SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3vgj'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FFY_A_MRCA1993_1
(ISOLEUCYL-TRNA
SYNTHETASE)		 3vgj TYROSYL-TRNA
SYNTHETASE, PUTATIVE
(Plasmodium
falciparum) 		5 / 12 HIS A  70
GLY A 207
ASP A 209
GLN A 210
HIS A 235
 AMP  A 402 (-4.4A)
AMP  A 402 (-3.1A)
AMP  A 402 (-2.8A)
TYR  A 401 ( 3.3A)
AMP  A 402 (-4.0A)
 0.56A 1ffyA-3vgjA:
undetectable		 1ffyA-3vgjA:
19.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JZS_A_MRCA1301_1
(ISOLEUCYL-TRNA
SYNTHETASE)		 3vgj TYROSYL-TRNA
SYNTHETASE, PUTATIVE
(Plasmodium
falciparum) 		5 / 11 GLY A  62
HIS A  70
GLY A 207
ASP A 209
GLN A 210
 TYR  A 401 ( 3.3A)
AMP  A 402 (-4.4A)
AMP  A 402 (-3.1A)
AMP  A 402 (-2.8A)
TYR  A 401 ( 3.3A)
 0.62A 1jzsA-3vgjA:
undetectable		 1jzsA-3vgjA:
17.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QU2_A_MRCA1993_1
(ISOLEUCYL-TRNA
SYNTHETASE)		 3vgj TYROSYL-TRNA
SYNTHETASE, PUTATIVE
(Plasmodium
falciparum) 		5 / 12 HIS A  70
GLY A 207
ASP A 209
GLN A 210
HIS A 235
 AMP  A 402 (-4.4A)
AMP  A 402 (-3.1A)
AMP  A 402 (-2.8A)
TYR  A 401 ( 3.3A)
AMP  A 402 (-4.0A)
 0.56A 1qu2A-3vgjA:
undetectable		 1qu2A-3vgjA:
19.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QWX_B_ML1B233_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 3vgj TYROSYL-TRNA
SYNTHETASE, PUTATIVE
(Plasmodium
falciparum) 		4 / 7 GLY A  74
GLY A 207
GLN A 205
PHE A  93
 None
AMP  A 402 (-3.1A)
None
None
 0.78A 2qwxA-3vgjA:
undetectable
2qwxB-3vgjA:
2.1		 2qwxA-3vgjA:
18.16
2qwxB-3vgjA:
18.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X0P_A_ADNA1607_1
(ALCALIGIN
BIOSYNTHESIS PROTEIN)		 3vgj TYROSYL-TRNA
SYNTHETASE, PUTATIVE
(Plasmodium
falciparum) 		4 / 8 GLY A  62
ILE A 196
ASN A 214
ALA A  96
 TYR  A 401 ( 3.3A)
None
None
TYR  A 401 (-3.6A)
 0.88A 2x0pA-3vgjA:
undetectable		 2x0pA-3vgjA:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X1L_B_ADNB601_1
(METHIONYL-TRNA
SYNTHETASE)		 3vgj TYROSYL-TRNA
SYNTHETASE, PUTATIVE
(Plasmodium
falciparum) 		5 / 12 HIS A  70
GLY A 207
ASP A 209
HIS A 235
LEU A 238
 AMP  A 402 (-4.4A)
AMP  A 402 (-3.1A)
AMP  A 402 (-2.8A)
AMP  A 402 (-4.0A)
AMP  A 402 (-4.3A)
 0.66A 2x1lB-3vgjA:
5.5		 2x1lB-3vgjA:
20.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XCT_H_CPFH1020_1
(DNA GYRASE SUBUNIT
B, DNA GYRASE
SUBUNIT A)		 3vgj TYROSYL-TRNA
SYNTHETASE, PUTATIVE
(Plasmodium
falciparum) 		3 / 3 ARG A 175
GLU A 179
SER A 255
 None
 0.92A 2xctD-3vgjA:
undetectable		 2xctD-3vgjA:
19.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_D_TFPD201_1
(PROTEIN S100-A4)		 3vgj TYROSYL-TRNA
SYNTHETASE, PUTATIVE
(Plasmodium
falciparum) 		4 / 8 GLY A  62
MET A 259
PHE A 353
PHE A 120
 TYR  A 401 ( 3.3A)
None
None
None
 0.94A 3ko0D-3vgjA:
undetectable
3ko0E-3vgjA:
undetectable		 3ko0D-3vgjA:
15.55
3ko0E-3vgjA:
15.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_J_TFPJ201_1
(PROTEIN S100-A4)		 3vgj TYROSYL-TRNA
SYNTHETASE, PUTATIVE
(Plasmodium
falciparum) 		4 / 8 PHE A 120
GLY A  62
MET A 259
PHE A 353
 None
TYR  A 401 ( 3.3A)
None
None
 0.97A 3ko0B-3vgjA:
undetectable
3ko0J-3vgjA:
undetectable		 3ko0B-3vgjA:
15.55
3ko0J-3vgjA:
15.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_K_TFPK201_1
(PROTEIN S100-A4)		 3vgj TYROSYL-TRNA
SYNTHETASE, PUTATIVE
(Plasmodium
falciparum) 		4 / 8 GLY A  62
MET A 259
PHE A 353
PHE A 120
 TYR  A 401 ( 3.3A)
None
None
None
 0.99A 3ko0K-3vgjA:
undetectable
3ko0S-3vgjA:
undetectable		 3ko0K-3vgjA:
15.55
3ko0S-3vgjA:
15.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_S_TFPS201_1
(PROTEIN S100-A4)		 3vgj TYROSYL-TRNA
SYNTHETASE, PUTATIVE
(Plasmodium
falciparum) 		4 / 7 PHE A 120
GLY A  62
MET A 259
PHE A 353
 None
TYR  A 401 ( 3.3A)
None
None
 0.97A 3ko0K-3vgjA:
undetectable
3ko0S-3vgjA:
undetectable		 3ko0K-3vgjA:
15.55
3ko0S-3vgjA:
15.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_T_TFPT201_1
(PROTEIN S100-A4)		 3vgj TYROSYL-TRNA
SYNTHETASE, PUTATIVE
(Plasmodium
falciparum) 		4 / 7 PHE A 120
GLY A  62
MET A 259
PHE A 353
 None
TYR  A 401 ( 3.3A)
None
None
 0.96A 3ko0R-3vgjA:
undetectable
3ko0T-3vgjA:
undetectable		 3ko0R-3vgjA:
15.55
3ko0T-3vgjA:
15.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LN1_D_CELD682_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		 3vgj TYROSYL-TRNA
SYNTHETASE, PUTATIVE
(Plasmodium
falciparum) 		4 / 5 ARG A  68
LEU A 346
ARG A 268
ILE A 270
 None
 1.15A 3ln1D-3vgjA:
undetectable		 3ln1D-3vgjA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XJE_A_TOYA202_1
(AADB)		 3vgj TYROSYL-TRNA
SYNTHETASE, PUTATIVE
(Plasmodium
falciparum) 		4 / 8 ASP A 261
TYR A 119
ASP A 260
TYR A 369
 None
 0.96A 4xjeA-3vgjA:
2.1		 4xjeA-3vgjA:
17.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZVM_B_DM2B303_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 3vgj TYROSYL-TRNA
SYNTHETASE, PUTATIVE
(Plasmodium
falciparum) 		5 / 11 GLN A 205
PHE A  91
PHE A  93
GLY A  74
ILE A 292
 None
 1.41A 4zvmA-3vgjA:
undetectable
4zvmB-3vgjA:
undetectable		 4zvmA-3vgjA:
17.90
4zvmB-3vgjA:
17.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CFS_A_TOYA203_1
(AAD(2''),GENTAMICIN
2''-NUCLEOTIDYLTRANS
FERASE,GENTAMICIN
RESISTANCE PROTEIN)		 3vgj TYROSYL-TRNA
SYNTHETASE, PUTATIVE
(Plasmodium
falciparum) 		4 / 8 ASP A 261
TYR A 119
ASP A 260
TYR A 369
 None
 0.91A 5cfsA-3vgjA:
2.1		 5cfsA-3vgjA:
17.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NZX_A_9F2A1102_1
(DNA CROSS-LINK
REPAIR 1A PROTEIN)		 3vgj TYROSYL-TRNA
SYNTHETASE, PUTATIVE
(Plasmodium
falciparum) 		4 / 8 ASN A 364
ARG A  68
ILE A 366
GLY A  67
 None
 1.00A 5nzxA-3vgjA:
undetectable		 5nzxA-3vgjA:
21.36