SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3vgp'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KQE_A_DVAA6_0
(MINI-GRAMICIDIN A)		 3vgp TRANSMEMBRANE
OLIGOSACCHARYL
TRANSFERASE,
PUTATIVE
(Archaeoglobus
fulgidus) 		3 / 3 ALA A 479
VAL A 475
TRP A 471
 None
 0.82A 1kqeA-3vgpA:
undetectable
1kqeE-3vgpA:
undetectable		 1kqeA-3vgpA:
6.19
1kqeE-3vgpA:
6.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KQE_B_DVAB6_0
(MINI-GRAMICIDIN A)		 3vgp TRANSMEMBRANE
OLIGOSACCHARYL
TRANSFERASE,
PUTATIVE
(Archaeoglobus
fulgidus) 		3 / 3 ALA A 479
VAL A 475
TRP A 471
 None
 0.81A 1kqeB-3vgpA:
undetectable
1kqeD-3vgpA:
undetectable		 1kqeB-3vgpA:
6.19
1kqeD-3vgpA:
6.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KQE_D_DVAD6_0
(MINI-GRAMICIDIN A)		 3vgp TRANSMEMBRANE
OLIGOSACCHARYL
TRANSFERASE,
PUTATIVE
(Archaeoglobus
fulgidus) 		3 / 3 TRP A 471
ALA A 479
VAL A 475
 None
 0.80A 1kqeB-3vgpA:
undetectable
1kqeD-3vgpA:
undetectable		 1kqeB-3vgpA:
6.19
1kqeD-3vgpA:
6.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KQE_E_DVAE6_0
(MINI-GRAMICIDIN A)		 3vgp TRANSMEMBRANE
OLIGOSACCHARYL
TRANSFERASE,
PUTATIVE
(Archaeoglobus
fulgidus) 		3 / 3 TRP A 471
ALA A 479
VAL A 475
 None
 0.81A 1kqeA-3vgpA:
undetectable
1kqeE-3vgpA:
undetectable		 1kqeA-3vgpA:
6.19
1kqeE-3vgpA:
6.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G1U_B_ADNB438_2
(ADENOSYLHOMOCYSTEINA
SE)		 3vgp TRANSMEMBRANE
OLIGOSACCHARYL
TRANSFERASE,
PUTATIVE
(Archaeoglobus
fulgidus) 		3 / 3 THR A 432
GLU A 521
HIS A 564
 None
 0.53A 3g1uB-3vgpA:
undetectable		 3g1uB-3vgpA:
17.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ME6_B_CGEB501_1
(CYTOCHROME P450 2B4)		 3vgp TRANSMEMBRANE
OLIGOSACCHARYL
TRANSFERASE,
PUTATIVE
(Archaeoglobus
fulgidus) 		4 / 8 PHE A 532
ALA A 493
THR A 497
VAL A 543
 None
 0.89A 3me6B-3vgpA:
undetectable		 3me6B-3vgpA:
16.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TBG_A_RTZA2_1
(CYTOCHROME P450 2D6)		 3vgp TRANSMEMBRANE
OLIGOSACCHARYL
TRANSFERASE,
PUTATIVE
(Archaeoglobus
fulgidus) 		5 / 11 THR A 518
LEU A 576
VAL A 577
PHE A 496
PHE A 495
 None
 1.42A 3tbgA-3vgpA:
undetectable		 3tbgA-3vgpA:
14.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TBG_C_RTZC2_1
(CYTOCHROME P450 2D6)		 3vgp TRANSMEMBRANE
OLIGOSACCHARYL
TRANSFERASE,
PUTATIVE
(Archaeoglobus
fulgidus) 		5 / 10 THR A 518
LEU A 576
VAL A 577
VAL A 513
PHE A 495
 None
 1.49A 3tbgC-3vgpA:
undetectable		 3tbgC-3vgpA:
14.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BTF_G_GFNG101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
TTACGTGCATAGTCATTCAT
GACC)		 3vgp TRANSMEMBRANE
OLIGOSACCHARYL
TRANSFERASE,
PUTATIVE
(Archaeoglobus
fulgidus) 		4 / 7 ASP A 491
ARG A 511
GLY A 512
GLU A 459
 None
 1.03A 5btfA-3vgpA:
undetectable
5btfC-3vgpA:
undetectable
5btfD-3vgpA:
undetectable		 5btfA-3vgpA:
14.74
5btfC-3vgpA:
14.74
5btfD-3vgpA:
18.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TRQ_B_ACTB306_0
(WELO5)		 3vgp TRANSMEMBRANE
OLIGOSACCHARYL
TRANSFERASE,
PUTATIVE
(Archaeoglobus
fulgidus) 		3 / 3 GLU A 587
ARG A 514
TYR A 515
 None
 0.50A 5trqB-3vgpA:
undetectable		 5trqB-3vgpA:
17.91