SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3vc7'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FDS_A_ESTA350_1
(17-BETA-HYDROXYSTERO
ID-DEHYDROGENASE)		 3vc7 PUTATIVE
OXIDOREDUCTASE
(Sinorhizobium
meliloti) 		5 / 12 SER A 138
VAL A 139
TYR A 151
GLY A 182
PHE A 202
 GOL  A 301 (-3.6A)
None
None
GOL  A 301 ( 4.7A)
None
 0.99A 1fdsA-3vc7A:
27.5		 1fdsA-3vc7A:
26.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTN_L_TRPL81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 3vc7 PUTATIVE
OXIDOREDUCTASE
(Sinorhizobium
meliloti) 		5 / 9 VAL A 111
GLY A 115
ALA A  89
THR A 119
ILE A  62
 None
 1.35A 1gtnL-3vc7A:
undetectable
1gtnM-3vc7A:
undetectable		 1gtnL-3vc7A:
15.26
1gtnM-3vc7A:
15.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JOM_A_FFOA161_0
(DIHYDROFOLATE
REDUCTASE)		 3vc7 PUTATIVE
OXIDOREDUCTASE
(Sinorhizobium
meliloti) 		5 / 11 ALA A 232
PHE A 230
LYS A   4
LEU A  27
THR A 233
 None
 1.30A 1jomA-3vc7A:
undetectable		 1jomA-3vc7A:
18.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1R9O_A_FLPA501_1
(CYTOCHROME P450 2C9)		 3vc7 PUTATIVE
OXIDOREDUCTASE
(Sinorhizobium
meliloti) 		5 / 12 ILE A  68
LEU A  71
GLY A 115
ALA A 116
LEU A  85
 None
 1.02A 1r9oA-3vc7A:
undetectable		 1r9oA-3vc7A:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2B25_B_SAMB602_0
(HYPOTHETICAL PROTEIN)		 3vc7 PUTATIVE
OXIDOREDUCTASE
(Sinorhizobium
meliloti) 		5 / 12 THR A 186
GLY A  18
MET A  19
ASP A  61
ILE A  62
 None
 1.18A 2b25B-3vc7A:
6.8		 2b25B-3vc7A:
22.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NNI_A_MTKA501_1
(CYTOCHROME P450 2C8)		 3vc7 PUTATIVE
OXIDOREDUCTASE
(Sinorhizobium
meliloti) 		5 / 12 THR A 186
VAL A 221
ALA A 222
VAL A  12
VAL A 134
 None
 1.02A 2nniA-3vc7A:
undetectable		 2nniA-3vc7A:
20.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OXT_C_SAMC300_0
(NUCLEOSIDE-2'-O-METH
YLTRANSFERASE)		 3vc7 PUTATIVE
OXIDOREDUCTASE
(Sinorhizobium
meliloti) 		5 / 12 GLY A 130
LEU A 169
GLU A 129
ILE A 133
ASP A  83
 None
 0.99A 2oxtC-3vc7A:
4.9		 2oxtC-3vc7A:
23.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2UVN_A_ECNA1409_1
(CYTOCHROME P450 130)		 3vc7 PUTATIVE
OXIDOREDUCTASE
(Sinorhizobium
meliloti) 		5 / 12 LEU A 123
THR A  37
GLY A  14
GLY A  15
LEU A  85
 None
 1.12A 2uvnA-3vc7A:
undetectable		 2uvnA-3vc7A:
21.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EQM_A_ASDA601_1
(CYTOCHROME P450 19A1)		 3vc7 PUTATIVE
OXIDOREDUCTASE
(Sinorhizobium
meliloti) 		5 / 10 ARG A 122
ILE A  68
ILE A  62
THR A  37
LEU A  85
 None
 1.26A 3eqmA-3vc7A:
undetectable		 3eqmA-3vc7A:
19.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S79_A_ASDA601_1
(CYTOCHROME P450 19A1)		 3vc7 PUTATIVE
OXIDOREDUCTASE
(Sinorhizobium
meliloti) 		5 / 12 ARG A 122
ILE A  68
ILE A  62
THR A  37
LEU A  85
 None
 1.23A 3s79A-3vc7A:
undetectable		 3s79A-3vc7A:
19.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BWL_C_MN9C1297_0
(N-ACETYLNEURAMINATE
LYASE)		 3vc7 PUTATIVE
OXIDOREDUCTASE
(Sinorhizobium
meliloti) 		5 / 10 ILE A  11
LEU A 123
GLY A  14
GLY A  38
SER A  60
 None
 1.28A 4bwlC-3vc7A:
undetectable		 4bwlC-3vc7A:
22.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EB6_C_VLBC503_1
(TUBULIN BETA CHAIN
TUBULIN ALPHA CHAIN)		 3vc7 PUTATIVE
OXIDOREDUCTASE
(Sinorhizobium
meliloti) 		5 / 12 VAL A 164
THR A 236
ILE A  87
VAL A 120
ILE A 127
 None
 1.41A 4eb6B-3vc7A:
6.6
4eb6C-3vc7A:
6.1		 4eb6B-3vc7A:
21.06
4eb6C-3vc7A:
23.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4I1N_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 3vc7 PUTATIVE
OXIDOREDUCTASE
(Sinorhizobium
meliloti) 		5 / 11 ALA A 232
PHE A 230
LYS A   4
LEU A  27
THR A 233
 None
 1.31A 4i1nA-3vc7A:
undetectable		 4i1nA-3vc7A:
20.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X5F_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 3vc7 PUTATIVE
OXIDOREDUCTASE
(Sinorhizobium
meliloti) 		5 / 12 ALA A 232
PHE A 230
LYS A   4
LEU A  27
THR A 233
 None
 1.15A 4x5fA-3vc7A:
undetectable		 4x5fA-3vc7A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X5H_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 3vc7 PUTATIVE
OXIDOREDUCTASE
(Sinorhizobium
meliloti) 		5 / 12 ALA A 232
PHE A 230
LYS A   4
LEU A  27
THR A 233
 None
 1.13A 4x5hA-3vc7A:
undetectable		 4x5hA-3vc7A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_2_BEZ2801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 1
BEZ-LEU-LEU)		 3vc7 PUTATIVE
OXIDOREDUCTASE
(Sinorhizobium
meliloti) 		4 / 4 LEU A 123
ARG A 172
ILE A 127
ILE A 174
 None
 1.36A 5dzk2-3vc7A:
undetectable
5dzkM-3vc7A:
undetectable
5dzkN-3vc7A:
1.7		 5dzk2-3vc7A:
1.18
5dzkM-3vc7A:
26.24
5dzkN-3vc7A:
26.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_V_BEZV801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 1
BEZ-LEU-LEU)		 3vc7 PUTATIVE
OXIDOREDUCTASE
(Sinorhizobium
meliloti) 		4 / 4 ILE A 127
ILE A 174
ARG A 172
LEU A 123
 None
 1.32A 5dzkh-3vc7A:
1.6
5dzkn-3vc7A:
1.7
5dzkv-3vc7A:
undetectable		 5dzkh-3vc7A:
26.24
5dzkn-3vc7A:
26.24
5dzkv-3vc7A:
1.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HNZ_B_TA1B902_1
(TUBULIN BETA-2B
CHAIN)		 3vc7 PUTATIVE
OXIDOREDUCTASE
(Sinorhizobium
meliloti) 		5 / 12 VAL A 134
ALA A 229
SER A 132
PHE A 230
ARG A  25
 None
 1.06A 5hnzB-3vc7A:
7.5		 5hnzB-3vc7A:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5J7W_C_MTXC402_1
(THYMIDYLATE SYNTHASE)		 3vc7 PUTATIVE
OXIDOREDUCTASE
(Sinorhizobium
meliloti) 		5 / 12 LEU A 205
ILE A 209
LEU A 250
GLY A 182
PHE A 183
 None
None
None
GOL  A 301 ( 4.7A)
GOL  A 301 (-4.0A)
 1.09A 5j7wC-3vc7A:
undetectable		 5j7wC-3vc7A:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JKV_A_ASDA602_1
(AROMATASE)		 3vc7 PUTATIVE
OXIDOREDUCTASE
(Sinorhizobium
meliloti) 		5 / 12 ARG A 122
ILE A  68
ILE A  62
THR A  37
LEU A  85
 None
 1.22A 5jkvA-3vc7A:
undetectable		 5jkvA-3vc7A:
19.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JKW_A_TESA601_1
(AROMATASE)		 3vc7 PUTATIVE
OXIDOREDUCTASE
(Sinorhizobium
meliloti) 		5 / 11 ARG A 122
ILE A  68
ILE A  62
THR A  37
LEU A  85
 None
 1.23A 5jkwA-3vc7A:
undetectable		 5jkwA-3vc7A:
19.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JL6_A_ASDA601_1
(AROMATASE)		 3vc7 PUTATIVE
OXIDOREDUCTASE
(Sinorhizobium
meliloti) 		5 / 9 ARG A 122
ILE A  68
ILE A  62
THR A  37
LEU A  85
 None
 1.24A 5jl6A-3vc7A:
0.0		 5jl6A-3vc7A:
19.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JL7_A_ASDA601_1
(AROMATASE)		 3vc7 PUTATIVE
OXIDOREDUCTASE
(Sinorhizobium
meliloti) 		5 / 10 ARG A 122
ILE A  68
ILE A  62
THR A  37
LEU A  85
 None
 1.23A 5jl7A-3vc7A:
undetectable		 5jl7A-3vc7A:
19.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JL9_A_ASDA601_1
(AROMATASE)		 3vc7 PUTATIVE
OXIDOREDUCTASE
(Sinorhizobium
meliloti) 		5 / 9 ARG A 122
ILE A  68
ILE A  62
THR A  37
LEU A  85
 None
 1.25A 5jl9A-3vc7A:
undetectable		 5jl9A-3vc7A:
19.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TIW_B_OAQB302_0
(SULFOTRANSFERASE)		 3vc7 PUTATIVE
OXIDOREDUCTASE
(Sinorhizobium
meliloti) 		5 / 12 ILE A  82
LEU A  27
VAL A  12
ILE A  87
THR A 119
 None
 1.33A 5tiwB-3vc7A:
undetectable		 5tiwB-3vc7A:
19.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BRD_A_RFPA502_1
(RIFAMPIN
MONOOXYGENASE)		 3vc7 PUTATIVE
OXIDOREDUCTASE
(Sinorhizobium
meliloti) 		5 / 12 HIS A  17
VAL A  91
LEU A  85
THR A  23
GLY A  20
 None
 1.43A 6brdA-3vc7A:
5.5		 6brdA-3vc7A:
17.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DJZ_B_GMJB301_0
(SIGMA NON-OPIOID
INTRACELLULAR
RECEPTOR 1)		 3vc7 PUTATIVE
OXIDOREDUCTASE
(Sinorhizobium
meliloti) 		5 / 12 LEU A 123
ILE A  87
VAL A 225
THR A  37
LEU A  58
 None
 1.37A 6djzB-3vc7A:
undetectable		 6djzB-3vc7A:
24.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6QXS_B_FOZB403_0
(THYMIDYLATE SYNTHASE)		 3vc7 PUTATIVE
OXIDOREDUCTASE
(Sinorhizobium
meliloti) 		5 / 12 LEU A 205
ILE A 209
LEU A 250
GLY A 182
PHE A 183
 None
None
None
GOL  A 301 ( 4.7A)
GOL  A 301 (-4.0A)
 1.06A 6qxsB-3vc7A:
undetectable		 6qxsB-3vc7A:
21.94