SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3vgl'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EKJ_C_ACTC3004_0
(BETA-CARBONIC
ANHYDRASE)		 3vgl GLUCOKINASE
(Streptomyces
griseus) 		4 / 6 TYR A 114
ASP A 123
VAL A 125
GLY A 121
 None
 0.96A 1ekjC-3vglA:
undetectable
1ekjD-3vglA:
undetectable		 1ekjC-3vglA:
23.64
1ekjD-3vglA:
23.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EKJ_C_ACTC3007_0
(BETA-CARBONIC
ANHYDRASE)		 3vgl GLUCOKINASE
(Streptomyces
griseus) 		4 / 6 ASP A 123
VAL A 125
GLY A 121
TYR A 114
 None
 0.96A 1ekjC-3vglA:
undetectable
1ekjD-3vglA:
undetectable		 1ekjC-3vglA:
23.64
1ekjD-3vglA:
23.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EKJ_F_ACTF3008_0
(BETA-CARBONIC
ANHYDRASE)		 3vgl GLUCOKINASE
(Streptomyces
griseus) 		4 / 8 TYR A 178
VAL A 160
GLY A 164
GLY A 173
 None
 0.87A 1ekjE-3vglA:
undetectable
1ekjF-3vglA:
undetectable		 1ekjE-3vglA:
23.64
1ekjF-3vglA:
23.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KQE_A_DVAA6_0
(MINI-GRAMICIDIN A)		 3vgl GLUCOKINASE
(Streptomyces
griseus) 		3 / 3 ALA A  73
VAL A  75
TRP A  83
 None
 0.79A 1kqeA-3vglA:
undetectable
1kqeE-3vglA:
undetectable		 1kqeA-3vglA:
3.66
1kqeE-3vglA:
3.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KQE_B_DVAB6_0
(MINI-GRAMICIDIN A)		 3vgl GLUCOKINASE
(Streptomyces
griseus) 		3 / 3 ALA A  73
VAL A  75
TRP A  83
 None
 0.81A 1kqeB-3vglA:
undetectable
1kqeD-3vglA:
undetectable		 1kqeB-3vglA:
3.66
1kqeD-3vglA:
3.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KQE_D_DVAD6_0
(MINI-GRAMICIDIN A)		 3vgl GLUCOKINASE
(Streptomyces
griseus) 		3 / 3 TRP A  83
ALA A  73
VAL A  75
 None
 0.80A 1kqeB-3vglA:
undetectable
1kqeD-3vglA:
undetectable		 1kqeB-3vglA:
3.66
1kqeD-3vglA:
3.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KQE_E_DVAE6_0
(MINI-GRAMICIDIN A)		 3vgl GLUCOKINASE
(Streptomyces
griseus) 		3 / 3 TRP A  83
ALA A  73
VAL A  75
 None
 0.82A 1kqeA-3vglA:
undetectable
1kqeE-3vglA:
undetectable		 1kqeA-3vglA:
3.66
1kqeE-3vglA:
3.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MIC_A_DVAA6_0
(GRAMICIDIN A)		 3vgl GLUCOKINASE
(Streptomyces
griseus) 		3 / 3 ALA A  73
VAL A  75
TRP A  83
 None
 0.84A 1micA-3vglA:
undetectable
1micB-3vglA:
undetectable		 1micA-3vglA:
4.63
1micB-3vglA:
4.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MUI_B_AB1B100_2
(PROTEASE)		 3vgl GLUCOKINASE
(Streptomyces
griseus) 		5 / 12 GLY A  50
ALA A  51
ILE A  14
VAL A  60
ILE A   5
 None
 0.82A 1muiB-3vglA:
undetectable		 1muiB-3vglA:
18.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1X7P_A_SAMA301_0
(RRNA
METHYLTRANSFERASE)		 3vgl GLUCOKINASE
(Streptomyces
griseus) 		5 / 11 GLU A 265
GLY A 260
GLY A 261
ALA A 295
ALA A 294
 ANP  A 325 (-3.7A)
ANP  A 325 ( 4.1A)
ANP  A 325 (-3.6A)
None
None
 1.03A 1x7pA-3vglA:
undetectable
1x7pB-3vglA:
undetectable		 1x7pA-3vglA:
21.47
1x7pB-3vglA:
21.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AQU_B_DR7B300_1
(HIV-1 PROTEASE)		 3vgl GLUCOKINASE
(Streptomyces
griseus) 		5 / 10 GLY A  50
ALA A  51
ILE A  14
VAL A  60
ILE A   5
 None
 0.79A 2aquA-3vglA:
undetectable		 2aquA-3vglA:
18.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AQU_B_DR7B300_2
(HIV-1 PROTEASE)		 3vgl GLUCOKINASE
(Streptomyces
griseus) 		5 / 11 GLY A  50
ALA A  51
ILE A  14
VAL A  60
ILE A   5
 None
 0.81A 2aquB-3vglA:
undetectable		 2aquB-3vglA:
18.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AVV_A_MK1A901_3
(POL POLYPROTEIN)		 3vgl GLUCOKINASE
(Streptomyces
griseus) 		5 / 12 GLY A  50
ALA A  51
ILE A  14
VAL A  60
ILE A   5
 None
 0.78A 2avvB-3vglA:
undetectable		 2avvB-3vglA:
18.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FXE_A_DR7A102_1
(POL PROTEIN)		 3vgl GLUCOKINASE
(Streptomyces
griseus) 		5 / 12 GLY A  50
ALA A  51
ILE A  14
VAL A  60
ILE A   5
 None
 0.85A 2fxeA-3vglA:
undetectable		 2fxeA-3vglA:
17.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IWK_A_CUA1599_0
(NITROUS OXIDE
REDUCTASE)		 3vgl GLUCOKINASE
(Streptomyces
griseus) 		3 / 3 CYH A 169
CYH A 174
HIS A 157
 ZN  A 322 (-2.2A)
ZN  A 322 (-2.2A)
ZN  A 322 ( 3.2A)
 0.75A 2iwkA-3vglA:
undetectable		 2iwkA-3vglA:
19.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IWK_B_CUB1599_0
(NITROUS OXIDE
REDUCTASE)		 3vgl GLUCOKINASE
(Streptomyces
griseus) 		3 / 3 CYH A 169
CYH A 174
HIS A 157
 ZN  A 322 (-2.2A)
ZN  A 322 (-2.2A)
ZN  A 322 ( 3.2A)
 0.76A 2iwkB-3vglA:
undetectable		 2iwkB-3vglA:
19.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2R5P_D_MK1D902_2
(PROTEASE)		 3vgl GLUCOKINASE
(Streptomyces
griseus) 		5 / 12 GLY A  50
ALA A  51
ILE A  14
VAL A  60
ILE A   5
 None
 0.86A 2r5pD-3vglA:
undetectable		 2r5pD-3vglA:
14.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2R5Q_B_1UNB900_2
(PROTEASE)		 3vgl GLUCOKINASE
(Streptomyces
griseus) 		5 / 11 GLY A  50
ALA A  51
ILE A  14
VAL A  60
ILE A   5
 None
 0.89A 2r5qB-3vglA:
undetectable		 2r5qB-3vglA:
14.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Z54_A_AB1A200_2
(HIV-1 PROTEASE)		 3vgl GLUCOKINASE
(Streptomyces
griseus) 		5 / 12 GLY A  50
ALA A  51
ILE A  14
VAL A  60
ILE A   5
 None
 0.86A 2z54B-3vglA:
undetectable		 2z54B-3vglA:
17.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AXZ_A_ADNA401_1
(TRNA
(GUANINE-N(1)-)-METH
YLTRANSFERASE)		 3vgl GLUCOKINASE
(Streptomyces
griseus) 		5 / 12 LEU A 297
GLY A 259
ILE A  25
LEU A 303
GLY A 302
 None
 1.02A 3axzA-3vglA:
undetectable		 3axzA-3vglA:
23.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DTU_B_CUB1022_0
(CYTOCHROME C OXIDASE
SUBUNIT 2)		 3vgl GLUCOKINASE
(Streptomyces
griseus) 		3 / 3 CYH A 169
CYH A 174
HIS A 157
 ZN  A 322 (-2.2A)
ZN  A 322 (-2.2A)
ZN  A 322 ( 3.2A)
 0.69A 3dtuB-3vglA:
undetectable		 3dtuB-3vglA:
23.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DTU_D_CUD3_0
(CYTOCHROME C OXIDASE
SUBUNIT 2)		 3vgl GLUCOKINASE
(Streptomyces
griseus) 		3 / 3 CYH A 169
CYH A 174
HIS A 157
 ZN  A 322 (-2.2A)
ZN  A 322 (-2.2A)
ZN  A 322 ( 3.2A)
 0.66A 3dtuD-3vglA:
undetectable		 3dtuD-3vglA:
23.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EKY_A_DR7A100_1
(PROTEASE)		 3vgl GLUCOKINASE
(Streptomyces
griseus) 		5 / 10 GLY A  50
ALA A  51
ILE A  14
VAL A  60
ILE A   5
 None
 0.82A 3ekyA-3vglA:
undetectable		 3ekyA-3vglA:
17.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EL4_A_ROCA100_2
(PROTEASE)		 3vgl GLUCOKINASE
(Streptomyces
griseus) 		5 / 9 ASP A 105
ALA A 106
ILE A 128
GLY A 259
THR A 132
 BGC  A 324 (-3.0A)
BGC  A 324 ( 3.9A)
None
None
ANP  A 325 (-3.6A)
 1.20A 3el4B-3vglA:
undetectable		 3el4B-3vglA:
17.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ELW_A_SAMA4633_0
(METHYLTRANSFERASE)		 3vgl GLUCOKINASE
(Streptomyces
griseus) 		5 / 12 GLY A 260
GLY A 112
GLY A 302
GLY A 299
LEU A 309
 ANP  A 325 ( 4.1A)
None
None
None
None
 0.88A 3elwA-3vglA:
undetectable		 3elwA-3vglA:
24.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GCZ_A_SAMA4633_0
(POLYPROTEIN)		 3vgl GLUCOKINASE
(Streptomyces
griseus) 		5 / 12 GLY A 260
GLY A 112
GLY A 302
GLY A 299
LEU A 309
 ANP  A 325 ( 4.1A)
None
None
None
None
 0.86A 3gczA-3vglA:
undetectable		 3gczA-3vglA:
21.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KU1_A_SAMA226_0
(SAM-DEPENDENT
METHYLTRANSFERASE)		 3vgl GLUCOKINASE
(Streptomyces
griseus) 		5 / 12 LEU A  88
GLY A  10
GLY A 131
ALA A  64
GLY A  63
 None
ANP  A 325 (-3.4A)
ANP  A 325 (-3.0A)
None
None
 0.90A 3ku1A-3vglA:
undetectable		 3ku1A-3vglA:
22.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KU1_C_SAMC226_0
(SAM-DEPENDENT
METHYLTRANSFERASE)		 3vgl GLUCOKINASE
(Streptomyces
griseus) 		5 / 12 LEU A  88
GLY A  10
GLY A 131
ALA A  64
GLY A  63
 None
ANP  A 325 (-3.4A)
ANP  A 325 (-3.0A)
None
None
 0.89A 3ku1C-3vglA:
undetectable		 3ku1C-3vglA:
22.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KU1_G_SAMG226_0
(SAM-DEPENDENT
METHYLTRANSFERASE)		 3vgl GLUCOKINASE
(Streptomyces
griseus) 		5 / 12 LEU A  88
GLY A  10
GLY A 133
ALA A  64
GLY A  63
 None
ANP  A 325 (-3.4A)
BGC  A 324 ( 3.9A)
None
None
 1.17A 3ku1G-3vglA:
undetectable		 3ku1G-3vglA:
22.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QXY_A_SAMA6734_0
(N-LYSINE
METHYLTRANSFERASE
SETD6)		 3vgl GLUCOKINASE
(Streptomyces
griseus) 		5 / 12 ALA A 152
GLY A 147
ALA A 110
LEU A 250
PHE A 155
 None
 1.18A 3qxyA-3vglA:
undetectable		 3qxyA-3vglA:
22.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RC0_A_SAMA484_0
(N-LYSINE
METHYLTRANSFERASE
SETD6)		 3vgl GLUCOKINASE
(Streptomyces
griseus) 		5 / 11 ALA A 152
GLY A 147
ALA A 110
LEU A 250
PHE A 155
 None
 1.18A 3rc0A-3vglA:
undetectable		 3rc0A-3vglA:
22.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RC0_B_SAMB480_0
(N-LYSINE
METHYLTRANSFERASE
SETD6)		 3vgl GLUCOKINASE
(Streptomyces
griseus) 		5 / 12 ALA A 152
GLY A 147
ALA A 110
LEU A 250
PHE A 155
 None
 1.17A 3rc0B-3vglA:
undetectable		 3rc0B-3vglA:
22.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UT5_D_LOCD502_1
(TUBULIN BETA CHAIN)		 3vgl GLUCOKINASE
(Streptomyces
griseus) 		5 / 12 LYS A  89
LEU A  88
ALA A  64
ALA A 306
ILE A   9
 None
 1.20A 3ut5D-3vglA:
undetectable		 3ut5D-3vglA:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4B17_A_SAMA1358_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE M)		 3vgl GLUCOKINASE
(Streptomyces
griseus) 		5 / 12 SER A 263
GLY A 302
GLY A 299
GLY A 298
ASP A   8
 None
None
None
None
ANP  A 325 ( 4.5A)
 1.00A 4b17A-3vglA:
undetectable		 4b17A-3vglA:
22.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DQF_B_017B101_2
(ASPARTYL PROTEASE)		 3vgl GLUCOKINASE
(Streptomyces
griseus) 		5 / 10 GLY A  50
ALA A  51
ILE A  14
VAL A  60
ILE A   5
 None
 0.88A 4dqfB-3vglA:
undetectable		 4dqfB-3vglA:
17.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FGL_C_CLQC303_0
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 3vgl GLUCOKINASE
(Streptomyces
griseus) 		4 / 5 GLY A 135
GLY A 136
ASN A 107
GLU A 176
 BGC  A 324 (-3.5A)
NA  A 323 (-4.1A)
NA  A 323 (-3.2A)
BGC  A 324 (-2.8A)
 1.23A 4fglC-3vglA:
undetectable		 4fglC-3vglA:
18.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KIC_A_SAMA401_0
(METHYLTRANSFERASE
MPPJ)		 3vgl GLUCOKINASE
(Streptomyces
griseus) 		5 / 12 GLY A  61
GLY A  63
ILE A   5
ALA A  16
ALA A  59
 None
 1.22A 4kicA-3vglA:
undetectable		 4kicA-3vglA:
24.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M93_B_ACTB303_0
(S25-26 FAB (IGG1K)
HEAVY CHAIN
S25-26 FAB (IGG1K)
LIGHT CHAIN)		 3vgl GLUCOKINASE
(Streptomyces
griseus) 		4 / 5 GLY A 305
ALA A 301
PHE A 116
GLU A 113
 None
 1.04A 4m93B-3vglA:
undetectable
4m93C-3vglA:
undetectable		 4m93B-3vglA:
19.50
4m93C-3vglA:
18.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NJU_C_TPVC500_2
(PROTEASE)		 3vgl GLUCOKINASE
(Streptomyces
griseus) 		5 / 10 ALA A  47
VAL A  31
PRO A  34
THR A  33
ILE A  14
 None
 1.09A 4njuD-3vglA:
undetectable		 4njuD-3vglA:
15.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVP_H_BO2H301_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-3)		 3vgl GLUCOKINASE
(Streptomyces
griseus) 		5 / 12 GLN A 120
CYH A 127
ALA A 108
GLY A 305
ALA A 301
 None
 1.06A 4qvpH-3vglA:
undetectable
4qvpI-3vglA:
undetectable		 4qvpH-3vglA:
24.15
4qvpI-3vglA:
20.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVP_V_BO2V301_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-3)		 3vgl GLUCOKINASE
(Streptomyces
griseus) 		5 / 12 GLN A 120
CYH A 127
ALA A 108
GLY A 305
ALA A 301
 None
 1.07A 4qvpV-3vglA:
undetectable
4qvpW-3vglA:
undetectable		 4qvpV-3vglA:
24.15
4qvpW-3vglA:
20.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVV_H_BO2H301_1
(PROTEASOME SUBUNIT
BETA TYPE-2)		 3vgl GLUCOKINASE
(Streptomyces
griseus) 		5 / 11 GLN A 120
CYH A 127
ALA A 108
GLY A 305
ALA A 301
 None
 1.11A 4qvvH-3vglA:
undetectable		 4qvvH-3vglA:
24.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVV_V_BO2V301_1
(PROTEASOME SUBUNIT
BETA TYPE-2)		 3vgl GLUCOKINASE
(Streptomyces
griseus) 		5 / 11 GLN A 120
CYH A 127
ALA A 108
GLY A 305
ALA A 301
 None
 1.10A 4qvvV-3vglA:
undetectable		 4qvvV-3vglA:
24.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RTM_A_SAMA301_0
(DNA ADENINE
METHYLASE)		 3vgl GLUCOKINASE
(Streptomyces
griseus) 		5 / 12 GLY A 260
GLY A 259
GLY A 302
ALA A 301
ILE A   9
 ANP  A 325 ( 4.1A)
None
None
None
None
 0.95A 4rtmA-3vglA:
undetectable		 4rtmA-3vglA:
20.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RTM_A_SAMA301_0
(DNA ADENINE
METHYLASE)		 3vgl GLUCOKINASE
(Streptomyces
griseus) 		5 / 12 GLY A 260
GLY A 259
GLY A 302
ALA A 301
ILE A  14
 ANP  A 325 ( 4.1A)
None
None
None
None
 0.99A 4rtmA-3vglA:
undetectable		 4rtmA-3vglA:
20.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5C0O_F_SAMF301_0
(TRNA
(ADENINE(58)-N(1))-M
ETHYLTRANSFERASE
TRMI)		 3vgl GLUCOKINASE
(Streptomyces
griseus) 		5 / 12 GLY A 260
GLY A 131
GLY A 133
LEU A 134
ALA A 294
 ANP  A 325 ( 4.1A)
ANP  A 325 (-3.0A)
BGC  A 324 ( 3.9A)
None
None
 0.97A 5c0oF-3vglA:
undetectable		 5c0oF-3vglA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DQY_A_BEZA401_0
(THIOREDOXIN)		 3vgl GLUCOKINASE
(Streptomyces
griseus) 		4 / 8 ILE A 139
VAL A 125
GLN A 120
GLU A 113
 None
 1.08A 5dqyA-3vglA:
undetectable		 5dqyA-3vglA:
16.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGI_A_ZITA402_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E)		 3vgl GLUCOKINASE
(Streptomyces
griseus) 		5 / 12 ILE A  44
VAL A 102
VAL A  75
GLY A 135
THR A 129
 None
None
None
BGC  A 324 (-3.5A)
None
 1.22A 5igiA-3vglA:
undetectable		 5igiA-3vglA:
24.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L5F_H_BO2H301_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-3)		 3vgl GLUCOKINASE
(Streptomyces
griseus) 		5 / 12 GLN A 120
CYH A 127
ALA A 108
GLY A 305
ALA A 301
 None
 1.10A 5l5fH-3vglA:
undetectable
5l5fI-3vglA:
undetectable		 5l5fH-3vglA:
24.15
5l5fI-3vglA:
20.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L5F_V_BO2V301_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-3)		 3vgl GLUCOKINASE
(Streptomyces
griseus) 		5 / 12 GLN A 120
CYH A 127
ALA A 108
GLY A 305
ALA A 301
 None
 1.10A 5l5fV-3vglA:
undetectable
5l5fW-3vglA:
undetectable		 5l5fV-3vglA:
24.15
5l5fW-3vglA:
20.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L5Z_H_BO2H301_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-3)		 3vgl GLUCOKINASE
(Streptomyces
griseus) 		5 / 12 GLN A 120
CYH A 127
ALA A 108
GLY A 305
ALA A 301
 None
 1.09A 5l5zH-3vglA:
undetectable
5l5zI-3vglA:
undetectable		 5l5zH-3vglA:
24.15
5l5zI-3vglA:
20.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L5Z_V_BO2V301_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-3)		 3vgl GLUCOKINASE
(Streptomyces
griseus) 		5 / 12 GLN A 120
CYH A 127
ALA A 108
GLY A 305
ALA A 301
 None
 1.09A 5l5zV-3vglA:
undetectable
5l5zW-3vglA:
undetectable		 5l5zV-3vglA:
24.15
5l5zW-3vglA:
20.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L66_H_BO2H301_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-3)		 3vgl GLUCOKINASE
(Streptomyces
griseus) 		5 / 12 GLN A 120
CYH A 127
ALA A 108
GLY A 305
ALA A 301
 None
 1.10A 5l66H-3vglA:
undetectable
5l66I-3vglA:
undetectable		 5l66H-3vglA:
24.15
5l66I-3vglA:
20.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L66_V_BO2V301_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-3)		 3vgl GLUCOKINASE
(Streptomyces
griseus) 		5 / 12 GLN A 120
CYH A 127
ALA A 108
GLY A 305
ALA A 301
 None
 1.10A 5l66V-3vglA:
undetectable
5l66W-3vglA:
undetectable		 5l66V-3vglA:
24.15
5l66W-3vglA:
20.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZW4_A_SAMA302_0
(PUTATIVE
O-METHYLTRANSFERASE
YRRM)		 3vgl GLUCOKINASE
(Streptomyces
griseus) 		5 / 12 ALA A 200
ASN A 198
ALA A 188
ALA A 221
ALA A 222
 None
 0.97A 5zw4A-3vglA:
undetectable		 5zw4A-3vglA:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZW4_A_SAMA302_0
(PUTATIVE
O-METHYLTRANSFERASE
YRRM)		 3vgl GLUCOKINASE
(Streptomyces
griseus) 		6 / 12 ILE A  62
GLY A 302
ALA A 306
ALA A 295
ALA A 109
ALA A 110
 None
 1.48A 5zw4A-3vglA:
undetectable		 5zw4A-3vglA:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DIL_B_TPVB201_1
(HIV-1 PROTEASE)		 3vgl GLUCOKINASE
(Streptomyces
griseus) 		5 / 12 GLY A  50
ALA A  51
ILE A  14
VAL A  60
ILE A   5
 None
 0.87A 6dilB-3vglA:
undetectable		 6dilB-3vglA:
13.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNG_B_QPSB601_2
(-)		 3vgl GLUCOKINASE
(Streptomyces
griseus) 		5 / 12 GLY A 112
GLY A 133
ASN A 107
PRO A  79
GLU A 176
 None
BGC  A 324 ( 3.9A)
NA  A 323 (-3.2A)
BGC  A 324 (-3.9A)
BGC  A 324 (-2.8A)
 1.08A 6gngB-3vglA:
undetectable		 6gngB-3vglA:
20.36