SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3v96'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1OS2_A_HAEA874_1
(MACROPHAGE
METALLOELASTASE)		 3v96 STROMELYSIN-2
(Homo
sapiens) 		5 / 5 HIS B 182
HIS B 217
GLU B 218
HIS B 221
HIS B 227
 ZN  B 302 (-3.2A)
ZN  B 301 (-3.2A)
ZN  B 301 ( 3.9A)
ZN  B 301 (-3.3A)
ZN  B 301 (-3.2A)
 0.23A 1os2A-3v96B:
29.3		 1os2A-3v96B:
55.76
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1OS2_D_HAED574_1
(MACROPHAGE
METALLOELASTASE)		 3v96 STROMELYSIN-2
(Homo
sapiens) 		4 / 4 HIS B 217
GLU B 218
HIS B 221
HIS B 227
 ZN  B 301 (-3.2A)
ZN  B 301 ( 3.9A)
ZN  B 301 (-3.3A)
ZN  B 301 (-3.2A)
 0.26A 1os2D-3v96B:
29.2		 1os2D-3v96B:
55.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TSN_A_C2FA266_0
(THYMIDYLATE SYNTHASE)		 3v96 STROMELYSIN-2
(Homo
sapiens) 		5 / 12 HIS B 195
ILE B 160
LEU B 211
VAL B 129
ALA B 128
 ZN  B 302 (-3.2A)
None
None
None
None
 1.15A 1tsnA-3v96B:
undetectable		 1tsnA-3v96B:
19.10
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1UTT_A_HAEA1265_1
(MACROPHAGE
METALLOELASTASE)		 3v96 STROMELYSIN-2
(Homo
sapiens) 		4 / 4 HIS B 217
GLU B 218
HIS B 221
HIS B 227
 ZN  B 301 (-3.2A)
ZN  B 301 ( 3.9A)
ZN  B 301 (-3.3A)
ZN  B 301 (-3.2A)
 0.33A 1uttA-3v96B:
29.6		 1uttA-3v96B:
58.12
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1UTZ_A_HAEA1267_1
(MACROPHAGE
METALLOELASTASE)		 3v96 STROMELYSIN-2
(Homo
sapiens) 		4 / 4 HIS B 217
GLU B 218
HIS B 221
HIS B 227
 ZN  B 301 (-3.2A)
ZN  B 301 ( 3.9A)
ZN  B 301 (-3.3A)
ZN  B 301 (-3.2A)
 0.26A 1utzA-3v96B:
30.2		 1utzA-3v96B:
58.12
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1UTZ_B_HAEB1266_1
(MACROPHAGE
METALLOELASTASE)		 3v96 STROMELYSIN-2
(Homo
sapiens) 		4 / 4 HIS B 217
GLU B 218
HIS B 221
HIS B 227
 ZN  B 301 (-3.2A)
ZN  B 301 ( 3.9A)
ZN  B 301 (-3.3A)
ZN  B 301 (-3.2A)
 0.29A 1utzB-3v96B:
30.3		 1utzB-3v96B:
58.12
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1Y93_A_HAEA301_1
(MACROPHAGE
METALLOELASTASE)		 3v96 STROMELYSIN-2
(Homo
sapiens) 		5 / 6 HIS B 182
HIS B 217
GLU B 218
HIS B 221
HIS B 227
 ZN  B 302 (-3.2A)
ZN  B 301 (-3.2A)
ZN  B 301 ( 3.9A)
ZN  B 301 (-3.3A)
ZN  B 301 (-3.2A)
 0.28A 1y93A-3v96B:
30.0		 1y93A-3v96B:
55.76
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2HU6_A_HAEA269_1
(MACROPHAGE
METALLOELASTASE)		 3v96 STROMELYSIN-2
(Homo
sapiens) 		4 / 4 HIS B 217
GLU B 218
HIS B 221
HIS B 227
 ZN  B 301 (-3.2A)
ZN  B 301 ( 3.9A)
ZN  B 301 (-3.3A)
ZN  B 301 (-3.2A)
 0.26A 2hu6A-3v96B:
30.2		 2hu6A-3v96B:
55.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JIH_A_097A1001_1
(ADAMTS-1)		 3v96 STROMELYSIN-2
(Homo
sapiens) 		5 / 9 LEU B 180
HIS B 217
GLU B 218
HIS B 221
HIS B 227
 None
ZN  B 301 (-3.2A)
ZN  B 301 ( 3.9A)
ZN  B 301 (-3.3A)
ZN  B 301 (-3.2A)
 0.38A 2jihA-3v96B:
10.4		 2jihA-3v96B:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JIH_B_097B1001_1
(ADAMTS-1)		 3v96 STROMELYSIN-2
(Homo
sapiens) 		5 / 8 LEU B 180
HIS B 217
GLU B 218
HIS B 221
HIS B 227
 None
ZN  B 301 (-3.2A)
ZN  B 301 ( 3.9A)
ZN  B 301 (-3.3A)
ZN  B 301 (-3.2A)
 0.45A 2jihB-3v96B:
10.6		 2jihB-3v96B:
20.26
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2OW9_A_HAEA502_1
(COLLAGENASE 3)		 3v96 STROMELYSIN-2
(Homo
sapiens) 		5 / 6 HIS B 182
HIS B 217
GLU B 218
HIS B 221
HIS B 227
 ZN  B 302 (-3.2A)
ZN  B 301 (-3.2A)
ZN  B 301 ( 3.9A)
ZN  B 301 (-3.3A)
ZN  B 301 (-3.2A)
 0.35A 2ow9A-3v96B:
28.9		 2ow9A-3v96B:
61.90
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2OW9_B_HAEB502_1
(COLLAGENASE 3)		 3v96 STROMELYSIN-2
(Homo
sapiens) 		4 / 4 HIS B 217
GLU B 218
HIS B 221
HIS B 227
 ZN  B 301 (-3.2A)
ZN  B 301 ( 3.9A)
ZN  B 301 (-3.3A)
ZN  B 301 (-3.2A)
 0.21A 2ow9B-3v96B:
29.2		 2ow9B-3v96B:
61.90
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2OZR_C_HAEC3001_1
(COLLAGENASE 3)		 3v96 STROMELYSIN-2
(Homo
sapiens) 		4 / 4 HIS B 217
GLU B 218
HIS B 221
HIS B 227
 ZN  B 301 (-3.2A)
ZN  B 301 ( 3.9A)
ZN  B 301 (-3.3A)
ZN  B 301 (-3.2A)
 0.19A 2ozrC-3v96B:
29.2		 2ozrC-3v96B:
61.90
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2OZR_D_HAED3002_1
(COLLAGENASE 3)		 3v96 STROMELYSIN-2
(Homo
sapiens) 		4 / 4 HIS B 217
GLU B 218
HIS B 221
HIS B 227
 ZN  B 301 (-3.2A)
ZN  B 301 ( 3.9A)
ZN  B 301 (-3.3A)
ZN  B 301 (-3.2A)
 0.15A 2ozrD-3v96B:
29.4		 2ozrD-3v96B:
61.90
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2OZR_E_HAEE3003_1
(COLLAGENASE 3)		 3v96 STROMELYSIN-2
(Homo
sapiens) 		4 / 4 HIS B 217
GLU B 218
HIS B 221
HIS B 227
 ZN  B 301 (-3.2A)
ZN  B 301 ( 3.9A)
ZN  B 301 (-3.3A)
ZN  B 301 (-3.2A)
 0.32A 2ozrE-3v96B:
28.9		 2ozrE-3v96B:
61.90
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2OZR_F_HAEF3004_1
(COLLAGENASE 3)		 3v96 STROMELYSIN-2
(Homo
sapiens) 		3 / 3 HIS B 217
HIS B 221
HIS B 227
 ZN  B 301 (-3.2A)
ZN  B 301 (-3.3A)
ZN  B 301 (-3.2A)
 0.30A 2ozrF-3v96B:
28.9		 2ozrF-3v96B:
61.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q0I_A_BEZA990_0
(QUINOLONE SIGNAL
RESPONSE PROTEIN)		 3v96 METALLOPROTEINASE
INHIBITOR 1
STROMELYSIN-2
(Homo
sapiens;
Homo
sapiens) 		4 / 8 ASP B 169
LEU B 190
HIS B 182
SER A  68
 ZN  B 302 (-2.1A)
None
ZN  B 302 (-3.2A)
None
 1.11A 2q0iA-3v96B:
undetectable		 2q0iA-3v96B:
20.72
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3BA0_A_HAEA477_1
(MACROPHAGE
METALLOELASTASE)		 3v96 STROMELYSIN-2
(Homo
sapiens) 		3 / 3 HIS B 182
GLU B 218
HIS B 221
 ZN  B 302 (-3.2A)
ZN  B 301 ( 3.9A)
ZN  B 301 (-3.3A)
 0.38A 3ba0A-3v96B:
27.2		 3ba0A-3v96B:
57.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HY7_A_097A801_1
(A DISINTEGRIN AND
METALLOPROTEINASE
WITH THROMBOSPONDIN
MOTIFS 5)		 3v96 STROMELYSIN-2
(Homo
sapiens) 		5 / 9 LEU B 180
HIS B 217
GLU B 218
HIS B 221
HIS B 227
 None
ZN  B 301 (-3.2A)
ZN  B 301 ( 3.9A)
ZN  B 301 (-3.3A)
ZN  B 301 (-3.2A)
 0.36A 3hy7A-3v96B:
10.8		 3hy7A-3v96B:
24.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HY7_B_097B801_1
(A DISINTEGRIN AND
METALLOPROTEINASE
WITH THROMBOSPONDIN
MOTIFS 5)		 3v96 STROMELYSIN-2
(Homo
sapiens) 		5 / 9 LEU B 180
HIS B 217
GLU B 218
HIS B 221
HIS B 227
 None
ZN  B 301 (-3.2A)
ZN  B 301 ( 3.9A)
ZN  B 301 (-3.3A)
ZN  B 301 (-3.2A)
 0.37A 3hy7B-3v96B:
10.7		 3hy7B-3v96B:
24.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JAY_A_SAMA1101_0
(STRUCTURAL PROTEIN
VP3)		 3v96 METALLOPROTEINASE
INHIBITOR 1
(Homo
sapiens) 		5 / 12 ASN A 106
GLU A  81
GLU A  82
VAL A  61
ILE A  85
 None
 1.35A 3jayA-3v96A:
undetectable		 3jayA-3v96A:
10.30
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3KEC_A_HAEA272_1
(COLLAGENASE 3)		 3v96 STROMELYSIN-2
(Homo
sapiens) 		4 / 5 HIS B 217
GLU B 218
HIS B 221
HIS B 227
 ZN  B 301 (-3.2A)
ZN  B 301 ( 3.9A)
ZN  B 301 (-3.3A)
ZN  B 301 (-3.2A)
 0.22A 3kecA-3v96B:
28.7		 3kecA-3v96B:
62.42
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3KEC_B_HAEB271_1
(COLLAGENASE 3)		 3v96 STROMELYSIN-2
(Homo
sapiens) 		3 / 3 HIS B 217
GLU B 218
HIS B 221
 ZN  B 301 (-3.2A)
ZN  B 301 ( 3.9A)
ZN  B 301 (-3.3A)
 0.14A 3kecB-3v96B:
28.9		 3kecB-3v96B:
62.42
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3LIK_A_HAEA302_1
(MACROPHAGE
METALLOELASTASE)		 3v96 STROMELYSIN-2
(Homo
sapiens) 		5 / 5 HIS B 182
HIS B 217
GLU B 218
HIS B 221
HIS B 227
 ZN  B 302 (-3.2A)
ZN  B 301 (-3.2A)
ZN  B 301 ( 3.9A)
ZN  B 301 (-3.3A)
ZN  B 301 (-3.2A)
 0.38A 3likA-3v96B:
30.1		 3likA-3v96B:
55.76
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3LIL_A_HAEA302_1
(MACROPHAGE
METALLOELASTASE)		 3v96 STROMELYSIN-2
(Homo
sapiens) 		4 / 4 HIS B 217
GLU B 218
HIS B 221
HIS B 227
 ZN  B 301 (-3.2A)
ZN  B 301 ( 3.9A)
ZN  B 301 (-3.3A)
ZN  B 301 (-3.2A)
 0.28A 3lilA-3v96B:
30.1		 3lilA-3v96B:
55.76
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3LJG_A_HAEA301_1
(MACROPHAGE
METALLOELASTASE)		 3v96 STROMELYSIN-2
(Homo
sapiens) 		4 / 5 HIS B 217
GLU B 218
HIS B 221
HIS B 227
 ZN  B 301 (-3.2A)
ZN  B 301 ( 3.9A)
ZN  B 301 (-3.3A)
ZN  B 301 (-3.2A)
 0.32A 3ljgA-3v96B:
29.9		 3ljgA-3v96B:
55.76
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3LKA_A_HAEA269_1
(MACROPHAGE
METALLOELASTASE)		 3v96 STROMELYSIN-2
(Homo
sapiens) 		5 / 5 HIS B 182
HIS B 217
GLU B 218
HIS B 221
HIS B 227
 ZN  B 302 (-3.2A)
ZN  B 301 (-3.2A)
ZN  B 301 ( 3.9A)
ZN  B 301 (-3.3A)
ZN  B 301 (-3.2A)
 0.36A 3lkaA-3v96B:
30.2		 3lkaA-3v96B:
57.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UA5_B_06XB502_1
(CYTOCHROME P450 2B6)		 3v96 METALLOPROTEINASE
INHIBITOR 1
(Homo
sapiens) 		5 / 10 LEU A 146
GLN A 160
LEU A 152
PRO A   5
VAL A 129
 None
 1.37A 3ua5B-3v96A:
undetectable		 3ua5B-3v96A:
16.81
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4A7B_A_HAEA1273_1
(COLLAGENASE 3)		 3v96 STROMELYSIN-2
(Homo
sapiens) 		5 / 6 HIS B 182
HIS B 217
GLU B 218
HIS B 221
HIS B 227
 ZN  B 302 (-3.2A)
ZN  B 301 (-3.2A)
ZN  B 301 ( 3.9A)
ZN  B 301 (-3.3A)
ZN  B 301 (-3.2A)
 0.35A 4a7bA-3v96B:
28.8		 4a7bA-3v96B:
62.42
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4A7B_B_HAEB1270_1
(COLLAGENASE 3)		 3v96 STROMELYSIN-2
(Homo
sapiens) 		4 / 5 HIS B 182
HIS B 217
GLU B 218
HIS B 221
 ZN  B 302 (-3.2A)
ZN  B 301 (-3.2A)
ZN  B 301 ( 3.9A)
ZN  B 301 (-3.3A)
 0.14A 4a7bB-3v96B:
29.5		 4a7bB-3v96B:
62.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FQS_A_LYAA302_1
(THYMIDYLATE SYNTHASE)		 3v96 STROMELYSIN-2
(Homo
sapiens) 		5 / 12 HIS B 195
ILE B 160
LEU B 211
VAL B 129
ALA B 128
 ZN  B 302 (-3.2A)
None
None
None
None
 1.25A 4fqsA-3v96B:
undetectable		 4fqsA-3v96B:
19.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LVC_B_ADNB501_2
(S-ADENOSYL-L-HOMOCYS
TEINE HYDROLASE
(SAHASE))		 3v96 STROMELYSIN-2
(Homo
sapiens) 		4 / 5 GLN B 259
THR B 144
LEU B 234
LEU B 250
 None
 0.99A 4lvcB-3v96B:
undetectable		 4lvcB-3v96B:
14.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OU1_A_BEZA302_0
(RETRO-ALDOLASE,
DESIGN RA114)		 3v96 STROMELYSIN-2
(Homo
sapiens) 		4 / 8 TYR B 115
ILE B 117
ILE B 160
ALA B 215
 None
 0.89A 4ou1A-3v96B:
undetectable		 4ou1A-3v96B:
21.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XQG_A_AG2A505_1
(HOMOSPERMIDINE
SYNTHASE)		 3v96 STROMELYSIN-2
(Homo
sapiens) 		4 / 8 ARG B 150
ARG B 126
ASP B 127
ASP B 130
 None
 0.87A 4xqgA-3v96B:
2.8		 4xqgA-3v96B:
16.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XQG_B_AG2B505_1
(HOMOSPERMIDINE
SYNTHASE)		 3v96 STROMELYSIN-2
(Homo
sapiens) 		4 / 8 ARG B 150
ARG B 126
ASP B 127
ASP B 130
 None
 0.88A 4xqgB-3v96B:
2.8		 4xqgB-3v96B:
16.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M5K_B_ADNB502_2
(ADENOSYLHOMOCYSTEINA
SE)		 3v96 STROMELYSIN-2
(Homo
sapiens) 		4 / 4 GLN B 259
THR B 144
LEU B 234
LEU B 250
 None
 0.98A 5m5kB-3v96B:
undetectable		 5m5kB-3v96B:
14.23
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5N5J_A_HAEA306_1
(MACROPHAGE
METALLOELASTASE)		 3v96 STROMELYSIN-2
(Homo
sapiens) 		4 / 4 HIS B 217
GLU B 218
HIS B 221
HIS B 227
 ZN  B 301 (-3.2A)
ZN  B 301 ( 3.9A)
ZN  B 301 (-3.3A)
ZN  B 301 (-3.2A)
 0.27A 5n5jA-3v96B:
30.2		 5n5jA-3v96B:
57.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5N5K_A_HAEA306_1
(MACROPHAGE
METALLOELASTASE)		 3v96 STROMELYSIN-2
(Homo
sapiens) 		4 / 5 HIS B 217
GLU B 218
HIS B 221
HIS B 227
 ZN  B 301 (-3.2A)
ZN  B 301 ( 3.9A)
ZN  B 301 (-3.3A)
ZN  B 301 (-3.2A)
 0.23A 5n5kA-3v96B:
30.0		 5n5kA-3v96B:
57.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NWW_A_ACAA18_2
(SCRFP-TAG,GP41)		 3v96 METALLOPROTEINASE
INHIBITOR 1
(Homo
sapiens) 		3 / 3 LYS A 157
TRP A 147
SER A 155
 PO4  A 202 (-4.0A)
None
None
 1.19A 5nwwA-3v96A:
undetectable		 5nwwA-3v96A:
14.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OEX_A_CUA602_0
(THIOCYANATE
DEHYDROGENASE)		 3v96 METALLOPROTEINASE
INHIBITOR 1
STROMELYSIN-2
(Homo
sapiens;
Homo
sapiens) 		3 / 3 LYS A   1
HIS B 217
HIS B 227
 ZN  B 301 (-2.9A)
ZN  B 301 (-3.2A)
ZN  B 301 (-3.2A)
 1.14A 5oexA-3v96A:
undetectable		 5oexA-3v96A:
16.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OEX_B_CUB602_0
(THIOCYANATE
DEHYDROGENASE)		 3v96 METALLOPROTEINASE
INHIBITOR 1
STROMELYSIN-2
(Homo
sapiens;
Homo
sapiens) 		3 / 3 LYS A   1
HIS B 217
HIS B 227
 ZN  B 301 (-2.9A)
ZN  B 301 (-3.2A)
ZN  B 301 (-3.2A)
 1.17A 5oexB-3v96A:
undetectable		 5oexB-3v96A:
16.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OEX_C_CUC603_0
(THIOCYANATE
DEHYDROGENASE)		 3v96 METALLOPROTEINASE
INHIBITOR 1
STROMELYSIN-2
(Homo
sapiens;
Homo
sapiens) 		3 / 3 LYS A   1
HIS B 217
HIS B 227
 ZN  B 301 (-2.9A)
ZN  B 301 (-3.2A)
ZN  B 301 (-3.2A)
 1.16A 5oexC-3v96A:
undetectable		 5oexC-3v96A:
16.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OEX_D_CUD603_0
(THIOCYANATE
DEHYDROGENASE)		 3v96 METALLOPROTEINASE
INHIBITOR 1
STROMELYSIN-2
(Homo
sapiens;
Homo
sapiens) 		3 / 3 LYS A   1
HIS B 217
HIS B 227
 ZN  B 301 (-2.9A)
ZN  B 301 (-3.2A)
ZN  B 301 (-3.2A)
 1.14A 5oexD-3v96A:
undetectable		 5oexD-3v96A:
16.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X80_A_SALA201_1
(UNCHARACTERIZED
HTH-TYPE
TRANSCRIPTIONAL
REGULATOR RV2887)		 3v96 STROMELYSIN-2
(Homo
sapiens) 		4 / 5 VAL B 143
PRO B 145
GLY B 263
TYR B 262
 None
 1.44A 5x80A-3v96B:
undetectable
5x80B-3v96B:
undetectable		 5x80A-3v96B:
19.65
5x80B-3v96B:
19.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X80_D_SALD201_1
(UNCHARACTERIZED
HTH-TYPE
TRANSCRIPTIONAL
REGULATOR RV2887)		 3v96 STROMELYSIN-2
(Homo
sapiens) 		4 / 5 PRO B 145
GLY B 263
TYR B 262
VAL B 143
 None
 1.43A 5x80C-3v96B:
undetectable
5x80D-3v96B:
undetectable		 5x80C-3v96B:
19.65
5x80D-3v96B:
19.65