SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3vh1'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ERE_A_ESTA600_1
(ESTROGEN RECEPTOR)		 3vh1 UBIQUITIN-LIKE
MODIFIER-ACTIVATING
ENZYME ATG7
(Saccharomyces
cerevisiae) 		5 / 9 ALA A 252
LEU A 238
LEU A 239
ILE A 182
LEU A 233
 None
 1.40A 1ereA-3vh1A:
undetectable		 1ereA-3vh1A:
18.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ERE_C_ESTC600_1
(ESTROGEN RECEPTOR)		 3vh1 UBIQUITIN-LIKE
MODIFIER-ACTIVATING
ENZYME ATG7
(Saccharomyces
cerevisiae) 		5 / 9 ALA A 252
LEU A 238
LEU A 239
ILE A 182
LEU A 233
 None
 1.39A 1ereC-3vh1A:
undetectable		 1ereC-3vh1A:
18.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ERE_D_ESTD600_1
(ESTROGEN RECEPTOR)		 3vh1 UBIQUITIN-LIKE
MODIFIER-ACTIVATING
ENZYME ATG7
(Saccharomyces
cerevisiae) 		5 / 9 ALA A 252
LEU A 238
LEU A 239
ILE A 182
LEU A 233
 None
 1.37A 1ereD-3vh1A:
undetectable		 1ereD-3vh1A:
18.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QKU_A_ESTA600_1
(ESTRADIOL RECEPTOR)		 3vh1 UBIQUITIN-LIKE
MODIFIER-ACTIVATING
ENZYME ATG7
(Saccharomyces
cerevisiae) 		5 / 10 ALA A 252
LEU A 238
LEU A 239
ILE A 182
LEU A 233
 None
 1.39A 1qkuA-3vh1A:
undetectable		 1qkuA-3vh1A:
18.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QKU_B_ESTB600_1
(ESTRADIOL RECEPTOR)		 3vh1 UBIQUITIN-LIKE
MODIFIER-ACTIVATING
ENZYME ATG7
(Saccharomyces
cerevisiae) 		5 / 10 ALA A 252
LEU A 238
LEU A 239
ILE A 182
LEU A 233
 None
 1.40A 1qkuB-3vh1A:
undetectable		 1qkuB-3vh1A:
18.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QKU_C_ESTC600_1
(ESTRADIOL RECEPTOR)		 3vh1 UBIQUITIN-LIKE
MODIFIER-ACTIVATING
ENZYME ATG7
(Saccharomyces
cerevisiae) 		5 / 10 ALA A 252
LEU A 238
LEU A 239
ILE A 182
LEU A 233
 None
 1.40A 1qkuC-3vh1A:
undetectable		 1qkuC-3vh1A:
18.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1U1J_A_C2FA773_0
(5-METHYLTETRAHYDROPT
EROYLTRIGLUTAMATE--H
OMOCYSTEINE
METHYLTRANSFERASE)		 3vh1 UBIQUITIN-LIKE
MODIFIER-ACTIVATING
ENZYME ATG7
(Saccharomyces
cerevisiae) 		4 / 8 ASN A 451
SER A 447
ARG A 443
VAL A 457
 None
 0.97A 1u1jA-3vh1A:
2.2		 1u1jA-3vh1A:
22.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1X70_A_715A801_2
(DIPEPTIDYL PEPTIDASE
IV)		 3vh1 UBIQUITIN-LIKE
MODIFIER-ACTIVATING
ENZYME ATG7
(Saccharomyces
cerevisiae) 		3 / 3 ARG A  65
SER A 127
TYR A 138
 None
 0.65A 1x70A-3vh1A:
undetectable		 1x70A-3vh1A:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YVM_A_TMGA501_1
(METHIONINE
AMINOPEPTIDASE)		 3vh1 UBIQUITIN-LIKE
MODIFIER-ACTIVATING
ENZYME ATG7
(Saccharomyces
cerevisiae) 		4 / 7 CYH A 488
CYH A 572
HIS A 472
HIS A 547
 ZN  A 701 (-2.1A)
ZN  A 701 (-2.1A)
None
None
 1.43A 1yvmA-3vh1A:
undetectable		 1yvmA-3vh1A:
19.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXG_B_IBPB2002_1
(SERUM ALBUMIN)		 3vh1 UBIQUITIN-LIKE
MODIFIER-ACTIVATING
ENZYME ATG7
(Saccharomyces
cerevisiae) 		6 / 10 ALA A 460
LEU A 462
LEU A 335
ALA A 515
SER A 340
LEU A 329
 None
 1.45A 2bxgB-3vh1A:
undetectable		 2bxgB-3vh1A:
22.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HMY_B_SAMB328_0
(PROTEIN
(CYTOSINE-SPECIFIC
METHYLTRANSFERASE
HHAI))		 3vh1 UBIQUITIN-LIKE
MODIFIER-ACTIVATING
ENZYME ATG7
(Saccharomyces
cerevisiae) 		5 / 12 GLY A 473
GLY A 484
ASP A 431
ILE A 432
LEU A 530
 None
 1.04A 2hmyB-3vh1A:
6.4		 2hmyB-3vh1A:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DQT_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 3vh1 UBIQUITIN-LIKE
MODIFIER-ACTIVATING
ENZYME ATG7
(Saccharomyces
cerevisiae) 		4 / 7 PHE A 172
SER A 177
VAL A  78
TRP A 179
 None
 1.23A 3dqtA-3vh1A:
undetectable
3dqtB-3vh1A:
undetectable		 3dqtA-3vh1A:
22.72
3dqtB-3vh1A:
22.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3H5G_C_LEIC16_0
(COIL SER L16D-PEN)		 3vh1 UBIQUITIN-LIKE
MODIFIER-ACTIVATING
ENZYME ATG7
(Saccharomyces
cerevisiae) 		4 / 6 LEU A  28
GLN A  23
LEU A  25
GLU A  24
 None
 0.95A 3h5gB-3vh1A:
undetectable
3h5gC-3vh1A:
undetectable		 3h5gB-3vh1A:
4.18
3h5gC-3vh1A:
4.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N5T_A_H4BA600_1
(NITRIC OXIDE
SYNTHASE)		 3vh1 UBIQUITIN-LIKE
MODIFIER-ACTIVATING
ENZYME ATG7
(Saccharomyces
cerevisiae) 		4 / 7 SER A 177
VAL A  78
TRP A 179
PHE A 172
 None
 1.24A 3n5tA-3vh1A:
undetectable
3n5tB-3vh1A:
undetectable		 3n5tA-3vh1A:
22.24
3n5tB-3vh1A:
22.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N61_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE)		 3vh1 UBIQUITIN-LIKE
MODIFIER-ACTIVATING
ENZYME ATG7
(Saccharomyces
cerevisiae) 		4 / 7 PHE A 172
SER A 177
VAL A  78
TRP A 179
 None
 1.28A 3n61A-3vh1A:
undetectable
3n61B-3vh1A:
undetectable		 3n61A-3vh1A:
22.09
3n61B-3vh1A:
22.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TYE_B_YTZB902_1
(DIHYDROPTEROATE
SYNTHASE)		 3vh1 UBIQUITIN-LIKE
MODIFIER-ACTIVATING
ENZYME ATG7
(Saccharomyces
cerevisiae) 		3 / 3 PHE A 128
LYS A  29
SER A  26
 None
 1.12A 3tyeB-3vh1A:
undetectable		 3tyeB-3vh1A:
19.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K5J_B_H4BB502_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 3vh1 UBIQUITIN-LIKE
MODIFIER-ACTIVATING
ENZYME ATG7
(Saccharomyces
cerevisiae) 		4 / 7 PHE A 172
SER A 177
VAL A  78
TRP A 179
 None
 1.28A 4k5jA-3vh1A:
undetectable
4k5jB-3vh1A:
undetectable		 4k5jA-3vh1A:
22.18
4k5jB-3vh1A:
22.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M6T_A_SAMA201_0
(RNA POLYMERASE
II-ASSOCIATED FACTOR
1 HOMOLOG, LINKER,
RNA
POLYMERASE-ASSOCIATE
D PROTEIN LEO1)		 3vh1 UBIQUITIN-LIKE
MODIFIER-ACTIVATING
ENZYME ATG7
(Saccharomyces
cerevisiae) 		4 / 4 ILE A 197
VAL A 225
VAL A 230
ARG A 198
 None
 1.30A 4m6tA-3vh1A:
undetectable		 4m6tA-3vh1A:
16.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ADL_B_H4BB600_1
(ENDOTHELIAL NITRIC
OXIDE SYNTHASE)		 3vh1 UBIQUITIN-LIKE
MODIFIER-ACTIVATING
ENZYME ATG7
(Saccharomyces
cerevisiae) 		4 / 7 PHE A 172
SER A 177
VAL A  78
TRP A 179
 None
 1.28A 5adlA-3vh1A:
undetectable
5adlB-3vh1A:
undetectable		 5adlA-3vh1A:
22.18
5adlB-3vh1A:
22.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DQF_A_LCRA612_1
(SERUM ALBUMIN)		 3vh1 UBIQUITIN-LIKE
MODIFIER-ACTIVATING
ENZYME ATG7
(Saccharomyces
cerevisiae) 		5 / 9 LEU A 462
GLY A 463
LEU A 503
LEU A 468
ALA A 461
 None
 1.13A 5dqfA-3vh1A:
undetectable		 5dqfA-3vh1A:
23.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FJ3_B_H4BB600_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 3vh1 UBIQUITIN-LIKE
MODIFIER-ACTIVATING
ENZYME ATG7
(Saccharomyces
cerevisiae) 		4 / 7 PHE A 172
SER A 177
VAL A  78
TRP A 179
 None
 1.31A 5fj3A-3vh1A:
undetectable
5fj3B-3vh1A:
undetectable		 5fj3A-3vh1A:
22.18
5fj3B-3vh1A:
22.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JW1_A_CELA602_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		 3vh1 UBIQUITIN-LIKE
MODIFIER-ACTIVATING
ENZYME ATG7
(Saccharomyces
cerevisiae) 		4 / 6 VAL A 437
LEU A 448
SER A 447
ILE A 452
 None
 0.82A 5jw1A-3vh1A:
undetectable		 5jw1A-3vh1A:
22.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UXD_B_ZITB501_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E MPHH)		 3vh1 UBIQUITIN-LIKE
MODIFIER-ACTIVATING
ENZYME ATG7
(Saccharomyces
cerevisiae) 		5 / 12 ILE A 427
ASP A 421
LEU A 435
VAL A 457
ALA A 591
 None
 1.11A 5uxdB-3vh1A:
undetectable		 5uxdB-3vh1A:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VV7_B_H4BB502_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 3vh1 UBIQUITIN-LIKE
MODIFIER-ACTIVATING
ENZYME ATG7
(Saccharomyces
cerevisiae) 		4 / 7 PHE A 172
SER A 177
VAL A  78
TRP A 179
 None
 1.29A 5vv7A-3vh1A:
undetectable
5vv7B-3vh1A:
undetectable		 5vv7A-3vh1A:
22.18
5vv7B-3vh1A:
22.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VVN_B_H4BB502_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 3vh1 UBIQUITIN-LIKE
MODIFIER-ACTIVATING
ENZYME ATG7
(Saccharomyces
cerevisiae) 		4 / 7 PHE A 172
SER A 177
VAL A  78
TRP A 179
 None
 1.23A 5vvnA-3vh1A:
undetectable
5vvnB-3vh1A:
undetectable		 5vvnA-3vh1A:
22.18
5vvnB-3vh1A:
22.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X6Y_A_SAMA902_1
(MRNA CAPPING ENZYME
P5)		 3vh1 UBIQUITIN-LIKE
MODIFIER-ACTIVATING
ENZYME ATG7
(Saccharomyces
cerevisiae) 		3 / 3 TYR A 137
ASP A 287
ASP A 130
 None
 0.77A 5x6yA-3vh1A:
2.8		 5x6yA-3vh1A:
22.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y2T_A_8LXA501_0
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 3vh1 UBIQUITIN-LIKE
MODIFIER-ACTIVATING
ENZYME ATG7
(Saccharomyces
cerevisiae) 		5 / 12 LEU A 281
PHE A  13
GLY A 141
LEU A  17
LEU A  46
 None
 1.23A 5y2tA-3vh1A:
undetectable		 5y2tA-3vh1A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AV6_B_H4BB501_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 3vh1 UBIQUITIN-LIKE
MODIFIER-ACTIVATING
ENZYME ATG7
(Saccharomyces
cerevisiae) 		4 / 7 SER A 177
VAL A  78
TRP A 179
PHE A 172
 None
 1.31A 6av6A-3vh1A:
undetectable
6av6B-3vh1A:
undetectable		 6av6A-3vh1A:
9.04
6av6B-3vh1A:
9.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AV6_D_H4BD502_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 3vh1 UBIQUITIN-LIKE
MODIFIER-ACTIVATING
ENZYME ATG7
(Saccharomyces
cerevisiae) 		4 / 7 PHE A 172
SER A 177
VAL A  78
TRP A 179
 None
 1.30A 6av6C-3vh1A:
undetectable
6av6D-3vh1A:
undetectable		 6av6C-3vh1A:
9.04
6av6D-3vh1A:
9.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AV7_A_H4BA502_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 3vh1 UBIQUITIN-LIKE
MODIFIER-ACTIVATING
ENZYME ATG7
(Saccharomyces
cerevisiae) 		4 / 7 SER A 177
VAL A  78
TRP A 179
PHE A 172
 None
 1.30A 6av7A-3vh1A:
undetectable
6av7B-3vh1A:
undetectable		 6av7A-3vh1A:
9.04
6av7B-3vh1A:
9.04