SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3vex'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CBR_A_REAA200_1
(CELLULAR RETINOIC
ACID BINDING PROTEIN
TYPE I)		 3vex O-CARBAMOYLTRANSFERA
SE TOBZ
(Streptoalloteich
us
tenebrarius) 		5 / 12 PHE A 205
LEU A 292
ALA A 288
ALA A 284
LEU A 241
 None
 1.12A 1cbrA-3vexA:
undetectable		 1cbrA-3vexA:
12.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CBR_B_REAB200_1
(CELLULAR RETINOIC
ACID BINDING PROTEIN
TYPE I)		 3vex O-CARBAMOYLTRANSFERA
SE TOBZ
(Streptoalloteich
us
tenebrarius) 		5 / 12 PHE A 205
LEU A 292
ALA A 288
ALA A 284
LEU A 241
 None
 1.12A 1cbrB-3vexA:
undetectable		 1cbrB-3vexA:
12.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FDS_A_ESTA350_1
(17-BETA-HYDROXYSTERO
ID-DEHYDROGENASE)		 3vex O-CARBAMOYLTRANSFERA
SE TOBZ
(Streptoalloteich
us
tenebrarius) 		5 / 12 VAL A 174
LEU A 241
TYR A 245
SER A 203
PHE A 170
 None
 1.23A 1fdsA-3vexA:
undetectable		 1fdsA-3vexA:
22.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJQ_B_SAMB200_0
(METHIONINE REPRESSOR)		 3vex O-CARBAMOYLTRANSFERA
SE TOBZ
(Streptoalloteich
us
tenebrarius) 		5 / 11 GLY A 407
GLU A 393
GLU A 395
LEU A 563
PRO A 389
 None
 1.42A 1mjqA-3vexA:
undetectable
1mjqB-3vexA:
undetectable		 1mjqA-3vexA:
11.99
1mjqB-3vexA:
11.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJQ_H_SAMH200_0
(METHIONINE REPRESSOR)		 3vex O-CARBAMOYLTRANSFERA
SE TOBZ
(Streptoalloteich
us
tenebrarius) 		5 / 10 GLY A 407
GLU A 393
GLU A 395
LEU A 563
PRO A 389
 None
 1.41A 1mjqG-3vexA:
undetectable
1mjqH-3vexA:
undetectable		 1mjqG-3vexA:
11.99
1mjqH-3vexA:
11.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MXD_A_ACRA732_1
(ALPHA AMYLASE)		 3vex O-CARBAMOYLTRANSFERA
SE TOBZ
(Streptoalloteich
us
tenebrarius) 		5 / 9 GLY A  70
GLY A 340
GLY A 309
GLY A 310
ASP A 137
 None
None
CA0  A 602 ( 4.0A)
CA0  A 602 (-3.2A)
FE2  A 601 ( 3.3A)
 1.04A 1mxdA-3vexA:
1.5		 1mxdA-3vexA:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_C_CTXC3_1
(CES1 PROTEIN)		 3vex O-CARBAMOYLTRANSFERA
SE TOBZ
(Streptoalloteich
us
tenebrarius) 		5 / 12 GLY A 291
VAL A 136
LEU A 321
LEU A 134
MET A 317
 None
 0.95A 1ya4C-3vexA:
undetectable		 1ya4C-3vexA:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXE_B_1FLB2002_1
(SERUM ALBUMIN)		 3vex O-CARBAMOYLTRANSFERA
SE TOBZ
(Streptoalloteich
us
tenebrarius) 		5 / 11 ALA A 347
ALA A 350
ALA A  66
SER A 342
LEU A 343
 None
 1.10A 2bxeB-3vexA:
undetectable		 2bxeB-3vexA:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OXT_A_SAMA300_1
(NUCLEOSIDE-2'-O-METH
YLTRANSFERASE)		 3vex O-CARBAMOYLTRANSFERA
SE TOBZ
(Streptoalloteich
us
tenebrarius) 		3 / 3 SER A 175
HIS A 194
ASP A 494
 None
 0.86A 2oxtA-3vexA:
undetectable		 2oxtA-3vexA:
18.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QL8_A_BEZA143_0
(PUTATIVE REDOX
PROTEIN)		 3vex O-CARBAMOYLTRANSFERA
SE TOBZ
(Streptoalloteich
us
tenebrarius) 		4 / 7 ALA A 279
THR A 280
ALA A 283
ARG A 287
 None
 0.99A 2ql8A-3vexA:
undetectable
2ql8B-3vexA:
undetectable		 2ql8A-3vexA:
13.53
2ql8B-3vexA:
13.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QL8_A_BEZA143_0
(PUTATIVE REDOX
PROTEIN)		 3vex O-CARBAMOYLTRANSFERA
SE TOBZ
(Streptoalloteich
us
tenebrarius) 		4 / 7 ALA A 281
THR A 280
ALA A 279
TYR A 245
 None
 0.97A 2ql8A-3vexA:
undetectable
2ql8B-3vexA:
undetectable		 2ql8A-3vexA:
13.53
2ql8B-3vexA:
13.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7H_C_SAMC530_1
(TYPE I RESTRICTION
ENZYME ECOKI M
PROTEIN)		 3vex O-CARBAMOYLTRANSFERA
SE TOBZ
(Streptoalloteich
us
tenebrarius) 		3 / 3 TYR A 230
GLU A 172
ASN A 184
 None
CA0  A 602 (-3.3A)
None
 0.97A 2y7hC-3vexA:
1.9		 2y7hC-3vexA:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YGN_A_PCFA1179_1
(WNT INHIBITORY
FACTOR 1)		 3vex O-CARBAMOYLTRANSFERA
SE TOBZ
(Streptoalloteich
us
tenebrarius) 		4 / 5 ILE A 474
PRO A 417
VAL A 351
PHE A  29
 None
None
EDO  A 606 ( 4.5A)
None
 1.23A 2ygnA-3vexA:
undetectable		 2ygnA-3vexA:
14.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AV6_A_SAMA1_0
(DNA
(CYTOSINE-5)-METHYLT
RANSFERASE 1)		 3vex O-CARBAMOYLTRANSFERA
SE TOBZ
(Streptoalloteich
us
tenebrarius) 		5 / 12 GLY A  70
GLY A   5
LEU A   6
ALA A  68
VAL A  67
 None
 1.04A 3av6A-3vexA:
undetectable		 3av6A-3vexA:
18.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FHJ_A_TRPA1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 3vex O-CARBAMOYLTRANSFERA
SE TOBZ
(Streptoalloteich
us
tenebrarius) 		5 / 10 GLY A 309
HIS A 114
ASP A 338
ILE A 339
VAL A 335
 CA0  A 602 ( 4.0A)
FE2  A 601 ( 3.4A)
CA0  A 602 ( 2.8A)
None
None
 1.20A 3fhjA-3vexA:
undetectable		 3fhjA-3vexA:
21.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FHJ_B_TRPB1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 3vex O-CARBAMOYLTRANSFERA
SE TOBZ
(Streptoalloteich
us
tenebrarius) 		5 / 10 GLY A 309
HIS A 114
ASP A 338
ILE A 339
VAL A 335
 CA0  A 602 ( 4.0A)
FE2  A 601 ( 3.4A)
CA0  A 602 ( 2.8A)
None
None
 1.20A 3fhjB-3vexA:
undetectable		 3fhjB-3vexA:
21.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FHJ_C_TRPC1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 3vex O-CARBAMOYLTRANSFERA
SE TOBZ
(Streptoalloteich
us
tenebrarius) 		5 / 10 GLY A 309
HIS A 114
ASP A 338
ILE A 339
VAL A 335
 CA0  A 602 ( 4.0A)
FE2  A 601 ( 3.4A)
CA0  A 602 ( 2.8A)
None
None
 1.21A 3fhjC-3vexA:
undetectable		 3fhjC-3vexA:
21.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FHJ_D_TRPD1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 3vex O-CARBAMOYLTRANSFERA
SE TOBZ
(Streptoalloteich
us
tenebrarius) 		5 / 9 GLY A 309
HIS A 114
ASP A 338
ILE A 339
VAL A 335
 CA0  A 602 ( 4.0A)
FE2  A 601 ( 3.4A)
CA0  A 602 ( 2.8A)
None
None
 1.21A 3fhjD-3vexA:
undetectable		 3fhjD-3vexA:
21.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FHJ_E_TRPE1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 3vex O-CARBAMOYLTRANSFERA
SE TOBZ
(Streptoalloteich
us
tenebrarius) 		5 / 10 GLY A 309
HIS A 114
ASP A 338
ILE A 339
VAL A 335
 CA0  A 602 ( 4.0A)
FE2  A 601 ( 3.4A)
CA0  A 602 ( 2.8A)
None
None
 1.20A 3fhjE-3vexA:
undetectable		 3fhjE-3vexA:
21.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FHJ_F_TRPF1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 3vex O-CARBAMOYLTRANSFERA
SE TOBZ
(Streptoalloteich
us
tenebrarius) 		5 / 9 GLY A 309
HIS A 114
ASP A 338
ILE A 339
VAL A 335
 CA0  A 602 ( 4.0A)
FE2  A 601 ( 3.4A)
CA0  A 602 ( 2.8A)
None
None
 1.20A 3fhjF-3vexA:
undetectable		 3fhjF-3vexA:
21.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FI0_A_TRPA1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 3vex O-CARBAMOYLTRANSFERA
SE TOBZ
(Streptoalloteich
us
tenebrarius) 		5 / 9 GLY A 309
HIS A 114
ASP A 338
ILE A 339
VAL A 335
 CA0  A 602 ( 4.0A)
FE2  A 601 ( 3.4A)
CA0  A 602 ( 2.8A)
None
None
 1.17A 3fi0A-3vexA:
undetectable		 3fi0A-3vexA:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FI0_C_TRPC1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 3vex O-CARBAMOYLTRANSFERA
SE TOBZ
(Streptoalloteich
us
tenebrarius) 		5 / 9 GLY A 309
HIS A 114
ASP A 338
ILE A 339
VAL A 335
 CA0  A 602 ( 4.0A)
FE2  A 601 ( 3.4A)
CA0  A 602 ( 2.8A)
None
None
 1.15A 3fi0C-3vexA:
undetectable		 3fi0C-3vexA:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FI0_D_TRPD1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 3vex O-CARBAMOYLTRANSFERA
SE TOBZ
(Streptoalloteich
us
tenebrarius) 		5 / 9 GLY A 309
HIS A 114
ASP A 338
ILE A 339
VAL A 335
 CA0  A 602 ( 4.0A)
FE2  A 601 ( 3.4A)
CA0  A 602 ( 2.8A)
None
None
 1.17A 3fi0D-3vexA:
undetectable		 3fi0D-3vexA:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FI0_F_TRPF1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 3vex O-CARBAMOYLTRANSFERA
SE TOBZ
(Streptoalloteich
us
tenebrarius) 		5 / 9 GLY A 309
HIS A 114
ASP A 338
ILE A 339
VAL A 335
 CA0  A 602 ( 4.0A)
FE2  A 601 ( 3.4A)
CA0  A 602 ( 2.8A)
None
None
 1.14A 3fi0F-3vexA:
undetectable		 3fi0F-3vexA:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FI0_H_TRPH1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 3vex O-CARBAMOYLTRANSFERA
SE TOBZ
(Streptoalloteich
us
tenebrarius) 		5 / 9 GLY A 309
HIS A 114
ASP A 338
ILE A 339
VAL A 335
 CA0  A 602 ( 4.0A)
FE2  A 601 ( 3.4A)
CA0  A 602 ( 2.8A)
None
None
 1.15A 3fi0H-3vexA:
undetectable		 3fi0H-3vexA:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FI0_J_TRPJ1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 3vex O-CARBAMOYLTRANSFERA
SE TOBZ
(Streptoalloteich
us
tenebrarius) 		5 / 9 GLY A 309
HIS A 114
ASP A 338
ILE A 339
VAL A 335
 CA0  A 602 ( 4.0A)
FE2  A 601 ( 3.4A)
CA0  A 602 ( 2.8A)
None
None
 1.16A 3fi0J-3vexA:
undetectable		 3fi0J-3vexA:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FI0_K_TRPK1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 3vex O-CARBAMOYLTRANSFERA
SE TOBZ
(Streptoalloteich
us
tenebrarius) 		5 / 9 GLY A 309
HIS A 114
ASP A 338
ILE A 339
VAL A 335
 CA0  A 602 ( 4.0A)
FE2  A 601 ( 3.4A)
CA0  A 602 ( 2.8A)
None
None
 1.15A 3fi0K-3vexA:
undetectable		 3fi0K-3vexA:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FI0_L_TRPL1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 3vex O-CARBAMOYLTRANSFERA
SE TOBZ
(Streptoalloteich
us
tenebrarius) 		5 / 9 GLY A 309
HIS A 114
ASP A 338
ILE A 339
VAL A 335
 CA0  A 602 ( 4.0A)
FE2  A 601 ( 3.4A)
CA0  A 602 ( 2.8A)
None
None
 1.16A 3fi0L-3vexA:
undetectable		 3fi0L-3vexA:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FI0_M_TRPM1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 3vex O-CARBAMOYLTRANSFERA
SE TOBZ
(Streptoalloteich
us
tenebrarius) 		5 / 9 GLY A 309
HIS A 114
ASP A 338
ILE A 339
VAL A 335
 CA0  A 602 ( 4.0A)
FE2  A 601 ( 3.4A)
CA0  A 602 ( 2.8A)
None
None
 1.20A 3fi0M-3vexA:
undetectable		 3fi0M-3vexA:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FI0_N_TRPN1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 3vex O-CARBAMOYLTRANSFERA
SE TOBZ
(Streptoalloteich
us
tenebrarius) 		5 / 9 GLY A 309
HIS A 114
ASP A 338
ILE A 339
VAL A 335
 CA0  A 602 ( 4.0A)
FE2  A 601 ( 3.4A)
CA0  A 602 ( 2.8A)
None
None
 1.13A 3fi0N-3vexA:
undetectable		 3fi0N-3vexA:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FI0_O_TRPO1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 3vex O-CARBAMOYLTRANSFERA
SE TOBZ
(Streptoalloteich
us
tenebrarius) 		5 / 9 GLY A 309
HIS A 114
ASP A 338
ILE A 339
VAL A 335
 CA0  A 602 ( 4.0A)
FE2  A 601 ( 3.4A)
CA0  A 602 ( 2.8A)
None
None
 1.19A 3fi0O-3vexA:
undetectable		 3fi0O-3vexA:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FI0_R_TRPR1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 3vex O-CARBAMOYLTRANSFERA
SE TOBZ
(Streptoalloteich
us
tenebrarius) 		5 / 9 GLY A 309
HIS A 114
ASP A 338
ILE A 339
VAL A 335
 CA0  A 602 ( 4.0A)
FE2  A 601 ( 3.4A)
CA0  A 602 ( 2.8A)
None
None
 1.11A 3fi0R-3vexA:
undetectable		 3fi0R-3vexA:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OZU_A_X89A411_1
(FLAVOHEMOPROTEIN)		 3vex O-CARBAMOYLTRANSFERA
SE TOBZ
(Streptoalloteich
us
tenebrarius) 		5 / 12 ALA A 336
VAL A 311
LEU A 321
ALA A 288
LEU A 292
 None
CA0  A 602 (-3.7A)
None
None
None
 1.27A 3ozuA-3vexA:
undetectable		 3ozuA-3vexA:
23.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OZW_A_KKKA413_1
(FLAVOHEMOGLOBIN)		 3vex O-CARBAMOYLTRANSFERA
SE TOBZ
(Streptoalloteich
us
tenebrarius) 		4 / 8 TYR A 171
GLN A 282
ALA A 193
LEU A 180
 CA0  A 602 (-3.4A)
None
None
None
 0.85A 3ozwA-3vexA:
undetectable		 3ozwA-3vexA:
23.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUD_D_SUED1201_1
(NS3 PROTEASE, NS4A
PROTEIN)		 3vex O-CARBAMOYLTRANSFERA
SE TOBZ
(Streptoalloteich
us
tenebrarius) 		5 / 12 GLY A 140
VAL A 161
GLY A  70
ALA A 119
ALA A 120
 CA0  A 602 ( 4.9A)
None
None
None
None
 1.02A 3sudD-3vexA:
undetectable		 3sudD-3vexA:
16.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUE_C_SUEC1201_1
(NS3 PROTEASE, NS4A
PROTEIN)		 3vex O-CARBAMOYLTRANSFERA
SE TOBZ
(Streptoalloteich
us
tenebrarius) 		5 / 12 GLY A 140
VAL A 161
GLY A  70
ALA A 119
ALA A 120
 CA0  A 602 ( 4.9A)
None
None
None
None
 0.99A 3sueC-3vexA:
undetectable		 3sueC-3vexA:
16.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUF_D_SUED1201_1
(NS3 PROTEASE, NS4A
PROTEIN)		 3vex O-CARBAMOYLTRANSFERA
SE TOBZ
(Streptoalloteich
us
tenebrarius) 		5 / 12 GLY A 140
VAL A 161
GLY A  70
ALA A 119
ALA A 120
 CA0  A 602 ( 4.9A)
None
None
None
None
 0.98A 3sufD-3vexA:
undetectable		 3sufD-3vexA:
16.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T7V_A_SAMA992_0
(METHYLORNITHINE
SYNTHASE PYLB)		 3vex O-CARBAMOYLTRANSFERA
SE TOBZ
(Streptoalloteich
us
tenebrarius) 		5 / 12 GLY A 309
GLY A 138
GLU A 141
VAL A 341
ALA A 345
 CA0  A 602 ( 4.0A)
CA0  A 602 (-3.1A)
None
None
None
 1.09A 3t7vA-3vexA:
undetectable		 3t7vA-3vexA:
21.16
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3VET_A_TOYA604_1
(O-CARBAMOYLTRANSFERA
SE TOBZ)		 3vex O-CARBAMOYLTRANSFERA
SE TOBZ
(Streptoalloteich
us
tenebrarius) 		8 / 9 ASP A  12
TYR A  42
PHE A 169
GLU A 172
GLU A 176
ASP A 183
ASP A 228
TYR A 230
 None
None
None
CA0  A 602 (-3.3A)
None
None
None
None
 0.42A 3vetA-3vexA:
64.3		 3vetA-3vexA:
99.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VT7_A_VDXA500_1
(VITAMIN D3 RECEPTOR)		 3vex O-CARBAMOYLTRANSFERA
SE TOBZ
(Streptoalloteich
us
tenebrarius) 		5 / 12 LEU A 464
VAL A 463
SER A 460
ARG A 457
VAL A 490
 None
None
None
None
EDO  A 605 ( 4.9A)
 1.43A 3vt7A-3vexA:
undetectable		 3vt7A-3vexA:
17.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C5N_C_PXLC300_1
(PHOSPHOMETHYLPYRIMID
INE KINASE)		 3vex O-CARBAMOYLTRANSFERA
SE TOBZ
(Streptoalloteich
us
tenebrarius) 		4 / 8 GLY A 522
ASP A 519
GLY A 518
VAL A 459
 None
 0.75A 4c5nC-3vexA:
undetectable		 4c5nC-3vexA:
19.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DU2_B_LDPB501_1
(CYTOCHROME P450 BM3
VARIANT B7)		 3vex O-CARBAMOYLTRANSFERA
SE TOBZ
(Streptoalloteich
us
tenebrarius) 		4 / 7 ALA A 347
PHE A 125
ALA A  19
LEU A  21
 None
 0.85A 4du2B-3vexA:
undetectable		 4du2B-3vexA:
22.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FGZ_B_CQAB302_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE)		 3vex O-CARBAMOYLTRANSFERA
SE TOBZ
(Streptoalloteich
us
tenebrarius) 		4 / 8 SER A 337
GLU A  33
ARG A 423
GLY A 367
 CA0  A 602 (-4.3A)
None
None
None
 1.04A 4fgzA-3vexA:
undetectable
4fgzB-3vexA:
undetectable		 4fgzA-3vexA:
17.34
4fgzB-3vexA:
17.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FP9_A_SAMA401_0
(METHYLTRANSFERASE
NSUN4)		 3vex O-CARBAMOYLTRANSFERA
SE TOBZ
(Streptoalloteich
us
tenebrarius) 		6 / 12 GLY A 413
GLY A 367
LEU A 425
SER A 530
GLY A 407
LEU A 557
 None
None
None
SO4  A 603 (-3.4A)
None
None
 1.41A 4fp9A-3vexA:
undetectable		 4fp9A-3vexA:
20.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FP9_C_SAMC401_0
(METHYLTRANSFERASE
NSUN4)		 3vex O-CARBAMOYLTRANSFERA
SE TOBZ
(Streptoalloteich
us
tenebrarius) 		6 / 12 GLY A 413
GLY A 367
LEU A 425
SER A 530
GLY A 407
LEU A 557
 None
None
None
SO4  A 603 (-3.4A)
None
None
 1.41A 4fp9C-3vexA:
undetectable		 4fp9C-3vexA:
20.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FP9_D_SAMD401_0
(METHYLTRANSFERASE
NSUN4)		 3vex O-CARBAMOYLTRANSFERA
SE TOBZ
(Streptoalloteich
us
tenebrarius) 		6 / 12 GLY A 413
GLY A 367
LEU A 425
SER A 530
GLY A 407
LEU A 557
 None
None
None
SO4  A 603 (-3.4A)
None
None
 1.41A 4fp9D-3vexA:
undetectable		 4fp9D-3vexA:
20.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FP9_F_SAMF401_0
(METHYLTRANSFERASE
NSUN4)		 3vex O-CARBAMOYLTRANSFERA
SE TOBZ
(Streptoalloteich
us
tenebrarius) 		6 / 12 GLY A 413
GLY A 367
LEU A 425
SER A 530
GLY A 407
LEU A 557
 None
None
None
SO4  A 603 (-3.4A)
None
None
 1.41A 4fp9F-3vexA:
undetectable		 4fp9F-3vexA:
20.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GKH_F_KANF301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 3vex O-CARBAMOYLTRANSFERA
SE TOBZ
(Streptoalloteich
us
tenebrarius) 		4 / 8 ASP A 223
ASP A  12
ARG A  11
GLU A 234
 None
 1.16A 4gkhF-3vexA:
undetectable		 4gkhF-3vexA:
18.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PO0_A_NPSA603_1
(SERUM ALBUMIN)		 3vex O-CARBAMOYLTRANSFERA
SE TOBZ
(Streptoalloteich
us
tenebrarius) 		5 / 10 VAL A 307
LEU A 305
ASN A 318
LEU A 321
VAL A 327
 None
 1.00A 4po0A-3vexA:
undetectable		 4po0A-3vexA:
22.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QDC_A_ASDA404_1
(3-KETOSTEROID
9ALPHA-HYDROXYLASE
OXYGENASE)		 3vex O-CARBAMOYLTRANSFERA
SE TOBZ
(Streptoalloteich
us
tenebrarius) 		5 / 12 VAL A 232
LEU A 167
ALA A 164
LEU A 214
PHE A 205
 None
 1.26A 4qdcA-3vexA:
undetectable		 4qdcA-3vexA:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5C0O_F_SAMF301_0
(TRNA
(ADENINE(58)-N(1))-M
ETHYLTRANSFERASE
TRMI)		 3vex O-CARBAMOYLTRANSFERA
SE TOBZ
(Streptoalloteich
us
tenebrarius) 		5 / 12 GLY A 140
GLY A 163
GLU A 141
HIS A 114
ASP A 228
 CA0  A 602 ( 4.9A)
None
None
FE2  A 601 ( 3.4A)
None
 0.90A 5c0oF-3vexA:
undetectable		 5c0oF-3vexA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FCT_B_C2FB402_1
(THYMIDYLATE SYNTHASE)		 3vex O-CARBAMOYLTRANSFERA
SE TOBZ
(Streptoalloteich
us
tenebrarius) 		3 / 3 ASN A   7
ASP A 137
GLY A 309
 None
FE2  A 601 ( 3.3A)
CA0  A 602 ( 4.0A)
 0.56A 5fctB-3vexA:
undetectable		 5fctB-3vexA:
20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FCT_B_C2FB402_1
(THYMIDYLATE SYNTHASE)		 3vex O-CARBAMOYLTRANSFERA
SE TOBZ
(Streptoalloteich
us
tenebrarius) 		3 / 3 ASN A  14
ASP A 137
GLY A 309
 None
FE2  A 601 ( 3.3A)
CA0  A 602 ( 4.0A)
 0.63A 5fctB-3vexA:
undetectable		 5fctB-3vexA:
20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5H4D_A_BBIA403_1
(NAD-DEPENDENT
PROTEIN DEACETYLASE
SIRTUIN-3,
MITOCHONDRIAL)		 3vex O-CARBAMOYLTRANSFERA
SE TOBZ
(Streptoalloteich
us
tenebrarius) 		4 / 6 PHE A 370
PHE A  35
GLU A 414
VAL A 415
 None
 1.41A 5h4dA-3vexA:
undetectable		 5h4dA-3vexA:
20.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V0I_A_TRPA402_0
(TRYPTOPHAN--TRNA
LIGASE)		 3vex O-CARBAMOYLTRANSFERA
SE TOBZ
(Streptoalloteich
us
tenebrarius) 		5 / 9 GLY A 309
HIS A 114
ASP A 338
ILE A 339
VAL A 335
 CA0  A 602 ( 4.0A)
FE2  A 601 ( 3.4A)
CA0  A 602 ( 2.8A)
None
None
 1.18A 5v0iA-3vexA:
undetectable		 5v0iA-3vexA:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V0I_B_TRPB402_0
(TRYPTOPHAN--TRNA
LIGASE)		 3vex O-CARBAMOYLTRANSFERA
SE TOBZ
(Streptoalloteich
us
tenebrarius) 		5 / 9 GLY A 309
HIS A 114
ASP A 338
ILE A 339
VAL A 335
 CA0  A 602 ( 4.0A)
FE2  A 601 ( 3.4A)
CA0  A 602 ( 2.8A)
None
None
 1.16A 5v0iB-3vexA:
undetectable		 5v0iB-3vexA:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AWP_A_FVXA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		 3vex O-CARBAMOYLTRANSFERA
SE TOBZ
(Streptoalloteich
us
tenebrarius) 		5 / 9 ASP A 338
ASN A  14
ILE A 135
SER A 337
GLY A 312
 CA0  A 602 ( 2.8A)
None
None
CA0  A 602 (-4.3A)
None
 1.34A 6awpA-3vexA:
1.3		 6awpA-3vexA:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6C2M_D_SUED1202_0
(NS3 PROTEASE)		 3vex O-CARBAMOYLTRANSFERA
SE TOBZ
(Streptoalloteich
us
tenebrarius) 		5 / 12 GLY A 140
VAL A 161
GLY A  70
ALA A 119
ALA A 120
 CA0  A 602 ( 4.9A)
None
None
None
None
 1.00A 6c2mD-3vexA:
undetectable		 6c2mD-3vexA:
8.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CZM_A_HISA402_0
(ATP
PHOSPHORIBOSYLTRANSF
ERASE CATALYTIC
SUBUNIT)		 3vex O-CARBAMOYLTRANSFERA
SE TOBZ
(Streptoalloteich
us
tenebrarius) 		5 / 10 LEU A 343
VAL A   3
VAL A 112
ALA A  68
LEU A  21
 None
 1.15A 6czmA-3vexA:
undetectable
6czmC-3vexA:
undetectable		 6czmA-3vexA:
21.96
6czmC-3vexA:
21.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNA_A_ACTA307_0
(THIOREDOXIN
REDUCTASE)		 3vex O-CARBAMOYLTRANSFERA
SE TOBZ
(Streptoalloteich
us
tenebrarius) 		3 / 3 ARG A 130
LYS A 154
TYR A 123
 None
 1.20A 6gnaA-3vexA:
undetectable		 6gnaA-3vexA:
19.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNB_A_ACTA307_0
(THIOREDOXIN
REDUCTASE)		 3vex O-CARBAMOYLTRANSFERA
SE TOBZ
(Streptoalloteich
us
tenebrarius) 		3 / 3 ARG A 130
LYS A 154
TYR A 123
 None
 1.20A 6gnbA-3vexA:
undetectable		 6gnbA-3vexA:
19.97