SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3vgo'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ERR_B_RALB600_1
(ESTROGEN RECEPTOR)		 3vgo E3 UBIQUITIN-PROTEIN
LIGASE CBL-B
(Homo
sapiens) 		5 / 12 ALA A 121
LEU A 143
LEU A  78
LEU A  67
LEU A  65
 None
 1.08A 1errB-3vgoA:
undetectable		 1errB-3vgoA:
18.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ERR_B_RALB600_1
(ESTROGEN RECEPTOR)		 3vgo E3 UBIQUITIN-PROTEIN
LIGASE CBL-B
(Homo
sapiens) 		5 / 12 ALA A 121
LEU A 146
LEU A  78
LEU A  67
LEU A  65
 None
 0.86A 1errB-3vgoA:
undetectable		 1errB-3vgoA:
18.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BDM_A_TMIA502_1
(CYTOCHROME P450 2B4)		 3vgo E3 UBIQUITIN-PROTEIN
LIGASE CBL-B
(Homo
sapiens) 		5 / 12 LEU A  78
LEU A 143
THR A 144
LEU A 146
PHE A 150
 None
 0.89A 2bdmA-3vgoA:
undetectable		 2bdmA-3vgoA:
23.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RLC_A_CHDA332_0
(CHOLOYLGLYCINE
HYDROLASE)		 3vgo E3 UBIQUITIN-PROTEIN
LIGASE CBL-B
(Homo
sapiens) 		5 / 12 ILE A 235
PHE A 231
ALA A 155
ILE A 109
THR A 223
 None
 1.15A 2rlcA-3vgoA:
undetectable		 2rlcA-3vgoA:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VLN_A_ACTA908_0
(GLUTATHIONE
S-TRANSFERASE
OMEGA-1)		 3vgo E3 UBIQUITIN-PROTEIN
LIGASE CBL-B
(Homo
sapiens) 		4 / 4 MET A  53
SER A 118
LEU A  78
VAL A  56
 None
 1.49A 3vlnA-3vgoA:
2.0		 3vlnA-3vgoA:
18.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5U4S_A_BEZA301_0
(PUTATIVE SHORT CHAIN
DEHYDROGENASE)		 3vgo E3 UBIQUITIN-PROTEIN
LIGASE CBL-B
(Homo
sapiens) 		4 / 7 SER A 151
ILE A  77
LEU A 292
PRO A  71
 None
 0.96A 5u4sA-3vgoA:
undetectable		 5u4sA-3vgoA:
18.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FGD_A_D8ZA831_0
(GEPHYRIN)		 3vgo E3 UBIQUITIN-PROTEIN
LIGASE CBL-B
(Homo
sapiens) 		5 / 11 MET A  53
ILE A 122
LEU A 114
ILE A 149
MET A 153
 None
 1.49A 6fgdA-3vgoA:
undetectable		 6fgdA-3vgoA:
9.64