SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3v98'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RG9_B_SAMB485_1
(S-ADENOSYLMETHIONINE
SYNTHETASE)		 3v98 ARACHIDONATE
5-LIPOXYGENASE
(Homo
sapiens) 		4 / 8 LYS A  71
THR A  12
PHE A  45
ASP A  21
 None
 1.15A 1rg9B-3v98A:
undetectable		 1rg9B-3v98A:
21.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RKY_A_CUA801_0
(LYSYL OXIDASE)		 3v98 ARACHIDONATE
5-LIPOXYGENASE
(Homo
sapiens) 		3 / 3 HIS A 372
HIS A 367
HIS A 550
 FE2  A 701 (-3.3A)
FE2  A 701 (-3.4A)
FE2  A 701 (-3.3A)
 0.69A 1rkyA-3v98A:
undetectable		 1rkyA-3v98A:
21.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1S9P_B_DESB459_2
(ESTROGEN-RELATED
RECEPTOR GAMMA)		 3v98 ARACHIDONATE
5-LIPOXYGENASE
(Homo
sapiens) 		3 / 3 LEU A 414
HIS A 372
ILE A 406
 None
FE2  A 701 (-3.3A)
None
 0.52A 1s9pB-3v98A:
undetectable		 1s9pB-3v98A:
17.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TKQ_B_DVAB8_0
(GRAMICIDIN A)		 3v98 ARACHIDONATE
5-LIPOXYGENASE
(Homo
sapiens) 		4 / 5 VAL A 581
GLY A 580
VAL A 582
TRP A 347
 None
 1.30A 1tkqB-3v98A:
undetectable		 1tkqB-3v98A:
4.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZQ9_A_SAMA4000_0
(PROBABLE
DIMETHYLADENOSINE
TRANSFERASE)		 3v98 ARACHIDONATE
5-LIPOXYGENASE
(Homo
sapiens) 		5 / 12 HIS A 130
ILE A 126
GLY A  30
VAL A   8
ILE A  85
 None
 1.27A 1zq9A-3v98A:
undetectable		 1zq9A-3v98A:
18.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2G70_A_SAMA2001_0
(PHENYLETHANOLAMINE
N-METHYLTRANSFERASE)		 3v98 ARACHIDONATE
5-LIPOXYGENASE
(Homo
sapiens) 		5 / 12 ASP A 358
VAL A 354
ALA A 324
CYH A 310
VAL A 284
 None
 1.45A 2g70A-3v98A:
undetectable		 2g70A-3v98A:
18.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QEU_B_ACTB141_0
(PUTATIVE
CARBOXYMUCONOLACTONE
DECARBOXYLASE)		 3v98 ARACHIDONATE
5-LIPOXYGENASE
(Homo
sapiens) 		3 / 3 PRO A 658
ASN A 652
ARG A 651
 None
 0.98A 2qeuB-3v98A:
undetectable		 2qeuB-3v98A:
11.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WEY_A_EV1A1771_1
(CAMP AND
CAMP-INHIBITED CGMP
3', 5'-CYCLIC
PHOSPHODIESTERASE)		 3v98 ARACHIDONATE
5-LIPOXYGENASE
(Homo
sapiens) 		5 / 12 LEU A 443
LEU A 448
VAL A 541
GLU A 376
PHE A 525
 None
 1.02A 2weyA-3v98A:
undetectable		 2weyA-3v98A:
17.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YQZ_A_SAMA301_0
(HYPOTHETICAL PROTEIN
TTHA0223)		 3v98 ARACHIDONATE
5-LIPOXYGENASE
(Homo
sapiens) 		5 / 12 GLY A 428
GLY A 430
ILE A 415
ALA A 294
ASP A 293
 None
 1.01A 2yqzA-3v98A:
2.7		 2yqzA-3v98A:
18.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG4_A_CUA517_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 3v98 ARACHIDONATE
5-LIPOXYGENASE
(Homo
sapiens) 		3 / 3 HIS A 550
HIS A 372
HIS A 367
 FE2  A 701 (-3.3A)
FE2  A 701 (-3.3A)
FE2  A 701 (-3.4A)
 0.73A 3ag4A-3v98A:
1.6		 3ag4A-3v98A:
20.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG4_N_CUN517_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 3v98 ARACHIDONATE
5-LIPOXYGENASE
(Homo
sapiens) 		3 / 3 HIS A 550
HIS A 372
HIS A 367
 FE2  A 701 (-3.3A)
FE2  A 701 (-3.3A)
FE2  A 701 (-3.4A)
 0.76A 3ag4N-3v98A:
undetectable		 3ag4N-3v98A:
20.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CLB_D_TMQD614_1
(DHFR-TS)		 3v98 ARACHIDONATE
5-LIPOXYGENASE
(Homo
sapiens) 		5 / 10 VAL A 647
ALA A 649
ILE A 667
PRO A 668
ILE A 644
 None
 1.21A 3clbD-3v98A:
undetectable		 3clbD-3v98A:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ELZ_B_CHDB153_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 3v98 ARACHIDONATE
5-LIPOXYGENASE
(Homo
sapiens) 		4 / 6 THR A 545
PHE A 378
PHE A 525
TYR A 445
 None
 1.25A 3elzB-3v98A:
undetectable		 3elzB-3v98A:
11.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FI0_B_TRPB1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 3v98 ARACHIDONATE
5-LIPOXYGENASE
(Homo
sapiens) 		4 / 8 GLY A 430
ASP A 293
ILE A 292
GLN A 437
 None
 0.69A 3fi0B-3v98A:
undetectable		 3fi0B-3v98A:
20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FI0_P_TRPP1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 3v98 ARACHIDONATE
5-LIPOXYGENASE
(Homo
sapiens) 		4 / 7 GLY A 430
ASP A 293
ILE A 292
GLN A 437
 None
 0.78A 3fi0P-3v98A:
undetectable		 3fi0P-3v98A:
20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FRQ_B_ERYB195_1
(REPRESSOR PROTEIN
MPHR(A))		 3v98 ARACHIDONATE
5-LIPOXYGENASE
(Homo
sapiens) 		4 / 7 ASN A 180
TYR A 181
ASN A 554
HIS A 367
 None
None
FE2  A 701 (-3.8A)
FE2  A 701 (-3.4A)
 1.13A 3frqB-3v98A:
0.9		 3frqB-3v98A:
15.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GWX_A_EPAA1_1
(PROTEIN (PEROXISOME
PROLIFERATOR
ACTIVATED RECEPTOR
(PPAR-DELTA)))		 3v98 ARACHIDONATE
5-LIPOXYGENASE
(Homo
sapiens) 		5 / 10 VAL A  10
ILE A 626
LEU A 111
VAL A  67
LEU A  82
 None
 1.00A 3gwxA-3v98A:
undetectable		 3gwxA-3v98A:
16.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HBB_D_TMQD614_1
(DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 3v98 ARACHIDONATE
5-LIPOXYGENASE
(Homo
sapiens) 		5 / 10 VAL A 647
ALA A 649
ILE A 667
PRO A 668
ILE A 644
 None
 1.25A 3hbbD-3v98A:
undetectable		 3hbbD-3v98A:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NRR_B_D16B520_1
(DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 3v98 ARACHIDONATE
5-LIPOXYGENASE
(Homo
sapiens) 		5 / 12 ALA A 426
HIS A 600
ARG A 355
THR A 590
THR A 427
 None
 1.14A 3nrrB-3v98A:
undetectable		 3nrrB-3v98A:
21.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R4X_A_PZAA598_0
(LACTOPEROXIDASE)		 3v98 ARACHIDONATE
5-LIPOXYGENASE
(Homo
sapiens) 		4 / 5 PHE A 637
ARG A 638
GLU A 642
PRO A 664
 None
 0.92A 3r4xA-3v98A:
undetectable		 3r4xA-3v98A:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZJQ_A_NCAA300_0
(PROTOGLOBIN)		 3v98 ARACHIDONATE
5-LIPOXYGENASE
(Homo
sapiens) 		4 / 7 TYR A 538
VAL A 541
PHE A 378
VAL A 512
 None
 0.90A 3zjqA-3v98A:
undetectable		 3zjqA-3v98A:
12.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZJQ_B_NCAB300_0
(PROTOGLOBIN)		 3v98 ARACHIDONATE
5-LIPOXYGENASE
(Homo
sapiens) 		4 / 7 TYR A 538
VAL A 541
PHE A 378
VAL A 512
 None
 0.90A 3zjqB-3v98A:
undetectable		 3zjqB-3v98A:
12.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AN2_A_EUIA1382_2
(DUAL SPECIFICITY
MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE 1)		 3v98 ARACHIDONATE
5-LIPOXYGENASE
(Homo
sapiens) 		4 / 4 ASN A 407
SER A 608
LEU A 607
THR A 403
 None
 1.37A 4an2A-3v98A:
undetectable		 4an2A-3v98A:
18.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E7C_A_ACTA504_0
(UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE)		 3v98 ARACHIDONATE
5-LIPOXYGENASE
(Homo
sapiens) 		3 / 3 ARG A 355
TRP A 560
GLY A 239
 None
 0.75A 4e7cA-3v98A:
undetectable		 4e7cA-3v98A:
22.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G10_A_ACTA301_0
(GLUTATHIONE
S-TRANSFERASE
HOMOLOG)		 3v98 ARACHIDONATE
5-LIPOXYGENASE
(Homo
sapiens) 		4 / 6 PRO A 242
ILE A 454
TYR A 659
PHE A 450
 None
 1.03A 4g10A-3v98A:
undetectable		 4g10A-3v98A:
16.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKX_D_STRD601_2
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 3v98 ARACHIDONATE
5-LIPOXYGENASE
(Homo
sapiens) 		4 / 5 ILE A 155
ASP A 511
GLU A 376
VAL A 400
 None
 1.26A 4nkxD-3v98A:
undetectable		 4nkxD-3v98A:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XV2_A_P06A801_2
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 3v98 ARACHIDONATE
5-LIPOXYGENASE
(Homo
sapiens) 		4 / 4 GLY A  13
LEU A 111
PHE A  97
ILE A  85
 None
 0.88A 4xv2A-3v98A:
undetectable		 4xv2A-3v98A:
18.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZJL_A_ERYA1101_0
(MULTIDRUG EFFLUX
PUMP SUBUNIT ACRB)		 3v98 ARACHIDONATE
5-LIPOXYGENASE
(Homo
sapiens) 		5 / 12 PHE A 151
GLU A 417
LEU A 368
THR A 427
GLY A 428
 None
 1.19A 4zjlA-3v98A:
undetectable		 4zjlA-3v98A:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZVM_A_DM2A303_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 3v98 ARACHIDONATE
5-LIPOXYGENASE
(Homo
sapiens) 		5 / 12 GLY A 430
GLY A 431
THR A 427
ILE A 415
PHE A 151
 None
 1.07A 4zvmA-3v98A:
undetectable
4zvmB-3v98A:
undetectable		 4zvmA-3v98A:
15.87
4zvmB-3v98A:
15.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5H5F_A_SAMA301_0
(PROTEIN ARGININE
N-METHYLTRANSFERASE
SFM1)		 3v98 ARACHIDONATE
5-LIPOXYGENASE
(Homo
sapiens) 		5 / 12 PHE A 544
GLY A 618
ARG A 638
LEU A 662
ALA A 548
 None
 1.03A 5h5fA-3v98A:
undetectable		 5h5fA-3v98A:
17.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KBW_B_RBFB201_1
(RIBOFLAVIN
TRANSPORTER RIBU)		 3v98 ARACHIDONATE
5-LIPOXYGENASE
(Homo
sapiens) 		5 / 12 GLY A 239
ASN A 241
ALA A 567
ASN A 566
TYR A 234
 None
 1.36A 5kbwB-3v98A:
1.2		 5kbwB-3v98A:
14.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VLM_F_CVIF301_1
(REGULATORY PROTEIN
TETR)		 3v98 ARACHIDONATE
5-LIPOXYGENASE
(Homo
sapiens) 		4 / 8 GLN A 141
TYR A 142
VAL A 109
ASP A  22
 None
 1.12A 5vlmF-3v98A:
undetectable		 5vlmF-3v98A:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y2T_A_8LXA501_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 3v98 ARACHIDONATE
5-LIPOXYGENASE
(Homo
sapiens) 		3 / 3 SER A 547
HIS A 399
TYR A 620
 None
 0.98A 5y2tA-3v98A:
undetectable		 5y2tA-3v98A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CK2_C_IPHC101_0
(INSULIN A CHAIN
INSULIN B CHAIN)		 3v98 ARACHIDONATE
5-LIPOXYGENASE
(Homo
sapiens) 		4 / 4 ILE A 352
LEU A 327
HIS A 360
ALA A 306
 None
 1.03A 6ck2C-3v98A:
undetectable
6ck2D-3v98A:
undetectable		 6ck2C-3v98A:
4.22
6ck2D-3v98A:
4.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EFN_A_SAMA501_0
(SPORULATION KILLING
FACTOR MATURATION
PROTEIN SKFB)		 3v98 ARACHIDONATE
5-LIPOXYGENASE
(Homo
sapiens) 		5 / 11 TYR A  94
ALA A  11
THR A   9
THR A   7
LEU A  87
 None
 1.38A 6efnA-3v98A:
undetectable		 6efnA-3v98A:
19.57