SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3vbe'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQB_A_GLYA1292_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 3vbe BETA-CYANOALNINE
SYNTHASE
(Glycine
max) 		4 / 8 SER A 244
LYS A 245
TYR A 241
PHE A 207
 None
 1.07A 1eqbA-3vbeA:
undetectable
1eqbB-3vbeA:
undetectable		 1eqbA-3vbeA:
22.12
1eqbB-3vbeA:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQB_B_GLYB2292_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 3vbe BETA-CYANOALNINE
SYNTHASE
(Glycine
max) 		4 / 8 TYR A 241
PHE A 207
SER A 244
LYS A 245
 None
 1.07A 1eqbA-3vbeA:
undetectable
1eqbB-3vbeA:
undetectable		 1eqbA-3vbeA:
22.12
1eqbB-3vbeA:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQB_C_GLYC3292_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 3vbe BETA-CYANOALNINE
SYNTHASE
(Glycine
max) 		4 / 8 SER A 244
LYS A 245
TYR A 241
PHE A 207
 None
 1.07A 1eqbC-3vbeA:
undetectable
1eqbD-3vbeA:
undetectable		 1eqbC-3vbeA:
22.12
1eqbD-3vbeA:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQB_D_GLYD4292_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 3vbe BETA-CYANOALNINE
SYNTHASE
(Glycine
max) 		4 / 8 TYR A 241
PHE A 207
SER A 244
LYS A 245
 None
 1.07A 1eqbC-3vbeA:
undetectable
1eqbD-3vbeA:
undetectable		 1eqbC-3vbeA:
22.12
1eqbD-3vbeA:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HXW_B_RITB301_1
(HIV-1 PROTEASE)		 3vbe BETA-CYANOALNINE
SYNTHASE
(Glycine
max) 		5 / 9 GLY A 239
GLY A 232
ILE A 229
PRO A 345
VAL A 343
 None
PLP  A 500 (-3.3A)
None
PLP  A 500 (-4.2A)
None
 1.12A 1hxwA-3vbeA:
undetectable		 1hxwA-3vbeA:
14.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JHA_A_NIOA991_1
(NICOTINATE
MONONUCLEOTIDE:5,6-D
IMETHYLBENZIMIDAZOLE
PHOSPHORIBOSYLTRANSF
ERASE)		 3vbe BETA-CYANOALNINE
SYNTHASE
(Glycine
max) 		4 / 8 GLY A 253
GLY A 233
LEU A 284
GLY A 230
 None
PLP  A 500 (-3.8A)
None
PLP  A 500 (-3.2A)
 0.74A 1jhaA-3vbeA:
undetectable		 1jhaA-3vbeA:
24.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A8T_B_ADNB252_1
(U8 SNORNA-BINDING
PROTEIN X29)		 3vbe BETA-CYANOALNINE
SYNTHASE
(Glycine
max) 		4 / 8 GLY A 233
ILE A 283
SER A 236
GLN A 240
 PLP  A 500 (-3.8A)
None
None
None
 1.07A 2a8tB-3vbeA:
undetectable		 2a8tB-3vbeA:
19.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QD3_A_CHDA502_0
(FERROCHELATASE)		 3vbe BETA-CYANOALNINE
SYNTHASE
(Glycine
max) 		4 / 8 SER A 318
VAL A 292
GLY A 253
MET A 227
 PLP  A 500 (-2.6A)
None
None
None
 1.04A 2qd3A-3vbeA:
2.7		 2qd3A-3vbeA:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XZ5_C_ACHC1210_0
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 3vbe BETA-CYANOALNINE
SYNTHASE
(Glycine
max) 		4 / 8 ILE A 340
TYR A  69
VAL A 222
TYR A  80
 None
 1.25A 2xz5A-3vbeA:
undetectable
2xz5C-3vbeA:
undetectable		 2xz5A-3vbeA:
20.93
2xz5C-3vbeA:
20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XZ5_D_ACHD1210_0
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 3vbe BETA-CYANOALNINE
SYNTHASE
(Glycine
max) 		4 / 8 ILE A 340
TYR A  69
VAL A 222
TYR A  80
 None
 1.23A 2xz5C-3vbeA:
undetectable
2xz5D-3vbeA:
undetectable		 2xz5C-3vbeA:
20.93
2xz5D-3vbeA:
20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XZ5_E_ACHE1210_0
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 3vbe BETA-CYANOALNINE
SYNTHASE
(Glycine
max) 		4 / 7 ILE A 340
TYR A  69
VAL A 222
TYR A  80
 None
 1.25A 2xz5D-3vbeA:
undetectable
2xz5E-3vbeA:
undetectable		 2xz5D-3vbeA:
20.93
2xz5E-3vbeA:
20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7W_B_SALB1300_1
(LYSR-TYPE REGULATORY
PROTEIN)		 3vbe BETA-CYANOALNINE
SYNTHASE
(Glycine
max) 		5 / 10 THR A 210
ILE A 214
GLY A 211
GLY A 237
THR A 234
 None
None
None
None
PLP  A 500 (-3.7A)
 1.18A 2y7wB-3vbeA:
undetectable		 2y7wB-3vbeA:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZJ0_A_2FAA500_2
(ADENOSYLHOMOCYSTEINA
SE)		 3vbe BETA-CYANOALNINE
SYNTHASE
(Glycine
max) 		4 / 5 GLN A 331
THR A  74
THR A 342
HIS A 344
 None
 1.35A 2zj0A-3vbeA:
5.3		 2zj0A-3vbeA:
22.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CE6_A_ADNA500_2
(ADENOSYLHOMOCYSTEINA
SE)		 3vbe BETA-CYANOALNINE
SYNTHASE
(Glycine
max) 		4 / 5 GLN A 331
THR A  74
THR A 342
HIS A 344
 None
 1.37A 3ce6A-3vbeA:
5.2		 3ce6A-3vbeA:
22.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CE6_B_ADNB500_2
(ADENOSYLHOMOCYSTEINA
SE)		 3vbe BETA-CYANOALNINE
SYNTHASE
(Glycine
max) 		4 / 5 GLN A 331
THR A  74
THR A 342
HIS A 344
 None
 1.36A 3ce6B-3vbeA:
3.5		 3ce6B-3vbeA:
22.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CE6_C_ADNC500_2
(ADENOSYLHOMOCYSTEINA
SE)		 3vbe BETA-CYANOALNINE
SYNTHASE
(Glycine
max) 		4 / 5 GLN A 331
THR A  74
THR A 342
HIS A 344
 None
 1.35A 3ce6C-3vbeA:
4.7		 3ce6C-3vbeA:
22.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D1Z_B_017B201_1
(HIV-1 PROTEASE)		 3vbe BETA-CYANOALNINE
SYNTHASE
(Glycine
max) 		5 / 12 GLY A 239
GLY A 232
ILE A 229
PRO A 345
VAL A 343
 None
PLP  A 500 (-3.3A)
None
PLP  A 500 (-4.2A)
None
 0.88A 3d1zA-3vbeA:
undetectable		 3d1zA-3vbeA:
14.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EL1_A_DR7A100_1
(PROTEASE)		 3vbe BETA-CYANOALNINE
SYNTHASE
(Glycine
max) 		5 / 11 GLY A 239
GLY A 232
ILE A 229
PRO A 345
VAL A 343
 None
PLP  A 500 (-3.3A)
None
PLP  A 500 (-4.2A)
None
 1.03A 3el1A-3vbeA:
undetectable		 3el1A-3vbeA:
15.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ELZ_A_CHDA200_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 3vbe BETA-CYANOALNINE
SYNTHASE
(Glycine
max) 		4 / 5 PRO A 267
THR A 177
VAL A 178
GLY A 175
 None
 1.01A 3elzA-3vbeA:
undetectable		 3elzA-3vbeA:
18.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GLQ_A_RABA602_2
(ADENOSYLHOMOCYSTEINA
SE)		 3vbe BETA-CYANOALNINE
SYNTHASE
(Glycine
max) 		4 / 5 GLN A 331
THR A  74
THR A 342
HIS A 344
 None
 1.39A 3glqA-3vbeA:
5.2		 3glqA-3vbeA:
23.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GLQ_B_RABB602_2
(ADENOSYLHOMOCYSTEINA
SE)		 3vbe BETA-CYANOALNINE
SYNTHASE
(Glycine
max) 		4 / 5 GLN A 331
THR A  74
THR A 342
HIS A 344
 None
 1.39A 3glqB-3vbeA:
5.7		 3glqB-3vbeA:
23.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K13_A_THHA642_0
(5-METHYLTETRAHYDROFO
LATE-HOMOCYSTEINE
METHYLTRANSFERASE)		 3vbe BETA-CYANOALNINE
SYNTHASE
(Glycine
max) 		5 / 12 GLY A 228
VAL A 222
GLY A 239
SER A 236
ILE A 251
 None
 1.25A 3k13A-3vbeA:
undetectable		 3k13A-3vbeA:
22.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K13_B_THHB643_0
(5-METHYLTETRAHYDROFO
LATE-HOMOCYSTEINE
METHYLTRANSFERASE)		 3vbe BETA-CYANOALNINE
SYNTHASE
(Glycine
max) 		5 / 12 GLY A 228
VAL A 222
GLY A 239
SER A 236
ILE A 251
 None
 1.28A 3k13B-3vbeA:
undetectable		 3k13B-3vbeA:
22.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K13_C_THHC643_0
(5-METHYLTETRAHYDROFO
LATE-HOMOCYSTEINE
METHYLTRANSFERASE)		 3vbe BETA-CYANOALNINE
SYNTHASE
(Glycine
max) 		5 / 12 GLY A 228
VAL A 222
GLY A 239
SER A 236
ILE A 251
 None
 1.28A 3k13C-3vbeA:
undetectable		 3k13C-3vbeA:
22.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NDW_A_RITA100_1
(PROTEASE)		 3vbe BETA-CYANOALNINE
SYNTHASE
(Glycine
max) 		5 / 12 GLY A 239
GLY A 232
ILE A 229
PRO A 345
VAL A 343
 None
PLP  A 500 (-3.3A)
None
PLP  A 500 (-4.2A)
None
 1.02A 3ndwA-3vbeA:
undetectable		 3ndwA-3vbeA:
14.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NDX_A_RITA100_1
(PROTEASE)		 3vbe BETA-CYANOALNINE
SYNTHASE
(Glycine
max) 		5 / 12 GLY A 239
GLY A 232
ILE A 229
PRO A 345
VAL A 343
 None
PLP  A 500 (-3.3A)
None
PLP  A 500 (-4.2A)
None
 1.04A 3ndxA-3vbeA:
undetectable		 3ndxA-3vbeA:
14.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P5N_A_RBFA190_2
(RIBOFLAVIN UPTAKE
PROTEIN)		 3vbe BETA-CYANOALNINE
SYNTHASE
(Glycine
max) 		4 / 4 TYR A 252
ASN A 275
ASN A 322
PHE A 225
 None
 1.22A 3p5nA-3vbeA:
1.8		 3p5nA-3vbeA:
19.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PWW_A_ROCA1001_1
(ENDOTHIAPEPSIN)		 3vbe BETA-CYANOALNINE
SYNTHASE
(Glycine
max) 		5 / 12 ILE A 229
GLY A 125
PHE A 197
THR A 273
TYR A 351
 None
 1.06A 3pwwA-3vbeA:
undetectable		 3pwwA-3vbeA:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TXN_D_URFD302_1
(URIDINE
PHOSPHORYLASE)		 3vbe BETA-CYANOALNINE
SYNTHASE
(Glycine
max) 		4 / 7 THR A  74
GLY A  78
ALA A 330
ILE A 340
 None
 0.96A 4txnD-3vbeA:
undetectable		 4txnD-3vbeA:
22.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XZK_A_AG2A700_1
(PUTATIVE
NAD(+)--ARGININE
ADP-RIBOSYLTRANSFERA
SE VIS)		 3vbe BETA-CYANOALNINE
SYNTHASE
(Glycine
max) 		4 / 7 SER A 151
ARG A 361
SER A 353
GLU A 153
 None
 1.39A 4xzkA-3vbeA:
undetectable		 4xzkA-3vbeA:
25.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZDY_A_1YNA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 3vbe BETA-CYANOALNINE
SYNTHASE
(Glycine
max) 		5 / 12 GLY A 125
PHE A 225
ILE A 214
GLY A 237
THR A 203
 None
 1.21A 4zdyA-3vbeA:
undetectable		 4zdyA-3vbeA:
18.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ESL_A_1YNA701_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 3vbe BETA-CYANOALNINE
SYNTHASE
(Glycine
max) 		5 / 12 GLY A 125
PHE A 225
ILE A 214
GLY A 237
THR A 203
 None
 1.20A 5eslA-3vbeA:
undetectable		 5eslA-3vbeA:
18.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ESL_A_1YNA701_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 3vbe BETA-CYANOALNINE
SYNTHASE
(Glycine
max) 		5 / 12 GLY A 128
PHE A 225
ILE A 214
GLY A 237
THR A 203
 None
 1.29A 5eslA-3vbeA:
undetectable		 5eslA-3vbeA:
18.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X19_G_CHDG104_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 2
CYTOCHROME C OXIDASE
SUBUNIT 6A2,
MITOCHONDRIAL)		 3vbe BETA-CYANOALNINE
SYNTHASE
(Glycine
max) 		5 / 11 GLY A 239
GLY A 233
GLN A 204
THR A 209
THR A 210
 None
PLP  A 500 (-3.8A)
None
None
None
 1.47A 5x19G-3vbeA:
undetectable
5x19N-3vbeA:
undetectable
5x19O-3vbeA:
undetectable		 5x19G-3vbeA:
14.08
5x19N-3vbeA:
20.77
5x19O-3vbeA:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X2S_I_PEMI202_1
(HEMOGLOBIN SUBUNIT
ALPHA
HEMOGLOBIN SUBUNIT
BETA)		 3vbe BETA-CYANOALNINE
SYNTHASE
(Glycine
max) 		4 / 8 LYS A 109
THR A 104
TYR A 140
PRO A 200
 None
 1.28A 5x2sI-3vbeA:
undetectable
5x2sJ-3vbeA:
undetectable
5x2sK-3vbeA:
undetectable		 5x2sI-3vbeA:
17.96
5x2sJ-3vbeA:
17.73
5x2sK-3vbeA:
17.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AK3_A_P2EA1201_1
(PROSTAGLANDIN E2
RECEPTOR EP3
SUBTYPE,SOLUBLE
CYTOCHROME B562)		 3vbe BETA-CYANOALNINE
SYNTHASE
(Glycine
max) 		4 / 4 PRO A  98
MET A 227
GLY A 253
VAL A 238
 None
 1.16A 6ak3A-3vbeA:
undetectable		 6ak3A-3vbeA:
13.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F3N_A_ADNA505_2
(-)		 3vbe BETA-CYANOALNINE
SYNTHASE
(Glycine
max) 		4 / 4 GLN A 331
THR A  74
THR A 342
HIS A 344
 None
 1.38A 6f3nA-3vbeA:
5.9		 6f3nA-3vbeA:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F3N_C_ADNC505_2
(-)		 3vbe BETA-CYANOALNINE
SYNTHASE
(Glycine
max) 		4 / 4 GLN A 331
THR A  74
THR A 342
HIS A 344
 None
 1.38A 6f3nC-3vbeA:
1.9		 6f3nC-3vbeA:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F3N_D_ADND506_2
(-)		 3vbe BETA-CYANOALNINE
SYNTHASE
(Glycine
max) 		4 / 4 GLN A 331
THR A  74
THR A 342
HIS A 344
 None
 1.38A 6f3nD-3vbeA:
4.3		 6f3nD-3vbeA:
21.83