SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3vk5'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ICU_B_NIOB219_1
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 3vk5 MOEO5
(Streptomyces
viridosporus) 		4 / 6 PHE A 215
GLU A 182
THR A 177
PHE A 160
 None
 1.12A 1icuA-3vk5A:
undetectable
1icuB-3vk5A:
undetectable		 1icuA-3vk5A:
21.91
1icuB-3vk5A:
21.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ICU_C_NIOC225_1
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 3vk5 MOEO5
(Streptomyces
viridosporus) 		4 / 6 THR A 177
PHE A 160
PHE A 215
GLU A 182
 None
 1.11A 1icuC-3vk5A:
undetectable
1icuD-3vk5A:
undetectable		 1icuC-3vk5A:
21.91
1icuD-3vk5A:
21.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1X8V_A_ESLA472_1
(CYTOCHROME P450 51)		 3vk5 MOEO5
(Streptomyces
viridosporus) 		4 / 6 VAL A  95
LEU A  96
PHE A  98
MET A  79
 None
 1.10A 1x8vA-3vk5A:
undetectable		 1x8vA-3vk5A:
23.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NYR_B_SVRB401_3
(NAD-DEPENDENT
DEACETYLASE
SIRTUIN-5)		 3vk5 MOEO5
(Streptomyces
viridosporus) 		5 / 12 PHE A 160
GLY A 161
ASN A 204
VAL A 227
TYR A 201
 None
None
None
None
FPQ  A 900 (-3.8A)
 1.44A 2nyrB-3vk5A:
undetectable		 2nyrB-3vk5A:
24.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q6O_A_SAMA500_0
(HYPOTHETICAL PROTEIN)		 3vk5 MOEO5
(Streptomyces
viridosporus) 		4 / 7 VAL A  95
ALA A  64
PRO A 118
THR A 155
 None
None
FPQ  A 900 ( 4.7A)
None
 1.08A 2q6oA-3vk5A:
undetectable		 2q6oA-3vk5A:
24.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LTW_A_HLZA300_1
(ARYLAMINE
N-ACETYLTRANSFERASE
NAT)		 3vk5 MOEO5
(Streptomyces
viridosporus) 		4 / 6 PHE A  43
TYR A  72
VAL A 109
PHE A  98
 None
 1.05A 3ltwA-3vk5A:
undetectable		 3ltwA-3vk5A:
24.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R9C_A_ECLA451_1
(CYTOCHROME P450
164A2)		 3vk5 MOEO5
(Streptomyces
viridosporus) 		5 / 10 ALA A 112
LEU A 115
LEU A 153
LEU A  66
VAL A 224
 None
 1.34A 3r9cA-3vk5A:
undetectable		 3r9cA-3vk5A:
24.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKX_A_STRA601_2
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 3vk5 MOEO5
(Streptomyces
viridosporus) 		4 / 6 LEU A 200
GLU A 182
VAL A 129
ALA A 119
 None
 0.98A 4nkxA-3vk5A:
undetectable		 4nkxA-3vk5A:
20.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JO9_A_SORA302_0
(RIBITOL
2-DEHYDROGENASE)		 3vk5 MOEO5
(Streptomyces
viridosporus) 		5 / 12 GLY A  35
PRO A  36
VAL A 248
PHE A  62
LEU A  60
 None
 1.41A 5jo9A-3vk5A:
undetectable		 5jo9A-3vk5A:
23.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_C_PCFC1805_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 3vk5 MOEO5
(Streptomyces
viridosporus) 		5 / 9 GLY A 167
LEU A 200
GLY A 124
PHE A 215
ILE A 183
 None
 0.92A 5vkqC-3vk5A:
undetectable
5vkqD-3vk5A:
undetectable		 5vkqC-3vk5A:
11.22
5vkqD-3vk5A:
11.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X7Z_A_BHAA201_0
(UNCHARACTERIZED
HTH-TYPE
TRANSCRIPTIONAL
REGULATOR RV2887)		 3vk5 MOEO5
(Streptomyces
viridosporus) 		4 / 6 LEU A 219
VAL A 198
LEU A 200
VAL A 156
 None
 0.90A 5x7zA-3vk5A:
undetectable		 5x7zA-3vk5A:
21.77