SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3vfd'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HRK_B_CHDB2501_0
(FERROCHELATASE)		 3vfd SPASTIN
(Homo
sapiens) 		5 / 12 LEU A 354
LEU A 378
MET A 484
ILE A 344
VAL A 443
 None
 1.37A 1hrkB-3vfdA:
2.4		 1hrkB-3vfdA:
23.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I9G_A_SAMA301_0
(HYPOTHETICAL PROTEIN
RV2118C)		 3vfd SPASTIN
(Homo
sapiens) 		5 / 12 GLY A 547
SER A 548
ALA A 552
LEU A 553
LEU A 516
 None
 0.97A 1i9gA-3vfdA:
undetectable		 1i9gA-3vfdA:
22.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KT5_A_RTLA176_0
(PLASMA
RETINOL-BINDING
PROTEIN)		 3vfd SPASTIN
(Homo
sapiens) 		5 / 12 LEU A 349
PHE A 403
ALA A 396
ALA A 394
MET A 484
 None
 1.25A 1kt5A-3vfdA:
undetectable		 1kt5A-3vfdA:
17.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RV7_B_AB1B1001_1
(PROTEASE)		 3vfd SPASTIN
(Homo
sapiens) 		5 / 11 ILE A 332
VAL A 472
LEU A 446
ALA A 408
VAL A 443
 None
 1.05A 1rv7A-3vfdA:
undetectable
1rv7B-3vfdA:
undetectable		 1rv7A-3vfdA:
16.77
1rv7B-3vfdA:
16.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A15_A_NCAA1001_0
(HYPOTHETICAL PROTEIN
RV0760C)		 3vfd SPASTIN
(Homo
sapiens) 		5 / 11 VAL A 358
ILE A 357
LEU A 378
LEU A 391
LEU A 380
 None
 1.06A 2a15A-3vfdA:
undetectable		 2a15A-3vfdA:
17.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2H42_C_VIAC903_2
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		 3vfd SPASTIN
(Homo
sapiens) 		3 / 3 ASN A 580
ILE A 562
MET A 573
 None
 0.76A 2h42C-3vfdA:
undetectable		 2h42C-3vfdA:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QD4_B_CHDB927_0
(FERROCHELATASE)		 3vfd SPASTIN
(Homo
sapiens) 		3 / 3 LEU A 602
PRO A 599
ARG A 515
 None
 0.62A 2qd4B-3vfdA:
2.5		 2qd4B-3vfdA:
23.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0M_D_KLND1499_1
(CYTOCHROME P450 3A4)		 3vfd SPASTIN
(Homo
sapiens) 		4 / 5 PHE A 469
SER A 399
PHE A 501
ILE A 359
 None
 1.21A 2v0mD-3vfdA:
undetectable		 2v0mD-3vfdA:
22.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YVL_C_SAMC604_0
(HYPOTHETICAL PROTEIN)		 3vfd SPASTIN
(Homo
sapiens) 		5 / 12 GLY A 547
SER A 548
ALA A 552
LEU A 553
ALA A 345
 None
 1.22A 2yvlC-3vfdA:
undetectable		 2yvlC-3vfdA:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AQI_B_CHDB6_0
(FERROCHELATASE)		 3vfd SPASTIN
(Homo
sapiens) 		5 / 12 LEU A 354
LEU A 378
MET A 484
ILE A 344
VAL A 443
 None
 1.33A 3aqiB-3vfdA:
undetectable		 3aqiB-3vfdA:
22.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W1W_A_CHDA1502_0
(FERROCHELATASE,
MITOCHONDRIAL)		 3vfd SPASTIN
(Homo
sapiens) 		5 / 12 LEU A 354
LEU A 378
MET A 484
ILE A 344
VAL A 443
 None
 1.36A 3w1wA-3vfdA:
2.4		 3w1wA-3vfdA:
23.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LUH_A_ACTA610_0
(SERUM ALBUMIN)		 3vfd SPASTIN
(Homo
sapiens) 		3 / 3 VAL A 597
SER A 598
THR A 601
 None
 0.44A 4luhA-3vfdA:
undetectable		 4luhA-3vfdA:
21.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XEY_A_1N1A601_2
(TYROSINE-PROTEIN
KINASE ABL1)		 3vfd SPASTIN
(Homo
sapiens) 		3 / 3 MET A 390
ASP A 334
PHE A 404
 None
 1.01A 4xeyA-3vfdA:
undetectable		 4xeyA-3vfdA:
23.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XEY_B_1N1B601_2
(TYROSINE-PROTEIN
KINASE ABL1)		 3vfd SPASTIN
(Homo
sapiens) 		3 / 3 MET A 390
ASP A 334
PHE A 404
 None
 0.99A 4xeyB-3vfdA:
undetectable		 4xeyB-3vfdA:
23.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z7F_C_FOLC201_0
(FOLATE ECF
TRANSPORTER)		 3vfd SPASTIN
(Homo
sapiens) 		5 / 12 ALA A 425
PHE A 404
ASN A 335
THR A 402
LEU A 433
 None
 1.43A 4z7fC-3vfdA:
undetectable		 4z7fC-3vfdA:
20.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E4D_A_BEZA201_0
(HYDROXYNITRILE LYASE)		 3vfd SPASTIN
(Homo
sapiens) 		5 / 9 VAL A 505
VAL A 507
ILE A 344
PHE A 341
LEU A 354
 None
 1.35A 5e4dA-3vfdA:
undetectable		 5e4dA-3vfdA:
18.97