
 None
 0.88A 2v41E-3v94A:
undetectable
2v41F-3v94A:
undetectable		 2v41E-3v94A:
20.17
2v41F-3v94A:
20.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V41_F_BEZF1222_0
(PEROXIREDOXIN 6.)		 3v94 CYCLIC NUCLEOTIDE
SPECIFIC
PHOSPHODIESTERASE
(Trypanosoma
cruzi) 		4 / 7 PRO A 284
PRO A 427
VAL A 428
SER A 429
 None
 0.79A 2v41E-3v94A:
undetectable
2v41F-3v94A:
undetectable		 2v41E-3v94A:
20.17
2v41F-3v94A:
20.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V41_G_BEZG1222_0
(PEROXIREDOXIN 6.)		 3v94 CYCLIC NUCLEOTIDE
SPECIFIC
PHOSPHODIESTERASE
(Trypanosoma
cruzi) 		4 / 8 PRO A 427
VAL A 428
SER A 429
PRO A 284
 None
 0.81A 2v41G-3v94A:
undetectable
2v41H-3v94A:
undetectable		 2v41G-3v94A:
20.17
2v41H-3v94A:
20.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V41_H_BEZH1222_0
(PEROXIREDOXIN 6.)		 3v94 CYCLIC NUCLEOTIDE
SPECIFIC
PHOSPHODIESTERASE
(Trypanosoma
cruzi) 		4 / 8 PRO A 284
PRO A 427
VAL A 428
SER A 429
 None
 0.90A 2v41G-3v94A:
undetectable
2v41H-3v94A:
undetectable		 2v41G-3v94A:
20.17
2v41H-3v94A:
20.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WEY_A_EV1A1771_1
(CAMP AND
CAMP-INHIBITED CGMP
3', 5'-CYCLIC
PHOSPHODIESTERASE)		 3v94 CYCLIC NUCLEOTIDE
SPECIFIC
PHOSPHODIESTERASE
(Trypanosoma
cruzi) 		7 / 12 TYR A 367
HIS A 368
ILE A 538
GLU A 541
PHE A 542
GLN A 570
PHE A 573
 WYQ  A 701 (-4.5A)
None
WYQ  A 701 ( 4.1A)
None
WYQ  A 701 (-4.7A)
WYQ  A 701 (-3.3A)
WYQ  A 701 (-3.4A)
 0.89A 2weyA-3v94A:
37.8		 2weyA-3v94A:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WEY_B_EV1B1771_1
(CAMP AND
CAMP-INHIBITED CGMP
3', 5'-CYCLIC
PHOSPHODIESTERASE)		 3v94 CYCLIC NUCLEOTIDE
SPECIFIC
PHOSPHODIESTERASE
(Trypanosoma
cruzi) 		4 / 8 ILE A 538
PHE A 542
GLN A 570
PHE A 573
 WYQ  A 701 ( 4.1A)
WYQ  A 701 (-4.7A)
WYQ  A 701 (-3.3A)
WYQ  A 701 (-3.4A)
 0.74A 2weyB-3v94A:
37.6		 2weyB-3v94A:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A50_A_VD3A2001_1
(VITAMIN D
HYDROXYLASE)		 3v94 CYCLIC NUCLEOTIDE
SPECIFIC
PHOSPHODIESTERASE
(Trypanosoma
cruzi) 		5 / 12 PRO A 389
ILE A 592
LEU A 383
ALA A 519
THR A 581
 None
 1.16A 3a50A-3v94A:
undetectable		 3a50A-3v94A:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B2R_A_VDNA1_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		 3v94 CYCLIC NUCLEOTIDE
SPECIFIC
PHOSPHODIESTERASE
(Trypanosoma
cruzi) 		6 / 12 TYR A 367
HIS A 368
ALA A 524
PHE A 542
GLN A 570
PHE A 573
 WYQ  A 701 (-4.5A)
None
None
WYQ  A 701 (-4.7A)
WYQ  A 701 (-3.3A)
WYQ  A 701 (-3.4A)
 0.77A 3b2rA-3v94A:
30.3		 3b2rA-3v94A:
28.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B2R_B_VDNB1_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		 3v94 CYCLIC NUCLEOTIDE
SPECIFIC
PHOSPHODIESTERASE
(Trypanosoma
cruzi) 		5 / 11 TYR A 367
HIS A 368
ALA A 524
GLN A 570
PHE A 573
 WYQ  A 701 (-4.5A)
None
None
WYQ  A 701 (-3.3A)
WYQ  A 701 (-3.4A)
 0.66A 3b2rB-3v94A:
30.2		 3b2rB-3v94A:
28.45
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3G4L_A_ROFA901_0
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		 3v94 CYCLIC NUCLEOTIDE
SPECIFIC
PHOSPHODIESTERASE
(Trypanosoma
cruzi) 		6 / 12 TYR A 367
HIS A 368
MET A 482
TRP A 535
ILE A 538
PHE A 573
 WYQ  A 701 (-4.5A)
None
WYQ  A 701 (-4.5A)
None
WYQ  A 701 ( 4.1A)
WYQ  A 701 (-3.4A)
 0.75A 3g4lA-3v94A:
39.7		 3g4lA-3v94A:
30.28
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3G4L_B_ROFB902_0
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		 3v94 CYCLIC NUCLEOTIDE
SPECIFIC
PHOSPHODIESTERASE
(Trypanosoma
cruzi) 		7 / 12 TYR A 367
HIS A 368
MET A 482
ASP A 521
TRP A 535
ILE A 538
PHE A 573
 WYQ  A 701 (-4.5A)
None
WYQ  A 701 (-4.5A)
ZN  A 702 (-1.9A)
None
WYQ  A 701 ( 4.1A)
WYQ  A 701 (-3.4A)
 0.78A 3g4lB-3v94A:
39.8		 3g4lB-3v94A:
30.28
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3G4L_C_ROFC903_0
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		 3v94 CYCLIC NUCLEOTIDE
SPECIFIC
PHOSPHODIESTERASE
(Trypanosoma
cruzi) 		6 / 12 TYR A 367
HIS A 368
MET A 482
ASP A 521
TRP A 535
ILE A 538
 WYQ  A 701 (-4.5A)
None
WYQ  A 701 (-4.5A)
ZN  A 702 (-1.9A)
None
WYQ  A 701 ( 4.1A)
 0.63A 3g4lC-3v94A:
39.7		 3g4lC-3v94A:
30.28
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3G4L_C_ROFC903_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		 3v94 CYCLIC NUCLEOTIDE
SPECIFIC
PHOSPHODIESTERASE
(Trypanosoma
cruzi) 		3 / 3 SER A 569
GLN A 570
PHE A 573
 None
WYQ  A 701 (-3.3A)
WYQ  A 701 (-3.4A)
 0.56A 3g4lC-3v94A:
39.7		 3g4lC-3v94A:
30.28
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3G4L_D_ROFD904_0
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		 3v94 CYCLIC NUCLEOTIDE
SPECIFIC
PHOSPHODIESTERASE
(Trypanosoma
cruzi) 		7 / 12 TYR A 367
HIS A 368
MET A 482
ASP A 521
TRP A 535
ILE A 538
GLN A 570
 WYQ  A 701 (-4.5A)
None
WYQ  A 701 (-4.5A)
ZN  A 702 (-1.9A)
None
WYQ  A 701 ( 4.1A)
WYQ  A 701 (-3.3A)
 0.73A 3g4lD-3v94A:
39.8		 3g4lD-3v94A:
30.28
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3IAK_A_EV1A415_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		 3v94 CYCLIC NUCLEOTIDE
SPECIFIC
PHOSPHODIESTERASE
(Trypanosoma
cruzi) 		6 / 9 TYR A 367
MET A 482
ILE A 538
PHE A 542
GLN A 570
PHE A 573
 WYQ  A 701 (-4.5A)
WYQ  A 701 (-4.5A)
WYQ  A 701 ( 4.1A)
WYQ  A 701 (-4.7A)
WYQ  A 701 (-3.3A)
WYQ  A 701 (-3.4A)
 0.52A 3iakA-3v94A:
39.9		 3iakA-3v94A:
30.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JWQ_B_VIAB901_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE
CATALYTIC DOMAIN,
CONE CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE
SUBUNIT ALPHA
CHIMERA)		 3v94 CYCLIC NUCLEOTIDE
SPECIFIC
PHOSPHODIESTERASE
(Trypanosoma
cruzi) 		5 / 11 TYR A 367
HIS A 368
ALA A 524
GLN A 570
PHE A 573
 WYQ  A 701 (-4.5A)
None
None
WYQ  A 701 (-3.3A)
WYQ  A 701 (-3.4A)
 0.71A 3jwqB-3v94A:
36.9
3jwqC-3v94A:
37.0		 3jwqB-3v94A:
27.67
3jwqC-3v94A:
27.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JWQ_C_VIAC901_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE
CATALYTIC DOMAIN,
CONE CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE
SUBUNIT ALPHA
CHIMERA)		 3v94 CYCLIC NUCLEOTIDE
SPECIFIC
PHOSPHODIESTERASE
(Trypanosoma
cruzi) 		4 / 7 TYR A 367
HIS A 368
GLN A 570
PHE A 573
 WYQ  A 701 (-4.5A)
None
WYQ  A 701 (-3.3A)
WYQ  A 701 (-3.4A)
 0.48A 3jwqC-3v94A:
37.0		 3jwqC-3v94A:
27.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JWQ_D_VIAD901_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE
CATALYTIC DOMAIN,
CONE CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE
SUBUNIT ALPHA
CHIMERA)		 3v94 CYCLIC NUCLEOTIDE
SPECIFIC
PHOSPHODIESTERASE
(Trypanosoma
cruzi) 		6 / 11 TYR A 367
HIS A 368
ALA A 524
PHE A 542
GLN A 570
PHE A 573
 WYQ  A 701 (-4.5A)
None
None
WYQ  A 701 (-4.7A)
WYQ  A 701 (-3.3A)
WYQ  A 701 (-3.4A)
 0.74A 3jwqA-3v94A:
37.0
3jwqD-3v94A:
36.8		 3jwqA-3v94A:
27.67
3jwqD-3v94A:
27.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RGL_A_GLYA301_0
(GLYCYL-TRNA
SYNTHETASE ALPHA
SUBUNIT)		 3v94 CYCLIC NUCLEOTIDE
SPECIFIC
PHOSPHODIESTERASE
(Trypanosoma
cruzi) 		4 / 8 ALA A 419
THR A 417
GLN A 545
THR A 557
 None
WYQ  A 701 (-4.5A)
None
None
 0.83A 3rglA-3v94A:
undetectable		 3rglA-3v94A:
23.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ROD_A_NCAA302_0
(NICOTINAMIDE
N-METHYLTRANSFERASE)		 3v94 CYCLIC NUCLEOTIDE
SPECIFIC
PHOSPHODIESTERASE
(Trypanosoma
cruzi) 		4 / 8 LEU A 536
ALA A 532
SER A 525
TYR A 606
 None
 1.06A 3rodA-3v94A:
undetectable		 3rodA-3v94A:
21.47
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3TVX_B_PNXB902_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4A)		 3v94 CYCLIC NUCLEOTIDE
SPECIFIC
PHOSPHODIESTERASE
(Trypanosoma
cruzi) 		5 / 7 TYR A 367
ILE A 538
PHE A 542
GLN A 570
PHE A 573
 WYQ  A 701 (-4.5A)
WYQ  A 701 ( 4.1A)
WYQ  A 701 (-4.7A)
WYQ  A 701 (-3.3A)
WYQ  A 701 (-3.4A)
 0.55A 3tvxB-3v94A:
39.8		 3tvxB-3v94A:
30.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UJ7_B_SAMB302_1
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE)		 3v94 CYCLIC NUCLEOTIDE
SPECIFIC
PHOSPHODIESTERASE
(Trypanosoma
cruzi) 		4 / 5 TYR A 367
SER A 525
ASP A 521
ASP A 481
 WYQ  A 701 (-4.5A)
None
ZN  A 702 (-1.9A)
None
 1.35A 3uj7B-3v94A:
undetectable		 3uj7B-3v94A:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VQR_B_ACTB1002_0
(PUTATIVE
OXIDOREDUCTASE)		 3v94 CYCLIC NUCLEOTIDE
SPECIFIC
PHOSPHODIESTERASE
(Trypanosoma
cruzi) 		4 / 5 GLY A 379
VAL A 376
ASP A 375
THR A 317
 None
 1.26A 3vqrB-3v94A:
undetectable		 3vqrB-3v94A:
19.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LTW_A_486A303_1
(ANCESTRAL STEROID
RECEPTOR 2)		 3v94 CYCLIC NUCLEOTIDE
SPECIFIC
PHOSPHODIESTERASE
(Trypanosoma
cruzi) 		5 / 9 LEU A 449
ALA A 357
GLN A 289
THR A 291
LEU A 293
 None
 1.37A 4ltwA-3v94A:
undetectable		 4ltwA-3v94A:
22.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5F1A_A_SALA601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 3v94 CYCLIC NUCLEOTIDE
SPECIFIC
PHOSPHODIESTERASE
(Trypanosoma
cruzi) 		4 / 8 LEU A 584
GLY A 493
ALA A 494
SER A 497
 None
 0.62A 5f1aA-3v94A:
undetectable		 5f1aA-3v94A:
19.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5F1A_B_SALB601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 3v94 CYCLIC NUCLEOTIDE
SPECIFIC
PHOSPHODIESTERASE
(Trypanosoma
cruzi) 		4 / 7 LEU A 584
GLY A 493
ALA A 494
SER A 497
 None
 0.62A 5f1aB-3v94A:
undetectable		 5f1aB-3v94A:
19.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IEN_A_VDYA201_1
(CDL2.2)		 3v94 CYCLIC NUCLEOTIDE
SPECIFIC
PHOSPHODIESTERASE
(Trypanosoma
cruzi) 		5 / 12 TRP A 339
LEU A 394
ILE A 472
ALA A 406
LEU A 476
 None
 1.24A 5ienA-3v94A:
undetectable		 5ienA-3v94A:
19.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OEX_A_CUA604_0
(THIOCYANATE
DEHYDROGENASE)		 3v94 CYCLIC NUCLEOTIDE
SPECIFIC
PHOSPHODIESTERASE
(Trypanosoma
cruzi) 		3 / 3 HIS A 372
HIS A 368
HIS A 413
 ZN  A 702 (-3.3A)
None
None
 0.98A 5oexA-3v94A:
undetectable		 5oexA-3v94A:
21.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F8C_A_STRA502_1
(CYTOCHROME P450
CYP260A1)		 3v94 CYCLIC NUCLEOTIDE
SPECIFIC
PHOSPHODIESTERASE
(Trypanosoma
cruzi) 		4 / 6 ALA A 446
SER A 474
GLY A 478
THR A 480
 None
 0.83A 6f8cA-3v94A:
undetectable		 6f8cA-3v94A:
17.05