SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3vc1'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PK2_A_ACAA91_1
(TISSUE-TYPE
PLASMINOGEN
ACTIVATOR)		 3vc1 GERANYL DIPHOSPHATE
2-C-METHYLTRANSFERAS
E
(Streptomyces
coelicolor) 		4 / 8 VAL A 102
ASP A 158
HIS A 187
LEU A 191
 None
 1.03A 1pk2A-3vc1A:
undetectable		 1pk2A-3vc1A:
14.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_F_FUAF704_1
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 3vc1 GERANYL DIPHOSPHATE
2-C-METHYLTRANSFERAS
E
(Streptomyces
coelicolor) 		5 / 11 SER A 169
TYR A 197
LEU A 157
VAL A 178
THR A 159
 None
None
GOL  A 304 (-4.0A)
None
None
 1.37A 1q23F-3vc1A:
undetectable		 1q23F-3vc1A:
18.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WOP_A_FFOA2887_1
(AMINOMETHYLTRANSFERA
SE)		 3vc1 GERANYL DIPHOSPHATE
2-C-METHYLTRANSFERAS
E
(Streptomyces
coelicolor) 		3 / 3 ASP A  42
GLU A 142
ARG A 117
 None
 0.88A 1wopA-3vc1A:
undetectable		 1wopA-3vc1A:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AB2_A_SNLA502_2
(MINERALOCORTICOID
RECEPTOR)		 3vc1 GERANYL DIPHOSPHATE
2-C-METHYLTRANSFERAS
E
(Streptomyces
coelicolor) 		4 / 6 LEU A 180
LEU A 183
LEU A 241
LEU A 233
 GOL  A 305 (-3.7A)
None
None
None
 0.94A 2ab2A-3vc1A:
undetectable		 2ab2A-3vc1A:
20.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OXT_A_SAMA300_0
(NUCLEOSIDE-2'-O-METH
YLTRANSFERASE)		 3vc1 GERANYL DIPHOSPHATE
2-C-METHYLTRANSFERAS
E
(Streptomyces
coelicolor) 		5 / 12 GLY A 105
GLY A 107
GLY A 110
THR A 127
LEU A 128
 SAH  A 302 (-3.4A)
SAH  A 302 (-3.3A)
None
SAH  A 302 (-4.0A)
SAH  A 302 (-4.1A)
 0.70A 2oxtA-3vc1A:
8.8		 2oxtA-3vc1A:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OXT_B_SAMB300_0
(NUCLEOSIDE-2'-O-METH
YLTRANSFERASE)		 3vc1 GERANYL DIPHOSPHATE
2-C-METHYLTRANSFERAS
E
(Streptomyces
coelicolor) 		5 / 12 GLY A 105
GLY A 107
GLY A 109
THR A 127
LEU A 128
 SAH  A 302 (-3.4A)
SAH  A 302 (-3.3A)
None
SAH  A 302 (-4.0A)
SAH  A 302 (-4.1A)
 0.83A 2oxtB-3vc1A:
8.1		 2oxtB-3vc1A:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OXT_C_SAMC300_0
(NUCLEOSIDE-2'-O-METH
YLTRANSFERASE)		 3vc1 GERANYL DIPHOSPHATE
2-C-METHYLTRANSFERAS
E
(Streptomyces
coelicolor) 		5 / 12 GLY A 105
GLY A 107
GLY A 110
THR A 127
LEU A 128
 SAH  A 302 (-3.4A)
SAH  A 302 (-3.3A)
None
SAH  A 302 (-4.0A)
SAH  A 302 (-4.1A)
 0.74A 2oxtC-3vc1A:
8.7		 2oxtC-3vc1A:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OXT_D_SAMD300_0
(NUCLEOSIDE-2'-O-METH
YLTRANSFERASE)		 3vc1 GERANYL DIPHOSPHATE
2-C-METHYLTRANSFERAS
E
(Streptomyces
coelicolor) 		6 / 12 ASP A 103
GLY A 105
GLY A 107
GLY A 110
THR A 127
LEU A 128
 SAH  A 302 ( 4.1A)
SAH  A 302 (-3.4A)
SAH  A 302 (-3.3A)
None
SAH  A 302 (-4.0A)
SAH  A 302 (-4.1A)
 0.85A 2oxtD-3vc1A:
8.7		 2oxtD-3vc1A:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BXO_B_SAMB238_0
(N,N-DIMETHYLTRANSFER
ASE)		 3vc1 GERANYL DIPHOSPHATE
2-C-METHYLTRANSFERAS
E
(Streptomyces
coelicolor) 		5 / 12 GLY A 107
HIS A  50
LEU A 128
SER A 129
TYR A  28
 SAH  A 302 (-3.3A)
SAH  A 302 ( 3.8A)
SAH  A 302 (-4.1A)
None
None
 1.45A 3bxoB-3vc1A:
15.7		 3bxoB-3vc1A:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ELU_A_SAMA4633_0
(METHYLTRANSFERASE)		 3vc1 GERANYL DIPHOSPHATE
2-C-METHYLTRANSFERAS
E
(Streptomyces
coelicolor) 		6 / 12 GLY A 105
GLY A 107
GLY A 110
THR A 127
LEU A 128
ASN A 155
 SAH  A 302 (-3.4A)
SAH  A 302 (-3.3A)
None
SAH  A 302 (-4.0A)
SAH  A 302 (-4.1A)
GOL  A 304 ( 3.4A)
 0.77A 3eluA-3vc1A:
8.6		 3eluA-3vc1A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ELW_A_SAMA4633_0
(METHYLTRANSFERASE)		 3vc1 GERANYL DIPHOSPHATE
2-C-METHYLTRANSFERAS
E
(Streptomyces
coelicolor) 		6 / 12 GLY A 105
GLY A 107
GLY A 110
THR A 127
LEU A 128
ASN A 155
 SAH  A 302 (-3.4A)
SAH  A 302 (-3.3A)
None
SAH  A 302 (-4.0A)
SAH  A 302 (-4.1A)
GOL  A 304 ( 3.4A)
 0.78A 3elwA-3vc1A:
8.4		 3elwA-3vc1A:
24.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EMB_A_SAMA4633_0
(METHYLTRANSFERASE)		 3vc1 GERANYL DIPHOSPHATE
2-C-METHYLTRANSFERAS
E
(Streptomyces
coelicolor) 		6 / 12 GLY A 105
GLY A 107
GLY A 110
THR A 127
LEU A 128
ASN A 155
 SAH  A 302 (-3.4A)
SAH  A 302 (-3.3A)
None
SAH  A 302 (-4.0A)
SAH  A 302 (-4.1A)
GOL  A 304 ( 3.4A)
 0.74A 3embA-3vc1A:
8.6		 3embA-3vc1A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G2O_A_SAMA500_0
(PCZA361.24)		 3vc1 GERANYL DIPHOSPHATE
2-C-METHYLTRANSFERAS
E
(Streptomyces
coelicolor) 		5 / 12 GLY A 107
LEU A 128
SER A 129
MET A 156
SER A 174
 SAH  A 302 (-3.3A)
SAH  A 302 (-4.1A)
None
SAH  A 302 (-3.9A)
SAH  A 302 (-4.5A)
 0.89A 3g2oA-3vc1A:
16.0		 3g2oA-3vc1A:
27.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GCZ_A_SAMA4633_0
(POLYPROTEIN)		 3vc1 GERANYL DIPHOSPHATE
2-C-METHYLTRANSFERAS
E
(Streptomyces
coelicolor) 		5 / 12 GLY A 105
GLY A 107
GLY A 110
THR A 127
LEU A 128
 SAH  A 302 (-3.4A)
SAH  A 302 (-3.3A)
None
SAH  A 302 (-4.0A)
SAH  A 302 (-4.1A)
 0.78A 3gczA-3vc1A:
8.7		 3gczA-3vc1A:
26.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ID5_B_SAMB301_0
(FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE)		 3vc1 GERANYL DIPHOSPHATE
2-C-METHYLTRANSFERAS
E
(Streptomyces
coelicolor) 		5 / 11 GLY A  54
ALA A  83
ASP A 252
ILE A  53
GLN A  84
 None
 1.32A 3id5B-3vc1A:
11.5		 3id5B-3vc1A:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ID5_F_SAMF301_0
(FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE)		 3vc1 GERANYL DIPHOSPHATE
2-C-METHYLTRANSFERAS
E
(Streptomyces
coelicolor) 		5 / 11 GLY A  54
ALA A  83
ASP A 252
ILE A  53
GLN A  84
 None
 1.32A 3id5F-3vc1A:
11.4		 3id5F-3vc1A:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NW2_A_H4BA902_1
(NITRIC OXIDE
SYNTHASE, INDUCIBLE)		 3vc1 GERANYL DIPHOSPHATE
2-C-METHYLTRANSFERAS
E
(Streptomyces
coelicolor) 		3 / 3 ARG A 229
ILE A 226
TRP A 204
 None
GST  A 303 ( 4.9A)
None
 0.96A 3nw2A-3vc1A:
undetectable		 3nw2A-3vc1A:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NW2_B_H4BB902_1
(NITRIC OXIDE
SYNTHASE, INDUCIBLE)		 3vc1 GERANYL DIPHOSPHATE
2-C-METHYLTRANSFERAS
E
(Streptomyces
coelicolor) 		3 / 3 ARG A 229
ILE A 226
TRP A 204
 None
GST  A 303 ( 4.9A)
None
 0.96A 3nw2B-3vc1A:
undetectable		 3nw2B-3vc1A:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R24_A_SAMA302_0
(2'-O-METHYL
TRANSFERASE)		 3vc1 GERANYL DIPHOSPHATE
2-C-METHYLTRANSFERAS
E
(Streptomyces
coelicolor) 		5 / 12 GLY A 110
SER A  82
GLY A  45
CYH A 106
MET A 112
 None
 1.33A 3r24A-3vc1A:
7.9		 3r24A-3vc1A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WRI_A_CAMA502_0
(CAMPHOR
5-MONOOXYGENASE)		 3vc1 GERANYL DIPHOSPHATE
2-C-METHYLTRANSFERAS
E
(Streptomyces
coelicolor) 		4 / 5 LEU A  46
GLY A 110
ILE A 145
VAL A 149
 None
 0.75A 3wriA-3vc1A:
undetectable		 3wriA-3vc1A:
20.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WRI_B_CAMB502_0
(CAMPHOR
5-MONOOXYGENASE)		 3vc1 GERANYL DIPHOSPHATE
2-C-METHYLTRANSFERAS
E
(Streptomyces
coelicolor) 		4 / 5 LEU A  46
GLY A 110
ILE A 145
VAL A 149
 None
 0.75A 3wriB-3vc1A:
undetectable		 3wriB-3vc1A:
20.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WRK_A_CAMA502_0
(CAMPHOR
5-MONOOXYGENASE)		 3vc1 GERANYL DIPHOSPHATE
2-C-METHYLTRANSFERAS
E
(Streptomyces
coelicolor) 		4 / 5 LEU A  46
GLY A 110
ILE A 145
VAL A 149
 None
 0.83A 3wrkA-3vc1A:
undetectable		 3wrkA-3vc1A:
20.66
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4F84_A_SAMA501_0
(GERANYL DIPHOSPHATE
2-C-METHYLTRANSFERAS
E)		 3vc1 GERANYL DIPHOSPHATE
2-C-METHYLTRANSFERAS
E
(Streptomyces
coelicolor) 		11 / 12 GLY A 105
GLY A 107
VAL A 126
THR A 127
LEU A 128
GLN A 132
ASN A 155
MET A 156
SER A 174
TYR A 177
VAL A 178
 SAH  A 302 (-3.4A)
SAH  A 302 (-3.3A)
SAH  A 302 ( 4.9A)
SAH  A 302 (-4.0A)
SAH  A 302 (-4.1A)
SAH  A 302 (-3.1A)
GOL  A 304 ( 3.4A)
SAH  A 302 (-3.9A)
SAH  A 302 (-4.5A)
SAH  A 302 ( 3.9A)
None
 0.46A 4f84A-3vc1A:
39.4		 4f84A-3vc1A:
85.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HTF_A_SAMA301_0
(S-ADENOSYLMETHIONINE
-DEPENDENT
METHYLTRANSFERASE)		 3vc1 GERANYL DIPHOSPHATE
2-C-METHYLTRANSFERAS
E
(Streptomyces
coelicolor) 		5 / 12 GLY A 105
GLY A 107
LEU A 128
SER A 129
VAL A 178
 SAH  A 302 (-3.4A)
SAH  A 302 (-3.3A)
SAH  A 302 (-4.1A)
None
None
 0.73A 4htfA-3vc1A:
16.7		 4htfA-3vc1A:
26.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HTF_B_SAMB301_0
(S-ADENOSYLMETHIONINE
-DEPENDENT
METHYLTRANSFERASE)		 3vc1 GERANYL DIPHOSPHATE
2-C-METHYLTRANSFERAS
E
(Streptomyces
coelicolor) 		5 / 12 GLY A 105
GLY A 107
LEU A 128
SER A 129
VAL A 178
 SAH  A 302 (-3.4A)
SAH  A 302 (-3.3A)
SAH  A 302 (-4.1A)
None
None
 0.67A 4htfB-3vc1A:
17.0		 4htfB-3vc1A:
26.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LRH_D_FOLD301_1
(FOLATE RECEPTOR
ALPHA)		 3vc1 GERANYL DIPHOSPHATE
2-C-METHYLTRANSFERAS
E
(Streptomyces
coelicolor) 		3 / 3 HIS A  50
TRP A 257
SER A 111
 SAH  A 302 ( 3.8A)
None
SAH  A 302 ( 4.1A)
 1.15A 4lrhD-3vc1A:
undetectable		 4lrhD-3vc1A:
21.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P7N_A_GCSA702_1
(POLY-BETA-1,6-N-ACET
YL-D-GLUCOSAMINE
N-DEACETYLASE)		 3vc1 GERANYL DIPHOSPHATE
2-C-METHYLTRANSFERAS
E
(Streptomyces
coelicolor) 		3 / 3 ASP A 279
TYR A 208
TRP A 214
 None
 1.42A 4p7nA-3vc1A:
undetectable		 4p7nA-3vc1A:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BW4_B_SAMB301_0
(16S RRNA
(ADENINE(1408)-N(1))
-METHYLTRANSFERASE)		 3vc1 GERANYL DIPHOSPHATE
2-C-METHYLTRANSFERAS
E
(Streptomyces
coelicolor) 		5 / 12 GLY A  41
GLY A  45
ALA A  75
ILE A  74
LEU A  40
 None
 1.22A 5bw4B-3vc1A:
12.1		 5bw4B-3vc1A:
27.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VCG_A_08YA602_1
(CYTOCHROME P450 3A4)		 3vc1 GERANYL DIPHOSPHATE
2-C-METHYLTRANSFERAS
E
(Streptomyces
coelicolor) 		5 / 12 PHE A 273
ILE A 269
PHE A 282
THR A 250
ALA A 220
 None
None
GST  A 303 (-4.9A)
None
None
 1.10A 5vcgA-3vc1A:
undetectable		 5vcgA-3vc1A:
19.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZRF_D_EVPD101_1
()		 3vc1 GERANYL DIPHOSPHATE
2-C-METHYLTRANSFERAS
E
(Streptomyces
coelicolor) 		4 / 5 GLY A  41
ASP A  42
ARG A 139
GLN A 132
 None
None
None
SAH  A 302 (-3.1A)
 1.43A 5zrfB-3vc1A:
undetectable		 5zrfB-3vc1A:
17.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BRD_A_RFPA502_2
(RIFAMPIN
MONOOXYGENASE)		 3vc1 GERANYL DIPHOSPHATE
2-C-METHYLTRANSFERAS
E
(Streptomyces
coelicolor) 		4 / 4 GLN A 283
VAL A 215
ARG A 234
ARG A 229
 None
 1.14A 6brdA-3vc1A:
3.0		 6brdA-3vc1A:
14.42