SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3vco'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1AO8_A_MTXA170_1
(DIHYDROFOLATE
REDUCTASE)		 3vco DIHYDROFOLATE
REDUCTASE
(Schistosoma
mansoni) 		7 / 12 ALA A   8
ASP A  28
PHE A  32
THR A  53
SER A  56
LEU A  64
ARG A  67
 None
None
None
SO4  A 201 (-3.7A)
None
None
None
 0.94A 1ao8A-3vcoA:
16.8		 1ao8A-3vcoA:
26.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1AO8_A_MTXA170_1
(DIHYDROFOLATE
REDUCTASE)		 3vco DIHYDROFOLATE
REDUCTASE
(Schistosoma
mansoni) 		6 / 12 ALA A   8
ASP A  28
PHE A  32
THR A  53
SER A  56
THR A 133
 None
None
None
SO4  A 201 (-3.7A)
None
None
 0.73A 1ao8A-3vcoA:
16.8		 1ao8A-3vcoA:
26.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1BZF_A_TMQA170_1
(DIHYDROFOLATE
REDUCTASE)		 3vco DIHYDROFOLATE
REDUCTASE
(Schistosoma
mansoni) 		5 / 12 ALA A   8
ASP A  28
PHE A  32
THR A  53
LEU A  64
 None
None
None
SO4  A 201 (-3.7A)
None
 0.80A 1bzfA-3vcoA:
16.7		 1bzfA-3vcoA:
26.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1BZF_A_TMQA170_1
(DIHYDROFOLATE
REDUCTASE)		 3vco DIHYDROFOLATE
REDUCTASE
(Schistosoma
mansoni) 		5 / 12 ALA A   8
ASP A  28
PHE A  32
THR A  53
THR A 133
 None
None
None
SO4  A 201 (-3.7A)
None
 0.87A 1bzfA-3vcoA:
16.7		 1bzfA-3vcoA:
26.13
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1CD2_A_FOLA307_0
(DIHYDROFOLATE
REDUCTASE)		 3vco DIHYDROFOLATE
REDUCTASE
(Schistosoma
mansoni) 		9 / 12 ALA A   8
PHE A  32
LYS A  33
THR A  53
PRO A  58
LEU A  64
ILE A 111
TYR A 117
THR A 133
 None
None
None
SO4  A 201 (-3.7A)
None
None
None
None
None
 0.93A 1cd2A-3vcoA:
22.2		 1cd2A-3vcoA:
34.23
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1CD2_A_FOLA307_0
(DIHYDROFOLATE
REDUCTASE)		 3vco DIHYDROFOLATE
REDUCTASE
(Schistosoma
mansoni) 		9 / 12 ALA A   8
PHE A  32
LYS A  33
THR A  53
PRO A  58
PHE A  61
LEU A  64
ILE A 111
TYR A 117
 None
None
None
SO4  A 201 (-3.7A)
None
None
None
None
None
 1.05A 1cd2A-3vcoA:
22.2		 1cd2A-3vcoA:
34.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1D1G_A_MTXA171_1
(DIHYDROFOLATE
REDUCTASE)		 3vco DIHYDROFOLATE
REDUCTASE
(Schistosoma
mansoni) 		7 / 12 ALA A   8
ASP A  28
ILE A  57
LEU A  64
ARG A  67
ILE A 111
THR A 133
 None
 0.59A 1d1gA-3vcoA:
16.7		 1d1gA-3vcoA:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1D1G_B_MTXB171_1
(DIHYDROFOLATE
REDUCTASE)		 3vco DIHYDROFOLATE
REDUCTASE
(Schistosoma
mansoni) 		8 / 12 VAL A   6
ALA A   8
ASP A  28
ILE A  57
LEU A  64
ARG A  67
ILE A 111
THR A 133
 None
 0.58A 1d1gB-3vcoA:
16.7		 1d1gB-3vcoA:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DDR_A_MTXA200_1
(DIHYDROFOLATE
REDUCTASE)		 3vco DIHYDROFOLATE
REDUCTASE
(Schistosoma
mansoni) 		8 / 12 ALA A   8
ASP A  28
LYS A  33
THR A  53
ILE A  57
LEU A  64
ARG A  67
TYR A 117
 None
None
None
SO4  A 201 (-3.7A)
None
None
None
None
 0.93A 1ddrA-3vcoA:
18.4		 1ddrA-3vcoA:
29.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DDR_A_MTXA200_1
(DIHYDROFOLATE
REDUCTASE)		 3vco DIHYDROFOLATE
REDUCTASE
(Schistosoma
mansoni) 		7 / 12 ALA A   8
ASP A  28
LYS A  33
THR A  53
SER A  56
LEU A  64
TYR A 117
 None
None
None
SO4  A 201 (-3.7A)
None
None
None
 1.02A 1ddrA-3vcoA:
18.4		 1ddrA-3vcoA:
29.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DDR_B_MTXB200_1
(DIHYDROFOLATE
REDUCTASE)		 3vco DIHYDROFOLATE
REDUCTASE
(Schistosoma
mansoni) 		9 / 12 ALA A   8
ASP A  28
PHE A  32
LYS A  33
ILE A  57
LEU A  64
ARG A  67
TYR A 117
THR A 133
 None
 0.62A 1ddrB-3vcoA:
18.5		 1ddrB-3vcoA:
29.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DDS_A_MTXA201_1
(DIHYDROFOLATE
REDUCTASE)		 3vco DIHYDROFOLATE
REDUCTASE
(Schistosoma
mansoni) 		9 / 12 ALA A   8
ASP A  28
LYS A  33
THR A  53
ILE A  57
LEU A  64
ARG A  67
TYR A 117
THR A 133
 None
None
None
SO4  A 201 (-3.7A)
None
None
None
None
None
 0.79A 1ddsA-3vcoA:
18.8		 1ddsA-3vcoA:
29.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DDS_B_MTXB201_1
(DIHYDROFOLATE
REDUCTASE)		 3vco DIHYDROFOLATE
REDUCTASE
(Schistosoma
mansoni) 		6 / 12 ALA A   8
ASP A  28
LYS A  33
ILE A  57
TYR A 117
THR A 133
 None
 0.86A 1ddsB-3vcoA:
18.8		 1ddsB-3vcoA:
29.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DDS_B_MTXB201_1
(DIHYDROFOLATE
REDUCTASE)		 3vco DIHYDROFOLATE
REDUCTASE
(Schistosoma
mansoni) 		8 / 12 ALA A   8
ASP A  28
SER A  56
ILE A  57
LEU A  64
ARG A  67
TYR A 117
THR A 133
 None
 0.62A 1ddsB-3vcoA:
18.8		 1ddsB-3vcoA:
29.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DF7_A_MTXA501_1
(DIHYDROFOLATE
REDUCTASE)		 3vco DIHYDROFOLATE
REDUCTASE
(Schistosoma
mansoni) 		7 / 12 ALA A   8
ASP A  28
PRO A  58
LEU A  64
ARG A  67
ILE A 111
TYR A 117
 None
 0.73A 1df7A-3vcoA:
17.5		 1df7A-3vcoA:
28.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DG5_A_TOPA201_1
(DIHYDROFOLATE
REDUCTASE)		 3vco DIHYDROFOLATE
REDUCTASE
(Schistosoma
mansoni) 		7 / 11 ALA A   8
ASP A  28
PHE A  32
SER A  56
PRO A  58
ILE A 111
TYR A 117
 None
 0.70A 1dg5A-3vcoA:
17.4		 1dg5A-3vcoA:
28.78
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1DHF_A_FOLA187_0
(DIHYDROFOLATE
REDUCTASE)		 3vco DIHYDROFOLATE
REDUCTASE
(Schistosoma
mansoni) 		8 / 12 ALA A   8
PHE A  32
THR A  53
ILE A  57
PRO A  58
LEU A  64
TYR A 117
THR A 133
 None
None
SO4  A 201 (-3.7A)
None
None
None
None
None
 0.70A 1dhfA-3vcoA:
23.6		 1dhfA-3vcoA:
36.62
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1DHF_B_FOLB187_0
(DIHYDROFOLATE
REDUCTASE)		 3vco DIHYDROFOLATE
REDUCTASE
(Schistosoma
mansoni) 		8 / 12 ALA A   8
PHE A  32
THR A  53
ILE A  57
LEU A  64
ARG A  67
TYR A 117
THR A 133
 None
None
SO4  A 201 (-3.7A)
None
None
None
None
None
 0.66A 1dhfB-3vcoA:
23.6		 1dhfB-3vcoA:
36.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DHI_A_MTXA161_1
(DIHYDROFOLATE
REDUCTASE)		 3vco DIHYDROFOLATE
REDUCTASE
(Schistosoma
mansoni) 		8 / 12 ALA A   8
LYS A  33
ILE A  57
LEU A  64
ARG A  67
ILE A 111
TYR A 117
THR A 133
 None
 0.83A 1dhiA-3vcoA:
18.9		 1dhiA-3vcoA:
28.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DHI_A_MTXA161_1
(DIHYDROFOLATE
REDUCTASE)		 3vco DIHYDROFOLATE
REDUCTASE
(Schistosoma
mansoni) 		6 / 12 ALA A   8
SER A  56
LEU A  64
ARG A  67
TYR A 117
THR A 133
 None
 0.75A 1dhiA-3vcoA:
18.9		 1dhiA-3vcoA:
28.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DHI_B_MTXB361_1
(DIHYDROFOLATE
REDUCTASE)		 3vco DIHYDROFOLATE
REDUCTASE
(Schistosoma
mansoni) 		8 / 11 ALA A   8
LYS A  33
ILE A  57
LEU A  64
ARG A  67
ILE A 111
TYR A 117
THR A 133
 None
 0.83A 1dhiB-3vcoA:
18.9		 1dhiB-3vcoA:
28.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DHJ_A_MTXA161_1
(DIHYDROFOLATE
REDUCTASE)		 3vco DIHYDROFOLATE
REDUCTASE
(Schistosoma
mansoni) 		7 / 12 ALA A   8
ILE A  57
LEU A  64
ARG A  67
ILE A 111
TYR A 117
THR A 133
 None
 0.53A 1dhjA-3vcoA:
19.1		 1dhjA-3vcoA:
28.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DHJ_A_MTXA161_1
(DIHYDROFOLATE
REDUCTASE)		 3vco DIHYDROFOLATE
REDUCTASE
(Schistosoma
mansoni) 		7 / 12 ALA A   8
LYS A  33
ILE A  57
LEU A  64
ILE A 111
TYR A 117
THR A 133
 None
 0.86A 1dhjA-3vcoA:
19.1		 1dhjA-3vcoA:
28.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DHJ_A_MTXA161_1
(DIHYDROFOLATE
REDUCTASE)		 3vco DIHYDROFOLATE
REDUCTASE
(Schistosoma
mansoni) 		6 / 12 ALA A   8
SER A  56
LEU A  64
ARG A  67
TYR A 117
THR A 133
 None
 0.72A 1dhjA-3vcoA:
19.1		 1dhjA-3vcoA:
28.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DHJ_B_MTXB361_1
(DIHYDROFOLATE
REDUCTASE)		 3vco DIHYDROFOLATE
REDUCTASE
(Schistosoma
mansoni) 		7 / 12 ALA A   8
ILE A  57
LEU A  64
ARG A  67
ILE A 111
TYR A 117
THR A 133
 None
 0.57A 1dhjB-3vcoA:
19.0		 1dhjB-3vcoA:
28.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DHJ_B_MTXB361_1
(DIHYDROFOLATE
REDUCTASE)		 3vco DIHYDROFOLATE
REDUCTASE
(Schistosoma
mansoni) 		7 / 12 ALA A   8
LYS A  33
ILE A  57
LEU A  64
ILE A 111
TYR A 117
THR A 133
 None
 0.87A 1dhjB-3vcoA:
19.0		 1dhjB-3vcoA:
28.86
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1DLS_A_MTXA188_1
(DIHYDROFOLATE
REDUCTASE)		 3vco DIHYDROFOLATE
REDUCTASE
(Schistosoma
mansoni) 		7 / 12 ALA A   8
SER A  56
ILE A  57
PRO A  58
LEU A  64
ARG A  67
TYR A 117
 None
 0.53A 1dlsA-3vcoA:
24.3		 1dlsA-3vcoA:
36.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DRA_A_MTXA161_1
(DIHYDROFOLATE
REDUCTASE)		 3vco DIHYDROFOLATE
REDUCTASE
(Schistosoma
mansoni) 		6 / 12 ALA A   8
ILE A  57
LEU A  64
ARG A  67
ILE A 111
TYR A 117
 None
 0.57A 1draA-3vcoA:
19.0		 1draA-3vcoA:
28.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DRA_A_MTXA161_1
(DIHYDROFOLATE
REDUCTASE)		 3vco DIHYDROFOLATE
REDUCTASE
(Schistosoma
mansoni) 		5 / 12 ALA A   8
LYS A  33
ILE A  57
ILE A 111
TYR A 117
 None
 0.96A 1draA-3vcoA:
19.0		 1draA-3vcoA:
28.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DRA_A_MTXA161_1
(DIHYDROFOLATE
REDUCTASE)		 3vco DIHYDROFOLATE
REDUCTASE
(Schistosoma
mansoni) 		5 / 12 ALA A   8
SER A  56
LEU A  64
ARG A  67
TYR A 117
 None
 0.81A 1draA-3vcoA:
19.0		 1draA-3vcoA:
28.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DRA_B_MTXB361_1
(DIHYDROFOLATE
REDUCTASE)		 3vco DIHYDROFOLATE
REDUCTASE
(Schistosoma
mansoni) 		8 / 12 ALA A   8
LYS A  33
ILE A  57
LEU A  64
ARG A  67
ILE A 111
TYR A 117
THR A 133
 None
 0.84A 1draB-3vcoA:
19.1		 1draB-3vcoA:
28.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DRB_A_MTXA161_1
(DIHYDROFOLATE
REDUCTASE)		 3vco DIHYDROFOLATE
REDUCTASE
(Schistosoma
mansoni) 		7 / 12 ALA A   8
ILE A  57
LEU A  64
ARG A  67
ILE A 111
TYR A 117
THR A 133
 None
 0.58A 1drbA-3vcoA:
19.0		 1drbA-3vcoA:
28.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DRB_A_MTXA161_1
(DIHYDROFOLATE
REDUCTASE)		 3vco DIHYDROFOLATE
REDUCTASE
(Schistosoma
mansoni) 		6 / 12 ALA A   8
LYS A  33
ILE A  57
ILE A 111
TYR A 117
THR A 133
 None
 0.92A 1drbA-3vcoA:
19.0		 1drbA-3vcoA:
28.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DRB_A_MTXA161_1
(DIHYDROFOLATE
REDUCTASE)		 3vco DIHYDROFOLATE
REDUCTASE
(Schistosoma
mansoni) 		6 / 12 ALA A   8
SER A  56
LEU A  64
ARG A  67
TYR A 117
THR A 133
 None
 0.79A 1drbA-3vcoA:
19.0		 1drbA-3vcoA:
28.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DRB_B_MTXB361_1
(DIHYDROFOLATE
REDUCTASE)		 3vco DIHYDROFOLATE
REDUCTASE
(Schistosoma
mansoni) 		9 / 12 ALA A   8
PHE A  32
LYS A  33
ILE A  57
LEU A  64
ARG A  67
ILE A 111
TYR A 117
THR A 133
 None
 0.80A 1drbB-3vcoA:
19.0		 1drbB-3vcoA:
28.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DRE_A_MTXA161_1
(DIHYDROFOLATE
REDUCTASE)		 3vco DIHYDROFOLATE
REDUCTASE
(Schistosoma
mansoni) 		9 / 12 ALA A   8
ASP A  28
PHE A  32
LYS A  33
SER A  56
ILE A  57
LEU A  64
ARG A  67
TYR A 117
 None
 0.79A 1dreA-3vcoA:
18.4		 1dreA-3vcoA:
29.35
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1DRF_A_FOLA187_0
(DIHYDROFOLATE
REDUCTASE)		 3vco DIHYDROFOLATE
REDUCTASE
(Schistosoma
mansoni) 		7 / 12 ALA A   8
PHE A  32
SER A  56
ILE A  57
PRO A  58
LEU A  64
TYR A 117
 None
 0.54A 1drfA-3vcoA:
23.8		 1drfA-3vcoA:
36.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DYI_A_FOLA161_0
(DIHYDROFOLATE
REDUCTASE)		 3vco DIHYDROFOLATE
REDUCTASE
(Schistosoma
mansoni) 		9 / 12 ALA A   8
ASP A  28
PHE A  32
LYS A  33
THR A  53
ILE A  57
LEU A  64
TYR A 117
THR A 133
 None
None
None
None
SO4  A 201 (-3.7A)
None
None
None
None
 0.84A 1dyiA-3vcoA:
19.0		 1dyiA-3vcoA:
29.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DYI_B_FOLB161_0
(DIHYDROFOLATE
REDUCTASE)		 3vco DIHYDROFOLATE
REDUCTASE
(Schistosoma
mansoni) 		9 / 12 ALA A   8
ASP A  28
PHE A  32
LYS A  33
THR A  53
ILE A  57
LEU A  64
TYR A 117
THR A 133
 None
None
None
None
SO4  A 201 (-3.7A)
None
None
None
None
 0.86A 1dyiB-3vcoA:
18.8		 1dyiB-3vcoA:
29.35
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1DYR_A_TOPA407_1
(DIHYDROFOLATE
REDUCTASE)		 3vco DIHYDROFOLATE
REDUCTASE
(Schistosoma
mansoni) 		7 / 11 ALA A   8
PHE A  32
ILE A  57
PRO A  58
ILE A 111
TYR A 117
THR A 133
 None
 0.51A 1dyrA-3vcoA:
22.4		 1dyrA-3vcoA:
34.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1J3J_A_CP6A609_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 3vco DIHYDROFOLATE
REDUCTASE
(Schistosoma
mansoni) 		8 / 10 ALA A   8
ASP A  28
PHE A  32
SER A  56
ILE A  57
ILE A 111
TYR A 117
THR A 133
 None
 0.65A 1j3jA-3vcoA:
19.6		 1j3jA-3vcoA:
27.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1J3J_B_CP6B709_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 3vco DIHYDROFOLATE
REDUCTASE
(Schistosoma
mansoni) 		8 / 9 ALA A   8
ASP A  28
PHE A  32
SER A  56
ILE A  57
ILE A 111
TYR A 117
THR A 133
 None
 0.71A 1j3jB-3vcoA:
19.6		 1j3jB-3vcoA:
27.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JOL_A_FFOA161_0
(DIHYDROFOLATE
REDUCTASE)		 3vco DIHYDROFOLATE
REDUCTASE
(Schistosoma
mansoni) 		7 / 12 ALA A   8
ASP A  28
PHE A  32
ILE A  57
LEU A  64
TYR A 117
THR A 133
 None
 0.59A 1jolA-3vcoA:
19.1		 1jolA-3vcoA:
29.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JOL_A_FFOA161_0
(DIHYDROFOLATE
REDUCTASE)		 3vco DIHYDROFOLATE
REDUCTASE
(Schistosoma
mansoni) 		7 / 12 ALA A   8
ASP A  28
PHE A  32
LYS A  33
ILE A  57
TYR A 117
THR A 133
 None
 0.90A 1jolA-3vcoA:
19.1		 1jolA-3vcoA:
29.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JOL_B_FFOB361_0
(DIHYDROFOLATE
REDUCTASE)		 3vco DIHYDROFOLATE
REDUCTASE
(Schistosoma
mansoni) 		7 / 12 ALA A   8
ASP A  28
PHE A  32
ILE A  57
LEU A  64
TYR A 117
THR A 133
 None
 0.62A 1jolB-3vcoA:
19.0		 1jolB-3vcoA:
29.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JOL_B_FFOB361_0
(DIHYDROFOLATE
REDUCTASE)		 3vco DIHYDROFOLATE
REDUCTASE
(Schistosoma
mansoni) 		6 / 12 ALA A   8
ASP A  28
PHE A  32
LYS A  33
TYR A 117
THR A 133
 None
 0.83A 1jolB-3vcoA:
19.0		 1jolB-3vcoA:
29.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JOM_A_FFOA161_0
(DIHYDROFOLATE
REDUCTASE)		 3vco DIHYDROFOLATE
REDUCTASE
(Schistosoma
mansoni) 		8 / 11 ALA A   8
ASP A  28
PHE A  32
ILE A  57
LEU A  64
ARG A  67
TYR A 117
THR A 133
 None
 0.57A 1jomA-3vcoA:
18.7		 1jomA-3vcoA:
29.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JOM_A_FFOA161_0
(DIHYDROFOLATE
REDUCTASE)		 3vco DIHYDROFOLATE
REDUCTASE
(Schistosoma
mansoni) 		7 / 11 ALA A   8
ASP A  28
PHE A  32
LYS A  33
ILE A  57
TYR A 117
THR A 133
 None
 0.93A 1jomA-3vcoA:
18.7		 1jomA-3vcoA:
29.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QZF_A_FOLA605_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 3vco DIHYDROFOLATE
REDUCTASE
(Schistosoma
mansoni) 		9 / 12 VAL A   6
ALA A   8
ASP A  28
THR A  53
ILE A  57
LEU A  64
ARG A  67
TYR A 117
THR A 133
 None
None
None
SO4  A 201 (-3.7A)
None
None
None
None
None
 0.67A 1qzfA-3vcoA:
19.1		 1qzfA-3vcoA:
16.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QZF_B_FOLB609_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 3vco DIHYDROFOLATE
REDUCTASE
(Schistosoma
mansoni) 		9 / 12 VAL A   6
ALA A   8
ASP A  28
THR A  53
ILE A  57
LEU A  64
ARG A  67
TYR A 117
THR A 133
 None
None
None
SO4  A 201 (-3.7A)
None
None
None
None
None
 0.67A 1qzfB-3vcoA:
19.0		 1qzfB-3vcoA:
16.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QZF_C_FOLC613_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 3vco DIHYDROFOLATE
REDUCTASE
(Schistosoma
mansoni) 		9 / 12 VAL A   6
ALA A   8
ASP A  28
THR A  53
ILE A  57
LEU A  64
ARG A  67
TYR A 117
THR A 133
 None
None
None
SO4  A 201 (-3.7A)
None
None
None
None
None
 0.67A 1qzfC-3vcoA:
18.9		 1qzfC-3vcoA:
16.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QZF_D_FOLD617_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 3vco DIHYDROFOLATE
REDUCTASE
(Schistosoma
mansoni) 		9 / 12 VAL A   6
ALA A   8
ASP A  28
THR A  53
ILE A  57
LEU A  64
ARG A  67
TYR A 117
THR A 133
 None
None
None
SO4  A 201 (-3.7A)
None
None
None
None
None
 0.68A 1qzfD-3vcoA:
19.0		 1qzfD-3vcoA:
16.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QZF_E_FOLE621_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 3vco DIHYDROFOLATE
REDUCTASE
(Schistosoma
mansoni) 		9 / 12 VAL A   6
ALA A   8
ASP A  28
THR A  53
ILE A  57
LEU A  64
ARG A  67
TYR A 117
THR A 133
 None
None
None
SO4  A 201 (-3.7A)
None
None
None
None
None
 0.68A 1qzfE-3vcoA:
18.9		 1qzfE-3vcoA:
16.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RA2_A_FOLA161_0
(DIHYDROFOLATE
REDUCTASE)		 3vco DIHYDROFOLATE
REDUCTASE
(Schistosoma
mansoni) 		8 / 12 ALA A   8
ASP A  28
PHE A  32
ILE A  57
LEU A  64
ILE A 111
TYR A 117
THR A 133
 None
 0.67A 1ra2A-3vcoA:
18.5		 1ra2A-3vcoA:
29.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RA2_A_FOLA161_0
(DIHYDROFOLATE
REDUCTASE)		 3vco DIHYDROFOLATE
REDUCTASE
(Schistosoma
mansoni) 		8 / 12 ASP A  28
PHE A  32
LYS A  33
ILE A  57
LEU A  64
ILE A 111
TYR A 117
THR A 133
 None
 0.95A 1ra2A-3vcoA:
18.5		 1ra2A-3vcoA:
29.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RA3_A_MTXA161_1
(DIHYDROFOLATE
REDUCTASE)		 3vco DIHYDROFOLATE
REDUCTASE
(Schistosoma
mansoni) 		9 / 12 ALA A   8
ASP A  28
LYS A  33
ILE A  57
LEU A  64
ARG A  67
ILE A 111
TYR A 117
THR A 133
 None
 0.74A 1ra3A-3vcoA:
18.6		 1ra3A-3vcoA:
29.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RA8_A_FOLA161_0
(DIHYDROFOLATE
REDUCTASE)		 3vco DIHYDROFOLATE
REDUCTASE
(Schistosoma
mansoni) 		8 / 12 ALA A   8
PHE A  32
THR A  53
ILE A  57
LEU A  64
ILE A 111
TYR A 117
THR A 133
 None
None
SO4  A 201 (-3.7A)
None
None
None
None
None
 0.62A 1ra8A-3vcoA:
18.5		 1ra8A-3vcoA:
29.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RB2_A_FOLA161_0
(DIHYDROFOLATE
REDUCTASE)		 3vco DIHYDROFOLATE
REDUCTASE
(Schistosoma
mansoni) 		9 / 12 ALA A   8
ASP A  28
PHE A  32
LYS A  33
ILE A  57
LEU A  64
ILE A 111
TYR A 117
THR A 133
 None
 0.84A 1rb2A-3vcoA:
18.4		 1rb2A-3vcoA:
29.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RB2_B_FOLB161_0
(DIHYDROFOLATE
REDUCTASE)		 3vco DIHYDROFOLATE
REDUCTASE
(Schistosoma
mansoni) 		8 / 12 ALA A   8
ASP A  28
PHE A  32
LEU A  64
ARG A  67
ILE A 111
TYR A 117
THR A 133
 None
 0.44A 1rb2B-3vcoA:
18.5		 1rb2B-3vcoA:
29.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RB2_B_FOLB161_0
(DIHYDROFOLATE
REDUCTASE)		 3vco DIHYDROFOLATE
REDUCTASE
(Schistosoma
mansoni) 		5 / 12 PHE A  32
LYS A  33
LEU A  64
ILE A 111
TYR A 117
 None
 1.10A 1rb2B-3vcoA:
18.5		 1rb2B-3vcoA:
29.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RB3_A_MTXA161_1
(DIHYDROFOLATE
REDUCTASE)		 3vco DIHYDROFOLATE
REDUCTASE
(Schistosoma
mansoni) 		7 / 10 ALA A   8
ASP A  28
ILE A  57
ARG A  67
ILE A 111
TYR A 117
THR A 133
 None
 0.58A 1rb3A-3vcoA:
18.7		 1rb3A-3vcoA:
29.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RB3_A_MTXA161_1
(DIHYDROFOLATE
REDUCTASE)		 3vco DIHYDROFOLATE
REDUCTASE
(Schistosoma
mansoni) 		7 / 10 ALA A   8
ASP A  28
LYS A  33
ILE A  57
ILE A 111
TYR A 117
THR A 133
 None
 0.87A 1rb3A-3vcoA:
18.7		 1rb3A-3vcoA:
29.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RB3_B_MTXB161_1
(DIHYDROFOLATE
REDUCTASE)		 3vco DIHYDROFOLATE
REDUCTASE
(Schistosoma
mansoni) 		8 / 12 ALA A   8
ASP A  28
LYS A  33
SER A  56
ARG A  67
ILE A 111
TYR A 117
THR A 133
 None
 0.77A 1rb3B-3vcoA:
18.8		 1rb3B-3vcoA:
29.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RB3_B_MTXB161_1
(DIHYDROFOLATE
REDUCTASE)		 3vco DIHYDROFOLATE
REDUCTASE
(Schistosoma
mansoni) 		9 / 12 ALA A   8
ASP A  28
SER A  56
ILE A  57
LEU A  64
ARG A  67
ILE A 111
TYR A 117
THR A 133
 None
 0.53A 1rb3B-3vcoA:
18.8		 1rb3B-3vcoA:
29.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RD7_A_FOLA161_0
(DIHYDROFOLATE
REDUCTASE)		 3vco DIHYDROFOLATE
REDUCTASE
(Schistosoma
mansoni) 		9 / 12 ALA A   8
PHE A  32
LYS A  33
THR A  53
ILE A  57
LEU A  64
ILE A 111
TYR A 117
THR A 133
 None
None
None
SO4  A 201 (-3.7A)
None
None
None
None
None
 0.86A 1rd7A-3vcoA:
18.4		 1rd7A-3vcoA:
29.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RD7_B_FOLB361_0
(DIHYDROFOLATE
REDUCTASE)		 3vco DIHYDROFOLATE
REDUCTASE
(Schistosoma
mansoni) 		9 / 12 ALA A   8
ASP A  28
LYS A  33
THR A  53
ILE A  57
LEU A  64
ILE A 111
TYR A 117
THR A 133
 None
None
None
SO4  A 201 (-3.7A)
None
None
None
None
None
 0.91A 1rd7B-3vcoA:
18.2		 1rd7B-3vcoA:
29.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RE7_A_FOLA161_0
(DIHYDROFOLATE
REDUCTASE)		 3vco DIHYDROFOLATE
REDUCTASE
(Schistosoma
mansoni) 		9 / 12 ALA A   8
ASP A  28
PHE A  32
LYS A  33
THR A  53
ILE A  57
ILE A 111
TYR A 117
THR A 133
 None
None
None
None
SO4  A 201 (-3.7A)
None
None
None
None
 0.87A 1re7A-3vcoA:
18.3		 1re7A-3vcoA:
29.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RE7_B_FOLB361_0
(DIHYDROFOLATE
REDUCTASE)		 3vco DIHYDROFOLATE
REDUCTASE
(Schistosoma
mansoni) 		8 / 12 ALA A   8
ASP A  28
PHE A  32
ILE A  57
LEU A  64
ILE A 111
TYR A 117
THR A 133
 None
 0.63A 1re7B-3vcoA:
18.3		 1re7B-3vcoA:
29.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RE7_B_FOLB361_0
(DIHYDROFOLATE
REDUCTASE)		 3vco DIHYDROFOLATE
REDUCTASE
(Schistosoma
mansoni) 		7 / 12 ALA A   8
ASP A  28
PHE A  32
LYS A  33
ILE A  57
TYR A 117
THR A 133
 None
 0.94A 1re7B-3vcoA:
18.3		 1re7B-3vcoA:
29.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RG7_A_MTXA161_1
(DIHYDROFOLATE
REDUCTASE)		 3vco DIHYDROFOLATE
REDUCTASE
(Schistosoma
mansoni) 		7 / 12 ALA A   8
ASP A  28
LYS A  33
THR A  53
ILE A  57
LEU A  64
TYR A 117
 None
None
None
SO4  A 201 (-3.7A)
None
None
None
 1.03A 1rg7A-3vcoA:
18.8		 1rg7A-3vcoA:
29.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RG7_A_MTXA161_1
(DIHYDROFOLATE
REDUCTASE)		 3vco DIHYDROFOLATE
REDUCTASE
(Schistosoma
mansoni) 		8 / 12 ALA A   8
ASP A  28
THR A  53
SER A  56
ILE A  57
LEU A  64
ARG A  67
TYR A 117
 None
None
SO4  A 201 (-3.7A)
None
None
None
None
None
 0.77A 1rg7A-3vcoA:
18.8		 1rg7A-3vcoA:
29.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RH3_A_MTXA161_1
(DIHYDROFOLATE
REDUCTASE)		 3vco DIHYDROFOLATE
REDUCTASE
(Schistosoma
mansoni) 		8 / 12 ASP A  28
PHE A  32
LYS A  33
SER A  56
ILE A  57
LEU A  64
ARG A  67
TYR A 117
 None
 0.76A 1rh3A-3vcoA:
18.4		 1rh3A-3vcoA:
29.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RX2_A_FOLA161_0
(DIHYDROFOLATE
REDUCTASE)		 3vco DIHYDROFOLATE
REDUCTASE
(Schistosoma
mansoni) 		8 / 12 ALA A   8
PHE A  32
LYS A  33
ILE A  57
LEU A  64
ILE A 111
TYR A 117
THR A 133
 None
 0.80A 1rx2A-3vcoA:
18.4		 1rx2A-3vcoA:
29.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RX3_A_MTXA161_1
(DIHYDROFOLATE
REDUCTASE)		 3vco DIHYDROFOLATE
REDUCTASE
(Schistosoma
mansoni) 		8 / 12 ALA A   8
ASP A  28
PHE A  32
SER A  56
ILE A  57
LEU A  64
ARG A  67
TYR A 117
 None
 0.72A 1rx3A-3vcoA:
18.5		 1rx3A-3vcoA:
29.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RX7_A_FOLA161_0
(DIHYDROFOLATE
REDUCTASE)		 3vco DIHYDROFOLATE
REDUCTASE
(Schistosoma
mansoni) 		9 / 12 ALA A   8
ASP A  28
PHE A  32
THR A  53
ILE A  57
LEU A  64
ILE A 111
TYR A 117
THR A 133
 None
None
None
SO4  A 201 (-3.7A)
None
None
None
None
None
 0.72A 1rx7A-3vcoA:
18.8		 1rx7A-3vcoA:
29.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RX7_A_FOLA161_0
(DIHYDROFOLATE
REDUCTASE)		 3vco DIHYDROFOLATE
REDUCTASE
(Schistosoma
mansoni) 		9 / 12 ASP A  28
PHE A  32
LYS A  33
THR A  53
ILE A  57
LEU A  64
ILE A 111
TYR A 117
THR A 133
 None
None
None
SO4  A 201 (-3.7A)
None
None
None
None
None
 0.77A 1rx7A-3vcoA:
18.8		 1rx7A-3vcoA:
29.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RX8_A_FOLA161_0
(DIHYDROFOLATE
REDUCTASE)		 3vco DIHYDROFOLATE
REDUCTASE
(Schistosoma
mansoni) 		6 / 12 ALA A   8
PHE A  32
ILE A  57
LEU A  64
TYR A 117
THR A 133
 None
 0.74A 1rx8A-3vcoA:
18.3		 1rx8A-3vcoA:
29.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RX8_A_FOLA161_0
(DIHYDROFOLATE
REDUCTASE)		 3vco DIHYDROFOLATE
REDUCTASE
(Schistosoma
mansoni) 		6 / 12 PHE A  32
LYS A  33
ILE A  57
LEU A  64
TYR A 117
THR A 133
 None
 0.75A 1rx8A-3vcoA:
18.3		 1rx8A-3vcoA:
29.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TDR_A_MTXA170_1
(TELLUROMETHIONYL
DIHYDROFOLATE
REDUCTASE)		 3vco DIHYDROFOLATE
REDUCTASE
(Schistosoma
mansoni) 		8 / 12 ALA A   8
ASP A  28
PHE A  32
LYS A  33
THR A  53
ILE A  57
ARG A  67
TYR A 117
 None
None
None
None
SO4  A 201 (-3.7A)
None
None
None
 0.87A 1tdrA-3vcoA:
19.1		 1tdrA-3vcoA:
29.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TDR_A_MTXA170_1
(TELLUROMETHIONYL
DIHYDROFOLATE
REDUCTASE)		 3vco DIHYDROFOLATE
REDUCTASE
(Schistosoma
mansoni) 		8 / 12 ALA A   8
ASP A  28
PHE A  32
THR A  53
ILE A  57
LEU A  64
ARG A  67
TYR A 117
 None
None
None
SO4  A 201 (-3.7A)
None
None
None
None
 0.61A 1tdrA-3vcoA:
19.1		 1tdrA-3vcoA:
29.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TDR_B_MTXB170_1
(TELLUROMETHIONYL
DIHYDROFOLATE
REDUCTASE)		 3vco DIHYDROFOLATE
REDUCTASE
(Schistosoma
mansoni) 		7 / 10 ALA A   8
ASP A  28
ILE A  57
LEU A  64
ARG A  67
TYR A 117
THR A 133
 None
 0.68A 1tdrB-3vcoA:
19.0		 1tdrB-3vcoA:
29.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TDR_B_MTXB170_1
(TELLUROMETHIONYL
DIHYDROFOLATE
REDUCTASE)		 3vco DIHYDROFOLATE
REDUCTASE
(Schistosoma
mansoni) 		7 / 10 ALA A   8
ASP A  28
LYS A  33
ILE A  57
LEU A  64
TYR A 117
THR A 133
 None
 0.97A 1tdrB-3vcoA:
19.0		 1tdrB-3vcoA:
29.35
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1U70_A_MTXA187_1
(DIHYDROFOLATE
REDUCTASE)		 3vco DIHYDROFOLATE
REDUCTASE
(Schistosoma
mansoni) 		5 / 12 ALA A   8
PRO A  58
LEU A  64
ARG A  67
TYR A 117
 None
 0.63A 1u70A-3vcoA:
24.4		 1u70A-3vcoA:
40.93
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1U72_A_MTXA188_1
(DIHYDROFOLATE
REDUCTASE)		 3vco DIHYDROFOLATE
REDUCTASE
(Schistosoma
mansoni) 		6 / 12 ALA A   8
SER A  56
PRO A  58
LEU A  64
ARG A  67
TYR A 117
 None
 0.63A 1u72A-3vcoA:
23.9		 1u72A-3vcoA:
36.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BL9_A_CP6A1240_1
(DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 3vco DIHYDROFOLATE
REDUCTASE
(Schistosoma
mansoni) 		9 / 12 ALA A   8
ASP A  28
MET A  29
PHE A  32
SER A  56
ILE A  57
ILE A 111
TYR A 117
THR A 133
 None
 0.77A 2bl9A-3vcoA:
19.9		 2bl9A-3vcoA:
29.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BL9_A_CP6A1240_1
(DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 3vco DIHYDROFOLATE
REDUCTASE
(Schistosoma
mansoni) 		5 / 12 ALA A   8
ASP A  28
PHE A  32
SER A  56
THR A 133
 None
 1.08A 2bl9A-3vcoA:
19.9		 2bl9A-3vcoA:
29.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BLA_A_CP6A302_1
(DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 3vco DIHYDROFOLATE
REDUCTASE
(Schistosoma
mansoni) 		5 / 11 ALA A   8
ASP A  28
MET A  29
SER A  56
THR A 133
 None
 1.17A 2blaA-3vcoA:
19.9		 2blaA-3vcoA:
29.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BLA_A_CP6A302_1
(DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 3vco DIHYDROFOLATE
REDUCTASE
(Schistosoma
mansoni) 		8 / 11 ALA A   8
ASP A  28
PHE A  32
SER A  56
ILE A  57
ILE A 111
TYR A 117
THR A 133
 None
 0.87A 2blaA-3vcoA:
19.9		 2blaA-3vcoA:
29.20
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2CD2_A_FOLA307_0
(DIHYDROFOLATE
REDUCTASE)		 3vco DIHYDROFOLATE
REDUCTASE
(Schistosoma
mansoni) 		8 / 12 ALA A   8
THR A  53
PRO A  58
LEU A  64
ARG A  67
ILE A 111
TYR A 117
THR A 133
 None
SO4  A 201 (-3.7A)
None
None
None
None
None
None
 0.65A 2cd2A-3vcoA:
22.3		 2cd2A-3vcoA:
34.23
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2CD2_A_FOLA307_0
(DIHYDROFOLATE
REDUCTASE)		 3vco DIHYDROFOLATE
REDUCTASE
(Schistosoma
mansoni) 		8 / 12 ALA A   8
THR A  53
PRO A  58
PHE A  61
LEU A  64
ARG A  67
ILE A 111
TYR A 117
 None
SO4  A 201 (-3.7A)
None
None
None
None
None
None
 0.74A 2cd2A-3vcoA:
22.3		 2cd2A-3vcoA:
34.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2D0K_A_FOLA1161_0
(DIHYDROFOLATE
REDUCTASE)		 3vco DIHYDROFOLATE
REDUCTASE
(Schistosoma
mansoni) 		8 / 12 ALA A   8
PHE A  32
ILE A  57
LEU A  64
ARG A  67
ILE A 111
TYR A 117
THR A 133
 None
 0.66A 2d0kA-3vcoA:
17.9		 2d0kA-3vcoA:
29.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2D0K_B_FOLB2161_0
(DIHYDROFOLATE
REDUCTASE)		 3vco DIHYDROFOLATE
REDUCTASE
(Schistosoma
mansoni) 		9 / 12 ALA A   8
PHE A  32
THR A  53
ILE A  57
LEU A  64
ARG A  67
ILE A 111
TYR A 117
THR A 133
 None
None
SO4  A 201 (-3.7A)
None
None
None
None
None
None
 0.64A 2d0kB-3vcoA:
18.2		 2d0kB-3vcoA:
29.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DRC_A_MTXA161_1
(DIHYDROFOLATE
REDUCTASE)		 3vco DIHYDROFOLATE
REDUCTASE
(Schistosoma
mansoni) 		7 / 12 ALA A   8
ASP A  28
ILE A  57
LEU A  64
ARG A  67
ILE A 111
TYR A 117
 None
 0.58A 2drcA-3vcoA:
19.0		 2drcA-3vcoA:
28.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DRC_A_MTXA161_1
(DIHYDROFOLATE
REDUCTASE)		 3vco DIHYDROFOLATE
REDUCTASE
(Schistosoma
mansoni) 		7 / 12 ALA A   8
ASP A  28
LYS A  33
ILE A  57
LEU A  64
ILE A 111
TYR A 117
 None
 0.89A 2drcA-3vcoA:
19.0		 2drcA-3vcoA:
28.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DRC_A_MTXA161_1
(DIHYDROFOLATE
REDUCTASE)		 3vco DIHYDROFOLATE
REDUCTASE
(Schistosoma
mansoni) 		6 / 12 ALA A   8
ASP A  28
SER A  56
LEU A  64
ARG A  67
TYR A 117
 None
 0.77A 2drcA-3vcoA:
19.0		 2drcA-3vcoA:
28.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DRC_B_MTXB161_1
(DIHYDROFOLATE
REDUCTASE)		 3vco DIHYDROFOLATE
REDUCTASE
(Schistosoma
mansoni) 		8 / 12 ALA A   8
ASP A  28
ILE A  57
LEU A  64
ARG A  67
ILE A 111
TYR A 117
THR A 133
 None
 0.53A 2drcB-3vcoA:
18.9		 2drcB-3vcoA:
28.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DRC_B_MTXB161_1
(DIHYDROFOLATE
REDUCTASE)		 3vco DIHYDROFOLATE
REDUCTASE
(Schistosoma
mansoni) 		7 / 12 ALA A   8
ASP A  28
LYS A  33
ILE A  57
ILE A 111
TYR A 117
THR A 133
 None
 0.84A 2drcB-3vcoA:
18.9		 2drcB-3vcoA:
28.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OIP_A_MTXA605_1
(CHAIN A, CRYSTAL
STRUCTURE OF DHFR)		 3vco DIHYDROFOLATE
REDUCTASE
(Schistosoma
mansoni) 		9 / 12 VAL A   6
ALA A   8
ASP A  28
PHE A  32
THR A  53
ILE A  57
LEU A  64
ARG A  67
TYR A 117
 None
None
None
None
SO4  A 201 (-3.7A)
None
None
None
None
 0.62A 2oipA-3vcoA:
19.7		 2oipA-3vcoA:
16.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OIP_B_MTXB609_1
(CHAIN A, CRYSTAL
STRUCTURE OF DHFR)		 3vco DIHYDROFOLATE
REDUCTASE
(Schistosoma
mansoni) 		8 / 12 ALA A   8
ASP A  28
PHE A  32
THR A  53
LEU A  64
ARG A  67
TYR A 117
THR A 133
 None
None
None
SO4  A 201 (-3.7A)
None
None
None
None
 0.58A 2oipB-3vcoA:
18.2		 2oipB-3vcoA:
16.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OIP_C_MTXC613_1
(CHAIN A, CRYSTAL
STRUCTURE OF DHFR)		 3vco DIHYDROFOLATE
REDUCTASE
(Schistosoma
mansoni) 		9 / 12 VAL A   6
ALA A   8
ASP A  28
PHE A  32
THR A  53
LEU A  64
ARG A  67
TYR A 117
THR A 133
 None
None
None
None
SO4  A 201 (-3.7A)
None
None
None
None
 0.59A 2oipC-3vcoA:
19.3		 2oipC-3vcoA:
16.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OIP_D_MTXD617_1
(CHAIN A, CRYSTAL
STRUCTURE OF DHFR)		 3vco DIHYDROFOLATE
REDUCTASE
(Schistosoma
mansoni) 		8 / 12 ALA A   8
ASP A  28
PHE A  32
THR A  53
ILE A  57
LEU A  64
ARG A  67
TYR A 117
 None
None
None
SO4  A 201 (-3.7A)
None
None
None
None
 0.74A 2oipD-3vcoA:
19.9		 2oipD-3vcoA:
16.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OIP_E_MTXE621_1
(CHAIN A, CRYSTAL
STRUCTURE OF DHFR)		 3vco DIHYDROFOLATE
REDUCTASE
(Schistosoma
mansoni) 		8 / 12 ALA A   8
ASP A  28
PHE A  32
THR A  53
ILE A  57
LEU A  64
ARG A  67
TYR A 117
 None
None
None
SO4  A 201 (-3.7A)
None
None
None
None
 0.75A 2oipE-3vcoA:
19.0		 2oipE-3vcoA:
16.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QK8_A_MTXA200_1
(DIHYDROFOLATE
REDUCTASE)		 3vco DIHYDROFOLATE
REDUCTASE
(Schistosoma
mansoni) 		6 / 12 ALA A   8
LYS A  33
ILE A  57
LEU A  64
ARG A  67
TYR A 117
 None
 0.92A 2qk8A-3vcoA:
17.9		 2qk8A-3vcoA:
29.85
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2W3A_A_TOPA1190_1
(DIHYDROFOLATE
REDUCTASE)		 3vco DIHYDROFOLATE
REDUCTASE
(Schistosoma
mansoni) 		6 / 11 ALA A   8
PHE A  32
THR A  53
ILE A  57
PRO A  58
TYR A 117
 None
None
SO4  A 201 (-3.7A)
None
None
None
 0.62A 2w3aA-3vcoA:
23.7		 2w3aA-3vcoA:
37.56
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2W3A_A_TOPA1190_1
(DIHYDROFOLATE
REDUCTASE)		 3vco DIHYDROFOLATE
REDUCTASE
(Schistosoma
mansoni) 		6 / 11 ALA A   8
PHE A  32
THR A  53
ILE A  57
TYR A 117
THR A 133
 None
None
SO4  A 201 (-3.7A)
None
None
None
 0.74A 2w3aA-3vcoA:
23.7		 2w3aA-3vcoA:
37.56
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2W3A_B_TOPB1189_1
(DIHYDROFOLATE
REDUCTASE)		 3vco DIHYDROFOLATE
REDUCTASE
(Schistosoma
mansoni) 		6 / 10 ALA A   8
PHE A  32
THR A  53
ILE A  57
LEU A  64
TYR A 117
 None
None
SO4  A 201 (-3.7A)
None
None
None
 0.65A 2w3aB-3vcoA:
23.5		 2w3aB-3vcoA:
37.56
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2W3A_B_TOPB1189_1
(DIHYDROFOLATE
REDUCTASE)		 3vco DIHYDROFOLATE
REDUCTASE
(Schistosoma
mansoni) 		6 / 10 ALA A   8
PHE A  32
THR A  53
LEU A  64
TYR A 117
THR A 133
 None
None
SO4  A 201 (-3.7A)
None
None
None
 0.70A 2w3aB-3vcoA:
23.5		 2w3aB-3vcoA:
37.56
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2W3B_A_FOLA401_0
(DIHYDROFOLATE
REDUCTASE)		 3vco DIHYDROFOLATE
REDUCTASE
(Schistosoma
mansoni) 		8 / 12 ALA A   8
PHE A  32
THR A  53
ILE A  57
PRO A  58
LEU A  64
TYR A 117
THR A 133
 None
None
SO4  A 201 (-3.7A)
None
None
None
None
None
 0.63A 2w3bA-3vcoA:
24.0		 2w3bA-3vcoA:
37.56
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2W3B_B_FOLB401_0
(DIHYDROFOLATE
REDUCTASE)		 3vco DIHYDROFOLATE
REDUCTASE
(Schistosoma
mansoni) 		7 / 12 ALA A   8
PHE A  32
ILE A  57
PRO A  58
LEU A  64
TYR A 117
THR A 133
 None
 0.72A 2w3bB-3vcoA:
23.7		 2w3bB-3vcoA:
37.56
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2W3M_A_FOLA1188_0
(DIHYDROFOLATE
REDUCTASE)		 3vco DIHYDROFOLATE
REDUCTASE
(Schistosoma
mansoni) 		7 / 12 ALA A   8
PHE A  32
ILE A  57
PRO A  58
LEU A  64
TYR A 117
THR A 133
 None
 0.77A 2w3mA-3vcoA:
23.6		 2w3mA-3vcoA:
37.56
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2W3M_B_FOLB1188_0
(DIHYDROFOLATE
REDUCTASE)		 3vco DIHYDROFOLATE
REDUCTASE
(Schistosoma
mansoni) 		6 / 12 ALA A   8
PHE A  32
LEU A  64
ARG A  67
TYR A 117
THR A 133
 None
 0.58A 2w3mB-3vcoA:
23.4		 2w3mB-3vcoA:
37.56
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2W3V_A_TOPA1169_1
(DIHYDROFOLATE
REDUCTASE)		 3vco DIHYDROFOLATE
REDUCTASE
(Schistosoma
mansoni) 		7 / 12 VAL A   6
ALA A   8
ASP A  28
PHE A  32
ILE A 111
TYR A 117
THR A 133
 None
 0.56A 2w3vA-3vcoA:
18.6		 2w3vA-3vcoA:
31.43
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2W3V_A_TOPA1169_1
(DIHYDROFOLATE
REDUCTASE)		 3vco DIHYDROFOLATE
REDUCTASE
(Schistosoma
mansoni) 		6 / 12 VAL A   6
ALA A   8
ASP A  28
SER A  56
TYR A 117
THR A 133
 None
 0.85A 2w3vA-3vcoA:
18.6		 2w3vA-3vcoA:
31.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W9G_A_TOPA1159_1
(DIHYDROFOLATE
REDUCTASE)		 3vco DIHYDROFOLATE
REDUCTASE
(Schistosoma
mansoni) 		5 / 10 ALA A   8
ASP A  28
SER A  56
ILE A  57
THR A 133
 None
 0.94A 2w9gA-3vcoA:
17.7		 2w9gA-3vcoA:
29.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W9H_A_TOPA1160_1
(DIHYDROFOLATE
REDUCTASE)		 3vco DIHYDROFOLATE
REDUCTASE
(Schistosoma
mansoni) 		5 / 10 ALA A   8
ASP A  28
SER A  56
ILE A  57
THR A 133
 None
 0.89A 2w9hA-3vcoA:
17.7		 2w9hA-3vcoA:
29.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W9S_A_TOPA1160_1
(DIHYDROFOLATE
REDUCTASE TYPE 1
FROM TN4003)		 3vco DIHYDROFOLATE
REDUCTASE
(Schistosoma
mansoni) 		6 / 11 ALA A   8
ASP A  28
SER A  56
ILE A  57
TYR A 117
THR A 133
 None
 0.91A 2w9sA-3vcoA:
17.4		 2w9sA-3vcoA:
29.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W9S_B_TOPB1160_1
(DIHYDROFOLATE
REDUCTASE TYPE 1
FROM TN4003)		 3vco DIHYDROFOLATE
REDUCTASE
(Schistosoma
mansoni) 		6 / 11 ALA A   8
ASP A  28
SER A  56
ILE A  57
TYR A 117
THR A 133
 None
 0.89A 2w9sB-3vcoA:
17.4		 2w9sB-3vcoA:
29.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W9S_C_TOPC1160_1
(DIHYDROFOLATE
REDUCTASE TYPE 1
FROM TN4003)		 3vco DIHYDROFOLATE
REDUCTASE
(Schistosoma
mansoni) 		6 / 10 ALA A   8
ASP A  28
SER A  56
ILE A  57
TYR A 117
THR A 133
 None
 0.90A 2w9sC-3vcoA:
17.4		 2w9sC-3vcoA:
29.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W9S_D_TOPD1158_1
(DIHYDROFOLATE
REDUCTASE TYPE 1
FROM TN4003)		 3vco DIHYDROFOLATE
REDUCTASE
(Schistosoma
mansoni) 		5 / 10 ALA A   8
ASP A  28
SER A  56
TYR A 117
THR A 133
 None
 0.63A 2w9sD-3vcoA:
17.4		 2w9sD-3vcoA:
29.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W9S_D_TOPD1158_1
(DIHYDROFOLATE
REDUCTASE TYPE 1
FROM TN4003)		 3vco DIHYDROFOLATE
REDUCTASE
(Schistosoma
mansoni) 		5 / 10 ILE A 111
ALA A  46
LEU A  96
LEU A   3
ILE A 110
 None
 1.19A 2w9sD-3vcoA:
17.4		 2w9sD-3vcoA:
29.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W9S_E_TOPE1160_1
(DIHYDROFOLATE
REDUCTASE TYPE 1
FROM TN4003)		 3vco DIHYDROFOLATE
REDUCTASE
(Schistosoma
mansoni) 		4 / 8 ALA A   8
ASP A  28
TYR A 117
THR A 133
 None
 0.50A 2w9sE-3vcoA:
17.4		 2w9sE-3vcoA:
29.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W9S_F_TOPF1159_1
(DIHYDROFOLATE
REDUCTASE TYPE 1
FROM TN4003)		 3vco DIHYDROFOLATE
REDUCTASE
(Schistosoma
mansoni) 		5 / 10 ALA A   8
ASP A  28
SER A  56
TYR A 117
THR A 133
 None
 0.62A 2w9sF-3vcoA:
17.5		 2w9sF-3vcoA:
29.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZM9_A_ACAA502_1
(6-AMINOHEXANOATE-DIM
ER HYDROLASE)		 3vco DIHYDROFOLATE
REDUCTASE
(Schistosoma
mansoni) 		4 / 8 ALA A   8
TYR A 117
GLY A  16
ILE A  15
 None
 0.91A 2zm9A-3vcoA:
undetectable		 2zm9A-3vcoA:
18.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZZA_A_FOLA164_0
(DIHYDROFOLATE
REDUCTASE)		 3vco DIHYDROFOLATE
REDUCTASE
(Schistosoma
mansoni) 		7 / 12 ALA A   8
LYS A  33
ILE A  57
LEU A  64
ARG A  67
TYR A 117
THR A 133
 None
 0.98A 2zzaA-3vcoA:
18.3		 2zzaA-3vcoA:
27.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZZA_B_FOLB164_0
(DIHYDROFOLATE
REDUCTASE)		 3vco DIHYDROFOLATE
REDUCTASE
(Schistosoma
mansoni) 		7 / 11 ALA A   8
LYS A  33
ILE A  57
LEU A  64
ARG A  67
TYR A 117
THR A 133
 None
 1.05A 2zzaB-3vcoA:
18.4		 2zzaB-3vcoA:
27.32
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3CD2_A_MTXA307_1
(DIHYDROFOLATE
REDUCTASE)		 3vco DIHYDROFOLATE
REDUCTASE
(Schistosoma
mansoni) 		7 / 12 LYS A  33
PRO A  58
PHE A  61
LEU A  64
ARG A  67
ILE A 111
TYR A 117
 None
 0.93A 3cd2A-3vcoA:
22.4		 3cd2A-3vcoA:
34.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CL9_A_MTXA602_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE (DHFR-TS))		 3vco DIHYDROFOLATE
REDUCTASE
(Schistosoma
mansoni) 		9 / 12 ALA A   8
ASP A  28
MET A  29
THR A  53
SER A  56
PRO A  58
LEU A  64
ARG A  67
TYR A 117
 None
None
None
SO4  A 201 (-3.7A)
None
None
None
None
None
 0.84A 3cl9A-3vcoA:
20.3		 3cl9A-3vcoA:
19.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CLB_A_TMQA611_1
(DHFR-TS)		 3vco DIHYDROFOLATE
REDUCTASE
(Schistosoma
mansoni) 		6 / 11 ALA A   8
ILE A  57
PRO A  58
LEU A  64
ILE A 111
TYR A 117
 None
 0.75A 3clbA-3vcoA:
20.0		 3clbA-3vcoA:
19.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CLB_A_TMQA611_1
(DHFR-TS)		 3vco DIHYDROFOLATE
REDUCTASE
(Schistosoma
mansoni) 		9 / 11 VAL A   6
ALA A   8
ASP A  28
MET A  29
ILE A  57
LEU A  64
ILE A 111
TYR A 117
THR A 133
 None
 0.72A 3clbA-3vcoA:
20.0		 3clbA-3vcoA:
19.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CLB_B_TMQB612_1
(DHFR-TS)		 3vco DIHYDROFOLATE
REDUCTASE
(Schistosoma
mansoni) 		9 / 12 ALA A   8
ASP A  28
MET A  29
PHE A  32
THR A  53
SER A  56
ILE A  57
ILE A 111
TYR A 117
 None
None
None
None
SO4  A 201 (-3.7A)
None
None
None
None
 0.75A 3clbB-3vcoA:
19.1		 3clbB-3vcoA:
19.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CLB_B_TMQB612_1
(DHFR-TS)		 3vco DIHYDROFOLATE
REDUCTASE
(Schistosoma
mansoni) 		6 / 12 THR A  53
SER A  56
ILE A  57
PRO A  58
ILE A 111
TYR A 117
 SO4  A 201 (-3.7A)
None
None
None
None
None
 0.86A 3clbB-3vcoA:
19.1		 3clbB-3vcoA:
19.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CLB_B_TMQB612_1
(DHFR-TS)		 3vco DIHYDROFOLATE
REDUCTASE
(Schistosoma
mansoni) 		6 / 12 THR A  53
SER A  56
ILE A  57
PRO A  58
PHE A  61
TYR A 117
 SO4  A 201 (-3.7A)
None
None
None
None
None
 0.83A 3clbB-3vcoA:
19.1		 3clbB-3vcoA:
19.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CLB_C_TMQC613_1
(DHFR-TS)		 3vco DIHYDROFOLATE
REDUCTASE
(Schistosoma
mansoni) 		7 / 12 ALA A   8
THR A  53
ILE A  57
PRO A  58
LEU A  64
ILE A 111
TYR A 117
 None
SO4  A 201 (-3.7A)
None
None
None
None
None
 0.71A 3clbC-3vcoA:
19.9		 3clbC-3vcoA:
19.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CLB_C_TMQC613_1
(DHFR-TS)		 3vco DIHYDROFOLATE
REDUCTASE
(Schistosoma
mansoni) 		10 / 12 VAL A   6
ALA A   8
ASP A  28
MET A  29
THR A  53
ILE A  57
LEU A  64
ILE A 111
TYR A 117
THR A 133
 None
None
None
None
SO4  A 201 (-3.7A)
None
None
None
None
None
 0.65A 3clbC-3vcoA:
19.9		 3clbC-3vcoA:
19.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CLB_D_TMQD614_1
(DHFR-TS)		 3vco DIHYDROFOLATE
REDUCTASE
(Schistosoma
mansoni) 		5 / 10 ALA A   8
ILE A  57
PRO A  58
ILE A 111
TYR A 117
 None
 0.70A 3clbD-3vcoA:
19.9		 3clbD-3vcoA:
19.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CLB_D_TMQD614_1
(DHFR-TS)		 3vco DIHYDROFOLATE
REDUCTASE
(Schistosoma
mansoni) 		8 / 10 VAL A   6
ALA A   8
ASP A  28
MET A  29
ILE A  57
ILE A 111
TYR A 117
THR A 133
 None
 0.68A 3clbD-3vcoA:
19.9		 3clbD-3vcoA:
19.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DAT_A_MTXA201_1
(DIHYDROFOLATE
REDUCTASE)		 3vco DIHYDROFOLATE
REDUCTASE
(Schistosoma
mansoni) 		5 / 12 ALA A   8
ILE A  57
LEU A  64
ARG A  67
TYR A 117
 None
 0.78A 3datA-3vcoA:
18.2		 3datA-3vcoA:
29.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DAU_A_MTXA201_1
(DIHYDROFOLATE
REDUCTASE)		 3vco DIHYDROFOLATE
REDUCTASE
(Schistosoma
mansoni) 		6 / 12 ALA A   8
ASP A  28
ILE A  57
LEU A  64
ARG A  67
TYR A 117
 None
 0.65A 3dauA-3vcoA:
18.7		 3dauA-3vcoA:
29.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DAU_A_MTXA201_1
(DIHYDROFOLATE
REDUCTASE)		 3vco DIHYDROFOLATE
REDUCTASE
(Schistosoma
mansoni) 		6 / 12 ALA A   8
ASP A  28
LYS A  33
ILE A  57
LEU A  64
TYR A 117
 None
 0.95A 3dauA-3vcoA:
18.7		 3dauA-3vcoA:
29.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DFR_A_MTXA164_1
(DIHYDROFOLATE
REDUCTASE)		 3vco DIHYDROFOLATE
REDUCTASE
(Schistosoma
mansoni) 		6 / 12 ALA A   8
ASP A  28
SER A  56
LEU A  64
ARG A  67
THR A 133
 None
 0.93A 3dfrA-3vcoA:
18.0		 3dfrA-3vcoA:
26.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DFR_A_MTXA164_1
(DIHYDROFOLATE
REDUCTASE)		 3vco DIHYDROFOLATE
REDUCTASE
(Schistosoma
mansoni) 		5 / 12 ALA A   8
ASP A  28
SER A  56
PRO A  58
THR A 133
 None
 0.78A 3dfrA-3vcoA:
18.0		 3dfrA-3vcoA:
26.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DRC_A_MTXA161_1
(DIHYDROFOLATE
REDUCTASE)		 3vco DIHYDROFOLATE
REDUCTASE
(Schistosoma
mansoni) 		7 / 12 ALA A   8
ASP A  28
ILE A  57
LEU A  64
ARG A  67
ILE A 111
TYR A 117
 None
 0.57A 3drcA-3vcoA:
19.1		 3drcA-3vcoA:
29.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DRC_A_MTXA161_1
(DIHYDROFOLATE
REDUCTASE)		 3vco DIHYDROFOLATE
REDUCTASE
(Schistosoma
mansoni) 		7 / 12 ALA A   8
ASP A  28
LYS A  33
ILE A  57
LEU A  64
ILE A 111
TYR A 117
 None
 0.88A 3drcA-3vcoA:
19.1		 3drcA-3vcoA:
29.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DRC_A_MTXA161_1
(DIHYDROFOLATE
REDUCTASE)		 3vco DIHYDROFOLATE
REDUCTASE
(Schistosoma
mansoni) 		6 / 12 ALA A   8
ASP A  28
SER A  56
LEU A  64
ARG A  67
TYR A 117
 None
 0.77A 3drcA-3vcoA:
19.1		 3drcA-3vcoA:
29.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DRC_B_MTXB361_1
(DIHYDROFOLATE
REDUCTASE)		 3vco DIHYDROFOLATE
REDUCTASE
(Schistosoma
mansoni) 		8 / 12 ALA A   8
ASP A  28
ILE A  57
LEU A  64
ARG A  67
ILE A 111
TYR A 117
THR A 133
 None
 0.53A 3drcB-3vcoA:
19.1		 3drcB-3vcoA:
29.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DRC_B_MTXB361_1
(DIHYDROFOLATE
REDUCTASE)		 3vco DIHYDROFOLATE
REDUCTASE
(Schistosoma
mansoni) 		8 / 12 ALA A   8
ASP A  28
LYS A  33
ILE A  57
LEU A  64
ILE A 111
TYR A 117
THR A 133
 None
 0.80A 3drcB-3vcoA:
19.1		 3drcB-3vcoA:
29.35
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3EIG_A_MTXA200_1
(DIHYDROFOLATE
REDUCTASE)		 3vco DIHYDROFOLATE
REDUCTASE
(Schistosoma
mansoni) 		6 / 12 ALA A   8
SER A  56
PRO A  58
LEU A  64
ARG A  67
TYR A 117
 None
 0.51A 3eigA-3vcoA:
24.1		 3eigA-3vcoA:
36.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FRB_X_TOPX300_1
(DIHYDROFOLATE
REDUCTASE)		 3vco DIHYDROFOLATE
REDUCTASE
(Schistosoma
mansoni) 		6 / 11 ALA A   8
ASP A  28
SER A  56
ILE A  57
TYR A 117
THR A 133
 None
 0.91A 3frbX-3vcoA:
17.7		 3frbX-3vcoA:
29.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FRE_X_TOPX300_1
(DIHYDROFOLATE
REDUCTASE)		 3vco DIHYDROFOLATE
REDUCTASE
(Schistosoma
mansoni) 		5 / 9 ALA A   8
ASP A  28
SER A  56
ILE A  57
THR A 133
 None
 0.97A 3freX-3vcoA:
17.6		 3freX-3vcoA:
28.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HBB_A_TMQA611_1
(DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 3vco DIHYDROFOLATE
REDUCTASE
(Schistosoma
mansoni) 		6 / 10 ALA A   8
ILE A  57
PRO A  58
LEU A  64
ILE A 111
TYR A 117
 None
 0.75A 3hbbA-3vcoA:
3.3		 3hbbA-3vcoA:
19.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HBB_A_TMQA611_1
(DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 3vco DIHYDROFOLATE
REDUCTASE
(Schistosoma
mansoni) 		8 / 10 VAL A   6
ALA A   8
ASP A  28
MET A  29
ILE A  57
LEU A  64
ILE A 111
TYR A 117
 None
 0.73A 3hbbA-3vcoA:
3.3		 3hbbA-3vcoA:
19.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HBB_B_TMQB612_1
(DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 3vco DIHYDROFOLATE
REDUCTASE
(Schistosoma
mansoni) 		5 / 9 ALA A   8
THR A  53
SER A  56
PHE A  61
TYR A 117
 None
SO4  A 201 (-3.7A)
None
None
None
 0.95A 3hbbB-3vcoA:
19.3		 3hbbB-3vcoA:
19.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HBB_B_TMQB612_1
(DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 3vco DIHYDROFOLATE
REDUCTASE
(Schistosoma
mansoni) 		7 / 9 VAL A   6
ALA A   8
ASP A  28
THR A  53
SER A  56
ILE A 111
TYR A 117
 None
None
None
SO4  A 201 (-3.7A)
None
None
None
 0.67A 3hbbB-3vcoA:
19.3		 3hbbB-3vcoA:
19.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HBB_C_TMQC613_1
(DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 3vco DIHYDROFOLATE
REDUCTASE
(Schistosoma
mansoni) 		6 / 11 ALA A   8
ILE A  57
PRO A  58
LEU A  64
ILE A 111
TYR A 117
 None
 0.76A 3hbbC-3vcoA:
20.0		 3hbbC-3vcoA:
19.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HBB_C_TMQC613_1
(DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 3vco DIHYDROFOLATE
REDUCTASE
(Schistosoma
mansoni) 		9 / 11 VAL A   6
ALA A   8
ASP A  28
MET A  29
ILE A  57
LEU A  64
ILE A 111
TYR A 117
THR A 133
 None
 0.66A 3hbbC-3vcoA:
20.0		 3hbbC-3vcoA:
19.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HBB_D_TMQD614_1
(DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 3vco DIHYDROFOLATE
REDUCTASE
(Schistosoma
mansoni) 		5 / 10 ALA A   8
ILE A  57
PRO A  58
ILE A 111
TYR A 117
 None
 0.64A 3hbbD-3vcoA:
20.0		 3hbbD-3vcoA:
19.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HBB_D_TMQD614_1
(DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 3vco DIHYDROFOLATE
REDUCTASE
(Schistosoma
mansoni) 		8 / 10 VAL A   6
ALA A   8
ASP A  28
MET A  29
ILE A  57
ILE A 111
TYR A 117
THR A 133
 None
 0.70A 3hbbD-3vcoA:
20.0		 3hbbD-3vcoA:
19.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HJ3_A_MTXA605_1
(CHAIN A, CRYSTAL
STRUCTURE OF DHFR)		 3vco DIHYDROFOLATE
REDUCTASE
(Schistosoma
mansoni) 		9 / 12 ALA A   8
ASP A  28
PHE A  32
THR A  53
ILE A  57
LEU A  64
ARG A  67
TYR A 117
THR A 133
 None
None
None
SO4  A 201 (-3.7A)
None
None
None
None
None
 0.62A 3hj3A-3vcoA:
20.4		 3hj3A-3vcoA:
16.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HJ3_B_MTXB609_1
(CHAIN A, CRYSTAL
STRUCTURE OF DHFR)		 3vco DIHYDROFOLATE
REDUCTASE
(Schistosoma
mansoni) 		8 / 12 ALA A   8
ASP A  28
PHE A  32
THR A  53
ILE A  57
LEU A  64
ARG A  67
TYR A 117
 None
None
None
SO4  A 201 (-3.7A)
None
None
None
None
 0.60A 3hj3B-3vcoA:
20.3		 3hj3B-3vcoA:
16.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HJ3_C_MTXC613_1
(CHAIN A, CRYSTAL
STRUCTURE OF DHFR)		 3vco DIHYDROFOLATE
REDUCTASE
(Schistosoma
mansoni) 		9 / 12 VAL A   6
ALA A   8
ASP A  28
PHE A  32
THR A  53
LEU A  64
ARG A  67
TYR A 117
THR A 133
 None
None
None
None
SO4  A 201 (-3.7A)
None
None
None
None
 0.59A 3hj3C-3vcoA:
6.5		 3hj3C-3vcoA:
16.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HJ3_D_MTXD615_1
(CHAIN A, CRYSTAL
STRUCTURE OF DHFR)		 3vco DIHYDROFOLATE
REDUCTASE
(Schistosoma
mansoni) 		9 / 12 VAL A   6
ALA A   8
ASP A  28
PHE A  32
THR A  53
ILE A  57
LEU A  64
ARG A  67
TYR A 117
 None
None
None
None
SO4  A 201 (-3.7A)
None
None
None
None
 0.76A 3hj3D-3vcoA:
16.4		 3hj3D-3vcoA:
16.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IA4_A_MTXA164_1
(DIHYDROFOLATE
REDUCTASE)		 3vco DIHYDROFOLATE
REDUCTASE
(Schistosoma
mansoni) 		7 / 12 ALA A   8
LYS A  33
SER A  56
ILE A  57
LEU A  64
ARG A  67
TYR A 117
 None
 0.91A 3ia4A-3vcoA:
18.4		 3ia4A-3vcoA:
27.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IA4_B_MTXB164_1
(DIHYDROFOLATE
REDUCTASE)		 3vco DIHYDROFOLATE
REDUCTASE
(Schistosoma
mansoni) 		6 / 12 ALA A   8
SER A  56
ILE A  57
LEU A  64
ARG A  67
TYR A 117
 None
 0.87A 3ia4B-3vcoA:
18.4		 3ia4B-3vcoA:
27.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IA4_B_MTXB164_2
(DIHYDROFOLATE
REDUCTASE)		 3vco DIHYDROFOLATE
REDUCTASE
(Schistosoma
mansoni) 		4 / 4 PHE A  32
LYS A  33
ILE A 111
THR A 133
 None
 0.82A 3ia4B-3vcoA:
18.4		 3ia4B-3vcoA:
27.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IA4_C_MTXC164_1
(DIHYDROFOLATE
REDUCTASE)		 3vco DIHYDROFOLATE
REDUCTASE
(Schistosoma
mansoni) 		8 / 12 ALA A   8
PHE A  32
LYS A  33
SER A  56
ILE A  57
LEU A  64
ARG A  67
TYR A 117
 None
 0.80A 3ia4C-3vcoA:
18.4		 3ia4C-3vcoA:
27.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IA4_D_MTXD164_1
(DIHYDROFOLATE
REDUCTASE)		 3vco DIHYDROFOLATE
REDUCTASE
(Schistosoma
mansoni) 		8 / 12 ALA A   8
PHE A  32
LYS A  33
SER A  56
ILE A  57
LEU A  64
ARG A  67
TYR A 117
 None
 0.97A 3ia4D-3vcoA:
18.3		 3ia4D-3vcoA:
27.80
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3IX9_A_MTXA200_1
(DIHYDROFOLATE
REDUCTASE)		 3vco DIHYDROFOLATE
REDUCTASE
(Schistosoma
mansoni) 		5 / 12 ALA A   8
LYS A  33
LEU A  64
ARG A  67
THR A 133
 None
 0.77A 3ix9A-3vcoA:
17.7		 3ix9A-3vcoA:
32.39
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3JW3_A_TOPA208_1
(DIHYDROFOLATE
REDUCTASE)		 3vco DIHYDROFOLATE
REDUCTASE
(Schistosoma
mansoni) 		5 / 10 ALA A   8
ILE A  57
ILE A 111
TYR A 117
THR A 133
 None
 0.70A 3jw3A-3vcoA:
18.1		 3jw3A-3vcoA:
33.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3JW3_A_TOPA208_1
(DIHYDROFOLATE
REDUCTASE)		 3vco DIHYDROFOLATE
REDUCTASE
(Schistosoma
mansoni) 		5 / 10 ALA A   8
ILE A  57
LEU A  64
TYR A 117
THR A 133
 None
 1.16A 3jw3A-3vcoA:
18.1		 3jw3A-3vcoA:
33.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3JW3_B_TOPB208_1
(DIHYDROFOLATE
REDUCTASE)		 3vco DIHYDROFOLATE
REDUCTASE
(Schistosoma
mansoni) 		5 / 9 ALA A   8
ILE A  57
LEU A  64
ILE A 111
TYR A 117
 None
 0.95A 3jw3B-3vcoA:
18.1		 3jw3B-3vcoA:
33.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K2H_A_LYAA514_1
(DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE)		 3vco DIHYDROFOLATE
REDUCTASE
(Schistosoma
mansoni) 		7 / 12 ALA A   8
ASP A  28
THR A  53
ILE A  57
LEU A  64
ARG A  67
TYR A 117
 None
None
SO4  A 201 (-3.7A)
None
None
None
None
 0.55A 3k2hA-3vcoA:
20.9		 3k2hA-3vcoA:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K2H_B_LYAB514_1
(DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE)		 3vco DIHYDROFOLATE
REDUCTASE
(Schistosoma
mansoni) 		7 / 12 ALA A   8
ASP A  28
SER A  56
ILE A  57
LEU A  64
ARG A  67
TYR A 117
 None
 0.55A 3k2hB-3vcoA:
20.4		 3k2hB-3vcoA:
20.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3N0H_A_TOPA187_1
(DIHYDROFOLATE
REDUCTASE)		 3vco DIHYDROFOLATE
REDUCTASE
(Schistosoma
mansoni) 		7 / 11 ALA A   8
PHE A  32
THR A  53
ILE A  57
LEU A  64
TYR A 117
THR A 133
 None
None
SO4  A 201 (-3.7A)
None
None
None
None
 0.72A 3n0hA-3vcoA:
24.3		 3n0hA-3vcoA:
37.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NRR_A_D16A520_1
(DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 3vco DIHYDROFOLATE
REDUCTASE
(Schistosoma
mansoni) 		6 / 12 ALA A   8
ASP A  28
THR A  53
ILE A  57
PRO A  58
THR A 133
 None
None
SO4  A 201 (-3.7A)
None
None
None
 0.71A 3nrrA-3vcoA:
20.1		 3nrrA-3vcoA:
20.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NRR_B_D16B520_1
(DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 3vco DIHYDROFOLATE
REDUCTASE
(Schistosoma
mansoni) 		6 / 12 ALA A   8
ASP A  28
THR A  53
ILE A  57
PRO A  58
THR A 133
 None
None
SO4  A 201 (-3.7A)
None
None
None
 0.72A 3nrrB-3vcoA:
20.9		 3nrrB-3vcoA:
20.27
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3QFX_A_CP6A602_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 3vco DIHYDROFOLATE
REDUCTASE
(Schistosoma
mansoni) 		9 / 12 VAL A   6
ALA A   8
ASP A  28
PHE A  32
THR A  53
SER A  56
ILE A 111
TYR A 117
THR A 133
 None
None
None
None
SO4  A 201 (-3.7A)
None
None
None
None
 0.57A 3qfxA-3vcoA:
20.1		 3qfxA-3vcoA:
31.80
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3QFX_B_CP6B702_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 3vco DIHYDROFOLATE
REDUCTASE
(Schistosoma
mansoni) 		9 / 12 VAL A   6
ALA A   8
ASP A  28
PHE A  32
THR A  53
SER A  56
ILE A 111
TYR A 117
THR A 133
 None
None
None
None
SO4  A 201 (-3.7A)
None
None
None
None
 0.57A 3qfxB-3vcoA:
20.1		 3qfxB-3vcoA:
31.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QG2_A_CP6A609_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 3vco DIHYDROFOLATE
REDUCTASE
(Schistosoma
mansoni) 		5 / 10 ALA A   8
ASP A  28
MET A  29
SER A  56
THR A 133
 None
 1.05A 3qg2A-3vcoA:
19.5		 3qg2A-3vcoA:
17.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QG2_A_CP6A609_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 3vco DIHYDROFOLATE
REDUCTASE
(Schistosoma
mansoni) 		7 / 10 ALA A   8
ASP A  28
PHE A  32
SER A  56
ILE A  57
TYR A 117
THR A 133
 None
 0.68A 3qg2A-3vcoA:
19.5		 3qg2A-3vcoA:
17.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QG2_B_CP6B709_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 3vco DIHYDROFOLATE
REDUCTASE
(Schistosoma
mansoni) 		8 / 11 ALA A   8
ASP A  28
MET A  29
PHE A  32
SER A  56
ILE A  57
TYR A 117
THR A 133
 None
 0.79A 3qg2B-3vcoA:
19.6		 3qg2B-3vcoA:
17.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QGT_A_CP6A609_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 3vco DIHYDROFOLATE
REDUCTASE
(Schistosoma
mansoni) 		8 / 10 ALA A   8
ASP A  28
PHE A  32
SER A  56
ILE A  57
ILE A 111
TYR A 117
THR A 133
 None
 0.65A 3qgtA-3vcoA:
19.7		 3qgtA-3vcoA:
17.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QGT_A_CP6A609_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 3vco DIHYDROFOLATE
REDUCTASE
(Schistosoma
mansoni) 		5 / 10 ALA A   8
ASP A  28
PHE A  32
SER A  56
THR A 133
 None
 1.10A 3qgtA-3vcoA:
19.7		 3qgtA-3vcoA:
17.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QGT_B_CP6B609_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 3vco DIHYDROFOLATE
REDUCTASE
(Schistosoma
mansoni) 		8 / 10 ALA A   8
ASP A  28
PHE A  32
SER A  56
ILE A  57
ILE A 111
TYR A 117
THR A 133
 None
 0.71A 3qgtB-3vcoA:
19.6		 3qgtB-3vcoA:
17.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QGT_B_CP6B609_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 3vco DIHYDROFOLATE
REDUCTASE
(Schistosoma
mansoni) 		6 / 10 ALA A   8
ASP A  28
PHE A  32
SER A  56
ILE A  57
THR A 133
 None
 1.36A 3qgtB-3vcoA:
19.6		 3qgtB-3vcoA:
17.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QL0_A_FOLA160_0
(DIHYDROFOLATE
REDUCTASE)		 3vco DIHYDROFOLATE
REDUCTASE
(Schistosoma
mansoni) 		8 / 12 ALA A   8
PHE A  32
LYS A  33
ILE A  57
LEU A  64
ARG A  67
TYR A 117
THR A 133
 None
 0.86A 3ql0A-3vcoA:
18.8		 3ql0A-3vcoA:
29.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QL3_A_FOLA161_0
(DIHYDROFOLATE
REDUCTASE)		 3vco DIHYDROFOLATE
REDUCTASE
(Schistosoma
mansoni) 		8 / 12 ALA A   8
ASP A  28
LYS A  33
ILE A  57
ARG A  67
ILE A 111
TYR A 117
THR A 133
 None
 0.77A 3ql3A-3vcoA:
18.5		 3ql3A-3vcoA:
29.35
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3S3V_A_TOPA187_1
(DIHYDROFOLATE
REDUCTASE)		 3vco DIHYDROFOLATE
REDUCTASE
(Schistosoma
mansoni) 		7 / 12 ALA A   8
PHE A  32
THR A  53
ILE A  57
LEU A  64
TYR A 117
THR A 133
 None
None
SO4  A 201 (-3.7A)
None
None
None
None
 0.73A 3s3vA-3vcoA:
24.1		 3s3vA-3vcoA:
38.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TQ8_A_TOPA2001_1
(DIHYDROFOLATE
REDUCTASE)		 3vco DIHYDROFOLATE
REDUCTASE
(Schistosoma
mansoni) 		7 / 9 ALA A   8
ASP A  28
PHE A  32
SER A  56
ILE A  57
ILE A 111
THR A 133
 None
 0.83A 3tq8A-3vcoA:
17.9		 3tq8A-3vcoA:
28.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TQ9_A_MTXA2001_1
(DIHYDROFOLATE
REDUCTASE)		 3vco DIHYDROFOLATE
REDUCTASE
(Schistosoma
mansoni) 		8 / 12 ALA A   8
ASP A  28
SER A  56
ILE A  57
LEU A  64
ARG A  67
ILE A 111
THR A 133
 None
 0.76A 3tq9A-3vcoA:
18.2		 3tq9A-3vcoA:
28.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TQB_A_FOLA2001_0
(DIHYDROFOLATE
REDUCTASE)		 3vco DIHYDROFOLATE
REDUCTASE
(Schistosoma
mansoni) 		9 / 11 ALA A   8
ASP A  28
LYS A  33
THR A  53
ILE A  57
LEU A  64
ARG A  67
ILE A 111
THR A 133
 None
None
None
SO4  A 201 (-3.7A)
None
None
None
None
None
 0.89A 3tqbA-3vcoA:
18.2		 3tqbA-3vcoA:
28.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UM5_A_CP6A609_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 3vco DIHYDROFOLATE
REDUCTASE
(Schistosoma
mansoni) 		7 / 10 ASP A  28
PHE A  32
THR A  53
SER A  56
ILE A 111
TYR A 117
THR A 133
 None
None
SO4  A 201 (-3.7A)
None
None
None
None
 0.69A 3um5A-3vcoA:
19.4		 3um5A-3vcoA:
17.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UM5_A_CP6A609_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 3vco DIHYDROFOLATE
REDUCTASE
(Schistosoma
mansoni) 		7 / 10 PHE A  32
THR A  53
SER A  56
ILE A  57
ILE A 111
TYR A 117
THR A 133
 None
SO4  A 201 (-3.7A)
None
None
None
None
None
 0.73A 3um5A-3vcoA:
19.4		 3um5A-3vcoA:
17.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UM5_B_CP6B709_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 3vco DIHYDROFOLATE
REDUCTASE
(Schistosoma
mansoni) 		6 / 10 ASP A  28
PHE A  32
THR A  53
ILE A 111
TYR A 117
THR A 133
 None
None
SO4  A 201 (-3.7A)
None
None
None
 0.53A 3um5B-3vcoA:
19.5		 3um5B-3vcoA:
17.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UM5_B_CP6B709_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 3vco DIHYDROFOLATE
REDUCTASE
(Schistosoma
mansoni) 		7 / 10 PHE A  32
THR A  53
SER A  56
ILE A  57
ILE A 111
TYR A 117
THR A 133
 None
SO4  A 201 (-3.7A)
None
None
None
None
None
 0.75A 3um5B-3vcoA:
19.5		 3um5B-3vcoA:
17.59
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4CD2_A_FOLA207_0
(DIHYDROFOLATE
REDUCTASE)		 3vco DIHYDROFOLATE
REDUCTASE
(Schistosoma
mansoni) 		8 / 12 ALA A   8
PHE A  32
LYS A  33
THR A  53
LEU A  64
ARG A  67
TYR A 117
THR A 133
 None
None
None
SO4  A 201 (-3.7A)
None
None
None
None
 0.81A 4cd2A-3vcoA:
22.7		 4cd2A-3vcoA:
34.23
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4CD2_A_FOLA207_0
(DIHYDROFOLATE
REDUCTASE)		 3vco DIHYDROFOLATE
REDUCTASE
(Schistosoma
mansoni) 		7 / 12 ALA A   8
PHE A  32
THR A  53
PHE A  61
LEU A  64
ARG A  67
TYR A 117
 None
None
SO4  A 201 (-3.7A)
None
None
None
None
 0.85A 4cd2A-3vcoA:
22.7		 4cd2A-3vcoA:
34.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DFR_A_MTXA161_1
(DIHYDROFOLATE
REDUCTASE)		 3vco DIHYDROFOLATE
REDUCTASE
(Schistosoma
mansoni) 		7 / 12 ALA A   8
ASP A  28
LYS A  33
THR A  53
ILE A  57
LEU A  64
TYR A 117
 None
None
None
SO4  A 201 (-3.7A)
None
None
None
 0.92A 4dfrA-3vcoA:
19.1		 4dfrA-3vcoA:
29.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DFR_A_MTXA161_1
(DIHYDROFOLATE
REDUCTASE)		 3vco DIHYDROFOLATE
REDUCTASE
(Schistosoma
mansoni) 		7 / 12 ALA A   8
ASP A  28
THR A  53
ILE A  57
LEU A  64
ARG A  67
TYR A 117
 None
None
SO4  A 201 (-3.7A)
None
None
None
None
 0.61A 4dfrA-3vcoA:
19.1		 4dfrA-3vcoA:
29.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DFR_A_MTXA161_1
(DIHYDROFOLATE
REDUCTASE)		 3vco DIHYDROFOLATE
REDUCTASE
(Schistosoma
mansoni) 		7 / 12 ALA A   8
ASP A  28
THR A  53
SER A  56
LEU A  64
ARG A  67
TYR A 117
 None
None
SO4  A 201 (-3.7A)
None
None
None
None
 0.75A 4dfrA-3vcoA:
19.1		 4dfrA-3vcoA:
29.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DFR_B_MTXB162_1
(DIHYDROFOLATE
REDUCTASE)		 3vco DIHYDROFOLATE
REDUCTASE
(Schistosoma
mansoni) 		8 / 12 ALA A   8
ASP A  28
ILE A  57
LEU A  64
ARG A  67
ILE A 111
TYR A 117
THR A 133
 None
 0.56A 4dfrB-3vcoA:
19.1		 4dfrB-3vcoA:
29.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DFR_B_MTXB162_1
(DIHYDROFOLATE
REDUCTASE)		 3vco DIHYDROFOLATE
REDUCTASE
(Schistosoma
mansoni) 		7 / 12 ALA A   8
ASP A  28
LYS A  33
ILE A  57
ILE A 111
TYR A 117
THR A 133
 None
 0.89A 4dfrB-3vcoA:
19.1		 4dfrB-3vcoA:
29.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ECK_A_FOLA703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 3vco DIHYDROFOLATE
REDUCTASE
(Schistosoma
mansoni) 		6 / 12 VAL A   6
ALA A   8
PHE A  32
LEU A  64
ARG A  67
THR A 133
 None
 0.72A 4eckA-3vcoA:
19.4		 4eckA-3vcoA:
15.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ECK_A_FOLA703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 3vco DIHYDROFOLATE
REDUCTASE
(Schistosoma
mansoni) 		6 / 12 VAL A   6
ALA A   8
PHE A  32
PHE A  61
LEU A  64
ARG A  67
 None
 0.81A 4eckA-3vcoA:
19.4		 4eckA-3vcoA:
15.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ECK_B_FOLB703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 3vco DIHYDROFOLATE
REDUCTASE
(Schistosoma
mansoni) 		8 / 12 VAL A   6
ALA A   8
ASP A  28
PHE A  32
PHE A  61
LEU A  64
ARG A  67
THR A 133
 None
 0.83A 4eckB-3vcoA:
19.5		 4eckB-3vcoA:
15.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EIL_A_FOLA703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 3vco DIHYDROFOLATE
REDUCTASE
(Schistosoma
mansoni) 		6 / 11 VAL A   6
ALA A   8
ASP A  28
LEU A  64
ARG A  67
THR A 133
 None
 0.42A 4eilA-3vcoA:
12.3		 4eilA-3vcoA:
16.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EIL_A_FOLA703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 3vco DIHYDROFOLATE
REDUCTASE
(Schistosoma
mansoni) 		5 / 11 VAL A   6
ALA A   8
PHE A  61
LEU A  64
ARG A  67
 None
 0.75A 4eilA-3vcoA:
12.3		 4eilA-3vcoA:
16.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EIL_B_FOLB703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 3vco DIHYDROFOLATE
REDUCTASE
(Schistosoma
mansoni) 		6 / 10 VAL A   6
ALA A   8
ASP A  28
LEU A  64
ARG A  67
THR A 133
 None
 0.47A 4eilB-3vcoA:
20.8		 4eilB-3vcoA:
16.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EIL_B_FOLB703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 3vco DIHYDROFOLATE
REDUCTASE
(Schistosoma
mansoni) 		5 / 10 VAL A   6
ALA A   8
PHE A  61
LEU A  64
ARG A  67
 None
 0.72A 4eilB-3vcoA:
20.8		 4eilB-3vcoA:
16.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EIL_C_FOLC703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 3vco DIHYDROFOLATE
REDUCTASE
(Schistosoma
mansoni) 		6 / 11 VAL A   6
ALA A   8
ASP A  28
LEU A  64
ARG A  67
THR A 133
 None
 0.42A 4eilC-3vcoA:
12.2		 4eilC-3vcoA:
16.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EIL_C_FOLC703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 3vco DIHYDROFOLATE
REDUCTASE
(Schistosoma
mansoni) 		5 / 11 VAL A   6
ALA A   8
PHE A  61
LEU A  64
ARG A  67
 None
 0.83A 4eilC-3vcoA:
12.2		 4eilC-3vcoA:
16.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EIL_D_FOLD703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 3vco DIHYDROFOLATE
REDUCTASE
(Schistosoma
mansoni) 		5 / 10 VAL A   6
ALA A   8
ASP A  28
ARG A  67
THR A 133
 None
 0.33A 4eilD-3vcoA:
20.0		 4eilD-3vcoA:
16.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EIL_D_FOLD703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 3vco DIHYDROFOLATE
REDUCTASE
(Schistosoma
mansoni) 		5 / 10 VAL A   6
ALA A   8
PHE A  61
ARG A  67
THR A 133
 None
 0.65A 4eilD-3vcoA:
20.0		 4eilD-3vcoA:
16.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EIL_E_FOLE703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 3vco DIHYDROFOLATE
REDUCTASE
(Schistosoma
mansoni) 		6 / 11 VAL A   6
ALA A   8
ASP A  28
LEU A  64
ARG A  67
THR A 133
 None
 0.41A 4eilE-3vcoA:
22.4		 4eilE-3vcoA:
16.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EIL_F_FOLF703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 3vco DIHYDROFOLATE
REDUCTASE
(Schistosoma
mansoni) 		5 / 9 ALA A   8
ASP A  28
LEU A  64
ARG A  67
THR A 133
 None
 0.49A 4eilF-3vcoA:
20.1		 4eilF-3vcoA:
16.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EIL_F_FOLF703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 3vco DIHYDROFOLATE
REDUCTASE
(Schistosoma
mansoni) 		5 / 9 ALA A   8
PHE A  61
LEU A  64
ARG A  67
THR A 133
 None
 0.78A 4eilF-3vcoA:
20.1		 4eilF-3vcoA:
16.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EIL_G_FOLG703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 3vco DIHYDROFOLATE
REDUCTASE
(Schistosoma
mansoni) 		6 / 10 VAL A   6
ALA A   8
ASP A  28
LEU A  64
ARG A  67
THR A 133
 None
 0.43A 4eilG-3vcoA:
21.9		 4eilG-3vcoA:
16.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EIL_H_FOLH703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 3vco DIHYDROFOLATE
REDUCTASE
(Schistosoma
mansoni) 		5 / 9 VAL A   6
ALA A   8
ASP A  28
ARG A  67
THR A 133
 None
 0.40A 4eilH-3vcoA:
13.6		 4eilH-3vcoA:
16.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EJ1_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 3vco DIHYDROFOLATE
REDUCTASE
(Schistosoma
mansoni) 		7 / 12 ALA A   8
PHE A  32
LYS A  33
THR A  53
ILE A  57
ILE A 111
TYR A 117
 None
None
None
SO4  A 201 (-3.7A)
None
None
None
 0.87A 4ej1A-3vcoA:
18.9		 4ej1A-3vcoA:
29.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EJ1_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 3vco DIHYDROFOLATE
REDUCTASE
(Schistosoma
mansoni) 		7 / 12 ALA A   8
PHE A  32
THR A  53
ILE A  57
LEU A  64
ILE A 111
TYR A 117
 None
None
SO4  A 201 (-3.7A)
None
None
None
None
 0.56A 4ej1A-3vcoA:
18.9		 4ej1A-3vcoA:
29.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EJ1_B_FOLB201_0
(DIHYDROFOLATE
REDUCTASE)		 3vco DIHYDROFOLATE
REDUCTASE
(Schistosoma
mansoni) 		8 / 12 ALA A   8
PHE A  32
LYS A  33
THR A  53
ILE A  57
LEU A  64
TYR A 117
THR A 133
 None
None
None
SO4  A 201 (-3.7A)
None
None
None
None
 0.87A 4ej1B-3vcoA:
18.7		 4ej1B-3vcoA:
29.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FHB_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 3vco DIHYDROFOLATE
REDUCTASE
(Schistosoma
mansoni) 		10 / 12 ALA A   8
PHE A  32
LYS A  33
THR A  53
ILE A  57
LEU A  64
ARG A  67
ILE A 111
TYR A 117
THR A 133
 None
None
None
SO4  A 201 (-3.7A)
None
None
None
None
None
None
 0.83A 4fhbA-3vcoA:
18.4		 4fhbA-3vcoA:
29.35
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4G8Z_X_TOPX301_1
(DIHYDROFOLATE
REDUCTASE)		 3vco DIHYDROFOLATE
REDUCTASE
(Schistosoma
mansoni) 		6 / 10 ALA A   8
PHE A  32
SER A  56
ILE A 111
TYR A 117
THR A 133
 None
 0.79A 4g8zX-3vcoA:
22.3		 4g8zX-3vcoA:
32.88
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4G8Z_X_TOPX301_1
(DIHYDROFOLATE
REDUCTASE)		 3vco DIHYDROFOLATE
REDUCTASE
(Schistosoma
mansoni) 		6 / 10 ALA A   8
PHE A  32
SER A  56
PRO A  58
ILE A 111
TYR A 117
 None
 0.93A 4g8zX-3vcoA:
22.3		 4g8zX-3vcoA:
32.88
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4GH8_A_MTXA201_1
(DIHYDROFOLATE
REDUCTASE)		 3vco DIHYDROFOLATE
REDUCTASE
(Schistosoma
mansoni) 		8 / 12 ALA A   8
ASP A  28
SER A  56
ILE A  57
PRO A  58
LEU A  64
ARG A  67
TYR A 117
 None
 0.49A 4gh8A-3vcoA:
19.3		 4gh8A-3vcoA:
30.35
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4GH8_B_MTXB201_1
(DIHYDROFOLATE
REDUCTASE)		 3vco DIHYDROFOLATE
REDUCTASE
(Schistosoma
mansoni) 		7 / 12 ALA A   8
ASP A  28
LYS A  33
SER A  56
ILE A  57
PRO A  58
TYR A 117
 None
 0.84A 4gh8B-3vcoA:
19.1		 4gh8B-3vcoA:
30.35
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4GH8_B_MTXB201_1
(DIHYDROFOLATE
REDUCTASE)		 3vco DIHYDROFOLATE
REDUCTASE
(Schistosoma
mansoni) 		7 / 12 ALA A   8
ASP A  28
SER A  56
ILE A  57
PRO A  58
ARG A  67
TYR A 117
 None
 0.51A 4gh8B-3vcoA:
19.1		 4gh8B-3vcoA:
30.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4I13_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 3vco DIHYDROFOLATE
REDUCTASE
(Schistosoma
mansoni) 		7 / 12 ALA A   8
PHE A  32
LYS A  33
THR A  53
ILE A  57
ILE A 111
TYR A 117
 None
None
None
SO4  A 201 (-3.7A)
None
None
None
 0.89A 4i13A-3vcoA:
18.8		 4i13A-3vcoA:
29.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4I13_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 3vco DIHYDROFOLATE
REDUCTASE
(Schistosoma
mansoni) 		7 / 12 ALA A   8
PHE A  32
THR A  53
ILE A  57
LEU A  64
ILE A 111
TYR A 117
 None
None
SO4  A 201 (-3.7A)
None
None
None
None
 0.62A 4i13A-3vcoA:
18.8		 4i13A-3vcoA:
29.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4I13_A_FOLA201_1
(DIHYDROFOLATE
REDUCTASE)		 3vco DIHYDROFOLATE
REDUCTASE
(Schistosoma
mansoni) 		3 / 3 ASP A  28
ARG A  67
THR A 133
 None
 0.17A 4i13A-3vcoA:
18.8		 4i13A-3vcoA:
29.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4I1N_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 3vco DIHYDROFOLATE
REDUCTASE
(Schistosoma
mansoni) 		8 / 11 ALA A   8
ASP A  28
PHE A  32
LYS A  33
LEU A  64
ARG A  67
TYR A 117
THR A 133
 None
 0.77A 4i1nA-3vcoA:
18.7		 4i1nA-3vcoA:
29.35
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4KEB_B_FOLB202_0
(DIHYDROFOLATE
REDUCTASE)		 3vco DIHYDROFOLATE
REDUCTASE
(Schistosoma
mansoni) 		7 / 12 ALA A   8
PHE A  32
THR A  53
ILE A  57
LEU A  64
TYR A 117
THR A 133
 None
None
SO4  A 201 (-3.7A)
None
None
None
None
 0.68A 4kebB-3vcoA:
23.8		 4kebB-3vcoA:
36.62
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4KFJ_B_FOLB202_0
(DIHYDROFOLATE
REDUCTASE)		 3vco DIHYDROFOLATE
REDUCTASE
(Schistosoma
mansoni) 		7 / 12 ALA A   8
PHE A  32
ILE A  57
PRO A  58
LEU A  64
TYR A 117
THR A 133
 None
 0.72A 4kfjB-3vcoA:
24.0		 4kfjB-3vcoA:
36.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KJJ_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 3vco DIHYDROFOLATE
REDUCTASE
(Schistosoma
mansoni) 		8 / 12 ALA A   8
PHE A  32
LYS A  33
THR A  53
ILE A  57
LEU A  64
ILE A 111
TYR A 117
 None
None
None
SO4  A 201 (-3.7A)
None
None
None
None
 0.98A 4kjjA-3vcoA:
17.4		 4kjjA-3vcoA:
29.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KJK_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 3vco DIHYDROFOLATE
REDUCTASE
(Schistosoma
mansoni) 		7 / 12 ALA A   8
PHE A  32
LYS A  33
THR A  53
ILE A  57
ILE A 111
TYR A 117
 None
None
None
SO4  A 201 (-3.7A)
None
None
None
 0.93A 4kjkA-3vcoA:
18.2		 4kjkA-3vcoA:
29.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KJK_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 3vco DIHYDROFOLATE
REDUCTASE
(Schistosoma
mansoni) 		7 / 12 ALA A   8
PHE A  32
THR A  53
ILE A  57
LEU A  64
ILE A 111
TYR A 117
 None
None
SO4  A 201 (-3.7A)
None
None
None
None
 0.66A 4kjkA-3vcoA:
18.2		 4kjkA-3vcoA:
29.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KJL_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 3vco DIHYDROFOLATE
REDUCTASE
(Schistosoma
mansoni) 		9 / 12 ALA A   8
PHE A  32
LYS A  33
THR A  53
ILE A  57
LEU A  64
ILE A 111
TYR A 117
THR A 133
 None
None
None
SO4  A 201 (-3.7A)
None
None
None
None
None
 0.85A 4kjlA-3vcoA:
18.2		 4kjlA-3vcoA:
29.21
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4KM0_A_CP6A201_1
(DIHYDROFOLATE
REDUCTASE)		 3vco DIHYDROFOLATE
REDUCTASE
(Schistosoma
mansoni) 		6 / 10 ALA A   8
ASP A  28
PHE A  32
ILE A 111
TYR A 117
THR A 133
 None
 0.54A 4km0A-3vcoA:
17.0		 4km0A-3vcoA:
37.38
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4KM0_B_CP6B201_1
(DIHYDROFOLATE
REDUCTASE)		 3vco DIHYDROFOLATE
REDUCTASE
(Schistosoma
mansoni) 		6 / 12 ALA A   8
ASP A  28
PHE A  32
ILE A 111
TYR A 117
THR A 133
 None
 0.53A 4km0B-3vcoA:
17.2		 4km0B-3vcoA:
37.38
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4KM0_B_CP6B201_1
(DIHYDROFOLATE
REDUCTASE)		 3vco DIHYDROFOLATE
REDUCTASE
(Schistosoma
mansoni) 		5 / 12 ALA A   8
PHE A  32
THR A  53
ILE A 111
TYR A 117
 None
None
SO4  A 201 (-3.7A)
None
None
 0.80A 4km0B-3vcoA:
17.2		 4km0B-3vcoA:
37.38
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4KM2_A_TOPA202_1
(DIHYDROFOLATE
REDUCTASE)		 3vco DIHYDROFOLATE
REDUCTASE
(Schistosoma
mansoni) 		7 / 12 ALA A   8
ASP A  28
PHE A  32
LEU A  64
ILE A 111
TYR A 117
THR A 133
 None
 0.63A 4km2A-3vcoA:
17.1		 4km2A-3vcoA:
37.38
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4KM2_B_TOPB202_1
(DIHYDROFOLATE
REDUCTASE)		 3vco DIHYDROFOLATE
REDUCTASE
(Schistosoma
mansoni) 		7 / 12 ALA A   8
ASP A  28
PHE A  32
LEU A  64
ILE A 111
TYR A 117
THR A 133
 None
 0.61A 4km2B-3vcoA:
16.8		 4km2B-3vcoA:
37.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KY8_A_MTXA603_1
(BIFUNCTIONAL
THYMIDYLATE
SYNTHASE-DIHYDROFOLA
TE REDUCTASE)		 3vco DIHYDROFOLATE
REDUCTASE
(Schistosoma
mansoni) 		8 / 12 VAL A   6
ALA A   8
ASP A  28
SER A  56
ILE A  57
LEU A  64
ARG A  67
THR A 133
 None
 0.70A 4ky8A-3vcoA:
13.7		 4ky8A-3vcoA:
16.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KY8_B_MTXB603_1
(BIFUNCTIONAL
THYMIDYLATE
SYNTHASE-DIHYDROFOLA
TE REDUCTASE)		 3vco DIHYDROFOLATE
REDUCTASE
(Schistosoma
mansoni) 		8 / 12 VAL A   6
ALA A   8
ASP A  28
SER A  56
ILE A  57
LEU A  64
ARG A  67
THR A 133
 None
 0.75A 4ky8B-3vcoA:
14.8		 4ky8B-3vcoA:
16.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KY8_C_MTXC603_1
(BIFUNCTIONAL
THYMIDYLATE
SYNTHASE-DIHYDROFOLA
TE REDUCTASE)		 3vco DIHYDROFOLATE
REDUCTASE
(Schistosoma
mansoni) 		7 / 12 VAL A   6
ALA A   8
ASP A  28
ILE A  57
LEU A  64
ARG A  67
THR A 133
 None
 0.66A 4ky8C-3vcoA:
20.4		 4ky8C-3vcoA:
16.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KY8_D_MTXD603_1
(BIFUNCTIONAL
THYMIDYLATE
SYNTHASE-DIHYDROFOLA
TE REDUCTASE)		 3vco DIHYDROFOLATE
REDUCTASE
(Schistosoma
mansoni) 		8 / 12 VAL A   6
ALA A   8
ASP A  28
SER A  56
ILE A  57
LEU A  64
ARG A  67
THR A 133
 None
 0.79A 4ky8D-3vcoA:
17.1		 4ky8D-3vcoA:
16.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KY8_E_MTXE603_1
(BIFUNCTIONAL
THYMIDYLATE
SYNTHASE-DIHYDROFOLA
TE REDUCTASE)		 3vco DIHYDROFOLATE
REDUCTASE
(Schistosoma
mansoni) 		8 / 12 VAL A   6
ALA A   8
ASP A  28
SER A  56
ILE A  57
LEU A  64
ARG A  67
THR A 133
 None
 0.79A 4ky8E-3vcoA:
6.7		 4ky8E-3vcoA:
16.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KYA_A_FOLA703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 3vco DIHYDROFOLATE
REDUCTASE
(Schistosoma
mansoni) 		7 / 11 VAL A   6
ALA A   8
ASP A  28
THR A  53
LEU A  64
ARG A  67
THR A 133
 None
None
None
SO4  A 201 (-3.7A)
None
None
None
 0.52A 4kyaA-3vcoA:
12.1		 4kyaA-3vcoA:
16.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KYA_A_FOLA703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 3vco DIHYDROFOLATE
REDUCTASE
(Schistosoma
mansoni) 		6 / 11 VAL A   6
ALA A   8
THR A  53
PHE A  61
LEU A  64
ARG A  67
 None
None
SO4  A 201 (-3.7A)
None
None
None
 0.69A 4kyaA-3vcoA:
12.1		 4kyaA-3vcoA:
16.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KYA_B_FOLB703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 3vco DIHYDROFOLATE
REDUCTASE
(Schistosoma
mansoni) 		6 / 12 VAL A   6
ALA A   8
ASP A  28
LEU A  64
ARG A  67
THR A 133
 None
 0.52A 4kyaB-3vcoA:
20.5		 4kyaB-3vcoA:
16.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KYA_B_FOLB703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 3vco DIHYDROFOLATE
REDUCTASE
(Schistosoma
mansoni) 		5 / 12 VAL A   6
ALA A   8
PHE A  61
LEU A  64
ARG A  67
 None
 0.68A 4kyaB-3vcoA:
20.5		 4kyaB-3vcoA:
16.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KYA_C_FOLC703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 3vco DIHYDROFOLATE
REDUCTASE
(Schistosoma
mansoni) 		6 / 10 VAL A   6
ALA A   8
ASP A  28
LEU A  64
ARG A  67
THR A 133
 None
 0.51A 4kyaC-3vcoA:
16.1		 4kyaC-3vcoA:
16.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KYA_C_FOLC703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 3vco DIHYDROFOLATE
REDUCTASE
(Schistosoma
mansoni) 		5 / 10 VAL A   6
ALA A   8
PHE A  61
LEU A  64
ARG A  67
 None
 0.73A 4kyaC-3vcoA:
16.1		 4kyaC-3vcoA:
16.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KYA_D_FOLD703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 3vco DIHYDROFOLATE
REDUCTASE
(Schistosoma
mansoni) 		6 / 12 VAL A   6
ALA A   8
ASP A  28
LEU A  64
ARG A  67
THR A 133
 None
 0.53A 4kyaD-3vcoA:
13.6		 4kyaD-3vcoA:
16.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KYA_D_FOLD703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 3vco DIHYDROFOLATE
REDUCTASE
(Schistosoma
mansoni) 		5 / 12 VAL A   6
ALA A   8
PHE A  61
LEU A  64
ARG A  67
 None
 0.69A 4kyaD-3vcoA:
13.6		 4kyaD-3vcoA:
16.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KYA_E_FOLE703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 3vco DIHYDROFOLATE
REDUCTASE
(Schistosoma
mansoni) 		7 / 11 VAL A   6
ALA A   8
ASP A  28
THR A  53
LEU A  64
ARG A  67
THR A 133
 None
None
None
SO4  A 201 (-3.7A)
None
None
None
 0.52A 4kyaE-3vcoA:
21.8		 4kyaE-3vcoA:
16.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KYA_E_FOLE703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 3vco DIHYDROFOLATE
REDUCTASE
(Schistosoma
mansoni) 		6 / 11 VAL A   6
ALA A   8
THR A  53
PHE A  61
LEU A  64
ARG A  67
 None
None
SO4  A 201 (-3.7A)
None
None
None
 0.73A 4kyaE-3vcoA:
21.8		 4kyaE-3vcoA:
16.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KYA_F_FOLF703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 3vco DIHYDROFOLATE
REDUCTASE
(Schistosoma
mansoni) 		6 / 12 VAL A   6
ALA A   8
ASP A  28
LEU A  64
ARG A  67
THR A 133
 None
 0.52A 4kyaF-3vcoA:
13.5		 4kyaF-3vcoA:
16.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KYA_F_FOLF703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 3vco DIHYDROFOLATE
REDUCTASE
(Schistosoma
mansoni) 		5 / 12 VAL A   6
ALA A   8
PHE A  61
LEU A  64
ARG A  67
 None
 0.69A 4kyaF-3vcoA:
13.5		 4kyaF-3vcoA:
16.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KYA_G_FOLG703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 3vco DIHYDROFOLATE
REDUCTASE
(Schistosoma
mansoni) 		7 / 11 VAL A   6
ALA A   8
ASP A  28
THR A  53
LEU A  64
ARG A  67
THR A 133
 None
None
None
SO4  A 201 (-3.7A)
None
None
None
 0.53A 4kyaG-3vcoA:
21.8		 4kyaG-3vcoA:
16.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KYA_G_FOLG703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 3vco DIHYDROFOLATE
REDUCTASE
(Schistosoma
mansoni) 		6 / 11 VAL A   6
ALA A   8
THR A  53
PHE A  61
LEU A  64
ARG A  67
 None
None
SO4  A 201 (-3.7A)
None
None
None
 0.69A 4kyaG-3vcoA:
21.8		 4kyaG-3vcoA:
16.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KYA_H_FOLH703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 3vco DIHYDROFOLATE
REDUCTASE
(Schistosoma
mansoni) 		6 / 12 VAL A   6
ALA A   8
ASP A  28
LEU A  64
ARG A  67
THR A 133
 None
 0.54A 4kyaH-3vcoA:
19.9		 4kyaH-3vcoA:
16.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KYA_H_FOLH703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 3vco DIHYDROFOLATE
REDUCTASE
(Schistosoma
mansoni) 		5 / 12 VAL A   6
ALA A   8
PHE A  61
LEU A  64
ARG A  67
 None
 0.68A 4kyaH-3vcoA:
19.9		 4kyaH-3vcoA:
16.44
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4M2X_A_TMQA202_1
(DIHYDROFOLATE
REDUCTASE)		 3vco DIHYDROFOLATE
REDUCTASE
(Schistosoma
mansoni) 		7 / 12 ALA A   8
ASP A  28
PHE A  32
PRO A  58
LEU A  64
ILE A 111
TYR A 117
 None
 0.72A 4m2xA-3vcoA:
17.3		 4m2xA-3vcoA:
31.75
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4M2X_C_TMQC202_1
(DIHYDROFOLATE
REDUCTASE)		 3vco DIHYDROFOLATE
REDUCTASE
(Schistosoma
mansoni) 		7 / 12 ALA A   8
ASP A  28
PRO A  58
LEU A  64
ILE A 111
TYR A 117
THR A 133
 None
 0.80A 4m2xC-3vcoA:
6.6		 4m2xC-3vcoA:
31.75
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4M2X_E_TMQE202_1
(DIHYDROFOLATE
REDUCTASE)		 3vco DIHYDROFOLATE
REDUCTASE
(Schistosoma
mansoni) 		6 / 12 ALA A   8
ASP A  28
PRO A  58
LEU A  64
ILE A 111
TYR A 117
 None
 0.73A 4m2xE-3vcoA:
6.6		 4m2xE-3vcoA:
31.75
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4M2X_G_TMQG202_1
(DIHYDROFOLATE
REDUCTASE)		 3vco DIHYDROFOLATE
REDUCTASE
(Schistosoma
mansoni) 		6 / 12 ALA A   8
ASP A  28
PRO A  58
ILE A 111
TYR A 117
THR A 133
 None
 0.77A 4m2xG-3vcoA:
6.6		 4m2xG-3vcoA:
31.75
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4M6K_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 3vco DIHYDROFOLATE
REDUCTASE
(Schistosoma
mansoni) 		8 / 12 ALA A   8
PHE A  32
THR A  53
ILE A  57
PRO A  58
LEU A  64
TYR A 117
THR A 133
 None
None
SO4  A 201 (-3.7A)
None
None
None
None
None
 0.63A 4m6kA-3vcoA:
24.5		 4m6kA-3vcoA:
37.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NX6_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 3vco DIHYDROFOLATE
REDUCTASE
(Schistosoma
mansoni) 		8 / 12 ALA A   8
PHE A  32
LYS A  33
THR A  53
ILE A  57
LEU A  64
ILE A 111
TYR A 117
 None
None
None
SO4  A 201 (-3.7A)
None
None
None
None
 0.75A 4nx6A-3vcoA:
18.5		 4nx6A-3vcoA:
29.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NX7_A_FOLA202_0
(DIHYDROFOLATE
REDUCTASE)		 3vco DIHYDROFOLATE
REDUCTASE
(Schistosoma
mansoni) 		8 / 12 ALA A   8
PHE A  32
LYS A  33
THR A  53
ILE A  57
LEU A  64
ILE A 111
TYR A 117
 None
None
None
SO4  A 201 (-3.7A)
None
None
None
None
 0.79A 4nx7A-3vcoA:
18.5		 4nx7A-3vcoA:
29.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P3Q_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 3vco DIHYDROFOLATE
REDUCTASE
(Schistosoma
mansoni) 		8 / 12 ALA A   8
PHE A  32
LYS A  33
THR A  53
ILE A  57
LEU A  64
ILE A 111
TYR A 117
 None
None
None
SO4  A 201 (-3.7A)
None
None
None
None
 0.78A 4p3qA-3vcoA:
18.5		 4p3qA-3vcoA:
29.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P3R_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 3vco DIHYDROFOLATE
REDUCTASE
(Schistosoma
mansoni) 		5 / 12 ALA A   8
PHE A  32
LYS A  33
ILE A 111
TYR A 117
 None
 0.91A 4p3rA-3vcoA:
18.3		 4p3rA-3vcoA:
29.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P3R_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 3vco DIHYDROFOLATE
REDUCTASE
(Schistosoma
mansoni) 		7 / 12 ALA A   8
PHE A  32
THR A  53
ILE A  57
LEU A  64
ILE A 111
TYR A 117
 None
None
SO4  A 201 (-3.7A)
None
None
None
None
 0.70A 4p3rA-3vcoA:
18.3		 4p3rA-3vcoA:
29.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P3R_A_FOLA201_1
(DIHYDROFOLATE
REDUCTASE)		 3vco DIHYDROFOLATE
REDUCTASE
(Schistosoma
mansoni) 		3 / 3 ASP A  28
ARG A  67
THR A 133
 None
 0.18A 4p3rA-3vcoA:
18.3		 4p3rA-3vcoA:
29.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P66_A_MTXA201_1
(DIHYDROFOLATE
REDUCTASE)		 3vco DIHYDROFOLATE
REDUCTASE
(Schistosoma
mansoni) 		7 / 11 ALA A   8
ASP A  28
LEU A  64
ARG A  67
ILE A 111
TYR A 117
THR A 133
 None
 0.52A 4p66A-3vcoA:
18.4		 4p66A-3vcoA:
28.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P66_A_MTXA201_1
(DIHYDROFOLATE
REDUCTASE)		 3vco DIHYDROFOLATE
REDUCTASE
(Schistosoma
mansoni) 		6 / 11 ALA A   8
ASP A  28
LYS A  33
ILE A 111
TYR A 117
THR A 133
 None
 0.83A 4p66A-3vcoA:
18.4		 4p66A-3vcoA:
28.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P68_A_MTXA201_1
(DIHYDROFOLATE
REDUCTASE)		 3vco DIHYDROFOLATE
REDUCTASE
(Schistosoma
mansoni) 		9 / 11 ASP A  28
PHE A  32
LYS A  33
SER A  56
ILE A  57
ARG A  67
ILE A 111
TYR A 117
THR A 133
 None
 0.90A 4p68A-3vcoA:
18.1		 4p68A-3vcoA:
28.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PSS_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 3vco DIHYDROFOLATE
REDUCTASE
(Schistosoma
mansoni) 		7 / 12 ALA A   8
PHE A  32
THR A  53
ILE A  57
LEU A  64
ILE A 111
TYR A 117
 None
None
SO4  A 201 (-3.7A)
None
None
None
None
 0.69A 4pssA-3vcoA:
undetectable		 4pssA-3vcoA:
29.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PST_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 3vco DIHYDROFOLATE
REDUCTASE
(Schistosoma
mansoni) 		8 / 12 ALA A   8
PHE A  32
LYS A  33
THR A  53
ILE A  57
ILE A 111
TYR A 117
THR A 133
 None
None
None
SO4  A 201 (-3.7A)
None
None
None
None
 0.94A 4pstA-3vcoA:
undetectable		 4pstA-3vcoA:
29.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PST_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 3vco DIHYDROFOLATE
REDUCTASE
(Schistosoma
mansoni) 		8 / 12 ALA A   8
PHE A  32
THR A  53
ILE A  57
LEU A  64
ILE A 111
TYR A 117
THR A 133
 None
None
SO4  A 201 (-3.7A)
None
None
None
None
None
 0.71A 4pstA-3vcoA:
undetectable		 4pstA-3vcoA:
29.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PSY_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 3vco DIHYDROFOLATE
REDUCTASE
(Schistosoma
mansoni) 		7 / 12 ALA A   8
PHE A  32
LYS A  33
ILE A  57
LEU A  64
TYR A 117
THR A 133
 None
 0.95A 4psyA-3vcoA:
18.4		 4psyA-3vcoA:
29.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PTH_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 3vco DIHYDROFOLATE
REDUCTASE
(Schistosoma
mansoni) 		6 / 12 ALA A   8
LYS A  33
THR A  53
ILE A 111
TYR A 117
THR A 133
 None
None
SO4  A 201 (-3.7A)
None
None
None
 0.84A 4pthA-3vcoA:
18.4		 4pthA-3vcoA:
29.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PTH_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 3vco DIHYDROFOLATE
REDUCTASE
(Schistosoma
mansoni) 		8 / 12 ALA A   8
THR A  53
ILE A  57
LEU A  64
ARG A  67
ILE A 111
TYR A 117
THR A 133
 None
SO4  A 201 (-3.7A)
None
None
None
None
None
None
 0.70A 4pthA-3vcoA:
18.4		 4pthA-3vcoA:
29.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PTJ_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 3vco DIHYDROFOLATE
REDUCTASE
(Schistosoma
mansoni) 		8 / 12 ALA A   8
PHE A  32
THR A  53
ILE A  57
ARG A  67
ILE A 111
TYR A 117
THR A 133
 None
None
SO4  A 201 (-3.7A)
None
None
None
None
None
 0.68A 4ptjA-3vcoA:
18.4		 4ptjA-3vcoA:
29.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PTJ_A_FOLA201_1
(DIHYDROFOLATE
REDUCTASE)		 3vco DIHYDROFOLATE
REDUCTASE
(Schistosoma
mansoni) 		3 / 3 ASP A  28
LYS A  33
LEU A  64
 None
 0.84A 4ptjA-3vcoA:
18.4		 4ptjA-3vcoA:
29.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q0D_A_MTXA604_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 3vco DIHYDROFOLATE
REDUCTASE
(Schistosoma
mansoni) 		8 / 12 VAL A   6
ALA A   8
ASP A  28
ILE A  57
LEU A  64
ARG A  67
TYR A 117
THR A 133
 None
 0.60A 4q0dA-3vcoA:
20.1		 4q0dA-3vcoA:
16.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q0D_B_MTXB604_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 3vco DIHYDROFOLATE
REDUCTASE
(Schistosoma
mansoni) 		8 / 12 VAL A   6
ALA A   8
ASP A  28
ILE A  57
LEU A  64
ARG A  67
TYR A 117
THR A 133
 None
 0.60A 4q0dB-3vcoA:
20.1		 4q0dB-3vcoA:
16.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q0D_C_MTXC604_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 3vco DIHYDROFOLATE
REDUCTASE
(Schistosoma
mansoni) 		6 / 12 ALA A   8
ASP A  28
LEU A  64
ARG A  67
TYR A 117
THR A 133
 None
 0.45A 4q0dC-3vcoA:
20.1		 4q0dC-3vcoA:
16.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q0D_D_MTXD604_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 3vco DIHYDROFOLATE
REDUCTASE
(Schistosoma
mansoni) 		6 / 12 ALA A   8
ASP A  28
LEU A  64
ARG A  67
TYR A 117
THR A 133
 None
 0.46A 4q0dD-3vcoA:
20.1		 4q0dD-3vcoA:
16.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q0D_E_MTXE604_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 3vco DIHYDROFOLATE
REDUCTASE
(Schistosoma
mansoni) 		8 / 12 VAL A   6
ALA A   8
ASP A  28
ILE A  57
LEU A  64
ARG A  67
TYR A 117
THR A 133
 None
 0.59A 4q0dE-3vcoA:
20.2		 4q0dE-3vcoA:
16.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QI9_A_MTXA201_1
(DIHYDROFOLATE
REDUCTASE)		 3vco DIHYDROFOLATE
REDUCTASE
(Schistosoma
mansoni) 		8 / 12 ALA A   8
ASP A  28
LYS A  33
ILE A  57
LEU A  64
ARG A  67
TYR A 117
THR A 133
 None
 0.90A 4qi9A-3vcoA:
18.7		 4qi9A-3vcoA:
29.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QI9_A_MTXA201_1
(DIHYDROFOLATE
REDUCTASE)		 3vco DIHYDROFOLATE
REDUCTASE
(Schistosoma
mansoni) 		6 / 12 ALA A   8
ASP A  28
SER A  56
LEU A  64
ARG A  67
TYR A 117
 None
 0.76A 4qi9A-3vcoA:
18.7		 4qi9A-3vcoA:
29.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QI9_B_MTXB201_1
(DIHYDROFOLATE
REDUCTASE)		 3vco DIHYDROFOLATE
REDUCTASE
(Schistosoma
mansoni) 		8 / 12 ALA A   8
ASP A  28
LYS A  33
ILE A  57
LEU A  64
ARG A  67
TYR A 117
THR A 133
 None
 0.91A 4qi9B-3vcoA:
18.5		 4qi9B-3vcoA:
29.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QI9_B_MTXB201_1
(DIHYDROFOLATE
REDUCTASE)		 3vco DIHYDROFOLATE
REDUCTASE
(Schistosoma
mansoni) 		6 / 12 ALA A   8
ASP A  28
SER A  56
LEU A  64
ARG A  67
TYR A 117
 None
 0.79A 4qi9B-3vcoA:
18.5		 4qi9B-3vcoA:
29.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QI9_C_MTXC201_1
(DIHYDROFOLATE
REDUCTASE)		 3vco DIHYDROFOLATE
REDUCTASE
(Schistosoma
mansoni) 		7 / 11 ALA A   8
ASP A  28
ILE A  57
LEU A  64
ARG A  67
TYR A 117
THR A 133
 None
 0.62A 4qi9C-3vcoA:
18.2		 4qi9C-3vcoA:
29.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QI9_C_MTXC201_1
(DIHYDROFOLATE
REDUCTASE)		 3vco DIHYDROFOLATE
REDUCTASE
(Schistosoma
mansoni) 		6 / 11 ALA A   8
ASP A  28
LYS A  33
ILE A  57
TYR A 117
THR A 133
 None
 0.91A 4qi9C-3vcoA:
18.2		 4qi9C-3vcoA:
29.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QI9_C_MTXC201_1
(DIHYDROFOLATE
REDUCTASE)		 3vco DIHYDROFOLATE
REDUCTASE
(Schistosoma
mansoni) 		6 / 11 ALA A   8
ASP A  28
SER A  56
LEU A  64
ARG A  67
TYR A 117
 None
 0.82A 4qi9C-3vcoA:
18.2		 4qi9C-3vcoA:
29.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QLE_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 3vco DIHYDROFOLATE
REDUCTASE
(Schistosoma
mansoni) 		9 / 12 ALA A   8
ASP A  28
PHE A  32
LYS A  33
THR A  53
ILE A  57
LEU A  64
TYR A 117
THR A 133
 None
None
None
None
SO4  A 201 (-3.7A)
None
None
None
None
 0.91A 4qleA-3vcoA:
18.8		 4qleA-3vcoA:
29.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QLE_B_FOLB201_0
(DIHYDROFOLATE
REDUCTASE)		 3vco DIHYDROFOLATE
REDUCTASE
(Schistosoma
mansoni) 		8 / 11 ALA A   8
ASP A  28
LYS A  33
ILE A  57
LEU A  64
ARG A  67
TYR A 117
THR A 133
 None
 0.83A 4qleB-3vcoA:
18.7		 4qleB-3vcoA:
29.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QLE_B_FOLB201_0
(DIHYDROFOLATE
REDUCTASE)		 3vco DIHYDROFOLATE
REDUCTASE
(Schistosoma
mansoni) 		8 / 11 ALA A   8
ASP A  28
SER A  56
ILE A  57
LEU A  64
ARG A  67
TYR A 117
THR A 133
 None
 0.81A 4qleB-3vcoA:
18.7		 4qleB-3vcoA:
29.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QLF_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 3vco DIHYDROFOLATE
REDUCTASE
(Schistosoma
mansoni) 		9 / 11 ALA A   8
ASP A  28
PHE A  32
LYS A  33
ILE A  57
LEU A  64
ARG A  67
TYR A 117
THR A 133
 None
 0.76A 4qlfA-3vcoA:
16.9		 4qlfA-3vcoA:
29.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QLG_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 3vco DIHYDROFOLATE
REDUCTASE
(Schistosoma
mansoni) 		8 / 12 ALA A   8
ASP A  28
PHE A  32
ILE A  57
LEU A  64
ARG A  67
TYR A 117
THR A 133
 None
 0.70A 4qlgA-3vcoA:
18.5		 4qlgA-3vcoA:
29.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QLG_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 3vco DIHYDROFOLATE
REDUCTASE
(Schistosoma
mansoni) 		7 / 12 ALA A   8
ASP A  28
PHE A  32
LYS A  33
ILE A  57
TYR A 117
THR A 133
 None
 0.96A 4qlgA-3vcoA:
18.5		 4qlgA-3vcoA:
29.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QLG_B_FOLB201_0
(DIHYDROFOLATE
REDUCTASE)		 3vco DIHYDROFOLATE
REDUCTASE
(Schistosoma
mansoni) 		9 / 12 ALA A   8
ASP A  28
PHE A  32
LYS A  33
THR A  53
ILE A  57
LEU A  64
TYR A 117
THR A 133
 None
None
None
None
SO4  A 201 (-3.7A)
None
None
None
None
 0.81A 4qlgB-3vcoA:
18.6		 4qlgB-3vcoA:
29.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QLG_B_FOLB201_0
(DIHYDROFOLATE
REDUCTASE)		 3vco DIHYDROFOLATE
REDUCTASE
(Schistosoma
mansoni) 		9 / 12 ALA A   8
ASP A  28
PHE A  32
THR A  53
ILE A  57
LEU A  64
ARG A  67
TYR A 117
THR A 133
 None
None
None
SO4  A 201 (-3.7A)
None
None
None
None
None
 0.58A 4qlgB-3vcoA:
18.6		 4qlgB-3vcoA:
29.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RGC_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 3vco DIHYDROFOLATE
REDUCTASE
(Schistosoma
mansoni) 		8 / 12 ALA A   8
ASP A  28
PHE A  32
ILE A  57
LEU A  64
ARG A  67
TYR A 117
THR A 133
 None
 0.68A 4rgcA-3vcoA:
18.4		 4rgcA-3vcoA:
29.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RGC_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 3vco DIHYDROFOLATE
REDUCTASE
(Schistosoma
mansoni) 		7 / 12 ALA A   8
ASP A  28
PHE A  32
LYS A  33
ILE A  57
TYR A 117
THR A 133
 None
 0.93A 4rgcA-3vcoA:
18.4		 4rgcA-3vcoA:
29.35
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4X5F_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 3vco DIHYDROFOLATE
REDUCTASE
(Schistosoma
mansoni) 		8 / 12 ALA A   8
PHE A  32
THR A  53
ILE A  57
LEU A  64
ARG A  67
TYR A 117
THR A 133
 None
None
SO4  A 201 (-3.7A)
None
None
None
None
None
 0.64A 4x5fA-3vcoA:
18.5		 4x5fA-3vcoA:
32.97
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4X5F_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 3vco DIHYDROFOLATE
REDUCTASE
(Schistosoma
mansoni) 		6 / 12 PHE A  32
LYS A  33
THR A  53
ILE A  57
TYR A 117
THR A 133
 None
None
SO4  A 201 (-3.7A)
None
None
None
 1.28A 4x5fA-3vcoA:
18.5		 4x5fA-3vcoA:
32.97
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4X5F_B_FOLB201_0
(DIHYDROFOLATE
REDUCTASE)		 3vco DIHYDROFOLATE
REDUCTASE
(Schistosoma
mansoni) 		8 / 12 ALA A   8
PHE A  32
THR A  53
ILE A  57
LEU A  64
ARG A  67
TYR A 117
THR A 133
 None
None
SO4  A 201 (-3.7A)
None
None
None
None
None
 0.64A 4x5fB-3vcoA:
18.7		 4x5fB-3vcoA:
32.97
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4X5G_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 3vco DIHYDROFOLATE
REDUCTASE
(Schistosoma
mansoni) 		8 / 12 ALA A   8
ASP A  28
PHE A  32
THR A  53
ILE A  57
LEU A  64
TYR A 117
THR A 133
 None
None
None
SO4  A 201 (-3.7A)
None
None
None
None
 0.72A 4x5gA-3vcoA:
18.5		 4x5gA-3vcoA:
32.97
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4X5G_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 3vco DIHYDROFOLATE
REDUCTASE
(Schistosoma
mansoni) 		7 / 12 PHE A  32
LYS A  33
THR A  53
ILE A  57
LEU A  64
TYR A 117
THR A 133
 None
None
SO4  A 201 (-3.7A)
None
None
None
None
 1.20A 4x5gA-3vcoA:
18.5		 4x5gA-3vcoA:
32.97
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4X5G_B_FOLB201_0
(DIHYDROFOLATE
REDUCTASE)		 3vco DIHYDROFOLATE
REDUCTASE
(Schistosoma
mansoni) 		8 / 12 ALA A   8
THR A  53
ILE A  57
LEU A  64
ARG A  67
ILE A 111
TYR A 117
THR A 133
 None
SO4  A 201 (-3.7A)
None
None
None
None
None
None
 0.68A 4x5gB-3vcoA:
18.8		 4x5gB-3vcoA:
32.97
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4X5H_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 3vco DIHYDROFOLATE
REDUCTASE
(Schistosoma
mansoni) 		7 / 12 ALA A   8
PHE A  32
THR A  53
ILE A  57
LEU A  64
TYR A 117
THR A 133
 None
None
SO4  A 201 (-3.7A)
None
None
None
None
 0.73A 4x5hA-3vcoA:
18.3		 4x5hA-3vcoA:
32.97
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4X5H_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 3vco DIHYDROFOLATE
REDUCTASE
(Schistosoma
mansoni) 		6 / 12 PHE A  32
LYS A  33
THR A  53
ILE A  57
LEU A  64
TYR A 117
 None
None
SO4  A 201 (-3.7A)
None
None
None
 1.11A 4x5hA-3vcoA:
18.3		 4x5hA-3vcoA:
32.97
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4X5I_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 3vco DIHYDROFOLATE
REDUCTASE
(Schistosoma
mansoni) 		8 / 12 ALA A   8
PHE A  32
THR A  53
ILE A  57
LEU A  64
ILE A 111
TYR A 117
THR A 133
 None
None
SO4  A 201 (-3.7A)
None
None
None
None
None
 0.70A 4x5iA-3vcoA:
18.2		 4x5iA-3vcoA:
32.97
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4X5I_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 3vco DIHYDROFOLATE
REDUCTASE
(Schistosoma
mansoni) 		7 / 12 PHE A  32
LYS A  33
THR A  53
ILE A  57
LEU A  64
ILE A 111
TYR A 117
 None
None
SO4  A 201 (-3.7A)
None
None
None
None
 1.02A 4x5iA-3vcoA:
18.2		 4x5iA-3vcoA:
32.97
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4X5J_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 3vco DIHYDROFOLATE
REDUCTASE
(Schistosoma
mansoni) 		7 / 12 ALA A   8
PHE A  32
THR A  53
ILE A  57
ILE A 111
TYR A 117
THR A 133
 None
None
SO4  A 201 (-3.7A)
None
None
None
None
 0.67A 4x5jA-3vcoA:
18.0		 4x5jA-3vcoA:
32.97
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4X5J_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 3vco DIHYDROFOLATE
REDUCTASE
(Schistosoma
mansoni) 		6 / 12 PHE A  32
LYS A  33
THR A  53
ILE A  57
ILE A 111
TYR A 117
 None
None
SO4  A 201 (-3.7A)
None
None
None
 0.96A 4x5jA-3vcoA:
18.0		 4x5jA-3vcoA:
32.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E8Q_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 3vco DIHYDROFOLATE
REDUCTASE
(Schistosoma
mansoni) 		8 / 12 ALA A   8
PHE A  32
LYS A  33
THR A  53
ILE A  57
ILE A 111
TYR A 117
THR A 133
 None
None
None
SO4  A 201 (-3.7A)
None
None
None
None
 0.83A 5e8qA-3vcoA:
18.9		 5e8qA-3vcoA:
29.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E8Q_A_FOLA201_1
(DIHYDROFOLATE
REDUCTASE)		 3vco DIHYDROFOLATE
REDUCTASE
(Schistosoma
mansoni) 		3 / 3 ASP A  28
LEU A  64
ARG A  67
 None
 0.31A 5e8qA-3vcoA:
18.9		 5e8qA-3vcoA:
29.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E8Q_B_FOLB201_0
(DIHYDROFOLATE
REDUCTASE)		 3vco DIHYDROFOLATE
REDUCTASE
(Schistosoma
mansoni) 		8 / 12 ALA A   8
PHE A  32
LYS A  33
THR A  53
ILE A  57
LEU A  64
TYR A 117
THR A 133
 None
None
None
SO4  A 201 (-3.7A)
None
None
None
None
 0.79A 5e8qB-3vcoA:
19.0		 5e8qB-3vcoA:
29.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EAJ_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 3vco DIHYDROFOLATE
REDUCTASE
(Schistosoma
mansoni) 		9 / 12 ALA A   8
PHE A  32
LYS A  33
THR A  53
ILE A  57
LEU A  64
ILE A 111
TYR A 117
THR A 133
 None
None
None
SO4  A 201 (-3.7A)
None
None
None
None
None
 0.80A 5eajA-3vcoA:
18.9		 5eajA-3vcoA:
29.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EAJ_B_FOLB201_0
(DIHYDROFOLATE
REDUCTASE)		 3vco DIHYDROFOLATE
REDUCTASE
(Schistosoma
mansoni) 		8 / 12 ALA A   8
PHE A  32
LYS A  33
THR A  53
ILE A  57
LEU A  64
TYR A 117
THR A 133
 None
None
None
SO4  A 201 (-3.7A)
None
None
None
None
 0.84A 5eajB-3vcoA:
18.9		 5eajB-3vcoA:
29.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5G08_A_Z80A1187_1
(FREQUENIN 2)		 3vco DIHYDROFOLATE
REDUCTASE
(Schistosoma
mansoni) 		4 / 6 ILE A 110
PHE A 109
PHE A 145
TRP A  13
 None
 1.28A 5g08A-3vcoA:
undetectable		 5g08A-3vcoA:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HI6_A_MTXA201_1
(DIHYDROFOLATE
REDUCTASE)		 3vco DIHYDROFOLATE
REDUCTASE
(Schistosoma
mansoni) 		6 / 12 ALA A   8
ASP A  28
LYS A  33
ILE A  57
TYR A 117
THR A 133
 None
 0.90A 5hi6A-3vcoA:
19.5		 5hi6A-3vcoA:
29.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HI6_A_MTXA201_1
(DIHYDROFOLATE
REDUCTASE)		 3vco DIHYDROFOLATE
REDUCTASE
(Schistosoma
mansoni) 		8 / 12 ALA A   8
ASP A  28
SER A  56
ILE A  57
LEU A  64
ARG A  67
TYR A 117
THR A 133
 None
 0.74A 5hi6A-3vcoA:
19.5		 5hi6A-3vcoA:
29.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HI6_B_MTXB201_1
(DIHYDROFOLATE
REDUCTASE)		 3vco DIHYDROFOLATE
REDUCTASE
(Schistosoma
mansoni) 		9 / 12 ALA A   8
ASP A  28
LYS A  33
SER A  56
ILE A  57
LEU A  64
ARG A  67
TYR A 117
THR A 133
 None
 0.74A 5hi6B-3vcoA:
19.4		 5hi6B-3vcoA:
29.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UIH_A_8CVA201_1
(DIHYDROFOLATE
REDUCTASE)		 3vco DIHYDROFOLATE
REDUCTASE
(Schistosoma
mansoni) 		5 / 8 ALA A   8
ASP A  28
ILE A 111
TYR A 117
THR A 133
 None
 0.47A 5uihA-3vcoA:
18.8		 5uihA-3vcoA:
20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UJX_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 3vco DIHYDROFOLATE
REDUCTASE
(Schistosoma
mansoni) 		9 / 12 ALA A   8
PHE A  32
LYS A  33
THR A  53
ILE A  57
LEU A  64
ILE A 111
TYR A 117
THR A 133
 None
None
None
SO4  A 201 (-3.7A)
None
None
None
None
None
 0.84A 5ujxA-3vcoA:
18.9		 5ujxA-3vcoA:
29.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UJX_B_FOLB201_0
(DIHYDROFOLATE
REDUCTASE)		 3vco DIHYDROFOLATE
REDUCTASE
(Schistosoma
mansoni) 		9 / 12 ALA A   8
PHE A  32
LYS A  33
THR A  53
ILE A  57
LEU A  64
ARG A  67
TYR A 117
THR A 133
 None
None
None
SO4  A 201 (-3.7A)
None
None
None
None
None
 0.75A 5ujxB-3vcoA:
19.0		 5ujxB-3vcoA:
29.35
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5Z6F_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 3vco DIHYDROFOLATE
REDUCTASE
(Schistosoma
mansoni) 		8 / 12 ALA A   8
PHE A  32
LYS A  33
THR A  53
ILE A  57
ARG A  67
TYR A 117
THR A 133
 None
None
None
SO4  A 201 (-3.7A)
None
None
None
None
 0.89A 5z6fA-3vcoA:
18.6		 5z6fA-3vcoA:
32.97
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5Z6J_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 3vco DIHYDROFOLATE
REDUCTASE
(Schistosoma
mansoni) 		9 / 12 ALA A   8
PHE A  32
LYS A  33
THR A  53
ILE A  57
LEU A  64
ILE A 111
TYR A 117
THR A 133
 None
None
None
SO4  A 201 (-3.7A)
None
None
None
None
None
 0.88A 5z6jA-3vcoA:
18.5		 5z6jA-3vcoA:
32.97
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5Z6K_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 3vco DIHYDROFOLATE
REDUCTASE
(Schistosoma
mansoni) 		9 / 12 ALA A   8
PHE A  32
LYS A  33
THR A  53
ILE A  57
LEU A  64
ILE A 111
TYR A 117
THR A 133
 None
None
None
SO4  A 201 (-3.7A)
None
None
None
None
None
 0.90A 5z6kA-3vcoA:
18.5		 5z6kA-3vcoA:
32.97
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5Z6L_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 3vco DIHYDROFOLATE
REDUCTASE
(Schistosoma
mansoni) 		5 / 9 ALA A   8
ASP A  28
LYS A  33
ILE A  57
ARG A  67
 None
 1.10A 5z6lA-3vcoA:
18.2		 5z6lA-3vcoA:
32.97
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5Z6M_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 3vco DIHYDROFOLATE
REDUCTASE
(Schistosoma
mansoni) 		6 / 11 ALA A   8
ASP A  28
PHE A  32
ILE A 111
TYR A 117
THR A 133
 None
 0.96A 5z6mA-3vcoA:
18.0		 5z6mA-3vcoA:
32.97
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5Z6M_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 3vco DIHYDROFOLATE
REDUCTASE
(Schistosoma
mansoni) 		6 / 11 ALA A   8
PHE A  32
LEU A  64
ILE A 111
TYR A 117
THR A 133
 None
 0.67A 5z6mA-3vcoA:
18.0		 5z6mA-3vcoA:
32.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A7J_A_TESA502_0
(CYTOCHROME P450)		 3vco DIHYDROFOLATE
REDUCTASE
(Schistosoma
mansoni) 		4 / 7 LEU A 116
LEU A  89
ALA A  91
ALA A  92
 None
 0.75A 6a7jA-3vcoA:
undetectable		 6a7jA-3vcoA:
18.39
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6AOG_A_CP6A704_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 3vco DIHYDROFOLATE
REDUCTASE
(Schistosoma
mansoni) 		7 / 10 VAL A   6
ALA A   8
ASP A  28
PHE A  32
THR A  53
TYR A 117
THR A 133
 None
None
None
None
SO4  A 201 (-3.7A)
None
None
 0.51A 6aogA-3vcoA:
21.9		 6aogA-3vcoA:
42.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6AOG_B_CP6B704_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 3vco DIHYDROFOLATE
REDUCTASE
(Schistosoma
mansoni) 		7 / 10 VAL A   6
ALA A   8
ASP A  28
PHE A  32
THR A  53
TYR A 117
THR A 133
 None
None
None
None
SO4  A 201 (-3.7A)
None
None
 0.57A 6aogB-3vcoA:
11.7		 6aogB-3vcoA:
42.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
7DFR_A_FOLA161_0
(DIHYDROFOLATE
REDUCTASE)		 3vco DIHYDROFOLATE
REDUCTASE
(Schistosoma
mansoni) 		9 / 12 ALA A   8
PHE A  32
LYS A  33
THR A  53
ILE A  57
LEU A  64
ILE A 111
TYR A 117
THR A 133
 None
None
None
SO4  A 201 (-3.7A)
None
None
None
None
None
 0.80A 7dfrA-3vcoA:
18.5		 7dfrA-3vcoA:
29.35