SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3vac'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QW6_A_H4BA901_1
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 3vac CFA/I FIMBRIAL
SUBUNIT E
(Escherichia
coli) 		3 / 3 ARG A  41
VAL A 196
TRP A 171
 None
 0.90A 1qw6A-3vacA:
undetectable		 1qw6A-3vacA:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QWC_A_H4BA901_1
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 3vac CFA/I FIMBRIAL
SUBUNIT E
(Escherichia
coli) 		3 / 3 ARG A  41
VAL A 196
TRP A 171
 None
 0.94A 1qwcA-3vacA:
undetectable		 1qwcA-3vacA:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RU9_H_ACTH611_0
(IMMUNOGLOBULIN
IGG2A, HEAVY CHAIN
IMMUNOGLOBULIN
IGG2A, LIGHT CHAIN)		 3vac CFA/I FIMBRIAL
SUBUNIT E
(Escherichia
coli) 		4 / 6 LEU A 285
TRP A 327
LEU A 250
PHE A 353
 None
 1.46A 1ru9H-3vacA:
3.9
1ru9L-3vacA:
4.1		 1ru9H-3vacA:
21.18
1ru9L-3vacA:
21.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RUK_H_BEZH601_0
(IMMUNOGLOBULIN
IGG2A, HEAVY CHAIN
IMMUNOGLOBULIN
IGG2A, LIGHT CHAIN)		 3vac CFA/I FIMBRIAL
SUBUNIT E
(Escherichia
coli) 		4 / 8 ALA A 373
TYR A 345
LEU A 219
GLY A 231
 None
 0.82A 1rukH-3vacA:
3.8
1rukL-3vacA:
4.1		 1rukH-3vacA:
21.18
1rukL-3vacA:
21.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RUK_L_ACTL611_0
(IMMUNOGLOBULIN
IGG2A, HEAVY CHAIN
IMMUNOGLOBULIN
IGG2A, LIGHT CHAIN)		 3vac CFA/I FIMBRIAL
SUBUNIT E
(Escherichia
coli) 		4 / 6 LEU A 285
TRP A 327
LEU A 250
PHE A 353
 None
 1.47A 1rukH-3vacA:
3.8
1rukL-3vacA:
4.1		 1rukH-3vacA:
21.18
1rukL-3vacA:
21.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VAG_A_H4BA901_1
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 3vac CFA/I FIMBRIAL
SUBUNIT E
(Escherichia
coli) 		3 / 3 ARG A  41
VAL A 196
TRP A 171
 None
 0.90A 1vagA-3vacA:
undetectable		 1vagA-3vacA:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZVI_A_H4BA901_1
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 3vac CFA/I FIMBRIAL
SUBUNIT E
(Escherichia
coli) 		3 / 3 ARG A  41
VAL A 196
TRP A 171
 None
 0.90A 1zviA-3vacA:
undetectable		 1zviA-3vacA:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J9D_A_ACTA1117_0
(HYPOTHETICAL
NITROGEN REGULATORY
PII-LIKE PROTEIN
MJ0059)		 3vac CFA/I FIMBRIAL
SUBUNIT E
(Escherichia
coli) 		3 / 3 ASP A 184
ARG A 182
ARG A  67
 None
 1.08A 2j9dA-3vacA:
undetectable
2j9dC-3vacA:
undetectable		 2j9dA-3vacA:
12.96
2j9dC-3vacA:
12.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OTH_A_IMNA301_1
(PHOSPHOLIPASE A2
VRV-PL-VIIIA)		 3vac CFA/I FIMBRIAL
SUBUNIT E
(Escherichia
coli) 		3 / 3 ASP A  24
TYR A  58
LYS A 126
 None
 1.13A 2othA-3vacA:
undetectable		 2othA-3vacA:
13.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K4V_B_ROCB201_4
(HIV-1 PROTEASE)		 3vac CFA/I FIMBRIAL
SUBUNIT E
(Escherichia
coli) 		4 / 4 ARG A 232
ASP A 256
GLY A 263
THR A 291
 None
 1.49A 3k4vB-3vacA:
undetectable		 3k4vB-3vacA:
14.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3O01_B_DXCB1_0
(CELL INVASION
PROTEIN SIPD)		 3vac CFA/I FIMBRIAL
SUBUNIT E
(Escherichia
coli) 		5 / 9 ILE A 351
PHE A 211
ASN A 233
ASN A 348
VAL A 371
 None
 1.41A 3o01A-3vacA:
undetectable
3o01B-3vacA:
undetectable		 3o01A-3vacA:
21.08
3o01B-3vacA:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OZU_A_X89A411_1
(FLAVOHEMOPROTEIN)		 3vac CFA/I FIMBRIAL
SUBUNIT E
(Escherichia
coli) 		5 / 12 PHE A 254
ALA A 215
VAL A 371
LEU A 281
ALA A 335
 None
 1.06A 3ozuA-3vacA:
undetectable		 3ozuA-3vacA:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PGY_A_GLYA510_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 3vac CFA/I FIMBRIAL
SUBUNIT E
(Escherichia
coli) 		4 / 6 ILE A 157
GLU A 161
ALA A 159
ASN A 163
 None
 1.10A 3pgyA-3vacA:
undetectable
3pgyB-3vacA:
undetectable		 3pgyA-3vacA:
21.57
3pgyB-3vacA:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MJW_A_ACTA603_0
(CHOLINE OXIDASE)		 3vac CFA/I FIMBRIAL
SUBUNIT E
(Escherichia
coli) 		3 / 3 ARG A 182
HIS A 140
SER A  69
 None
 0.93A 4mjwA-3vacA:
undetectable
4mjwB-3vacA:
undetectable		 4mjwA-3vacA:
20.76
4mjwB-3vacA:
20.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MJW_B_ACTB603_0
(CHOLINE OXIDASE)		 3vac CFA/I FIMBRIAL
SUBUNIT E
(Escherichia
coli) 		3 / 3 SER A  69
ARG A 182
HIS A 140
 None
 0.94A 4mjwA-3vacA:
undetectable
4mjwB-3vacA:
undetectable		 4mjwA-3vacA:
20.76
4mjwB-3vacA:
20.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FVO_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3vac CFA/I FIMBRIAL
SUBUNIT E
(Escherichia
coli) 		3 / 3 ARG A  41
VAL A 196
TRP A 171
 None
 0.99A 5fvoA-3vacA:
undetectable		 5fvoA-3vacA:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F88_A_STRA502_1
(CYTOCHROME P450
CYP260A1)		 3vac CFA/I FIMBRIAL
SUBUNIT E
(Escherichia
coli) 		5 / 6 PHE A 123
ALA A 151
SER A 154
THR A  98
ASN A 137
 None
 1.42A 6f88A-3vacA:
undetectable		 6f88A-3vacA:
12.50