SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3vi3'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1BZF_A_TMQA170_1
(DIHYDROFOLATE
REDUCTASE)		 3vi3 INTEGRIN ALPHA-5
(Homo
sapiens) 		5 / 12 LEU A 361
ALA A 370
LEU A 419
PHE A  25
LEU A 425
 None
 1.05A 1bzfA-3vi3A:
undetectable		 1bzfA-3vi3A:
13.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ESW_A_ACRA652_1
(AMYLOMALTASE)		 3vi3 INTEGRIN ALPHA-5
(Homo
sapiens) 		4 / 6 GLY A 166
GLY A 190
TYR A 186
SER A 169
 None
 0.95A 1eswA-3vi3A:
undetectable		 1eswA-3vi3A:
22.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JB0_B_PQNB2002_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A2)		 3vi3 INTEGRIN ALPHA-5
(Homo
sapiens) 		5 / 11 SER A 590
ILE A 499
ALA A 490
LEU A 488
ALA A 456
 None
 1.44A 1jb0B-3vi3A:
undetectable		 1jb0B-3vi3A:
23.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JN3_A_JN3A131_2
(FATTY ACID-BINDING
PROTEIN, LIVER)		 3vi3 INTEGRIN ALPHA-5
(Homo
sapiens) 		4 / 6 LEU A 113
ASN A 211
GLN A 218
PHE A 172
 None
 1.24A 2jn3A-3vi3A:
undetectable		 2jn3A-3vi3A:
11.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NMZ_B_ROCB401_2
(PROTEASE)		 3vi3 INTEGRIN ALPHA-5
(Homo
sapiens) 		3 / 3 ARG A 423
VAL A 369
THR A 292
 None
 0.77A 2nmzA-3vi3A:
undetectable		 2nmzA-3vi3A:
11.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NNK_A_ROCA401_2
(PROTEASE)		 3vi3 INTEGRIN ALPHA-5
(Homo
sapiens) 		3 / 3 ARG A 423
VAL A 369
THR A 292
 None
 0.77A 2nnkA-3vi3A:
undetectable		 2nnkA-3vi3A:
10.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BF1_C_PAUC248_0
(TYPE III
PANTOTHENATE KINASE)		 3vi3 INTEGRIN ALPHA-5
(Homo
sapiens) 		5 / 11 VAL A 235
GLY A 181
ILE A 270
LEU A 265
THR A 219
 None
 1.34A 3bf1C-3vi3A:
undetectable
3bf1D-3vi3A:
undetectable		 3bf1C-3vi3A:
17.56
3bf1D-3vi3A:
17.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_C_SVRC507_2
(PHOSPHOLIPASE A2)		 3vi3 INTEGRIN ALPHA-5
(Homo
sapiens) 		4 / 6 VAL A 435
VAL A 444
GLN A  66
PHE A 438
 None
 1.22A 3bjwF-3vi3A:
undetectable		 3bjwF-3vi3A:
11.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_G_SVRG506_2
(PHOSPHOLIPASE A2)		 3vi3 INTEGRIN ALPHA-5
(Homo
sapiens) 		4 / 5 VAL A 435
VAL A 444
GLN A  66
PHE A 438
 None
 1.28A 3bjwB-3vi3A:
undetectable		 3bjwB-3vi3A:
11.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BOG_D_DHID8_0
(6.5 KDA GLYCINE-RICH
ANTIFREEZE PROTEIN)		 3vi3 INTEGRIN ALPHA-5
(Homo
sapiens) 		4 / 4 SER A 437
GLY A 439
GLY A 416
GLY A 382
 None
 0.90A 3bogB-3vi3A:
undetectable
3bogD-3vi3A:
undetectable		 3bogB-3vi3A:
undetectable
3bogD-3vi3A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GYQ_A_SAMA270_0
(RRNA
(ADENOSINE-2'-O-)-ME
THYLTRANSFERASE)		 3vi3 INTEGRIN ALPHA-5
(Homo
sapiens) 		5 / 12 ALA A 370
GLY A 436
ILE A 371
LEU A 355
ARG A 106
 None
 1.35A 3gyqA-3vi3A:
undetectable
3gyqB-3vi3A:
undetectable		 3gyqA-3vi3A:
18.68
3gyqB-3vi3A:
18.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K4V_B_ROCB201_2
(HIV-1 PROTEASE)		 3vi3 INTEGRIN ALPHA-5
(Homo
sapiens) 		3 / 3 ARG A 423
VAL A 369
THR A 292
 None
 0.80A 3k4vA-3vi3A:
undetectable		 3k4vA-3vi3A:
10.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K4V_D_ROCD201_4
(HIV-1 PROTEASE)		 3vi3 INTEGRIN ALPHA-5
(Homo
sapiens) 		3 / 3 ARG A 423
VAL A 369
THR A 292
 None
 0.81A 3k4vD-3vi3A:
undetectable		 3k4vD-3vi3A:
10.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NDU_D_ROCD100_3
(PROTEASE)		 3vi3 INTEGRIN ALPHA-5
(Homo
sapiens) 		3 / 3 ARG A 423
VAL A 369
THR A 292
 None
 0.80A 3nduD-3vi3A:
undetectable		 3nduD-3vi3A:
10.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PCQ_B_PQNB842_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A2)		 3vi3 INTEGRIN ALPHA-5
(Homo
sapiens) 		5 / 11 SER A 590
ILE A 499
ALA A 490
LEU A 488
ALA A 456
 None
 1.43A 3pcqB-3vi3A:
undetectable		 3pcqB-3vi3A:
23.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PWR_A_ROCA401_2
(PROTEASE)		 3vi3 INTEGRIN ALPHA-5
(Homo
sapiens) 		3 / 3 ARG A 423
VAL A 369
THR A 292
 None
 0.78A 3pwrA-3vi3A:
undetectable		 3pwrA-3vi3A:
11.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QT0_A_486A4_2
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 3vi3 INTEGRIN ALPHA-5
(Homo
sapiens) 		4 / 4 LYS A 559
GLN A 599
ILE A 565
LEU A 520
 None
 1.21A 3qt0A-3vi3A:
undetectable		 3qt0A-3vi3A:
18.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T7S_D_SAMD300_0
(PUTATIVE
METHYLTRANSFERASE)		 3vi3 INTEGRIN ALPHA-5
(Homo
sapiens) 		5 / 12 GLY A 376
GLY A 377
GLN A 403
PHE A 348
ALA A 373
 None
 1.23A 3t7sD-3vi3A:
undetectable		 3t7sD-3vi3A:
16.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3THR_C_C2FC1410_0
(GLYCINE
N-METHYLTRANSFERASE)		 3vi3 INTEGRIN ALPHA-5
(Homo
sapiens) 		3 / 3 ARG A 420
PRO A 431
PHE A  25
 None
 0.99A 3thrC-3vi3A:
undetectable		 3thrC-3vi3A:
19.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TL9_A_ROCA401_2
(PROTEASE)		 3vi3 INTEGRIN ALPHA-5
(Homo
sapiens) 		3 / 3 ARG A 423
VAL A 369
THR A 292
 None
 0.80A 3tl9A-3vi3A:
undetectable		 3tl9A-3vi3A:
11.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VQR_B_ACTB1002_0
(PUTATIVE
OXIDOREDUCTASE)		 3vi3 INTEGRIN ALPHA-5
(Homo
sapiens) 		4 / 5 ASP A 413
GLY A 439
VAL A 440
THR A 411
 None
 1.08A 3vqrB-3vi3A:
undetectable		 3vqrB-3vi3A:
21.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DXU_A_ACAA711_1
(LACTOTRANSFERRIN)		 3vi3 INTEGRIN ALPHA-5
(Homo
sapiens) 		4 / 6 GLY A 255
PRO A 253
GLY A 232
TYR A 233
 None
 0.81A 4dxuA-3vi3A:
undetectable		 4dxuA-3vi3A:
19.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E3A_A_ADNA500_2
(SUGAR KINASE PROTEIN)		 3vi3 INTEGRIN ALPHA-5
(Homo
sapiens) 		4 / 4 SER A 229
TYR A 261
GLY A 190
PRO A 183
 None
NAG  A2009 (-4.7A)
None
None
 1.12A 4e3aA-3vi3A:
undetectable		 4e3aA-3vi3A:
19.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E3A_B_ADNB500_1
(SUGAR KINASE PROTEIN)		 3vi3 INTEGRIN ALPHA-5
(Homo
sapiens) 		6 / 12 GLY A 390
GLY A 389
THR A 292
LEU A 303
GLY A 365
ASP A 364
 None
None
None
None
None
CA  A2003 (-2.8A)
 1.43A 4e3aB-3vi3A:
undetectable		 4e3aB-3vi3A:
19.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JKU_B_ADNB500_1
(PROBABLE SUGAR
KINASE PROTEIN)		 3vi3 INTEGRIN ALPHA-5
(Homo
sapiens) 		5 / 12 GLY A 390
GLY A 389
THR A 292
LEU A 303
ASP A 362
 None
None
None
None
CA  A2003 (-3.0A)
 1.09A 4jkuB-3vi3A:
undetectable		 4jkuB-3vi3A:
19.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K8T_A_ADNA401_1
(SUGAR KINASE)		 3vi3 INTEGRIN ALPHA-5
(Homo
sapiens) 		5 / 12 GLY A 390
GLY A 389
THR A 292
LEU A 303
ASP A 362
 None
None
None
None
CA  A2003 (-3.0A)
 1.09A 4k8tA-3vi3A:
undetectable		 4k8tA-3vi3A:
19.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K93_B_ADNB402_1
(SUGAR KINASE)		 3vi3 INTEGRIN ALPHA-5
(Homo
sapiens) 		5 / 12 GLY A 390
GLY A 389
THR A 292
LEU A 303
ASP A 362
 None
None
None
None
CA  A2003 (-3.0A)
 1.09A 4k93B-3vi3A:
undetectable		 4k93B-3vi3A:
19.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KAD_A_ADNA401_1
(PROBABLE SUGAR
KINASE PROTEIN)		 3vi3 INTEGRIN ALPHA-5
(Homo
sapiens) 		5 / 12 GLY A 390
GLY A 389
THR A 292
LEU A 303
ASP A 362
 None
None
None
None
CA  A2003 (-3.0A)
 1.08A 4kadA-3vi3A:
undetectable		 4kadA-3vi3A:
19.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KAD_B_ADNB401_1
(PROBABLE SUGAR
KINASE PROTEIN)		 3vi3 INTEGRIN ALPHA-5
(Homo
sapiens) 		5 / 12 GLY A 390
GLY A 389
THR A 292
LEU A 303
ASP A 362
 None
None
None
None
CA  A2003 (-3.0A)
 1.10A 4kadB-3vi3A:
undetectable		 4kadB-3vi3A:
19.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QTU_B_SAMB301_0
(PUTATIVE
METHYLTRANSFERASE
BUD23)		 3vi3 INTEGRIN ALPHA-5
(Homo
sapiens) 		5 / 12 GLY A  20
GLY A  38
LEU A  36
ILE A 434
ALA A 443
 None
 1.08A 4qtuB-3vi3A:
undetectable		 4qtuB-3vi3A:
16.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XK8_B_PQNB842_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A2)		 3vi3 INTEGRIN ALPHA-5
(Homo
sapiens) 		5 / 10 SER A 590
ILE A 499
ALA A 490
LEU A 488
ALA A 456
 None
 1.48A 4xk8B-3vi3A:
undetectable		 4xk8B-3vi3A:
23.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZOW_A_CLMA500_0
(MULTIDRUG
TRANSPORTER MDFA)		 3vi3 INTEGRIN ALPHA-5
(Homo
sapiens) 		5 / 11 LEU A 394
LEU A 342
LEU A 402
LEU A 361
LEU A   3
 None
 0.96A 4zowA-3vi3A:
undetectable		 4zowA-3vi3A:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ALB_L_TIQL1210_2
(MEDI2452 LIGHT CHAIN)		 3vi3 INTEGRIN ALPHA-5
(Homo
sapiens) 		4 / 8 SER A 234
GLY A 251
ALA A 282
GLY A 260
 None
 0.84A 5albL-3vi3A:
undetectable		 5albL-3vi3A:
19.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5D0Y_A_FOLA201_0
(CONSERVED
HYPOTHETICAL
MEMBRANE PROTEIN)		 3vi3 INTEGRIN ALPHA-5
(Homo
sapiens) 		5 / 12 GLY A 333
ASP A 243
ASN A 266
THR A 245
VAL A 249
 None
CA  A2001 (-2.7A)
NAG  A2008 (-1.9A)
CA  A2001 (-4.8A)
None
 0.87A 5d0yA-3vi3A:
undetectable		 5d0yA-3vi3A:
14.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NZY_A_CE3A1103_1
(DNA CROSS-LINK
REPAIR 1A PROTEIN)		 3vi3 INTEGRIN ALPHA-5
(Homo
sapiens) 		4 / 8 TYR A 325
GLN A 280
ASP A 311
GLY A 352
 None
 0.88A 5nzyA-3vi3A:
undetectable		 5nzyA-3vi3A:
19.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OY0_B_PQNB1844_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A2)		 3vi3 INTEGRIN ALPHA-5
(Homo
sapiens) 		5 / 10 SER A 590
ILE A 499
ALA A 490
LEU A 488
ALA A 456
 None
 1.45A 5oy0b-3vi3A:
undetectable		 5oy0b-3vi3A:
8.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X80_A_SALA201_1
(UNCHARACTERIZED
HTH-TYPE
TRANSCRIPTIONAL
REGULATOR RV2887)		 3vi3 INTEGRIN ALPHA-5
(Homo
sapiens) 		4 / 5 VAL A 252
PRO A 183
GLY A 190
TYR A 230
 None
 1.42A 5x80A-3vi3A:
undetectable
5x80B-3vi3A:
undetectable		 5x80A-3vi3A:
14.17
5x80B-3vi3A:
14.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZHM_B_SAMB301_1
(TRNA
(GUANINE-N(1)-)-METH
YLTRANSFERASE)		 3vi3 INTEGRIN ALPHA-5
(Homo
sapiens) 		5 / 12 LEU A 394
GLY A 390
SER A 396
GLY A 392
GLY A 393
 None
 0.88A 5zhmB-3vi3A:
undetectable		 5zhmB-3vi3A:
17.86