SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3vab'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IOL_A_ESTA400_1
(ESTROGENIC 17-BETA
HYDROXYSTEROID
DEHYDROGENASE)		 3vab DIAMINOPIMELATE
DECARBOXYLASE 1
(Brucella
melitensis) 		5 / 11 VAL A 282
GLY A 283
TYR A 245
GLY A 278
GLU A 392
 None
None
None
LLP  A  61 ( 3.5A)
None
 1.34A 1iolA-3vabA:
2.2		 1iolA-3vabA:
23.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MAA_B_DMEB996_1
(ACETYLCHOLINESTERASE)		 3vab DIAMINOPIMELATE
DECARBOXYLASE 1
(Brucella
melitensis) 		4 / 6 GLU A  86
ILE A  38
TYR A  33
GLY A 286
 LLP  A  61 ( 3.5A)
None
None
None
 1.09A 1maaB-3vabA:
undetectable
1maaD-3vabA:
undetectable		 1maaB-3vabA:
21.99
1maaD-3vabA:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OT7_B_IU5B1002_1
(BILE ACID RECEPTOR)		 3vab DIAMINOPIMELATE
DECARBOXYLASE 1
(Brucella
melitensis) 		5 / 12 LEU A 280
HIS A 200
SER A 203
ILE A 205
ILE A 243
 None
LLP  A  61 ( 3.6A)
LLP  A  61 ( 2.5A)
None
None
 1.25A 1ot7B-3vabA:
undetectable		 1ot7B-3vabA:
18.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QHS_A_CLMA888_0
(PROTEIN
(CHLORAMPHENICOL
PHOSPHOTRANSFERASE))		 3vab DIAMINOPIMELATE
DECARBOXYLASE 1
(Brucella
melitensis) 		4 / 5 PRO A 175
LYS A 178
ALA A 181
GLU A 128
 None
 1.02A 1qhsA-3vabA:
0.3		 1qhsA-3vabA:
19.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QHS_A_CLMA888_0
(PROTEIN
(CHLORAMPHENICOL
PHOSPHOTRANSFERASE))		 3vab DIAMINOPIMELATE
DECARBOXYLASE 1
(Brucella
melitensis) 		4 / 5 PRO A 175
LYS A 178
ALA A 182
GLU A 128
 None
 1.41A 1qhsA-3vabA:
0.3		 1qhsA-3vabA:
19.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QHY_A_CLMA888_0
(CHLORAMPHENICOL
PHOSPHOTRANSFERASE)		 3vab DIAMINOPIMELATE
DECARBOXYLASE 1
(Brucella
melitensis) 		4 / 6 PRO A 175
LYS A 178
ALA A 181
GLU A 128
 None
 1.39A 1qhyA-3vabA:
undetectable		 1qhyA-3vabA:
19.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QZZ_A_ACTA421_0
(ACLACINOMYCIN-10-HYD
ROXYLASE)		 3vab DIAMINOPIMELATE
DECARBOXYLASE 1
(Brucella
melitensis) 		4 / 8 TYR A  58
GLY A 283
GLY A 278
LEU A 280
 None
None
LLP  A  61 ( 3.5A)
None
 0.66A 1qzzA-3vabA:
undetectable		 1qzzA-3vabA:
24.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RLB_F_REAF177_1
(RETINOL BINDING
PROTEIN)		 3vab DIAMINOPIMELATE
DECARBOXYLASE 1
(Brucella
melitensis) 		5 / 11 ALA A 140
ALA A 138
VAL A 147
LEU A 149
LEU A 131
 None
 1.10A 1rlbF-3vabA:
undetectable		 1rlbF-3vabA:
17.66
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1TUF_A_AZ1A502_1
(DIAMINOPIMELATE
DECARBOXYLASE)		 3vab DIAMINOPIMELATE
DECARBOXYLASE 1
(Brucella
melitensis) 		6 / 9 HIS A 200
GLY A 202
SER A 203
ARG A 279
ARG A 315
TYR A 319
 LLP  A  61 ( 3.6A)
None
LLP  A  61 ( 2.5A)
None
None
None
 0.62A 1tufA-3vabA:
50.0
1tufB-3vabA:
50.2		 1tufA-3vabA:
37.04
1tufB-3vabA:
37.04
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1TUF_B_AZ1B503_1
(DIAMINOPIMELATE
DECARBOXYLASE)		 3vab DIAMINOPIMELATE
DECARBOXYLASE 1
(Brucella
melitensis) 		5 / 6 SER A 203
ARG A 279
ARG A 315
TYR A 319
TYR A 376
 LLP  A  61 ( 2.5A)
None
None
None
LLP  A  61 ( 4.6A)
 0.67A 1tufA-3vabA:
50.0
1tufB-3vabA:
50.2		 1tufA-3vabA:
37.04
1tufB-3vabA:
37.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TYR_A_9CRA131_1
(TRANSTHYRETIN)		 3vab DIAMINOPIMELATE
DECARBOXYLASE 1
(Brucella
melitensis) 		4 / 6 LEU A  69
ALA A  79
LEU A  72
THR A  57
 None
 1.19A 1tyrA-3vabA:
undetectable		 1tyrA-3vabA:
16.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXG_A_IBPA2002_1
(SERUM ALBUMIN)		 3vab DIAMINOPIMELATE
DECARBOXYLASE 1
(Brucella
melitensis) 		4 / 8 ALA A  14
GLU A  21
LEU A 394
VAL A 393
 None
 0.85A 2bxgA-3vabA:
undetectable		 2bxgA-3vabA:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F9W_A_PAUA6001_0
(PANTOTHENATE KINASE)		 3vab DIAMINOPIMELATE
DECARBOXYLASE 1
(Brucella
melitensis) 		5 / 11 ASN A 311
VAL A 346
GLY A 344
ASP A 351
THR A 290
 None
 1.31A 2f9wA-3vabA:
undetectable
2f9wB-3vabA:
undetectable		 2f9wA-3vabA:
22.89
2f9wB-3vabA:
22.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HMY_B_SAMB328_0
(PROTEIN
(CYTOSINE-SPECIFIC
METHYLTRANSFERASE
HHAI))		 3vab DIAMINOPIMELATE
DECARBOXYLASE 1
(Brucella
melitensis) 		5 / 12 GLY A 240
GLY A 278
ASP A 212
PRO A 253
TYR A 376
 LLP  A  61 ( 3.3A)
LLP  A  61 ( 3.5A)
None
None
LLP  A  61 ( 4.6A)
 1.09A 2hmyB-3vabA:
undetectable		 2hmyB-3vabA:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q6K_A_ADNA699_1
(CHLORINASE)		 3vab DIAMINOPIMELATE
DECARBOXYLASE 1
(Brucella
melitensis) 		4 / 7 ASP A 341
PHE A 303
TYR A 352
THR A 349
 EDO  A 424 (-3.8A)
EDO  A 424 (-4.6A)
EDO  A 424 ( 4.8A)
None
 1.34A 2q6kA-3vabA:
undetectable		 2q6kA-3vabA:
23.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QD5_A_CHDA701_0
(FERROCHELATASE)		 3vab DIAMINOPIMELATE
DECARBOXYLASE 1
(Brucella
melitensis) 		4 / 8 LEU A  55
SER A 103
VAL A 195
GLY A 196
 None
LLP  A  61 ( 3.9A)
None
None
 1.11A 2qd5A-3vabA:
2.8		 2qd5A-3vabA:
21.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CYX_A_ROCA201_4
(HIV-1 PROTEASE)		 3vab DIAMINOPIMELATE
DECARBOXYLASE 1
(Brucella
melitensis) 		4 / 4 LEU A 313
ASP A 341
VAL A 306
THR A 290
 None
EDO  A 424 (-3.8A)
None
None
 1.10A 3cyxB-3vabA:
undetectable		 3cyxB-3vabA:
13.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HS6_B_EPAB1_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 3vab DIAMINOPIMELATE
DECARBOXYLASE 1
(Brucella
melitensis) 		5 / 12 ILE A  22
GLY A 286
ALA A 285
SER A  34
GLY A 395
 None
 0.90A 3hs6B-3vabA:
undetectable		 3hs6B-3vabA:
20.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3M6V_A_SAMA465_0
(RRNA METHYLASE)		 3vab DIAMINOPIMELATE
DECARBOXYLASE 1
(Brucella
melitensis) 		5 / 12 GLY A 239
GLY A 238
VAL A 282
ASP A  80
LEU A  69
 LLP  A  61 ( 3.6A)
LLP  A  61 ( 4.8A)
None
LLP  A  61 ( 4.0A)
None
 1.05A 3m6vA-3vabA:
undetectable		 3m6vA-3vabA:
23.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3M6V_B_SAMB465_0
(RRNA METHYLASE)		 3vab DIAMINOPIMELATE
DECARBOXYLASE 1
(Brucella
melitensis) 		5 / 12 GLY A 239
GLY A 238
VAL A 282
ASP A  80
LEU A  69
 LLP  A  61 ( 3.6A)
LLP  A  61 ( 4.8A)
None
LLP  A  61 ( 4.0A)
None
 1.06A 3m6vB-3vabA:
undetectable		 3m6vB-3vabA:
23.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N2O_B_AG2B1002_1
(BIOSYNTHETIC
ARGININE
DECARBOXYLASE)		 3vab DIAMINOPIMELATE
DECARBOXYLASE 1
(Brucella
melitensis) 		5 / 9 HIS A 200
GLY A 202
SER A 203
TYR A 376
LEU A 380
 LLP  A  61 ( 3.6A)
None
LLP  A  61 ( 2.5A)
LLP  A  61 ( 4.6A)
None
 0.79A 3n2oA-3vabA:
28.1
3n2oB-3vabA:
28.2		 3n2oA-3vabA:
24.25
3n2oB-3vabA:
24.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N2O_D_AG2D1002_1
(BIOSYNTHETIC
ARGININE
DECARBOXYLASE)		 3vab DIAMINOPIMELATE
DECARBOXYLASE 1
(Brucella
melitensis) 		5 / 10 HIS A 200
GLY A 202
ARG A 279
TYR A 376
LEU A 380
 LLP  A  61 ( 3.6A)
None
None
LLP  A  61 ( 4.6A)
None
 0.64A 3n2oC-3vabA:
28.1
3n2oD-3vabA:
28.1		 3n2oC-3vabA:
24.25
3n2oD-3vabA:
24.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OWX_B_XRAB233_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 3vab DIAMINOPIMELATE
DECARBOXYLASE 1
(Brucella
melitensis) 		5 / 11 PHE A  49
PHE A  45
GLY A 238
GLY A 239
ILE A 201
 None
None
LLP  A  61 ( 4.8A)
LLP  A  61 ( 3.6A)
None
 1.27A 3owxA-3vabA:
undetectable
3owxB-3vabA:
undetectable		 3owxA-3vabA:
20.95
3owxB-3vabA:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RUN_A_CCSA165_0
(LYSOZYME)		 3vab DIAMINOPIMELATE
DECARBOXYLASE 1
(Brucella
melitensis) 		3 / 3 ASN A 302
ALA A 340
LYS A 301
 None
None
EDO  A 424 ( 3.7A)
 0.98A 3runA-3vabA:
undetectable		 3runA-3vabA:
17.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S45_B_478B201_1
(PROTEASE)		 3vab DIAMINOPIMELATE
DECARBOXYLASE 1
(Brucella
melitensis) 		5 / 9 ILE A 370
GLY A 344
ILE A 305
ILE A 368
ILE A 325
 None
 1.02A 3s45A-3vabA:
undetectable		 3s45A-3vabA:
12.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V3N_B_MIYB2001_1
(TETX2 PROTEIN)		 3vab DIAMINOPIMELATE
DECARBOXYLASE 1
(Brucella
melitensis) 		4 / 8 GLN A 204
GLY A 242
GLY A 286
ASN A  63
 None
 0.93A 3v3nB-3vabA:
undetectable		 3v3nB-3vabA:
23.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V3N_C_MIYC2001_1
(TETX2 PROTEIN)		 3vab DIAMINOPIMELATE
DECARBOXYLASE 1
(Brucella
melitensis) 		4 / 8 GLN A 204
GLY A 242
GLY A 286
ASN A  63
 None
 0.93A 3v3nC-3vabA:
undetectable		 3v3nC-3vabA:
23.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BLV_A_SAMA1281_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE J)		 3vab DIAMINOPIMELATE
DECARBOXYLASE 1
(Brucella
melitensis) 		5 / 12 ASP A 198
HIS A 234
GLY A 239
LEU A 271
GLY A 196
 None
None
LLP  A  61 ( 3.6A)
None
None
 1.14A 4blvA-3vabA:
undetectable		 4blvA-3vabA:
23.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CD2_A_FOLA207_0
(DIHYDROFOLATE
REDUCTASE)		 3vab DIAMINOPIMELATE
DECARBOXYLASE 1
(Brucella
melitensis) 		5 / 12 ALA A 308
ILE A 325
THR A 317
PHE A 322
LEU A 355
 None
 1.28A 4cd2A-3vabA:
undetectable		 4cd2A-3vabA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D7B_A_TCWA1126_1
(TRANSTHYRETIN)		 3vab DIAMINOPIMELATE
DECARBOXYLASE 1
(Brucella
melitensis) 		4 / 6 LEU A  69
ALA A  79
LEU A  72
THR A  57
 None
 1.20A 4d7bB-3vabA:
undetectable		 4d7bB-3vabA:
16.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FGL_A_CLQA303_0
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 3vab DIAMINOPIMELATE
DECARBOXYLASE 1
(Brucella
melitensis) 		5 / 12 GLY A 238
GLY A 239
ILE A 201
PHE A  49
PHE A  45
 LLP  A  61 ( 4.8A)
LLP  A  61 ( 3.6A)
None
None
None
 1.25A 4fglA-3vabA:
undetectable
4fglB-3vabA:
undetectable		 4fglA-3vabA:
20.70
4fglB-3vabA:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FGL_A_CLQA303_0
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 3vab DIAMINOPIMELATE
DECARBOXYLASE 1
(Brucella
melitensis) 		5 / 12 GLY A 239
GLY A 240
ILE A 201
VAL A 235
PHE A  45
 LLP  A  61 ( 3.6A)
LLP  A  61 ( 3.3A)
None
None
None
 1.26A 4fglA-3vabA:
undetectable
4fglB-3vabA:
undetectable		 4fglA-3vabA:
20.70
4fglB-3vabA:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4POO_B_SAMB301_0
(PUTATIVE RNA
METHYLASE)		 3vab DIAMINOPIMELATE
DECARBOXYLASE 1
(Brucella
melitensis) 		5 / 12 THR A 372
GLY A 374
ASN A  63
ILE A 370
ASN A 284
 None
 1.18A 4pooB-3vabA:
undetectable		 4pooB-3vabA:
19.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QB9_E_PARE500_1
(ENHANCED
INTRACELLULAR
SURVIVAL PROTEIN)		 3vab DIAMINOPIMELATE
DECARBOXYLASE 1
(Brucella
melitensis) 		5 / 12 LEU A 388
TYR A 409
GLU A 291
ASP A 307
GLY A  27
 None
 1.46A 4qb9E-3vabA:
undetectable		 4qb9E-3vabA:
24.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R1Z_A_AERA601_1
(CYP17A1 PROTEIN)		 3vab DIAMINOPIMELATE
DECARBOXYLASE 1
(Brucella
melitensis) 		5 / 9 ALA A  93
ILE A 281
GLY A  78
ALA A  79
THR A  81
 None
 1.02A 4r1zA-3vabA:
undetectable		 4r1zA-3vabA:
22.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YBN_A_ACTA303_0
(FLAVIN-NUCLEOTIDE-BI
NDING PROTEIN)		 3vab DIAMINOPIMELATE
DECARBOXYLASE 1
(Brucella
melitensis) 		3 / 3 VAL A 194
TYR A 183
ALA A 186
 None
 0.51A 4ybnA-3vabA:
undetectable		 4ybnA-3vabA:
22.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZE2_A_1YNA602_2
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 3vab DIAMINOPIMELATE
DECARBOXYLASE 1
(Brucella
melitensis) 		4 / 5 ALA A 257
TYR A 258
PRO A 210
PHE A 215
 None
 1.18A 4ze2A-3vabA:
undetectable		 4ze2A-3vabA:
22.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZVM_A_DM2A303_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 3vab DIAMINOPIMELATE
DECARBOXYLASE 1
(Brucella
melitensis) 		5 / 12 GLY A 238
GLY A 239
ILE A 201
PHE A  49
PHE A  45
 LLP  A  61 ( 4.8A)
LLP  A  61 ( 3.6A)
None
None
None
 1.19A 4zvmA-3vabA:
undetectable
4zvmB-3vabA:
undetectable		 4zvmA-3vabA:
20.75
4zvmB-3vabA:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZVM_B_DM2B303_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 3vab DIAMINOPIMELATE
DECARBOXYLASE 1
(Brucella
melitensis) 		5 / 11 PHE A  49
PHE A  45
GLY A 238
GLY A 239
ILE A 201
 None
None
LLP  A  61 ( 4.8A)
LLP  A  61 ( 3.6A)
None
 1.19A 4zvmA-3vabA:
undetectable
4zvmB-3vabA:
undetectable		 4zvmA-3vabA:
20.75
4zvmB-3vabA:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HIE_B_P06B801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 3vab DIAMINOPIMELATE
DECARBOXYLASE 1
(Brucella
melitensis) 		5 / 12 GLY A 242
ALA A  62
PHE A  45
ILE A 281
GLY A 239
 None
LLP  A  61 ( 3.7A)
None
None
LLP  A  61 ( 3.6A)
 0.83A 5hieB-3vabA:
undetectable		 5hieB-3vabA:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KIR_B_RCXB601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 3vab DIAMINOPIMELATE
DECARBOXYLASE 1
(Brucella
melitensis) 		5 / 12 VAL A 379
SER A  64
ALA A  67
GLY A 374
ALA A 375
 LLP  A  61 (-4.3A)
None
None
None
None
 1.07A 5kirB-3vabA:
undetectable		 5kirB-3vabA:
22.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L4I_B_6J3B201_0
(TRANSTHYRETIN)		 3vab DIAMINOPIMELATE
DECARBOXYLASE 1
(Brucella
melitensis) 		4 / 6 LEU A  69
ALA A  79
LEU A  72
THR A  57
 None
 1.19A 5l4iB-3vabA:
undetectable		 5l4iB-3vabA:
16.47