SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3vax'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E7B_A_HLTA4002_1
(SERUM ALBUMIN)		 3vax PUTATIVE
UNCHARACTERIZED
PROTEIN DNDA
(Streptomyces
lividans) 		4 / 4 ARG A  49
ALA A  53
ALA A 209
GLU A 235
 None
 1.21A 1e7bA-3vaxA:
undetectable		 1e7bA-3vaxA:
20.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TDR_B_MTXB170_1
(TELLUROMETHIONYL
DIHYDROFOLATE
REDUCTASE)		 3vax PUTATIVE
UNCHARACTERIZED
PROTEIN DNDA
(Streptomyces
lividans) 		5 / 10 ALA A 101
LEU A  78
ILE A  92
LEU A 142
THR A  70
 PLP  A 400 ( 4.5A)
None
None
None
PLP  A 400 (-3.6A)
 1.35A 1tdrB-3vaxA:
undetectable		 1tdrB-3vaxA:
16.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7H_C_SAMC530_0
(TYPE I RESTRICTION
ENZYME ECOKI M
PROTEIN)		 3vax PUTATIVE
UNCHARACTERIZED
PROTEIN DNDA
(Streptomyces
lividans) 		5 / 12 THR A 212
ILE A  64
GLY A  79
PRO A 224
THR A  87
 None
 1.07A 2y7hC-3vaxA:
2.8		 2y7hC-3vaxA:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PFG_A_SAMA264_1
(N-METHYLTRANSFERASE)		 3vax PUTATIVE
UNCHARACTERIZED
PROTEIN DNDA
(Streptomyces
lividans) 		3 / 3 TYR A  51
TYR A 180
GLU A 253
 None
 0.78A 3pfgA-3vaxA:
undetectable		 3pfgA-3vaxA:
23.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S8P_B_SAMB500_1
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SUV420H1)		 3vax PUTATIVE
UNCHARACTERIZED
PROTEIN DNDA
(Streptomyces
lividans) 		3 / 3 HIS A  99
SER A 144
ASN A  74
 PLP  A 400 (-3.7A)
None
None
 0.88A 3s8pB-3vaxA:
undetectable		 3s8pB-3vaxA:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V4T_A_ACTA503_0
(UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE)		 3vax PUTATIVE
UNCHARACTERIZED
PROTEIN DNDA
(Streptomyces
lividans) 		3 / 3 ARG A 236
GLU A  62
THR A 212
 None
 0.74A 3v4tA-3vaxA:
1.0		 3v4tA-3vaxA:
25.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KCN_A_MTLA804_0
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3vax PUTATIVE
UNCHARACTERIZED
PROTEIN DNDA
(Streptomyces
lividans) 		4 / 6 GLU A 221
ARG A 214
ASP A  61
ARG A 236
 None
 1.20A 4kcnA-3vaxA:
undetectable		 4kcnA-3vaxA:
21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KCN_B_MTLB805_0
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3vax PUTATIVE
UNCHARACTERIZED
PROTEIN DNDA
(Streptomyces
lividans) 		4 / 6 GLU A 221
ARG A 214
ASP A  61
ARG A 236
 None
 1.19A 4kcnB-3vaxA:
undetectable		 4kcnB-3vaxA:
21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZN7_A_DESA601_1
(ESTROGEN RECEPTOR)		 3vax PUTATIVE
UNCHARACTERIZED
PROTEIN DNDA
(Streptomyces
lividans) 		5 / 12 ALA A  81
LEU A 141
MET A 193
HIS A 173
LEU A 109
 None
 1.17A 4zn7A-3vaxA:
undetectable		 4zn7A-3vaxA:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CPR_B_SAMB402_1
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SUV420H1)		 3vax PUTATIVE
UNCHARACTERIZED
PROTEIN DNDA
(Streptomyces
lividans) 		3 / 3 HIS A  99
SER A 144
ASN A  74
 PLP  A 400 (-3.7A)
None
None
 0.86A 5cprB-3vaxA:
undetectable		 5cprB-3vaxA:
21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FA8_A_SAMA301_0
(RIBOSOMAL PROTEIN
L11
METHYLTRANSFERASE,
PUTATIVE)		 3vax PUTATIVE
UNCHARACTERIZED
PROTEIN DNDA
(Streptomyces
lividans) 		5 / 12 PRO A 204
GLY A 208
GLY A 206
ILE A 248
ASN A  73
 None
None
None
None
PLP  A 400 ( 4.8A)
 1.07A 5fa8A-3vaxA:
undetectable		 5fa8A-3vaxA:
17.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VLM_D_CVID301_1
(REGULATORY PROTEIN
TETR)		 3vax PUTATIVE
UNCHARACTERIZED
PROTEIN DNDA
(Streptomyces
lividans) 		4 / 8 GLN A 178
GLY A 179
ILE A 155
ASP A 186
 None
 0.83A 5vlmD-3vaxA:
undetectable		 5vlmD-3vaxA:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z6F_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 3vax PUTATIVE
UNCHARACTERIZED
PROTEIN DNDA
(Streptomyces
lividans) 		5 / 12 ALA A 101
LEU A  78
THR A  94
ILE A  92
THR A  70
 PLP  A 400 ( 4.5A)
None
None
None
PLP  A 400 (-3.6A)
 1.29A 5z6fA-3vaxA:
undetectable		 5z6fA-3vaxA:
17.82