SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3vdz'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NT2_A_SAMA301_1
(FIBRILLARIN-LIKE
PRE-RRNA PROCESSING
PROTEIN)		 3vdz UBIQUITIN-40S
RIBOSOMAL PROTEIN
S27A
(Homo
sapiens;
synthetic
construct) 		3 / 3 THR A 155
GLU A 118
ASP A  86
 None
None
GD  A 202 (-3.3A)
 0.55A 1nt2A-3vdzA:
undetectable		 1nt2A-3vdzA:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z2B_C_VLBC800_1
(TUBULIN BETA CHAIN
TUBULIN ALPHA CHAIN)		 3vdz UBIQUITIN-40S
RIBOSOMAL PROTEIN
S27A
(Homo
sapiens;
synthetic
construct) 		4 / 8 LYS A 127
VAL A 126
ASP A 132
LEU A 156
 SO4  A 204 (-2.9A)
None
None
None
 0.79A 1z2bB-3vdzA:
undetectable		 1z2bB-3vdzA:
15.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CD2_A_FOLA307_0
(DIHYDROFOLATE
REDUCTASE)		 3vdz UBIQUITIN-40S
RIBOSOMAL PROTEIN
S27A
(Homo
sapiens;
synthetic
construct) 		5 / 12 ILE A 103
THR A 107
PHE A 145
LEU A 143
ILE A 130
 None
 0.96A 2cd2A-3vdzA:
undetectable		 2cd2A-3vdzA:
17.14
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2FCN_A_DVAA35_0
(UBIQUITIN)		 3vdz UBIQUITIN-40S
RIBOSOMAL PROTEIN
S27A
(Homo
sapiens;
synthetic
construct) 		4 / 4 GLN A 131
GLU A 134
ILE A 136
PRO A 137
 None
 0.90A 2fcnA-3vdzA:
16.1		 2fcnA-3vdzA:
94.94
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2FCN_B_DVAB35_0
(UBIQUITIN)		 3vdz UBIQUITIN-40S
RIBOSOMAL PROTEIN
S27A
(Homo
sapiens;
synthetic
construct) 		4 / 6 GLN A 131
GLU A 134
ILE A 136
PRO A 137
 None
 0.48A 2fcnA-3vdzA:
16.1
2fcnB-3vdzA:
16.1		 2fcnA-3vdzA:
94.94
2fcnB-3vdzA:
94.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GC9_A_SAMA401_1
(DIMETHYLADENOSINE
TRANSFERASE 1,
MITOCHONDRIAL)		 3vdz UBIQUITIN-40S
RIBOSOMAL PROTEIN
S27A
(Homo
sapiens;
synthetic
construct) 		3 / 3 GLU A 118
ASP A  96
ASP A  86
 None
None
GD  A 202 (-3.3A)
 0.60A 4gc9A-3vdzA:
undetectable		 4gc9A-3vdzA:
15.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4W5O_A_IPHA904_0
(PROTEIN ARGONAUTE-2)		 3vdz UBIQUITIN-40S
RIBOSOMAL PROTEIN
S27A
(Homo
sapiens;
synthetic
construct) 		4 / 7 ILE A 144
GLN A 149
ILE A 123
ASP A 152
 None
None
None
SO4  A 204 (-3.5A)
 0.97A 4w5oA-3vdzA:
undetectable		 4w5oA-3vdzA:
8.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4W5Q_A_IPHA902_0
(PROTEIN ARGONAUTE-2)		 3vdz UBIQUITIN-40S
RIBOSOMAL PROTEIN
S27A
(Homo
sapiens;
synthetic
construct) 		4 / 6 ILE A 144
GLN A 149
ILE A 123
ASP A 152
 None
None
None
SO4  A 204 (-3.5A)
 0.87A 4w5qA-3vdzA:
undetectable		 4w5qA-3vdzA:
8.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4W5T_A_IPHA902_0
(PROTEIN ARGONAUTE-2)		 3vdz UBIQUITIN-40S
RIBOSOMAL PROTEIN
S27A
(Homo
sapiens;
synthetic
construct) 		4 / 6 ILE A 144
GLN A 149
ILE A 123
ASP A 152
 None
None
None
SO4  A 204 (-3.5A)
 0.75A 4w5tA-3vdzA:
undetectable		 4w5tA-3vdzA:
8.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4C_A_IPHA903_0
(PROTEIN ARGONAUTE-2)		 3vdz UBIQUITIN-40S
RIBOSOMAL PROTEIN
S27A
(Homo
sapiens;
synthetic
construct) 		4 / 6 ILE A 144
GLN A 149
ILE A 123
ASP A 152
 None
None
None
SO4  A 204 (-3.5A)
 0.89A 4z4cA-3vdzA:
undetectable		 4z4cA-3vdzA:
8.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4D_A_IPHA902_0
(PROTEIN ARGONAUTE-2)		 3vdz UBIQUITIN-40S
RIBOSOMAL PROTEIN
S27A
(Homo
sapiens;
synthetic
construct) 		4 / 6 ILE A 144
GLN A 149
ILE A 123
ASP A 152
 None
None
None
SO4  A 204 (-3.5A)
 0.94A 4z4dA-3vdzA:
undetectable		 4z4dA-3vdzA:
8.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4E_A_IPHA904_0
(PROTEIN ARGONAUTE-2)		 3vdz UBIQUITIN-40S
RIBOSOMAL PROTEIN
S27A
(Homo
sapiens;
synthetic
construct) 		4 / 7 ILE A 144
GLN A 149
ILE A 123
ASP A 152
 None
None
None
SO4  A 204 (-3.5A)
 0.89A 4z4eA-3vdzA:
undetectable		 4z4eA-3vdzA:
8.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4G_A_IPHA902_0
(PROTEIN ARGONAUTE-2)		 3vdz UBIQUITIN-40S
RIBOSOMAL PROTEIN
S27A
(Homo
sapiens;
synthetic
construct) 		4 / 7 ILE A 144
GLN A 149
ILE A 123
ASP A 152
 None
None
None
SO4  A 204 (-3.5A)
 0.93A 4z4gA-3vdzA:
undetectable		 4z4gA-3vdzA:
8.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CBD_A_TRPA903_0
(PROTEIN ARGONAUTE-2)		 3vdz UBIQUITIN-40S
RIBOSOMAL PROTEIN
S27A
(Homo
sapiens;
synthetic
construct) 		4 / 6 ILE A 144
GLN A 149
ILE A 123
ASP A 152
 None
None
None
SO4  A 204 (-3.5A)
 0.81A 6cbdA-3vdzA:
undetectable		 6cbdA-3vdzA:
8.56