SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3vdg'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LQT_B_ACTB1868_0
(FPRA)		 3vdg PROBABLE GLUCARATE
DEHYDRATASE
(Mycolicibacteriu
m
smegmatis) 		3 / 3 ALA A  67
HIS A  68
VAL A  71
 None
 0.27A 1lqtB-3vdgA:
undetectable		 1lqtB-3vdgA:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LQU_B_ACTB1425_0
(FPRA)		 3vdg PROBABLE GLUCARATE
DEHYDRATASE
(Mycolicibacteriu
m
smegmatis) 		3 / 3 ALA A  67
HIS A  68
VAL A  71
 None
 0.28A 1lquB-3vdgA:
undetectable		 1lquB-3vdgA:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XVA_A_SAMA293_0
(GLYCINE
N-METHYLTRANSFERASE)		 3vdg PROBABLE GLUCARATE
DEHYDRATASE
(Mycolicibacteriu
m
smegmatis) 		5 / 12 VAL A  27
ASP A 405
HIS A 321
ARG A 112
GLY A  95
 None
None
FMT  A 501 (-4.0A)
None
None
 0.95A 1xvaA-3vdgA:
undetectable		 1xvaA-3vdgA:
24.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XVA_A_SAMA293_0
(GLYCINE
N-METHYLTRANSFERASE)		 3vdg PROBABLE GLUCARATE
DEHYDRATASE
(Mycolicibacteriu
m
smegmatis) 		5 / 12 VAL A  27
ASP A 405
HIS A 321
GLY A  95
TYR A 297
 None
None
FMT  A 501 (-4.0A)
None
None
 1.19A 1xvaA-3vdgA:
undetectable		 1xvaA-3vdgA:
24.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F8L_A_SAMA400_0
(HYPOTHETICAL PROTEIN
LMO1582)		 3vdg PROBABLE GLUCARATE
DEHYDRATASE
(Mycolicibacteriu
m
smegmatis) 		5 / 12 ASN A 323
ASP A 404
GLY A 399
ASP A  20
PRO A  32
 FMT  A 501 (-4.0A)
None
None
None
None
 1.12A 2f8lA-3vdgA:
undetectable		 2f8lA-3vdgA:
20.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VMY_B_GLYB502_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 3vdg PROBABLE GLUCARATE
DEHYDRATASE
(Mycolicibacteriu
m
smegmatis) 		4 / 8 TYR A 150
SER A 322
HIS A  30
SER A 324
 None
None
ACT  A 504 (-4.0A)
None
 1.20A 2vmyA-3vdgA:
undetectable
2vmyB-3vdgA:
undetectable		 2vmyA-3vdgA:
25.00
2vmyB-3vdgA:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WEK_A_DIFA1373_1
(ZINC-BINDING ALCOHOL
DEHYDROGENASE
DOMAIN-CONTAINING
PROTEIN 2)		 3vdg PROBABLE GLUCARATE
DEHYDRATASE
(Mycolicibacteriu
m
smegmatis) 		4 / 8 ASN A 323
SER A 324
MET A 103
ASN A  25
 FMT  A 501 (-4.0A)
None
None
ACT  A 504 (-3.9A)
 1.25A 2wekA-3vdgA:
undetectable		 2wekA-3vdgA:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WEK_B_DIFB1373_1
(ZINC-BINDING ALCOHOL
DEHYDROGENASE
DOMAIN-CONTAINING
PROTEIN 2)		 3vdg PROBABLE GLUCARATE
DEHYDRATASE
(Mycolicibacteriu
m
smegmatis) 		4 / 8 ASN A 323
SER A 324
MET A 103
ASN A  25
 FMT  A 501 (-4.0A)
None
None
ACT  A 504 (-3.9A)
 1.25A 2wekB-3vdgA:
undetectable		 2wekB-3vdgA:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XAD_E_GCSE710_1
(N-ACYL GLM
PEUDO-TEICOPLANIN
DEACETYLASE
TEICOPLANIN)		 3vdg PROBABLE GLUCARATE
DEHYDRATASE
(Mycolicibacteriu
m
smegmatis) 		4 / 8 HIS A 295
SER A 329
ILE A 328
HIS A 296
 None
 1.00A 2xadA-3vdgA:
undetectable		 2xadA-3vdgA:
24.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XAD_F_GCSF710_1
(N-ACYL GLM
PEUDO-TEICOPLANIN
DEACETYLASE
TEICOPLANIN)		 3vdg PROBABLE GLUCARATE
DEHYDRATASE
(Mycolicibacteriu
m
smegmatis) 		4 / 8 HIS A 295
SER A 329
ILE A 328
HIS A 296
 None
 1.00A 2xadB-3vdgA:
undetectable		 2xadB-3vdgA:
24.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XAD_G_GCSG710_1
(N-ACYL GLM
PEUDO-TEICOPLANIN
DEACETYLASE
TEICOPLANIN)		 3vdg PROBABLE GLUCARATE
DEHYDRATASE
(Mycolicibacteriu
m
smegmatis) 		4 / 8 HIS A 295
SER A 329
ILE A 328
HIS A 296
 None
 1.00A 2xadC-3vdgA:
undetectable		 2xadC-3vdgA:
24.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XAD_H_GCSH710_1
(N-ACYL GLM
PEUDO-TEICOPLANIN
DEACETYLASE
TEICOPLANIN)		 3vdg PROBABLE GLUCARATE
DEHYDRATASE
(Mycolicibacteriu
m
smegmatis) 		4 / 8 HIS A 295
SER A 329
ILE A 328
HIS A 296
 None
 1.02A 2xadD-3vdgA:
undetectable		 2xadD-3vdgA:
24.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B0W_B_DGXB1_2
(NUCLEAR RECEPTOR
ROR-GAMMA)		 3vdg PROBABLE GLUCARATE
DEHYDRATASE
(Mycolicibacteriu
m
smegmatis) 		3 / 3 LEU A 343
VAL A 371
ARG A 142
 None
 0.81A 3b0wB-3vdgA:
undetectable		 3b0wB-3vdgA:
17.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GN0_A_DMOA551_1
(ARGINASE-1)		 3vdg PROBABLE GLUCARATE
DEHYDRATASE
(Mycolicibacteriu
m
smegmatis) 		5 / 9 HIS A 321
ASP A 348
HIS A 350
ASP A 222
GLU A 247
 FMT  A 501 (-4.0A)
None
ACT  A 504 (-4.0A)
NA  A 502 (-2.9A)
NA  A 502 (-3.1A)
 1.33A 3gn0A-3vdgA:
undetectable		 3gn0A-3vdgA:
23.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GN0_B_DMOB552_1
(ARGINASE-1)		 3vdg PROBABLE GLUCARATE
DEHYDRATASE
(Mycolicibacteriu
m
smegmatis) 		5 / 9 HIS A 321
ASP A 348
HIS A 350
ASP A 222
GLU A 247
 FMT  A 501 (-4.0A)
None
ACT  A 504 (-4.0A)
NA  A 502 (-2.9A)
NA  A 502 (-3.1A)
 1.35A 3gn0B-3vdgA:
undetectable		 3gn0B-3vdgA:
23.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PS9_A_SAMA670_1
(TRNA
5-METHYLAMINOMETHYL-
2-THIOURIDINE
BIOSYNTHESIS
BIFUNCTIONAL PROTEIN
MNMC)		 3vdg PROBABLE GLUCARATE
DEHYDRATASE
(Mycolicibacteriu
m
smegmatis) 		4 / 6 GLY A 196
THR A  26
GLU A 203
ASP A 222
 None
None
None
NA  A 502 (-2.9A)
 0.91A 3ps9A-3vdgA:
undetectable		 3ps9A-3vdgA:
23.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SG9_B_KANB305_1
(APH(2'')-ID)		 3vdg PROBABLE GLUCARATE
DEHYDRATASE
(Mycolicibacteriu
m
smegmatis) 		4 / 8 ASN A 270
HIS A 350
ASP A 348
GLU A 203
 NA  A 502 ( 2.6A)
ACT  A 504 (-4.0A)
None
None
 1.03A 3sg9B-3vdgA:
undetectable		 3sg9B-3vdgA:
17.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TTR_A_LQZA90_1
(LACTOTRANSFERRIN)		 3vdg PROBABLE GLUCARATE
DEHYDRATASE
(Mycolicibacteriu
m
smegmatis) 		3 / 3 PRO A 341
THR A 340
LEU A 318
 None
 0.78A 3ttrA-3vdgA:
undetectable		 3ttrA-3vdgA:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A99_C_MIYC392_1
(TETX2 PROTEIN)		 3vdg PROBABLE GLUCARATE
DEHYDRATASE
(Mycolicibacteriu
m
smegmatis) 		5 / 12 TYR A 395
VAL A 358
ILE A 383
GLN A  40
ILE A  39
 None
 0.86A 4a99A-3vdgA:
undetectable
4a99C-3vdgA:
undetectable		 4a99A-3vdgA:
23.55
4a99C-3vdgA:
23.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QZT_C_RTLC201_0
(RETINOL-BINDING
PROTEIN 2)		 3vdg PROBABLE GLUCARATE
DEHYDRATASE
(Mycolicibacteriu
m
smegmatis) 		5 / 12 ALA A 337
THR A  53
SER A 304
LEU A 301
LEU A 379
 None
 1.27A 4qztC-3vdgA:
undetectable		 4qztC-3vdgA:
13.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FCT_A_C2FA402_0
(THYMIDYLATE SYNTHASE)		 3vdg PROBABLE GLUCARATE
DEHYDRATASE
(Mycolicibacteriu
m
smegmatis) 		5 / 11 LEU A 301
ASP A 123
LEU A  50
GLY A  49
ALA A 331
 None
 1.36A 5fctA-3vdgA:
undetectable		 5fctA-3vdgA:
23.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FHQ_A_SAMA301_0
(CATECHOL
O-METHYLTRANSFERASE)		 3vdg PROBABLE GLUCARATE
DEHYDRATASE
(Mycolicibacteriu
m
smegmatis) 		5 / 12 VAL A  27
TYR A 153
ALA A 149
ARG A 220
ASP A 348
 None
 1.27A 5fhqA-3vdgA:
undetectable		 5fhqA-3vdgA:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GQB_A_GCSA602_1
(CHITINASE)		 3vdg PROBABLE GLUCARATE
DEHYDRATASE
(Mycolicibacteriu
m
smegmatis) 		3 / 3 TRP A 227
GLU A 203
ASP A 222
 None
None
NA  A 502 (-2.9A)
 0.60A 5gqbA-3vdgA:
5.4		 5gqbA-3vdgA:
22.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5J7W_D_MTXD402_1
(THYMIDYLATE SYNTHASE)		 3vdg PROBABLE GLUCARATE
DEHYDRATASE
(Mycolicibacteriu
m
smegmatis) 		6 / 12 LEU A 301
ASP A 123
LEU A  50
GLY A  49
ILE A 328
ALA A 331
 None
 1.23A 5j7wD-3vdgA:
undetectable		 5j7wD-3vdgA:
22.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MVM_A_PFLA510_1
(PROTON-GATED ION
CHANNEL)		 3vdg PROBABLE GLUCARATE
DEHYDRATASE
(Mycolicibacteriu
m
smegmatis) 		5 / 9 ILE A 183
ALA A 149
ILE A 191
ILE A 175
LEU A 210
 None
 1.12A 5mvmA-3vdgA:
undetectable
5mvmE-3vdgA:
undetectable		 5mvmA-3vdgA:
11.40
5mvmE-3vdgA:
11.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TRQ_B_ACTB306_0
(WELO5)		 3vdg PROBABLE GLUCARATE
DEHYDRATASE
(Mycolicibacteriu
m
smegmatis) 		3 / 3 GLU A 244
ARG A 220
TYR A 245
 None
 0.60A 5trqB-3vdgA:
undetectable		 5trqB-3vdgA:
21.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VIM_A_SAMA301_1
(METHYLTRANSFERASE)		 3vdg PROBABLE GLUCARATE
DEHYDRATASE
(Mycolicibacteriu
m
smegmatis) 		4 / 4 SER A 232
THR A  26
ASP A 405
ASP A 248
 None
 1.27A 5vimA-3vdgA:
undetectable		 5vimA-3vdgA:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X7P_A_ACRA1431_1
(GLYCOSIDE HYDROLASE
FAMILY 31
ALPHA-GLUCOSIDASE)		 3vdg PROBABLE GLUCARATE
DEHYDRATASE
(Mycolicibacteriu
m
smegmatis) 		4 / 7 HIS A  30
ASP A 222
GLY A 195
ASN A  25
 ACT  A 504 (-4.0A)
NA  A 502 (-2.9A)
None
ACT  A 504 (-3.9A)
 1.11A 5x7pA-3vdgA:
undetectable		 5x7pA-3vdgA:
17.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X7P_B_ACRB1431_1
(GLYCOSIDE HYDROLASE
FAMILY 31
ALPHA-GLUCOSIDASE)		 3vdg PROBABLE GLUCARATE
DEHYDRATASE
(Mycolicibacteriu
m
smegmatis) 		4 / 5 HIS A  30
ASP A 222
GLY A 195
ASN A  25
 ACT  A 504 (-4.0A)
NA  A 502 (-2.9A)
None
ACT  A 504 (-3.9A)
 1.12A 5x7pB-3vdgA:
undetectable		 5x7pB-3vdgA:
17.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6QXS_D_FOZD403_0
(THYMIDYLATE SYNTHASE)		 3vdg PROBABLE GLUCARATE
DEHYDRATASE
(Mycolicibacteriu
m
smegmatis) 		5 / 12 LEU A 301
ASP A 123
LEU A  50
GLY A  49
ILE A 328
 None
 1.13A 6qxsD-3vdgA:
undetectable		 6qxsD-3vdgA:
22.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6R2E_B_FFOB403_0
(THYMIDYLATE SYNTHASE)		 3vdg PROBABLE GLUCARATE
DEHYDRATASE
(Mycolicibacteriu
m
smegmatis) 		5 / 10 ILE A  39
LEU A 301
ASP A 123
LEU A  50
GLY A  49
 None
 1.37A 6r2eB-3vdgA:
undetectable		 6r2eB-3vdgA:
23.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6R2E_C_FFOC404_0
(THYMIDYLATE SYNTHASE)		 3vdg PROBABLE GLUCARATE
DEHYDRATASE
(Mycolicibacteriu
m
smegmatis) 		5 / 10 ILE A  39
LEU A 301
ASP A 123
LEU A  50
GLY A  49
 None
 1.31A 6r2eC-3vdgA:
undetectable		 6r2eC-3vdgA:
23.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6R2E_D_FFOD403_0
(THYMIDYLATE SYNTHASE)		 3vdg PROBABLE GLUCARATE
DEHYDRATASE
(Mycolicibacteriu
m
smegmatis) 		5 / 10 ILE A  39
LEU A 301
ASP A 123
LEU A  50
GLY A  49
 None
 1.30A 6r2eD-3vdgA:
undetectable		 6r2eD-3vdgA:
23.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6R2E_F_FFOF403_0
(THYMIDYLATE SYNTHASE)		 3vdg PROBABLE GLUCARATE
DEHYDRATASE
(Mycolicibacteriu
m
smegmatis) 		5 / 11 ILE A  39
LEU A 301
ASP A 123
LEU A  50
GLY A  49
 None
 1.26A 6r2eF-3vdgA:
undetectable		 6r2eF-3vdgA:
23.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6R2E_G_FFOG403_0
(THYMIDYLATE SYNTHASE)		 3vdg PROBABLE GLUCARATE
DEHYDRATASE
(Mycolicibacteriu
m
smegmatis) 		5 / 11 ILE A  39
LEU A 301
ASP A 123
LEU A  50
GLY A  49
 None
 1.35A 6r2eG-3vdgA:
undetectable		 6r2eG-3vdgA:
23.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6R2E_H_FFOH403_0
(THYMIDYLATE SYNTHASE)		 3vdg PROBABLE GLUCARATE
DEHYDRATASE
(Mycolicibacteriu
m
smegmatis) 		5 / 12 ILE A  39
LEU A 301
ASP A 123
LEU A  50
GLY A  49
 None
 1.31A 6r2eH-3vdgA:
undetectable		 6r2eH-3vdgA:
23.85