SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3vay'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XDK_B_9CRB600_1
(RETINOIC ACID
RECEPTOR, BETA)		 3vay HAD-SUPERFAMILY
HYDROLASE
(Pseudomonas
syringae
group
genomosp.
3) 		5 / 12 ALA A  90
LEU A  38
LEU A  76
LEU A  46
LEU A  31
 None
 1.21A 1xdkB-3vayA:
undetectable		 1xdkB-3vayA:
22.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HRD_B_NIOB5661_1
(NICOTINATE
DEHYDROGENASE LARGE
MOLYBDOPTERIN
SUBUNIT
NICOTINATE
DEHYDROGENASE MEDIUM
MOLYBDOPTERIN
SUBUNIT)		 3vay HAD-SUPERFAMILY
HYDROLASE
(Pseudomonas
syringae
group
genomosp.
3) 		4 / 8 ILE A   2
ALA A 175
THR A   6
ALA A 168
 None
 0.90A 3hrdA-3vayA:
undetectable
3hrdB-3vayA:
undetectable		 3hrdA-3vayA:
21.19
3hrdB-3vayA:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LTW_A_HLZA302_1
(ARYLAMINE
N-ACETYLTRANSFERASE
NAT)		 3vay HAD-SUPERFAMILY
HYDROLASE
(Pseudomonas
syringae
group
genomosp.
3) 		4 / 6 LEU A 219
GLU A 109
PRO A 108
HIS A 217
 None
 1.38A 3ltwA-3vayA:
undetectable		 3ltwA-3vayA:
23.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V81_A_NVPA901_1
(HIV-1 REVERSE
TRANSCRIPTASE P66
SUBUNIT)		 3vay HAD-SUPERFAMILY
HYDROLASE
(Pseudomonas
syringae
group
genomosp.
3) 		4 / 8 LEU A  76
VAL A  41
TRP A  30
TYR A  81
 None
 1.12A 3v81A-3vayA:
undetectable		 3v81A-3vayA:
17.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KRH_B_SAMB900_1
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE
2)		 3vay HAD-SUPERFAMILY
HYDROLASE
(Pseudomonas
syringae
group
genomosp.
3) 		4 / 4 ILE A  64
SER A  65
ASP A  10
ASP A  15
 None
 1.42A 4krhB-3vayA:
undetectable		 4krhB-3vayA:
20.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MDB_A_RLTA401_1
(MARINER MOS1
TRANSPOSASE)		 3vay HAD-SUPERFAMILY
HYDROLASE
(Pseudomonas
syringae
group
genomosp.
3) 		4 / 6 ASP A   8
ASP A 185
ALA A 187
ASP A 180
 MG  A 301 (-2.4A)
MG  A 301 ( 4.7A)
None
MG  A 301 (-2.8A)
 1.16A 4mdbA-3vayA:
undetectable		 4mdbA-3vayA:
23.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X5I_A_FOLA201_1
(DIHYDROFOLATE
REDUCTASE)		 3vay HAD-SUPERFAMILY
HYDROLASE
(Pseudomonas
syringae
group
genomosp.
3) 		3 / 3 ASP A  10
ARG A  50
ARG A  68
 None
IOD  A 305 (-3.4A)
IOD  A 305 ( 4.1A)
 0.98A 4x5iA-3vayA:
undetectable		 4x5iA-3vayA:
22.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AG0_A_ACRA605_0
(ALPHA-AMYLASE)		 3vay HAD-SUPERFAMILY
HYDROLASE
(Pseudomonas
syringae
group
genomosp.
3) 		4 / 8 GLY A 154
ASP A 185
ASP A   8
HIS A 181
 None
MG  A 301 ( 4.7A)
MG  A 301 (-2.4A)
None
 0.94A 6ag0A-3vayA:
undetectable		 6ag0A-3vayA:
17.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NCS_A_ACTA303_0
(N-ACETYLNEURAMINIC
ACID (SIALIC ACID)
SYNTHETASE)		 3vay HAD-SUPERFAMILY
HYDROLASE
(Pseudomonas
syringae
group
genomosp.
3) 		3 / 3 ILE A 126
THR A 127
PRO A 160
 None
 0.46A 6ncsA-3vayA:
undetectable		 6ncsA-3vayA:
19.87